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T. Heinzel · SciRah

Researcher profile · Semantic Scholar

T. Heinzel

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T. Heinzel — researcher profile on SciRah

h-index: 43
Works: 99
Citations: 15K

Most-cited papers

A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors.
Yasutomi Kamei, Lan Xu, T. Heinzel, J. Torchia +7 more
1996Cell2,269 citations Open access
Semantic Scholar
Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor
A. Horlein, A. Näär, T. Heinzel, J. Torchia +7 more
1995Nature2,121 citations
Semantic Scholar
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
M. Göttlicher, S. Minucci, P. Zhu, O. Krämer +7 more
2001EMBO Journal1,917 citations Open access
Semantic Scholar
A complex containing N-CoR, mSln3 and histone deacetylase mediates transcriptional repression
T. Heinzel, Robert M. Lavinsky, T. Mullen, M. Söderström +11 more
1997Nature1,289 citations
Semantic Scholar
Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes.
Robert M. Lavinsky, K. Jepsen, T. Heinzel, J. Torchia +11 more
1998Proceedings of the National Academy of Sciences of the United States of America710 citations Open access
Semantic Scholar
Acetylation of non-histone proteins modulates cellular signalling at multiple levels.
Stephanie Spange, T. Wagner, T. Heinzel, O. Krämer
2009International Journal of Biochemistry and Cell Biology691 citations
Semantic Scholar
The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2
O. Krämer, P. Zhu, Heather P. Ostendorff, Martin Golebiewski +7 more
2003EMBO Journal534 citations Open access
Semantic Scholar
P-Lim, a LIM homeodomain factor, is expressed during pituitary organ and cell commitment and synergizes with Pit-1.
Ingolf Bach, S. Rhodes, R. Pearse, T. Heinzel +4 more
1995Proceedings of the National Academy of Sciences of the United States of America299 citations Open access
Semantic Scholar
Signal-specific co-activator domain requirements for Pit-1 activation
Lan Xu, Robert M. Lavinsky, J. Dasen, S. E. Flynn +10 more
1998Nature298 citations
Semantic Scholar
A phosphorylation-acetylation switch regulates STAT1 signaling.
O. Krämer, S. Knauer, G. Greiner, E. Jandt +5 more
2009Genes & Development287 citations Open access
Semantic Scholar
Histone deacetylase as a therapeutic target.
O. Krämer, M. Göttlicher, T. Heinzel
2001Trends in endocrinology and metabolism268 citations
Semantic Scholar
Negative glucocorticoid receptor response elements and their role in glucocorticoid action.
A. Dostert, T. Heinzel
2004Current pharmaceutical design231 citations
Semantic Scholar
Acetylation of Stat1 modulates NF-B activity
O. Krämer, D. Baus, S. Knauer, S. Stein +5 more
2006209 citations Open access
Semantic Scholar
VDR‐Alien: a novel, DNA‐selective vitamin D3 receptor‐corepressor partnership
P. Polly, M. Herdick, U. Moehren, A. Baniahmad +2 more
2000The FASEB Journal201 citations
Semantic Scholar
Clinical trial of valproic acid and all‐trans retinoic acid in patients with poor‐risk acute myeloid leukemia
G. Bug, M. Ritter, B. Wassmann, C. Schoch +9 more
2005Cancer190 citations
Semantic Scholar
HDACi--targets beyond chromatin.
Marc Buchwald, O. Krämer, T. Heinzel
2009Cancer Letters167 citations
Semantic Scholar
RU486-induced Glucocorticoid Receptor Agonism Is Controlled by the Receptor N Terminus and by Corepressor Binding*
M. Schulz, M. Eggert, A. Baniahmad, A. Dostert +2 more
2002Journal of Biological Chemistry151 citations Open access
Semantic Scholar
