Ian S. Hitchcock

Most-cited papers

1. Thrombopoietin from beginning to end

   Ian S. Hitchcock, K. Kaushansky

   2014British Journal of Haematology205 citations Open access

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2. Single-Cell Analyses Reveal Megakaryocyte-Biased Hematopoiesis in Myelofibrosis and Identify Mutant Clone-Specific Targets

   B. Psaila, Guan-Lin Wang, A. Rodriguez-Meira, Rong Li +17 more

   2020Molecules and Cells157 citations Open access

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3. Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

   S. Wilmes, M. Hafer, Joni Vuorio, J. Tucker +14 more

   2020Science154 citations Open access

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4. Ubiquitination and degradation of the thrombopoietin receptor c-Mpl.

   S. Saur, Veena Sangkhae, A. Geddis, K. Kaushansky +1 more

   2010Blood100 citations Open access

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5. Roles of focal adhesion kinase (FAK) in megakaryopoiesis and platelet function: studies using a megakaryocyte lineage specific FAK knockout.

   Ian S. Hitchcock, N. Fox, N. Prévost, K. Sear +2 more

   2008Blood99 citations Open access

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6. JAK2V617F-positive endothelial cells contribute to clotting abnormalities in myeloproliferative neoplasms

   S. L. Etheridge, Michelle E. Roh, Megan E. Cosgrove, Veena Sangkhae +5 more

   2014Proceedings of the National Academy of Sciences of the United States of America94 citations Open access

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7. The thrombopoietin receptor, MPL, is critical for development of a JAK2V617F-induced myeloproliferative neoplasm.

   Veena Sangkhae, S. L. Etheridge, K. Kaushansky, Ian S. Hitchcock

   2014Blood86 citations Open access

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8. YRRL motifs in the cytoplasmic domain of the thrombopoietin receptor regulate receptor internalization and degradation.

   Ian S. Hitchcock, Maximus M Chen, J. King, K. Kaushansky

   2007Blood84 citations Open access

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9. A novel activating, germline JAK2 mutation, JAK2R564Q, causes familial essential thrombocytosis.

   S. L. Etheridge, Megan E. Cosgrove, Veena Sangkhae, L. Corbo +4 more

   2014Blood67 citations Open access

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10. Essential components for a glutamatergic synapse between Merkel cell and nerve terminal in rats.

    Ian S. Hitchcock, P. Genever, P. Cahusac

    2004Neuroscience Letters61 citations

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11. NMDA receptor-mediated regulation of human megakaryocytopoiesis.

    Ian S. Hitchcock, T. Skerry, M. Howard, P. Genever

    2003Blood59 citations

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12. The Thrombopoietin receptor: Revisiting the master regulator of platelet production.

    Ian S. Hitchcock, M. Hafer, Veena Sangkhae, J. Tucker

    2021Platelets57 citations Open access

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13. Structure of the thrombopoietin MPL receptor complex is a blueprint for biasing hematopoiesis

    N. Tsutsumi, Zahra Masoumi, Sophie C. James, J. Tucker +11 more

    2023Cell47 citations Open access

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14. Emerging neuroskeletal signalling pathways: a review

    Gary J. Spencer, Ian S. Hitchcock, P. Genever

    2004FEBS Letters46 citations Open access

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15. Systematic analysis of microRNA fingerprints in thrombocythemic platelets using integrated platforms.

    Xiao Xu, D. Gnatenko, J. Ju, Ian S. Hitchcock +3 more

    2012Blood44 citations Open access

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16. Quantifying single-cell secretion in real time using resonant hyperspectral imaging

    José Juan-Colás, Ian S. Hitchcock, M. Coles, Steven D. Johnson +1 more

    2018Proceedings of the National Academy of Sciences of the United States of America36 citations Open access

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17. Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors

    L. Cui, I. Moraga, Tristan Lerbs, Camille van Neste +13 more

    2020Proceedings of the National Academy of Sciences of the United States of America33 citations Open access

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18. Compound heterozygous c-Mpl mutations in a child with congenital amegakaryocytic thrombocytopenia: Functional characterization and a review of the literature

