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N. Tsutsumi · SciRah

Researcher profile · Semantic Scholar

N. Tsutsumi

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N. Tsutsumi — researcher profile on SciRah

h-index: 18
Works: 39
Citations: 1,372

Most-cited papers

Structure-based decoupling of the pro- and anti-inflammatory functions of interlukin-10
R. Saxton, N. Tsutsumi, L. Su, Gita C. Abhiraman +5 more
2021Science216 citations Open access
Semantic Scholar
Structure of a Janus Kinase cytokine receptor complex reveals the basis for dimeric activation
C. Glassman, N. Tsutsumi, R. Saxton, P. Lupardus +2 more
2022Science156 citations Open access
Semantic Scholar
The structural basis for receptor recognition of human interleukin-18
N. Tsutsumi, Takeshi Kimura, K. Arita, M. Ariyoshi +9 more
2014Nature Communications142 citations Open access
Semantic Scholar
Structure of the IFNγ receptor complex guides design of biased agonists
J. L. Mendoza, N. Escalante, K. Jude, J. S. Bellón +8 more
2019Nature120 citations Open access
Semantic Scholar
Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling
N. Tsutsumi, S. Mukherjee, D. Waghray, C. Y. Janda +7 more
2020eLife107 citations Open access
Semantic Scholar
Organizing structural principles of the IL-17 ligand–receptor axis
Steven C. Wilson, N. Caveney, Michelle Yen, Christoph Pollmann +6 more
2022Nature84 citations Open access
Semantic Scholar
Structure and selectivity engineering of the M1 muscarinic receptor toxin complex
S. Maeda, Jun Xu, F. M. N. Kadji, M. Clark +7 more
2020Science55 citations Open access
Semantic Scholar
Structural basis of Janus kinase trans-activation
N. Caveney, R. Saxton, D. Waghray, C. Glassman +3 more
2023Cell Reports53 citations Open access
Semantic Scholar
Structure of the Wnt–Frizzled–LRP6 initiation complex reveals the basis for coreceptor discrimination
N. Tsutsumi, Sunhee Hwang, D. Waghray, Simon Hansen +8 more
2022bioRxiv49 citations Open access
Semantic Scholar
Structure of the thrombopoietin MPL receptor complex is a blueprint for biasing hematopoiesis
N. Tsutsumi, Zahra Masoumi, Sophie C. James, J. Tucker +11 more
2023Cell47 citations Open access
Semantic Scholar
Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy
Timothy F. Miles, K. Spiess, K. Jude, N. Tsutsumi +8 more
2018eLife41 citations Open access
Semantic Scholar
Structural basis for the constitutive activity and immunomodulatory properties of the Epstein-Barr virus-encoded G protein-coupled receptor BILF1
N. Tsutsumi, Q. Qu, Maša Mavri, Maibritt S Baggesen +7 more
2021Immunity38 citations Open access
Semantic Scholar
Structure of the IL-27 quaternary receptor signaling complex
Nathanael A. Caveney, C. Glassman, K. Jude, N. Tsutsumi +1 more
2022bioRxiv36 citations Open access
Semantic Scholar
Expanded π-electron systems, tri(phenanthro)hexaazatriphenylenes and tri(phenanthrolino)hexaazatriphenylenes, that are self-assembled to form one-dimensional aggregates.
Tsutomu Ishi-i, Ryo Hirashima, N. Tsutsumi, Shogo Amemori +4 more
2010Journal of Organic Chemistry35 citations Open access
Semantic Scholar
Functional assessment of the mutational effects of human IRAK4 and MyD88 genes.
Takahiro Yamamoto, N. Tsutsumi, H. Tochio, Hidenori Ohnishi +4 more
2014Molecular Immunology34 citations Open access
Semantic Scholar
Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors
L. Cui, I. Moraga, Tristan Lerbs, Camille van Neste +13 more
2020Proceedings of the National Academy of Sciences of the United States of America33 citations Open access
Semantic Scholar
Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins
N. Tsutsumi, S. Maeda, Q. Qu, Martin Vögele +10 more
2022Science Advances32 citations Open access
Semantic Scholar
Viral G Protein–Coupled Receptors Encoded by β- and γ-Herpesviruses
M. Rosenkilde, N. Tsutsumi, J. M. Knerr, D. F. Kildedal +1 more
2022Annual Review of Virology30 citations Open access
Semantic Scholar
An innate interaction between IL-18 and the propeptide that inactivates its precursor form
