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A. Näär · SciRah

Researcher profile · Semantic Scholar

A. Näär

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A. Näär — researcher profile on SciRah

h-index: 45
Works: 76
Citations: 15K

Most-cited papers

Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor
A. Horlein, A. Näär, T. Heinzel, J. Torchia +7 more
1995Nature2,121 citations
Semantic Scholar
RXRβ: A coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements
V. Yu, C. Delsert, B. Andersen, J. M. Holloway +6 more
19911,111 citations
Semantic Scholar
MicroRNAs in metabolism and metabolic disorders
V. Rottiers, A. Näär
2012Nature reviews. Molecular cell biology1,100 citations Open access
Semantic Scholar
MicroRNA-33 and the SREBP Host Genes Cooperate to Control Cholesterol Homeostasis
S. H. Najafi-Shoushtari, F. Kristo, Ying-Xia Li, Toshi Shioda +3 more
2010Science1,018 citations Open access
Semantic Scholar
Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex
C. Rachez, B. Lemon, Z. Suldan, V. Bromleigh +5 more
1999Nature765 citations
Semantic Scholar
Transcriptional coactivator complexes.
A. Näär, B. Lemon, R. Tjian
2001Annual Review of Biochemistry609 citations
Semantic Scholar
Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II.
David Baillat, M. Hakimi, A. Näär, A. Shilatifard +2 more
2005Cell554 citations Open access
Semantic Scholar
The orientation and spacing of core DNA-binding motifs dictate selective transcriptional responses to three nuclear receptors.
A. Näär, J. Boutin, S. Lipkin, V. Yu +3 more
1991Cell536 citations
Semantic Scholar
Composite co-activator ARC mediates chromatin-directed transcriptional activation
A. Näär, P. Beaurang, Sharleen Zhou, S. Abraham +2 more
1999Nature449 citations
Semantic Scholar
A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans
A. Walker, René L. Jacobs, J. Watts, V. Rottiers +10 more
2011Cell441 citations Open access
Semantic Scholar
An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis
Fa-Jun Yang, B. Vought, John S. Satterlee, A. Walker +13 more
2006Nature422 citations
Semantic Scholar
Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.
A. Walker, Fa-Jun Yang, K. Jiang, Jun-Yuan Ji +23 more
2010Genes & Development368 citations Open access
Semantic Scholar
SIRT6 recruits SNF2H to sites of DNA breaks, preventing genomic instability through chromatin remodeling
D. Toiber, Fabian Erdel, Karim Bouazoune, Dafne M. Silberman +11 more
2013Molecules and Cells364 citations Open access
Semantic Scholar
A nuclear receptor-like pathway regulating multidrug resistance in fungi
J. Thakur, H. Arthanari, Fa-Jun Yang, S. Pan +11 more
2008Nature362 citations
Semantic Scholar
Differential orientations of the DNA-binding domain and carboxy-terminal dimerization interface regulate binding site selection by nuclear receptor heterodimers.
R. Kurokawa, V. C. Yu, A. Näär, S. Kyakumoto +4 more
1993Genes & Development357 citations Open access
Semantic Scholar
E2F1 represses β-catenin transcription and is antagonized by both pRB and CDK8
E. Morris, Jun-Yuan Ji, Fa-Jun Yang, Luisa Di Stefano +6 more
2008Nature324 citations Open access
Semantic Scholar
Structure, Function, and Activator-Induced Conformations of the CRSP Coactivator
D. Taatjes, A. Näär, F. Andel, E. Nogales +1 more
2002Science283 citations
Semantic Scholar
Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis
Alexandre Wagschal, S. H. Najafi-Shoushtari, Li-Feng Wang, L. Goedeke +27 more
2015Nature Medicine260 citations Open access
Semantic Scholar
Identification of miR-148a as a novel regulator of cholesterol metabolism
L. Goedeke, N. Rotllan, A. Canfrán-Duque, J. F. Aranda +11 more
2015Nature Medicine217 citations Open access
Semantic Scholar
Chromatin, TAFs, and a novel multiprotein coactivator are required for synergistic activation by Sp1 and SREBP-1a in vitro.
A. Näär, P. Beaurang, Karen M. Robinson, J. Oliner +5 more
1998Genes & Development210 citations Open access
Semantic Scholar
A SIRT1-LSD1 Co-repressor Complex Regulates Notch Target Gene Expression and Development
P. Mulligan, Fa-Jun Yang, Luisa Di Stefano, Jun-Yuan Ji +11 more
2011Molecules and Cells208 citations Open access
Semantic Scholar
The lipogenic regulator SREBF2 induces Transferrin in circulating melanoma cells and suppresses ferroptosis
Xin Hong, W. Roh, R. Sullivan, Keith H. K. Wong +25 more
2020Cancer Discovery204 citations Open access
Semantic Scholar
Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit
Ulrich K. Binné, M. Classon, F. Dick, Wenyi Wei +4 more
2007Nature Cell Biology178 citations
Semantic Scholar
Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation.
A. Näär, D. Taatjes, W. Zhai, E. Nogales +1 more
2002Genes & Development167 citations Open access
Semantic Scholar
Inhibiting Fungal Multidrug Resistance by Disrupting an Activator-Mediator Interaction
Joy L. Nishikawa, A. Boeszoermenyi, L. Vale-Silva, R. Torelli +14 more
2016Nature142 citations Open access
Semantic Scholar
The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator.