Nuclear export is essential for the tumor‐promoting activity of survivin
S. Knauer, O. Krämer, T. Knösel, K. Engels +12 more
2007The FASEB Journal140 citations
Semantic Scholar
Survivin and YM155: how faithful is the liaison?
Anke Rauch, Dorle Hennig, Claudia Schäfer, M. Wirth +4 more
2014Biochimica et Biophysica Acta136 citations
Semantic Scholar
Cross talk between stimulated NF-κB and the tumor suppressor p53
G. Schneider, A. Henrich, G. Greiner, V. Wolf +10 more
2010Oncogene135 citations
Semantic Scholar
Acetylation of Stat1 modulates NF-kappaB activity.
O. Krämer, D. Baus, S. Knauer, S. Stein +5 more
2006Genes & Development135 citations
Semantic Scholar
Nuclear receptors: overview and classification.
N. Novac, T. Heinzel
2004Current drug targets. Inflammation & allergy120 citations
Semantic Scholar
Histone deacetylases: salesmen and customers in the post‐translational modification market
André Brandl, T. Heinzel, O. Krämer
2009Biology of the Cell114 citations Open access
Semantic Scholar
Multiple Regions of ETO Cooperate in Transcriptional Repression*
Daniel Hildebrand, Jens Tiefenbach, T. Heinzel, M. Grez +1 more
2001Journal of Biological Chemistry107 citations Open access
Semantic Scholar
Phosphorylation-acetylation switch in the regulation of STAT1 signaling.
O. Krämer, T. Heinzel
2010Molecular and Cellular Endocrinology101 citations Open access
Semantic Scholar
Glucocorticoids inhibit activation-induced cell death (AICD) via direct DNA-dependent repression of the CD95 ligand gene by a glucocorticoid receptor dimer.
S. Baumann, A. Dostert, N. Novac, A. Bauer +7 more
2005Blood95 citations Open access
Semantic Scholar
Histone deacetylase 2 controls p53 and is a critical factor in tumorigenesis.
T. Wagner, P. Brand, T. Heinzel, O. Krämer
2014Biochimica et Biophysica Acta91 citations
Semantic Scholar
Histone deacetylase inhibitors and hydroxyurea modulate the cell cycle and cooperatively induce apoptosis
O. Krämer, S. Knauer, D. Zimmermann, R. Stauber +1 more
2008Oncogene86 citations
Semantic Scholar
Dynamically regulated sumoylation of HDAC2 controls p53 deacetylation and restricts apoptosis following genotoxic stress.
André Brandl, T. Wagner, K. Uhlig, S. Knauer +5 more
2012Journal of Molecular Cell Biology83 citations Open access
Semantic Scholar
Acetylation modulates the STAT signaling code.
Martin Wieczorek, Torsten Ginter, P. Brand, T. Heinzel +1 more
2012Cytokine & growth factor reviews80 citations
Semantic Scholar
Differential effects of nuclear receptor corepressor (N-CoR) expression levels on retinoic acid receptor-mediated repression support the existence of dynamically regulated corepressor complexes.
M. Söderström, A. Vo, T. Heinzel, Robert M. Lavinsky +5 more
1997Molecular Endocrinology75 citations Open access
Semantic Scholar
Mechanism for ubiquitylation of the leukemia fusion proteins AML1‐ETO and PML‐RARα
O. Krämer, Sylvia Müller, Marc Buchwald, Sigrid Reichardt +1 more
2008The FASEB Journal74 citations
Semantic Scholar
HDAC1 and HDAC2 integrate checkpoint kinase phosphorylation and cell fate through the phosphatase-2A subunit PR130
Anja Göder, Claudia Emmerich, T. Nikolova, N. Kiweler +7 more
2018Nature Communications70 citations Open access
Semantic Scholar
Ubiquitin conjugase UBCH8 targets active FMS-like tyrosine kinase 3 for proteasomal degradation
Marc Buchwald, K. Pietschmann, J. Müller, F. Böhmer +2 more
2010Leukemia70 citations Open access
Semantic Scholar
SUMOylation of the corepressor N-CoR modulates its capacity to repress transcription.
Jens Tiefenbach, N. Novac, M. Ducasse, M. Eck +2 more
