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I. Huitinga · SciRah

Researcher profile · Semantic Scholar

I. Huitinga

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I. Huitinga — researcher profile on SciRah

h-index: 60
Works: 148
Citations: 11K

Most-cited papers

Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease.
Wei-Ting Chen, A. Lu, K. Craessaerts, B. Pavie +19 more
2020Cell821 citations Open access
Semantic Scholar
Tissue-resident memory T cells populate the human brain
J. Smolders, K. Heutinck, N. Fransen, E. Remmerswaal +5 more
2018Nature Communications391 citations Open access
Semantic Scholar
Progressive multiple sclerosis patients show substantial lesion activity that correlates with clinical disease severity and sex: a retrospective autopsy cohort analysis
S. Luchetti, N. Fransen, C. V. van Eden, V. Ramaglia +2 more
2018Acta Neuropathologica364 citations Open access
Semantic Scholar
Extensive Hippocampal Demyelination in Multiple Sclerosis
J. Geurts, Lars Bö, S. Roosendaal, Thierry Hazes +5 more
2007Journal of Neuropathology and Experimental Neurology302 citations Open access
Semantic Scholar
Staining of HLA-DR, Iba1 and CD68 in human microglia reveals partially overlapping expression depending on cellular morphology and pathology.
D. Hendrickx, C. V. van Eden, K. Schuurman, J. Hamann +1 more
2017Journal of Neuroimmunology299 citations Open access
Semantic Scholar
Transcriptional profiling of human microglia reveals grey–white matter heterogeneity and multiple sclerosis-associated changes
Marlijn van der Poel, T. Ulas, Mark R Mizee, Cheng-Chih Hsiao +8 more
2019Nature Communications289 citations Open access
Semantic Scholar
Acute isolation and transcriptome characterization of cortical astrocytes and microglia from young and aged mice.
M. Orre, W. Kamphuis, Lana M. Osborn, J. Melief +5 more
2014Neurobiology of Aging277 citations
Semantic Scholar
Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis
Stefan A Berghoff, L. Spieth, T. Sun, Leon Hosang +24 more
2020Nature Neuroscience268 citations Open access
Semantic Scholar
Gene expression analysis in the human hypothalamus in depression by laser microdissection and real-time PCR: the presence of multiple receptor imbalances
S.-S. Wang, W. Kamphuis, I. Huitinga, J.-N. Zhou +1 more
2008Molecular Psychiatry253 citations
Semantic Scholar
Tissue-resident memory T cells invade the brain parenchyma in multiple sclerosis white matter lesions.
N. Fransen, Cheng-Chih Hsiao, Marlijn van der Poel, Hendrik J. Engelenburg +8 more
2020Brain : a journal of neurology235 citations Open access
Semantic Scholar
Complement C1q‐C3–associated synaptic changes in multiple sclerosis hippocampus
I. Michailidou, J. Willems, E. Kooi, C. V. van Eden +5 more
2015Annals of Neurology222 citations Open access
Semantic Scholar
Distribution of the Immune Inhibitory Molecules CD200 and CD200R in the Normal Central Nervous System and Multiple Sclerosis Lesions Suggests Neuron-Glia and Glia-Glia Interactions
N. Koning, D. Swaab, R. Hoek, I. Huitinga
2009Journal of Neuropathology and Experimental Neurology199 citations
Semantic Scholar
Epstein Barr virus is not a characteristic feature in the central nervous system in established multiple sclerosis.
L. Peferoen, Floris Lamers, Lenthe N R Lodder, W. Gerritsen +12 more
2009Brain : a journal of neurology170 citations Open access
Semantic Scholar
C3-dependent mechanism of microglial priming relevant to multiple sclerosis
V. Ramaglia, T. Hughes, R. Donev, Marieta M. Ruseva +5 more
2012Proceedings of the National Academy of Sciences of the United States of America169 citations Open access
Semantic Scholar
Effects of Antemortem and Postmortem Variables on Human Brain mRNA Quality: A BrainNet Europe Study
P. Durrenberger, Shama Fernando, Samira N. Kashefi, I. Ferrer +13 more
2010Journal of Neuropathology and Experimental Neurology166 citations Open access
Semantic Scholar
Phenotyping primary human microglia: Tight regulation of LPS responsiveness
J. Melief, N. Koning, K. Schuurman, M. V. D. van de Garde +5 more
2012Glia153 citations