Fa-Jun Yang, Rosalie S. deBeaumont, Sharleen Zhou, A. Näär
2004Proceedings of the National Academy of Sciences of the United States of America133 citations Open access
Semantic Scholar
Identification of a novel zinc finger protein binding a conserved element critical for Pit-1-dependent growth hormone gene expression.
Steven M. Lipkin, A. Näär, K. Kalla, R. A. Sack +1 more
1993Genes & Development133 citations Open access
Semantic Scholar
Pharmacological inhibition of a microRNA family in non-human primates by a seed-targeting 8-mer antimiR
V. Rottiers, S. Obad, A. Petri, R. McGarrah +16 more
2013Science Translational Medicine130 citations Open access
Semantic Scholar
MicroRNAs in metabolism and metabolic diseases
V. Rottiers, S. H. Najafi-Shoushtari, F. Kristo, S. Gurumurthy +7 more
2011Cold Spring Harbor Symposia on Quantitative Biology130 citations Open access
Semantic Scholar
Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence
Maja Sedic, Adam Skibinski, Nelson E. Brown, M. Gallardo +14 more
2015Nature Communications126 citations Open access
Semantic Scholar
A component of the ARC/Mediator complex required for TGFβ/Nodal signalling
Y. Kato, Raymond Habas, Yu Katsuyama, A. Näär +1 more
2002Nature117 citations
Semantic Scholar
Structure of the VP16 Transactivator Target in ARC/Mediator
A. Milbradt, Madhura Kulkarni, T. Yi, K. Takeuchi +5 more
2011Nature Structural &Molecular Biology96 citations Open access
Semantic Scholar
Mediator Subunit Gal11p/MED15 Is Required for Fatty Acid-dependent Gene Activation by Yeast Transcription Factor Oaf1p*
J. Thakur, H. Arthanari, Fa-Jun Yang, Katherine Chau +2 more
2009Journal of Biological Chemistry94 citations Open access
Semantic Scholar
An intranasal ASO therapeutic targeting SARS-CoV-2
Chi Zhu, Justin Y. Lee, Jia Z. Woo, Lei Xu +19 more
2021Nature Communications77 citations Open access
Semantic Scholar
A component of the ARC/Mediator complex required for TGF beta/Nodal signalling.
Y. Kato, Raymond Habas, Yu Katsuyama, A. Näär +1 more
2002Nature77 citations
Semantic Scholar
A microRNA linking human positive selection and metabolic disorders
Li-Feng Wang, N. Sinnott-Armstrong, Alexandre Wagschal, A. Wark +28 more
2020Cell74 citations Open access
Semantic Scholar
Nuclear receptor-like transcription factors in fungi.
A. Näär, J. Thakur
2009Genes & Development64 citations Open access
Semantic Scholar
MicroRNA-33 Regulates the Innate Immune Response via ATP Binding Cassette Transporter-mediated Remodeling of Membrane Microdomains *
Li-Hua Lai, Kathleen M. Azzam, Wan-Chi Lin, P. Rai +7 more
2016Journal of Biological Chemistry62 citations Open access
Semantic Scholar
Functional antagonism between histone H3K4 demethylases in vivo.
Luisa Di Stefano, J. Walker, Giosalba Burgio, D. Corona +3 more
2011Genes & Development61 citations Open access
Semantic Scholar
RXR beta: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements.
V. Yu, C. Delsert, B. Andersen, J. M. Holloway +6 more
1991Cell60 citations
Semantic Scholar
A multi-pronged approach targeting SARS-CoV-2 proteins using ultra-large virtual screening
Christoph Gorgulla, K. M. Padmanabha Das, K. Leigh, M. Cespugli +33 more
2021iScience57 citations Open access
Semantic Scholar
SREBP1-dependent de novo fatty acid synthesis gene expression is elevated in malignant melanoma and represents a cellular survival trait
Su Wu, A. Näär
2019Scientific Reports53 citations Open access
Semantic Scholar
Secondary structural ensembles of the SARS-CoV-2 RNA genome in infected cells
T. C. Lan, Matthew F. Allan, Lauren E. Malsick, Jia Z. Woo +10 more
2022Nature Communications52 citations Open access
Semantic Scholar
Differential Roles of Transcriptional Mediator Subunits in Regulation of Multidrug Resistance Gene Expression in Saccharomyces cerevisiae
Puja Shahi, Kailash Gulshan, A. Näär, W. Moye-Rowley
2010Molecular Biology of the Cell49 citations Open access
Semantic Scholar
Cofactor requirements for transcriptional activation by Sp1.
A. Näär, Soojin Ryu, R. Tjian
1998Cold Spring Harbor Symposia on Quantitative Biology47 citations
Semantic Scholar
miRNA regulation of LDL-cholesterol metabolism
L. Goedeke, Alexandre Wagschal, C. Fernández-Hernando, A. Näär
2016Biochimica et Biophysica Acta43 citations Open access
Semantic Scholar
Transcriptional regulation by the nuclear receptor superfamily.
V. C. Yu, A. Näär, M. G. Rosenfeld
1992Current Opinion in Biotechnology43 citations
Semantic Scholar
Active repression and E2F inhibition by pRB are biochemically distinguishable.
John F. Ross, A. Näär, Hieu Cam, Richard I Gregory +1 more
2001Genes & Development40 citations Open access
Semantic Scholar
A Role for FACT in Repopulation of Nucleosomes at Inducible Genes
W. Voth, Shinya Takahata, Joy L. Nishikawa, B. Metcalfe +2 more
2014PLoS ONE37 citations Open access
Semantic Scholar
MicroRNAs in Metabolism and Metabolic Disorders
V. Rottiers, A. Näär
2012Nature reviews. Molecular cell biology37 citations Open access
Semantic Scholar

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