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L. Spieth · SciRah

Researcher profile · Semantic Scholar

L. Spieth

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L. Spieth — researcher profile on SciRah

h-index: 14
Works: 22
Citations: 1,350

Most-cited papers

Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease
Constanze Depp, T. Sun, Andrew Octavian Sasmita, L. Spieth +26 more
2023Nature413 citations Open access
Semantic Scholar
Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis
Stefan A Berghoff, L. Spieth, T. Sun, Leon Hosang +24 more
2020Nature Neuroscience268 citations Open access
Semantic Scholar
Local cholesterol metabolism orchestrates remyelination.
Stefan A Berghoff, L. Spieth, G. Saher
2022Trends in Neurosciences114 citations Open access
Semantic Scholar
Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer’s disease model mice
Andrew Octavian Sasmita, Constanze Depp, T. Nazarenko, T. Sun +31 more
2024Nature Neuroscience98 citations Open access
Semantic Scholar
Blood-brain barrier hyperpermeability precedes demyelination in the cuprizone model
Stefan A Berghoff, T. Düking, L. Spieth, J. Winchenbach +6 more
2017Acta Neuropathologica Communications91 citations Open access
Semantic Scholar
Ketogenic diet ameliorates axonal defects and promotes myelination in Pelizaeus–Merzbacher disease
S. Stumpf, Stefan A Berghoff, Andrea Trevisiol, L. Spieth +16 more
2019Acta Neuropathologica71 citations Open access
Semantic Scholar
Neuronal cholesterol synthesis is essential for repair of chronically demyelinated lesions in mice
Stefan A Berghoff, L. Spieth, Ting Sun, Leon Hosang +16 more
2021bioRxiv64 citations Open access
Semantic Scholar
Ketogenic diet uncovers differential metabolic plasticity of brain cells
T. Düking, L. Spieth, Stefan A Berghoff, Lars Piepkorn +24 more
2022Science Advances58 citations Open access
Semantic Scholar
Parental origin of transgene modulates amyloid-β plaque burden in the 5xFAD mouse model of Alzheimer's disease.
Andrew Octavian Sasmita, Erinne Cherisse Ong, T. Nazarenko, Shu-Ying Mao +13 more
2025Neuron40 citations Open access
Semantic Scholar
Apolipoprotein E aggregation in microglia initiates Alzheimer's disease pathology by seeding β-amyloidosis.
Seiji Kaji, Stefan A Berghoff, L. Spieth, Lennart Schlaphoff +25 more
2024Immunity31 citations Open access
Semantic Scholar
NMDAR1 autoantibodies amplify behavioral phenotypes of genetic white matter inflammation: a mild encephalitis model with neuropsychiatric relevance
Sahab Arinrad, Justus B. H. Wilke, Anna Seelbach, José Doeren +12 more
2021Molecular Psychiatry21 citations Open access
Semantic Scholar
Anesthesia triggers drug delivery to experimental glioma in mice by hijacking caveolar transport
L. Spieth, Stefan A Berghoff, S. Stumpf, J. Winchenbach +20 more
2021Neuro-Oncology Advances21 citations Open access
Semantic Scholar
Ageing-associated myelin dysfunction drives amyloid deposition in mouse models of Alzheimer’s disease
Constanze Depp, T. Sun, Andrew Octavian Sasmita, L. Spieth +19 more
2021bioRxiv20 citations Open access
Semantic Scholar
Nedd4-2-dependent regulation of astrocytic Kir4.1 and Connexin43 controls neuronal network activity
Bekir Altas, H. Rhee, A. Ju, H. Solís +26 more
2023Journal of Cell Biology16 citations Open access
Semantic Scholar
Liver kinase B1 depletion from astrocytes worsens disease in a mouse model of multiple sclerosis
S. Kalinin, Gordon P. Meares, Shao-Xia Lin, Elizabeth A Pietruczyk +7 more
2019Glia12 citations Open access
Semantic Scholar
Correction to: Ketogenic diet ameliorates axonal defects and promotes myelination in Pelizaeus–Merzbacher disease
S. Stumpf, Stefan A Berghoff, Andrea Trevisiol, L. Spieth +16 more
2019Acta Neuropathologica6 citations Open access
Semantic Scholar
Blood-brain barrier hyperpermeability precedes demyelination in the cuprizone model
Stefan A Berghoff, T. Düking, L. Spieth, J. Winchenbach +6 more
2017Acta Neuropathologica Communications5 citations Open access
Semantic Scholar
Oligodendrocytes and neurons contribute to amyloid-β deposition in Alzheimer’s disease
Andrew Octavian Sasmita, Constanze Depp, T. Nazarenko, T. Sun +28 more
2023bioRxiv4 citations Open access
Semantic Scholar
In-Source Fragmentation Annotation in Sterol Mass Spectrometry Imaging.
Iulia Sidorov, Nina Ogrinc, L. Spieth, Michal Kopcil +6 more
2025Analytical Chemistry3 citations
Semantic Scholar
Activity-dependent regulation of vascular cholesterol metabolism acts as a negative feedback mechanism for neurovascular coupling
CP Profaci, K. Foreman, L. Spieth, V. Coelho-Santos +9 more
2024bioRxiv1 citations
Semantic Scholar
Ablation of cell-specific cholesterol synthesis affects cerebral β-amyloidosis
L. Spieth
20230 citations Open access
Semantic Scholar
Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis
Stefan A Berghoff, L. Spieth, T. Sun, Leon Hosang +24 more
2020Nature Neuroscience0 citations Open access
Semantic Scholar

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G. Saher×18
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Stefan A Berghoff×17
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Stefan A Berghoff — researcher profile on SciRah
K. Nave×13
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Constanze Depp — researcher profile on SciRah

Andrew Octavian Sasmita×9

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Andrew Octavian Sasmita — researcher profile on SciRah

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T. Düking — researcher profile on SciRah

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