Semantic Scholar
Longterm quiescent cells in the aged human subventricular neurogenic system specifically express GFAP‐δ
S. A. van den Berge, J. Middeldorp, C. E. Zhang, M. Curtis +6 more
2010Aging Cell148 citations Open access
Semantic Scholar
Decreased expression of mineralocorticoid receptor mRNA and its splice variants in postmortem brain regions of patients with major depressive disorder.
M. D. Klok, Simone R. Alt, Alicia J. M. Irurzun Lafitte, Jonathan D. Turner +6 more
2011Journal of Psychiatric Research144 citations Open access
Semantic Scholar
Gene Expression Profiling of Multiple Sclerosis Pathology Identifies Early Patterns of Demyelination Surrounding Chronic Active Lesions
D. Hendrickx, J. van Scheppingen, Marlijn van der Poel, K. Bossers +5 more
2017Frontiers in Immunology137 citations Open access
Semantic Scholar
Expression of vitamin D receptor and metabolizing enzymes in multiple sclerosis-affected brain tissue.
J. Smolders, K. Schuurman, M. V. van Strien, J. Melief +5 more
2013Journal of Neuropathology and Experimental Neurology131 citations
Semantic Scholar
Expression of the Inhibitory CD200 Receptor Is Associated with Alternative Macrophage Activation
N. Koning, M. van Eijk, W. Pouwels, Michael S. M. Brouwer +5 more
2009Journal of Innate Immunity131 citations Open access
Semantic Scholar
Management of a twenty-first century brain bank: experience in the BrainNet Europe consortium
J. Bell, I. Alafuzoff, S. Al-Sarraj, T. Arzberger +25 more
2008Acta Neuropathologica124 citations
Semantic Scholar
Lesion stage-dependent causes for impaired remyelination in MS
K. Hess, Laura Starost, N. Kieran, C. Thomas +6 more
2020Acta Neuropathologica121 citations Open access
Semantic Scholar
Characteristics of differentiated CD8+ and CD4+ T cells present in the human brain
J. Smolders, E. Remmerswaal, K. Schuurman, J. Melief +4 more
2013Acta Neuropathologica118 citations
Semantic Scholar
Spleen Vagal Denervation Inhibits the Production of Antibodies to Circulating Antigens
R. Buijs, J. A. van der Vliet, M. Garidou, I. Huitinga +1 more
2008PLoS ONE112 citations Open access
Semantic Scholar
Isolation of primary microglia from the human post-mortem brain: effects of ante- and post-mortem variables
Mark R Mizee, S. S. M. Miedema, Marlijn van der Poel, Adelia +8 more
2017Acta Neuropathologica Communications111 citations Open access
Semantic Scholar
Stress and hypothalamic-pituitary-adrenal axis function in experimental autoimmune encephalomyelitis and multiple sclerosis - a review.
C. Heesen, S. Gold, I. Huitinga, J. M. Reul
2007Psychoneuroendocrinology103 citations
Semantic Scholar
Gender differences in multiple sclerosis: induction of estrogen signaling in male and progesterone signaling in female lesions.
S. Luchetti, C. V. van Eden, K. Schuurman, M. V. van Strien +2 more
2014Journal of Neuropathology and Experimental Neurology102 citations
Semantic Scholar
Brain banking for neurological disorders.
Neshika Samarasekera, R. Salman, I. Huitinga, Natasja M. Klioueva +4 more
2013Lancet Neurology101 citations
Semantic Scholar
Selective upregulation of scavenger receptors in and around demyelinating areas in multiple sclerosis.
D. Hendrickx, N. Koning, K. Schuurman, M. V. van Strien +3 more
2013Journal of Neuropathology and Experimental Neurology95 citations
Semantic Scholar
Identification of low molecular weight pyroglutamate A{beta} oligomers in Alzheimer disease: a novel tool for therapy and diagnosis.
O. Wirths, C. Erck, H. Martens, A. Harmeier +11 more
2010Journal of Biological Chemistry93 citations Open access
Semantic Scholar
Characterizing primary human microglia: A comparative study with myeloid subsets and culture models
J. Melief, M. A. M. Sneeboer, M. Litjens, P. R. Ormel +5 more
2016Glia91 citations Open access
Semantic Scholar
The Microtubule Regulator Stathmin Is an Endogenous Protein Agonist for TLR3
M. Bsibsi, J. Bajramovic, M. Vogt, Eveline van Duijvenvoorden +10 more
2010Journal of Immunology89 citations Open access
Semantic Scholar
Vitamin D in the healthy and inflamed central nervous system: access and function.