N. Tsutsumi, Ayumi Yokota, Takeshi Kimura, Z. Kato +4 more
2019Scientific Reports16 citations Open access
Semantic Scholar
Molecular analysis of the binding mode of Toll/interleukin-1 receptor (TIR) domain proteins during TLR2 signaling.
M. Nada, Hidenori Ohnishi, H. Tochio, Z. Kato +7 more
2012Molecular Immunology16 citations Open access
Semantic Scholar
Insight into structural properties of viral G protein‐coupled receptors and their role in the viral infection: IUPHAR Review 41
N. Tsutsumi, D. F. Kildedal, O. K. Hansen, Qian-Qian Kong +3 more
2024British Journal of Pharmacology14 citations Open access
Semantic Scholar
Structural insight into guanylyl cyclase receptor hijacking of the kinase–Hsp90 regulatory mechanism
N. Caveney, N. Tsutsumi, K. Garcia
2023bioRxiv10 citations Open access
Semantic Scholar
Purification, crystallization and preliminary X-ray crystallographic analysis of human IL-18 and its extracellular complexes.
Takeshi Kimura, N. Tsutsumi, K. Arita, M. Ariyoshi +5 more
2014Acta Crystallographica Section F Structural Biology Communications10 citations Open access
Semantic Scholar
Intramolecular interaction suggests an autosuppression mechanism for the innate immune adaptor protein MyD88.
M. Uno, T. Watanabe-Nakayama, H. Konno, K. Akagi +5 more
2018Chemical Communications4 citations
Semantic Scholar
Tuning TPO-R signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia
L. Cui, I. Moraga, Tristan Lerbs, Camille van Neste +13 more
2020bioRxiv1 citations Open access
Semantic Scholar
3521 Evaluation on Fracture Toughness of IF method by Nanoindentation
K. Fukuda, T. Sawada, Takuji Ito, Mitsuo Kobayashi +2 more
20061 citations Open access
Semantic Scholar
S252: MODULATING HEMATOPOIESIS: ENGINEERING TPO VARIANTS WITH DISTINCT HEMATOPOIETIC FUNCTION
Zahra Masoumi, Lucie Moss, Julie Tucker, Sophie James +5 more
2023HemaSphere0 citations Open access
Semantic Scholar
Interleukin-10 signaling complex with IL-10RA and IL-10RB
R. Saxton, N. Tsutsumi, C. Gati, K. Garcia
20210 citations
Semantic Scholar
Structure of human Frizzled5 by fiducial-assisted cryo-EM
N. Tsutsumi, K. Jude, C. Gati, K. Garcia
20200 citations
Semantic Scholar
Author response: Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling
N. Tsutsumi, S. Mukherjee, D. Waghray, C. Y. Janda +7 more
20200 citations Open access
Semantic Scholar
Author response: Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy
Timothy F. Miles, K. Spiess, K. Jude, N. Tsutsumi +8 more
20180 citations Open access
Semantic Scholar
X-Ray Diffraction data from complex of engineered human chemokine CX3CL1 with viral US28 and two nanobodies, source of 5WB2 structure
K. Jude, K. Garcia, N. Tsutsumi, K. Garcia
20180 citations
Semantic Scholar
US28 bound to engineered chemokine CX3CL1.35 and nanobodies
K. Jude, J. S. Burg, N. Tsutsumi, Timothy F. Miles +1 more
20180 citations
Semantic Scholar
Functional study of unique member of IL-1 family cytokines
K. Imamura, C. Noda, N. Sekiyama, N. Tsutsumi +3 more
20160 citations
Semantic Scholar
Crystal structure of human interleukin-18
N. Tsutsumi, Takeshi Kimura, K. Arita, M. Ariyoshi +5 more
20140 citations
Semantic Scholar
EAAS3-1 Structural basis for the receptor recognitions of interleukin-18(EAAS3 Innate/adaptive immunity and allergy,Free Paper Session 1,East Asia Allergy Symposium 2014)
Hidenori Ohnishi, N. Tsutsumi, Takeshi Kimura, N. Kondo +3 more
20140 citations
Semantic Scholar
Crystal structure of IL-18 in complex with IL-18 receptor alpha
N. Tsutsumi, Takeshi Kimura, K. Arita, M. Ariyoshi +5 more
20140 citations
Semantic Scholar
Crystal structure of the IL-18 signaling ternary complex
N. Tsutsumi, Takeshi Kimura, K. Arita, M. Ariyoshi +5 more
20140 citations
Semantic Scholar
Crystal structure of the extracellular signaling complex of interleukin-18
N. Tsutsumi, Takeshi Kimura, K. Arita, M. Ariyoshi +7 more
20140 citations Open access
Semantic Scholar

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