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Mihalis S. Kariolis · SciRah

Researcher profile · Semantic Scholar

Mihalis S. Kariolis

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Mihalis S. Kariolis — researcher profile on SciRah

h-index: 17
Works: 35
Citations: 1,998

Most-cited papers

Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys
Mihalis S. Kariolis, R. C. Wells, Jennifer A. Getz, W. Kwan +28 more
2020Science Translational Medicine312 citations
Semantic Scholar
Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET
Erinn B. Rankin, K. Fuh, L. Castellini, K. Viswanathan +10 more
2014Proceedings of the National Academy of Sciences of the United States of America256 citations Open access
Semantic Scholar
Rescue of a lysosomal storage disorder caused by Grn loss-of-function with a brain penetrant progranulin biologic
Todd Logan, Matthew J. Simon, A. Rana, G. M. Cherf +49 more
2021Cell204 citations Open access
Semantic Scholar
Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice
Julie C. Ullman, Annie Arguello, Jennifer A. Getz, Akhil Bhalla +42 more
2020Science Translational Medicine177 citations
Semantic Scholar
Reprogramming the immunological microenvironment through radiation and targeting Axl
T. Aguilera, M. Rafat, L. Castellini, Hussein Shehade +11 more
2016Nature Communications175 citations Open access
Semantic Scholar
An engineered Axl ‘decoy receptor’ effectively silences the Gas6/Axl signaling axis
Mihalis S. Kariolis, Y. Miao, Douglas S. Jones, Shiven Kapur +3 more
2014Nature Chemical Biology139 citations Open access
Semantic Scholar
Carbon nanotubes increase the electrical conductivity of fibroblast-seeded collagen hydrogels.
Rebecca A Macdonald, Christopher M Voge, Mihalis S. Kariolis, J. Stegemann
2008Acta Biomaterialia135 citations
Semantic Scholar
Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies
Mihalis S. Kariolis, Y. Miao, Anh Diep, Shannon E. Nash +9 more
2017Journal of Clinical Investigation97 citations Open access
Semantic Scholar
CD98hc is a target for brain delivery of biotherapeutics
Kylie S Chew, R. C. Wells, A. Moshkforoush, Darren Chan +46 more
2023Nature Communications84 citations Open access
Semantic Scholar
Molecular architecture determines brain delivery of a transferrin receptor–targeted lysosomal enzyme
Annie Arguello, Cathal S. Mahon, Meredith E. K. Calvert, D. Chan +31 more
2021bioRxiv79 citations Open access
Semantic Scholar
Directional conductivity in SWNT-collagen-fibrin composite biomaterials through strain-induced matrix alignment.
Christopher M Voge, Mihalis S. Kariolis, Rebecca A Macdonald, J. Stegemann
2008Journal of Biomedical Materials Research. Part A67 citations
Semantic Scholar
Neutralization of PD-L2 is Essential for Overcoming Immune Checkpoint Blockade Resistance in Ovarian Cancer
Y. Miao, Kaushik N. Thakkar, Jin Qian, Mihalis S. Kariolis +15 more
2021Clinical Cancer Research56 citations Open access
Semantic Scholar
Transferrin receptor-targeted anti-amyloid antibody enhances brain delivery and mitigates ARIA.
Michelle E. Pizzo, E. Plowey, Nathalie Khoury, W. Kwan +45 more
2025Science55 citations
Semantic Scholar
Beyond antibodies: using biological principles to guide the development of next-generation protein therapeutics.
Mihalis S. Kariolis, Shiven Kapur, J. Cochran
2013Current Opinion in Biotechnology46 citations
Semantic Scholar
Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration
Marvin Reich, Matthew J. Simon, Beate Polke, Iñaki Paris +23 more
2024Science Translational Medicine27 citations Open access
Semantic Scholar
Dual targeting of transferrin receptor and CD98hc enhances brain exposure of large molecules
Robert C. Wells, Padma Akkapeddi, Darren Chan, David Joy +33 more
2025bioRxiv21 citations
Semantic Scholar
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two
C. Ager, M. Reilley, C. Nicholas, Todd Bartkowiak +496 more
2016Journal for ImmunoTherapy of Cancer18 citations Open access
Semantic Scholar