    N. Fox, Rose Chen, Ian S. Hitchcock, J. Keates-Baleeiro +2 more

    2009Experimental Hematology28 citations Open access

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19. Discovery of INCA033989, a Monoclonal Antibody That Selectively Antagonizes Mutant Calreticulin Oncogenic Function in Myeloproliferative Neoplasms (MPNs)

    Edimara Reis, Rebecca A Buonpane, H. Çelik, C. Marty +12 more

    2022Blood27 citations Open access

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20. Phosphorylated c-MPL tyrosine 591 regulates thrombopoietin-induced signaling

    Veena Sangkhae, S. Saur, A. Kaushansky, K. Kaushansky +1 more

    2014Experimental Hematology19 citations Open access

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21. CD4+ T Cells Alter the Stromal Microenvironment and Repress Medullary Erythropoiesis in Murine Visceral Leishmaniasis

    O. Preham, F. A. Pinho, A. Pinto, Gulab Fatima Rani +4 more

    2018Frontiers in Immunology17 citations Open access

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22. A Novel Activating JAK2 Mutation, JAK2R564Q, Causes Familial Essential Thrombocytosis (fET) Via Mechanisms Distinct From JAK2V617F

    L. Etheridge, L. Corbo, K. Kaushansky, E. Chan +1 more

    201115 citations

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23. Dissecting pathways to thrombocytopenia in a mouse model of visceral leishmaniasis.

    Gulab Fatima Rani, O. Preham, H. Ashwin, Najmeeyah Brown +2 more

    2021Blood Advances13 citations Open access

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24. Off-targets effects underlie the inhibitory effect of FAK inhibitors on platelet activation: studies using Fak-deficient mice

    M. Roh, Megan E. Cosgrove, K. Gorski, Ian S. Hitchcock

    2013Journal of Thrombosis and Haemostasis13 citations Open access

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25. G12/13 Signaling Pathways Substitute for Integrin αIIbβ3-Signaling for Thromboxane Generation in Platelets

    Kamala Bhavaraju, Parth Lakhani, R. Dorsam, Jian-Guo Jin +3 more

    2011PLoS ONE12 citations Open access

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26. Bone marrow remodeling supports hematopoiesis in response to immune thrombocytopenia progression in mice

    Oliver J Herd, Gulab Fatima Rani, James P. Hewitson, Karen G. Hogg +5 more

    2021Blood Advances11 citations Open access

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27. Quantitative Optical Diffraction Tomography Imaging of Mouse Platelets

    T. Stanly, R. Suman, Gulab Fatima Rani, P. O'Toole +2 more

    2020Frontiers in Physiology11 citations Open access

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28. Endothelial JAK2V617F Expression Drives Inflammation and Cellular Senescence; New Evidence for the Roles of Endothelial Cells in MPN-Related Clotting Abnormalities?

    Megan E. Cosgrove, R. Suman, H. Harrison, G. Jackson +2 more

    20166 citations

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29. Thrombopoietin promotes beta1-integrin-mediated adhesion in hematopoietic cells via the small GTPase Rapl.

    Ian S. Hitchcock, K. Kaushansky

    2007Experimental Hematology4 citations

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30. Thrombopoietin promotes β1-integrin–mediated adhesion in hematopoietic cells via the small GTPase Rap1

    Ian S. Hitchcock, K. Kaushansky

    20073 citations Open access

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31. Hematological consequences of malaria infection in mice previously treated for visceral leishmaniasis

    Gulab Fatima Rani, H. Ashwin, Najmeeyah Brown, Ian S. Hitchcock +1 more

    2021Wellcome Open Research2 citations Open access

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32. Understanding the Mechanisms Underlying Thrombocytopenia in Visceral Leishmaniasis

    Gulab Fatima Rani, O. Preham, Ian S. Hitchcock, P. Kaye

    2019Blood2 citations Open access

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33. Tuning TPO-R signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia

    L. Cui, I. Moraga, Tristan Lerbs, Camille van Neste +13 more

    2020bioRxiv1 citations Open access

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34. New Paradigms for the Mechanisms of Thrombopoietin Receptor Activation and Dysregulation By the JAK2V617F Mutation

    S. Wilmes, M. Hafer, T. Stanly, I. Moraga +11 more

    2019Blood1 citations Open access

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35. Thrombopoietin Promotes b1 Integrin-Mediated Adhesion in Hematopoietic Cells Via the Small GTPase Rap1.