J. Smolders, S. Moen, J. Damoiseaux, I. Huitinga +1 more
2011Journal of Neurological Sciences84 citations
Semantic Scholar
Microglial Activation After Systemic Stimulation With Lipopolysaccharide and Escherichia coli
I. Hoogland, D. Westhoff, Joo-Yeon Engelen-Lee, J. Melief +7 more
2018Frontiers in Cellular Neuroscience74 citations Open access
Semantic Scholar
Profiling of microglia nodules in multiple sclerosis reveals propensity for lesion formation
A. V. D. van den Bosch, Marlijn van der Poel, N. Fransen, M. C. Vincenten +7 more
2023bioRxiv69 citations Open access
Semantic Scholar
Microglia in normal appearing white matter of multiple sclerosis are alerted but immunosuppressed
J. Melief, K. Schuurman, M. V. D. van de Garde, J. Smolders +3 more
2013Glia67 citations
Semantic Scholar
BrainNet Europe’s Code of Conduct for brain banking
Natasja M. Klioueva, Marleen C Rademaker, D. Dexter, S. Al-Sarraj +7 more
2015Journal of neural transmission66 citations Open access
Semantic Scholar
The stress-axis in multiple sclerosis: Clinical, cellular, and molecular aspects.
J. Melief, I. Huitinga, S. Gold
2021Handbook of Clinical Neurology64 citations
Semantic Scholar
Neurofilament Light Chain Levels in Multiple Sclerosis Correlate With Lesions Containing Foamy Macrophages and With Acute Axonal Damage
A. V. D. van den Bosch, N. Fransen, Matthew Mason, A. Rozemuller +3 more
2022Neurology: Neuroimmunology & Neuroinflammation62 citations Open access
Semantic Scholar
CCL5 and CCR5 genotypes modify clinical, radiological and pathological features of multiple sclerosis.
T. van Veen, J. Nielsen, J. Berkhof, F. Barkhof +7 more
2007Journal of Neuroimmunology62 citations
Semantic Scholar
Complement-associated loss of CA2 inhibitory synapses in the demyelinated hippocampus impairs memory
V. Ramaglia, M. Dubey, M. A. Malpede, Naomi Petersen +9 more
2021bioRxiv54 citations Open access
Semantic Scholar
Ultrastructural Axon–Myelin Unit Alterations in Multiple Sclerosis Correlate with Inflammation
A. V. D. van den Bosch, Sophie Hümmert, A. Steyer, T. Ruhwedel +7 more
2022Annals of Neurology51 citations Open access
Semantic Scholar
GPCRomics of Homeostatic and Disease-Associated Human Microglia
Cheng-Chih Hsiao, R. Sankowski, M. Prinz, J. Smolders +2 more
2021Frontiers in Immunology50 citations Open access
Semantic Scholar
Microglia transcriptional profiling in major depressive disorder shows inhibition of cortical grey matter microglia
K. Scheepstra, Mark R Mizee, J. van Scheppingen, Adelia Adelia +7 more
2023medRxiv49 citations Open access
Semantic Scholar
Enhanced uptake of multiple sclerosis-derived myelin by THP-1 macrophages and primary human microglia
D. Hendrickx, K. Schuurman, Michael van Draanen, J. Hamann +1 more
2014Journal of Neuroinflammation49 citations Open access
Semantic Scholar
Osteopontin associates with brain TRM-cell transcriptome and compartmentalization in donors with and without multiple sclerosis
Cheng-Chih Hsiao, Hendrik J. Engelenburg, A. Jongejan, Jing Zhu +6 more
2022iScience47 citations Open access
Semantic Scholar
Absence of B Cells in Brainstem and White Matter Lesions Associates With Less Severe Disease and Absence of Oligoclonal Bands in MS
N. Fransen, B. D. de Jong, K. Hess, T. Kuhlmann +4 more
2021Neurology: Neuroimmunology & Neuroinflammation47 citations Open access
Semantic Scholar
Prefrontal cortex alterations in glia gene expression in schizophrenia with and without suicide.
Lin Zhang, R. Verwer, P. Lucassen, I. Huitinga +1 more
2019Journal of Psychiatric Research47 citations Open access
Semantic Scholar
IgG Immune Complexes Break Immune Tolerance of Human Microglia
Marlijn van der Poel, Willianne Hoepel, J. Hamann, I. Huitinga +1 more
2020Journal of Immunology46 citations Open access
Semantic Scholar

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C. V. van Eden — researcher profile on SciRah

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V. Ramaglia — researcher profile on SciRah

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D. Swaab — researcher profile on SciRah