2006Molecular Biology of the Cell61 citations Open access
Semantic Scholar
The histone deacetylases HDAC1 and HDAC2 are required for the growth and survival of renal carcinoma cells
N. Kiweler, B. Brill, M. Wirth, Ines Breuksch +9 more
2018Archives of Toxicology56 citations
Semantic Scholar
TSA downregulates Wilms tumor gene 1 (Wt1) expression at multiple levels
M. Makki, T. Heinzel, C. Englert
2008Nucleic Acids Research47 citations Open access
Semantic Scholar
SIAH ubiquitin ligases target the nonreceptor tyrosine kinase ACK1 for ubiquitinylation and proteasomal degradation
Marc Buchwald, K. Pietschmann, P. Brand, A. Günther +3 more
2012Oncogene46 citations Open access
Semantic Scholar
Sumoylation of HDAC2 promotes NF-κB-dependent gene expression
T. Wagner, N. Kiweler, Katharina Wolff, S. Knauer +6 more
2015OncoTarget45 citations Open access
Semantic Scholar
HSP90 is necessary for the ACK1-dependent phosphorylation of STAT1 and STAT3.
Nisintha Mahendrarajah, M. E. Borisova, Sigrid Reichardt, Maren Godmann +8 more
2017Cellular Signalling44 citations Open access
Semantic Scholar
Histone deacetylase inhibitors block IFNγ-induced STAT1 phosphorylation.
Torsten Ginter, Carolin Bier, S. Knauer, K. Sughra +11 more
2012Cellular Signalling44 citations
Semantic Scholar
Breakdown of the FLT3-ITD/STAT5 Axis and Synergistic Apoptosis Induction by the Histone Deacetylase Inhibitor Panobinostat and FLT3-Specific Inhibitors
K. Pietschmann, H. Bolck, Marc Buchwald, S. Spielberg +6 more
2012Molecular Cancer Therapeutics44 citations Open access
Semantic Scholar
The Stat5-RARalpha fusion protein represses transcription and differentiation through interaction with a corepressor complex.
A. Maurer, C. Wichmann, A. Gross, Hana Kunkel +4 more
2002Blood44 citations
Semantic Scholar
Class I histone deacetylases regulate p53/NF-κB crosstalk in cancer cells.
Claudia Schäfer, Anja Göder, M. Beyer, N. Kiweler +15 more
2017Cellular Signalling43 citations
Semantic Scholar
Glucocorticoids regulate lipid mediator networks by reciprocal modulation of 15-lipoxygenase isoforms affecting inflammation resolution
Zhigang Rao, E. Brunner, Benjamin Giszas, Aishwarya Iyer-Bierhoff +14 more
2023Proceedings of the National Academy of Sciences of the United States of America37 citations Open access
Semantic Scholar
SIAH2 antagonizes TYK2-STAT3 signaling in lung carcinoma cells
Sylvia Müller, Yuan-Hua Chen, Torsten Ginter, Claudia Schäfer +13 more
2014OncoTarget34 citations Open access
Semantic Scholar
Survivin antagonizes chemotherapy-induced cell death of colorectal cancer cells
Anke Rauch, Annemarie Carlstedt, Claudia Emmerich, Al-Hassan M. Mustafa +5 more
2018OncoTarget28 citations Open access
Semantic Scholar
Differential regulation of PML-RARα stability by the ubiquitin ligases SIAH1/SIAH2 and TRIAD1.
K. Pietschmann, Marc Buchwald, Sylvia Müller, S. Knauer +3 more
2012International Journal of Biochemistry and Cell Biology28 citations
Semantic Scholar
Author response: Chromatin mapping identifies BasR, a key regulator of bacteria-triggered production of fungal secondary metabolites
J. Fischer, Sebastian Y. Müller, Tina Netzker, Nils Jäger +16 more
201826 citations Open access
Semantic Scholar
Analysis of the interplay between all-trans retinoic acid and histone deacetylase inhibitors in leukemic cells
Katrin Noack, Nisintha Mahendrarajah, Dorle Hennig, L. Schmidt +9 more
2016Archives of Toxicology24 citations Open access
Semantic Scholar

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