    Ian S. Hitchcock, K. Kaushansky

    20061 citations

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36. Glutamate: Teaching Old Bones New Tricks—Implications for Skeletal Biology

    Gary J. Spencer, Ian S. Hitchcock, P. Genever

    20051 citations

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37. Minireview Emerging neuroskeletal signalling pathways: a review

    Gary J. Spencer, Ian S. Hitchcock, P. Genever

    20041 citations

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38. Functional activity of NMDA receptors on megakaryocytes

    Ian S. Hitchcock

    20031 citations

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39. Extracellular matrices of bone marrow stroma regulate cell phenotype and contribute to distinct stromal niches in vivo

    A. Stone, Emma Rand, Gabriel Thornes, A. Kay +3 more

    2023bioRxiv0 citations Open access

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40. 2018 – UNRAVELLING THE EFFECTS OF THE JAK2 V617F MUTATION ON HIF-1 FUNCTION AT THE CHROMATIN

    D. Kealy, Cathy Hawley, Ruth Ellerington, B. Ferreira +5 more

    2023Experimental Hematology0 citations Open access

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41. S252: MODULATING HEMATOPOIESIS: ENGINEERING TPO VARIANTS WITH DISTINCT HEMATOPOIETIC FUNCTION

    Zahra Masoumi, Lucie Moss, Julie Tucker, Sophie James +5 more

    2023HemaSphere0 citations Open access

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42. 3162 – DISTINCT CELLULAR RESPONSE OF PRELEUKAEMIC TET2 MUTANT PROGENITORS TO MECHANICAL COMPRESSION

    R. Rezk, M. Jassinskaja, Monika Gonka, J. Mediavillo +16 more

    2023Experimental Hematology0 citations

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43. 3167 – A NOVEL MICROFLUIDIC DEVICE FOR INVESTIGATING NORMAL AND MALIGNANT HEMATOPOIETIC STEM CELL FATE UNDER COMPRESSIVE STRESSES

    R. Rezk, M. Jassinskaja, Monika Gonka, Fiona Bain +14 more

    2022Experimental Hematology0 citations Open access

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44. Pre-clinical investigation of inhibition of the DNA damage response as a targetted therapy in myeloproliferative neoplasms shows synergism of ATR inhibitors with standard-of-care treatment.

    A. Ślusarczyk, Helen E. Bryant, E. Chen, Ian S. Hitchcock +3 more

    2021Proceedings of The 1st International Electronic Conference on Cancers: Exploiting Cancer Vulnerability by Targeting the DNA Damage Response0 citations Open access

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45. Novel ET mutations: stuck in the MPL with you.

    Ian S. Hitchcock

    2020Blood0 citations

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46. The secretome of mesenchymal stromal cells drives functional heterogeneity

    A. Stone, R. Crossland, Emma Rand, A. Kay +6 more

    2020Bone Reports0 citations Open access

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47. An Adapting Bone Marrow Niche Creates a Nurturing Environment for Hematopoiesis during Immune Thrombocytopenia Progression

    Oliver Herd, Maria Garcia, James P. Hewitson, Karen G. Hogg +5 more

    2019Blood0 citations

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48. CD4 + T cells alter the stromal microenvironment and repress 1 medullary erythropoiesis in murine visceral leishmaniasis. 2

    O. Preham, F. A. Pinho, A. Pinto, Gulab Fatima Rani +5 more

    20190 citations

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49. regulate receptor internalization and degradation YRRL motifs in the cytoplasmic domain of the thrombopoietin receptor

    Ian S. Hitchcock, Maximus M Chen, J. King, K. Kaushansky

    20130 citations

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50. using integrated platforms Systematic analysis of microRNA fingerprints in thrombocythemic platelets

    Xiao Xu, D. Gnatenko, J. Ju, Ian S. Hitchcock +3 more

    20130 citations

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