Engineering High Affinity Protein-Protein Interactions Using a High-Throughput Microcapillary Array Platform.
Sungwon Lim, Bob Chen, Mihalis S. Kariolis, I. Dimov +2 more
2017ACS Chemical Biology12 citations
Semantic Scholar
Induced tumor heterogeneity reveals factors informing radiation and immunotherapy combinations
T. Aguilera, E. Elghonaimy, Hussein Shehade, M. Rafat +9 more
2020Clinical Cancer Research10 citations Open access
Semantic Scholar
Engineering anti-amyloid antibodies with transferrin receptor targeting improves brain biodistribution and mitigates ARIA
Michelle E. Pizzo, E. Plowey, Nathalie Khoury, W. Kwan +39 more
2024bioRxiv7 citations
Semantic Scholar
Enhanced legumain activity links progranulin deficiency to TDP-43 pathology in frontotemporal lobar degeneration
Sophie Robinson, Marvin Reich, Maria-Teresa Mühlhofer, Katrin Buschmann +21 more
2024bioRxiv6 citations Open access
Semantic Scholar
Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic
Todd Logan, Matthew J. Simon, Anil Rana, G. M. Cherf +49 more
2024Cell6 citations Open access
Semantic Scholar
Engineering anti-amyloid antibodies with transferrin receptor targeting improves safety and brain biodistribution
Michelle E. Pizzo, E. Plowey, Nathalie Khoury, W. Kwan +43 more
5 citations
Semantic Scholar
Tumor immunologic heterogeneity influences response to radiation and combination immunotherapy
T. Aguilera, M. Rafat, Mihalis S. Kariolis, R. von Eyben +2 more
2015Journal of Immunotherapy for Cancer4 citations Open access
Semantic Scholar
Neutralizing PD-L1 and PD-L2 Enhances the Efficacy of Immune Checkpoint Inhibitors in Ovarian Cancer
Y. Miao, Kaushik N. Thakkar, Jin Qian, Mihalis S. Kariolis +14 more
2020bioRxiv3 citations Open access
Semantic Scholar
A Common PD-Risk GBA1 Variant Disrupts LIMP2 Interaction, Impairs Glucocerebrosidase Function, and Drives Lysosomal and Mitochondrial Dysfunction
Oliver B. Davis, Jennifer E. Kung, Sonnet S. Davis, Rajarshi Ghosh +32 more
2025bioRxiv2 citations Open access
Semantic Scholar
Author Correction: CD98hc is a target for brain delivery of biotherapeutics
Kylie S. Chew, Robert C. Wells, Arash Moshkforoush, Darren Chan +46 more
2023Nature Communications2 citations Open access
Semantic Scholar
Rescue of FTLD-associated TDP-43 pathology and neurodegeneration by peripheral AAV-mediated expression of brain-penetrant progranulin
Marvin Reich, Matthew J. Simon, Beate Polke, G. Werner +22 more
2023bioRxiv1 citations Open access
Semantic Scholar
Brain delivery and efficacy of an intravenously-administered lysosomal enzyme using a blood-brain barrier transport vehicle
Anastasia G. Henry, Julie C. Ullman, Annie Arguello, Jennifer A. Getz +21 more
20201 citations
Semantic Scholar
Novel FACS based method demonstrates CNS cell-type distribution and efficacy of a BBB penetrant ERT in a mouse model of MPS II
Julie C. Ullman, Alicia A. Nugent, Annie Arguello, Akhil Bhalla +18 more
20201 citations
Semantic Scholar
Improved brain uptake and efficacy of iduronate 2-sulfatase with the enzyme transport vehicle
Anastasia G. Henry, Mihalis S. Kariolis, Julie C. Ullman, Jennifer A. Getz +21 more
2019Molecular Genetics and Metabolism1 citations
Semantic Scholar
Directional conductivity in protein-nanotube biomaterials through strain-induced matrix alignment
Christopher M Voge, Mihalis S. Kariolis, Rebecca A Macdonald, J. Stegemann
20081 citations
Semantic Scholar
High-affinity AXL decoy receptor
I. I. Mathrews, Shiven Kapur, Mihalis S. Kariolis, J. Cochran
20170 citations
Semantic Scholar
Abstract 4988: Reprogramming the immunologic microenvironment through radiation and Axl targeting
T. Aguilera, M. Rafat, L. Castellini, Mihalis S. Kariolis +3 more
20160 citations
Semantic Scholar
Tumor Immunologic Heterogeneity Influences Response to Radiation and Anti-PD-1 Immunotherapy
T. Aguilera, M. Rafat, Mihalis S. Kariolis, E. Graves +1 more
20150 citations
Semantic Scholar

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