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H. Hirano · SciRah

Researcher profile · Semantic Scholar

H. Hirano

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H. Hirano — researcher profile on SciRah

h-index: 12
Works: 29
Citations: 2,895

Most-cited papers

Engineered CRISPR-Cas9 nuclease with expanded targeting space
H. Nishimasu, Xi Shi, Soh Ishiguro, L. Gao +17 more
2018Science975 citations Open access
Semantic Scholar
Crystal structure of Cpf1 in complex with guide RNA and target DNA
T. Yamano, H. Nishimasu, Bernd Zetsche, H. Hirano +9 more
2016Cell686 citations Open access
Semantic Scholar
Structure and Engineering of Francisella novicida Cas9
H. Hirano, J. Gootenberg, T. Horii, Omar O. Abudayyeh +8 more
2016Cell340 citations Open access
Semantic Scholar
Structure of the miniature type V-F CRISPR-Cas effector enzyme.
S. Takeda, R. Nakagawa, S. Okazaki, H. Hirano +6 more
2020Molecules and Cells169 citations Open access
Semantic Scholar
Crystal Structure of the Minimal Cas9 from Campylobacter jejuni Reveals the Molecular Diversity in the CRISPR-Cas9 Systems.
Mari Yamada, Yuto Watanabe, J. Gootenberg, H. Hirano +6 more
2017Molecules and Cells158 citations Open access
Semantic Scholar
Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1
Kazuki Kato, H. Nishimasu, Daisuke Oikawa, S. Hirano +5 more
2018Nature Communications156 citations Open access
Semantic Scholar
An AsCas12f-based compact genome-editing tool derived by deep mutational scanning and structural analysis.
Tomohiro Hino, Satoshi N. Omura, R. Nakagawa, T. Togashi +23 more
2023Cell117 citations Open access
Semantic Scholar
Cryo-EM structure of the transposon-associated TnpB enzyme
R. Nakagawa, H. Hirano, Satoshi N. Omura, Suchita P. Nety +18 more
2023Nature99 citations Open access
Semantic Scholar
Structural basis for pegRNA-guided reverse transcription by a prime editor
Yuta Shuto, R. Nakagawa, Shiyou Zhu, Mizuki Hoki +5 more
2024Nature42 citations Open access
Semantic Scholar
Structure and engineering of the minimal type VI CRISPR-Cas13bt3
R. Nakagawa, Soumya Kannan, Altae-Tran Han, S. Takeda +8 more
2022Molecules and Cells41 citations Open access
Semantic Scholar
Structure of the type V-C CRISPR-Cas effector enzyme
N. Kurihara, R. Nakagawa, H. Hirano, S. Okazaki +8 more
2022Molecules and Cells37 citations Open access
Semantic Scholar
Mechanistic and evolutionary insights into a type V-M CRISPR–Cas effector enzyme
Satoshi N. Omura, R. Nakagawa, C. Sudfeld, Ricardo Villegas Warren +9 more
2023Nature Structural & Molecular Biology29 citations Open access
Semantic Scholar
Insights into G-protein coupling preference from cryo-EM structures of Gq-bound PTH1R
Fumiya K. Sano, Kota Shimizume, Kazuhiro Kobayashi, Toshikuni Awazu +16 more
2025Nature Chemical Biology12 citations Open access
Semantic Scholar
Expanded genetic alphabet increases structural and chemical diversity of six-letter DNA for high-affinity protein-targeting aptamers
Kazuhiro Sawada, Michiko Kimoto, Ken-ichiro Matsunaga, Hui-Pen Tan +9 more
2025Nature Communications11 citations Open access
Semantic Scholar
Structural insights into how Cas9 targets nucleosomes
R. Nagamura, T. Kujirai, Junko Kato, Yuta Shuto +7 more
2024Nature Communications10 citations Open access
Semantic Scholar
Structural basis for target DNA cleavage and guide RNA processing by CRISPR-Casλ2
Satoshi N. Omura, Lauren E. Alfonse, Alexa Ornstein, H. Morinaga +11 more
2025Communications Biology5 citations Open access
Semantic Scholar
Structural basis for DNA processing and membrane translocation by ComEC in natural transformation.
H. Hirano, Naoko Tsuji, Shinobu Chiba, O. Nureki
2026Science4 citations
Semantic Scholar
Engineering a compact high-fidelity Staphylococcus aureus Cas9 variant with broader targeting range and mechanistic insights into its activation
Satoshi N. Omura, R. Nakagawa, Shohei Kajimoto, S. Okazaki +15 more
2026Nature Communications3 citations Open access
Semantic Scholar
Molecular mechanism of CRISPR
O. Nureki, H. Hirano, S. Hirano, T. Yamano +1 more
20172 citations Open access
Semantic Scholar
Structure and evolution of the sequence-specific anti-silencing factor VANC21 and its target DNA.
Yusaku Tanaka, A. Osakabe, W. Shihoya, H. Hirano +3 more
2025Genes & Genetic Systems1 citations Open access
Semantic Scholar
Structural basis of lipid-mediated gating in a two-pore domain potassium channel
Fumiya K. Sano, G. Kasuya, Kohei Yamaguchi, Takehiro Suzuki +12 more
2025bioRxiv1 citations
Semantic Scholar
Cryo-EM structure of the Cas12f1-sgRNA-target DNA complex
N. Takeda, R. Nakagawa, S. Okazaki, H. Hirano +6 more
20200 citations
Semantic Scholar
Crystal structure of ENPP1 in complex with 3'3'-cGAMP
K. Kato, H. Nishimasu, S. Hirano, H. Hirano +2 more
20190 citations
Semantic Scholar
Crystal structure of ENPP1 in complex with pApG
K. Kato, H. Nishimasu, S. Hirano, H. Hirano +2 more
20190 citations
Semantic Scholar
Structure-based development of genome-editing tools of CRISPR-Cas towards medical applications
H. Hirano, Mari Yamada, T. Yamano, H. Nishimasu +1 more
20170 citations
Semantic Scholar
Crystal structure of Campylobacter jejuni Cas9 in complex with sgRNA and target DNA (AGAAACA PAM)
Mari Yamada, Yuto Watanabe, H. Hirano, T. Nakane +3 more
20170 citations
Semantic Scholar
Crystal structure of Acidaminococcus sp. Cpf1 in complex with crRNA and target DNA
T. Yamano, H. Nishimasu, H. Hirano, T. Nakane +2 more
20160 citations
Semantic Scholar
Crystal structure of Francisella novicida Cas9 RHA in complex with sgRNA and target DNA (TGG PAM)
H. Hirano, H. Nishimasu, T. Nakane, R. Ishitani +1 more
20160 citations
Semantic Scholar
Structure-based engineering of the PAM specificity of Cas9
H. Hirano, H. Nishimasu, O. Nureki
20150 citations
Semantic Scholar

Frequent co-authors

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O. Nureki×20
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O. Nureki — researcher profile on SciRah
H. Nishimasu×18
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H. Nishimasu — researcher profile on SciRah
R. Ishitani×11
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R. Nakagawa×9
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T. Kusakizako — researcher profile on SciRah

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O. Nureki — researcher profile on SciRah

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Yuzuru Itoh — researcher profile on SciRah

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T. Nakane — researcher profile on SciRah

Satoshi N. Omura×6

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Satoshi N. Omura — researcher profile on SciRah

Yoshiaki Kise×6

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Yoshiaki Kise — researcher profile on SciRah

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S. Hirano — researcher profile on SciRah

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S. Okazaki — researcher profile on SciRah