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L. J. Hunter · SciRah

Researcher profile · Semantic Scholar

L. J. Hunter

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L. J. Hunter — researcher profile on SciRah

h-index: 9
Works: 20
Citations: 650

Most-cited papers

Up-regulation of p21(WAF1/CIP1) by histone deacetylase inhibitors reduces their cytotoxicity.
A. Burgess, S. Pavey, Robyn Warrener, L. J. Hunter +5 more
2001Molecular Pharmacology147 citations Open access
Semantic Scholar
Discovery of 4-Amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides As Selective, Orally Active Inhibitors of Protein Kinase B (Akt)
T. McHardy, J. Caldwell, Kwai-Ming J. Cheung, L. J. Hunter +14 more
2010Journal of Medicinal Chemistry85 citations Open access
Semantic Scholar
Regulation of cyclin expression and cell cycle progression in breast epithelial cells by the helix–loop–helix protein Id1
A. Swarbrick, M. C. Åkerfeldt, Christine S. L. Lee, C. M. Sergio +4 more
2005Oncogene75 citations
Semantic Scholar
Preclinical pharmacology, antitumor activity and development of pharmacodynamic markers for the novel, potent AKT inhibitor CCT128930
T. Yap, M. Walton, L. J. Hunter, M. Valenti +15 more
2010Molecular Cancer Therapeutics71 citations Open access
Semantic Scholar
Rapid evolution of 6-phenylpurine inhibitors of protein kinase B through structure-based design.
A. Donald, T. McHardy, M. Rowlands, L. J. Hunter +6 more
2007Journal of Medicinal Chemistry63 citations Open access
Semantic Scholar
AT7867 is a potent and oral inhibitor of AKT and p70 S6 kinase that induces pharmacodynamic changes and inhibits human tumor xenograft growth
Kyla M. Grimshaw, L. J. Hunter, T. Yap, S. Heaton +11 more
2010Molecular Cancer Therapeutics58 citations Open access
Semantic Scholar
Cyclin D1 Overexpression Induces Progestin Resistance in T-47D Breast Cancer Cells Despite p27Kip1 Association with Cyclin E-Cdk2*
E. Musgrove, L. J. Hunter, Christine S. L. Lee, A. Swarbrick +2 more
2001Journal of Biological Chemistry57 citations Open access
Semantic Scholar
Application of Meso Scale Technology for the Measurement of Phosphoproteins in Human Tumor Xenografts
Sharon M. Gowan, A. Hardcastle, A. Hallsworth, M. Valenti +7 more
2007Assay and drug development technologies50 citations
Semantic Scholar
Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B.
I. Collins, J. Caldwell, T. Fonseca, A. Donald +13 more
2006Bioorganic & Medicinal Chemistry35 citations Open access
Semantic Scholar
Is a Potent and Oral Inhibitor of AKT and p 70 S 6 Kinase That Induces Pharmacodynamic Changes and Inhibits Human Tumor Xenograft Growth
Kyla M. Grimshaw, L. J. Hunter, T. Yap, S. Heaton +11 more
20109 citations
Semantic Scholar
322 Novel isoquinoline-5-sulfonamides as biochemical and cellular inhibitors of PKB/AKt
M. Garrett, L. J. Hunter, T. F. Da Fonseca, J. Caldwell +6 more
20042 citations
Semantic Scholar
Abstract 4481: First report of preclinical pharmacology of two novel potent AKT inhibitors and development of pharmacodynamic (PD) biomarkers in tumor and surrogate tissue
T. Yap, M. Walton, L. J. Hunter, Kyla M. Grimshaw +12 more
20100 citations
Semantic Scholar
Structure of 4-(4-tert-Butylbenzyl)-1-(7H-pyrrolo(2,3-d)pyrimidin-4- yl)piperidin-4-amine bound to PKB
T. G. Davies, T. McHardy, J. Caldwell, Kwai-Ming J. Cheung +14 more
20100 citations
Semantic Scholar
Structure of 4-Amino-N-(4-chlorobenzyl)-1-(7H-pyrrolo(2,3-d)pyrimidin- 4-yl)piperidine-4-carboxamide bound to PKB
T. G. Davies, T. McHardy, J. Caldwell, Kwai-Ming J. Cheung +14 more
20100 citations
Semantic Scholar
Structure of PKA-PKB chimera complexed with 6-(4-(4-(4-Chloro-phenyl) -piperidin-4-yl)-phenyl)-9H-purine
T. G. Davies, A. Donald, T. McHardy, M. Rowlands +5 more
20070 citations
Semantic Scholar
Structure of PKA-PKB chimera complexed with methyl-(4-(9H-purin-6-yl)- benzyl)-amine
T. G. Davies, A. Donald, T. McHardy, M. Rowlands +5 more
20070 citations
Semantic Scholar
Structure of PKA-PKB chimera complexed with 7-azaindole
T. G. Davies, A. Donald, T. McHardy, M. Rowlands +5 more
20070 citations
Semantic Scholar
Structure of PKA-PKB chimera complexed with C-Phenyl-C-(4-(9H-purin-6- yl)-phenyl)-methylamine
T. G. Davies, A. Donald, T. McHardy, M. Rowlands +5 more
20070 citations
Semantic Scholar
Structure of cAMP-dependent protein kinase complexed with Isoquinoline-5-sulfonic acid (2-(2-(4-chlorobenzyloxy)ethylamino) ethyl)amide
I. Collins, J. Caldwell, T. F. Da Fonseca, A. Donald +12 more
20050 citations
Semantic Scholar
Structure of cAMP-dependent protein kinase complexed with (4R,2S)-5'-(4-(4-Chlorobenzyloxy)pyrrolidin-2-ylmethanesulfonyl)isoquinoline
I. Collins, J. Caldwell, T. F. Da Fonseca, A. Donald +12 more
20050 citations
Semantic Scholar

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