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D. Soncini · SciRah

Researcher profile · Semantic Scholar

D. Soncini

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D. Soncini — researcher profile on SciRah

h-index: 20
Works: 64
Citations: 1,556

Most-cited papers

Catastrophic NAD+ Depletion in Activated T Lymphocytes through Nampt Inhibition Reduces Demyelination and Disability in EAE
Santina Bruzzone, Floriana Fruscione, S. Morando, T. Ferrando +15 more
2009PLoS ONE188 citations Open access
Semantic Scholar
The NAD+-dependent Histone Deacetylase SIRT6 Promotes Cytokine Production and Migration in Pancreatic Cancer Cells by Regulating Ca2+ Responses*
Inga Bauer, Alessia Grozio, D. Lasiglié, Giovanna Basile +14 more
2012Journal of Biological Chemistry171 citations Open access
Semantic Scholar
CD73 Protein as a Source of Extracellular Precursors for Sustained NAD+ Biosynthesis in FK866-treated Tumor Cells*
Alessia Grozio, Giovanna Sociali, L. Sturla, I. Caffa +6 more
2013Journal of Biological Chemistry147 citations Open access
Semantic Scholar
Long non-coding RNA NEAT1 targeting impairs the DNA repair machinery and triggers anti-tumor activity in multiple myeloma
E. Taiana, V. Favasuli, D. Ronchetti, K. Todoerti +17 more
2019Leukemia96 citations Open access
Semantic Scholar
Synergistic Interactions between HDAC and Sirtuin Inhibitors in Human Leukemia Cells
M. Cea, D. Soncini, Floriana Fruscione, Lizzia Raffaghello +20 more
2011PLoS ONE83 citations Open access
Semantic Scholar
Fasting potentiates the anticancer activity of tyrosine kinase inhibitors by strengthening MAPK signaling inhibition
I. Caffa, V. D'Agostino, P. Damonte, D. Soncini +7 more
2015OncoTarget79 citations Open access
Semantic Scholar
Nicotinamide Phosphoribosyltransferase Promotes Epithelial-to-Mesenchymal Transition as a Soluble Factor Independent of Its Enzymatic Activity*
D. Soncini, I. Caffa, G. Zoppoli, M. Cea +18 more
2014Journal of Biological Chemistry77 citations Open access
Semantic Scholar
Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors as therapeutics: rationales, controversies, clinical experience.
F. Montecucco, M. Cea, Inga Bauer, D. Soncini +6 more
2013Current Drug Targets67 citations Open access
Semantic Scholar
Depletion of SIRT6 enzymatic activity increases acute myeloid leukemia cells’ vulnerability to DNA-damaging agents
A. Cagnetta, D. Soncini, S. Orecchioni, G. Talarico +19 more
2017Haematologica57 citations Open access
Semantic Scholar
Treatment with the CC chemokine-binding protein Evasin-4 improves post-infarction myocardial injury and survival in mice
V. Braunersreuther, F. Montecucco, G. Pelli, Katia Galan +10 more
2013Thrombosis and Haemostasis55 citations Open access
Semantic Scholar
Therapy‐induced antitumor vaccination in neuroblastomas by the combined targeting of IL‐2 and TNFα
E. Balza, B. Carnemolla, L. Mortara, P. Castellani +3 more
2010International Journal of Cancer53 citations Open access
Semantic Scholar
Potent synergistic interaction between the Nampt inhibitor APO866 and the apoptosis activator TRAIL in human leukemia cells.
G. Zoppoli, M. Cea, D. Soncini, Floriana Fruscione +13 more
2010Experimental Hematology53 citations Open access
Semantic Scholar
Treatment with Angiotensin-(1–7) reduces inflammation in carotid atherosclerotic plaques
Rodrigo A. Fraga-Silva, S. Savergnini, F. Montecucco, A. Nencioni +19 more
2014Thrombosis and Haemostasis50 citations Open access
Semantic Scholar
Grb7 Upregulation Is a Molecular Adaptation to HER2 Signaling Inhibition Due to Removal of Akt-Mediated Gene Repression
A. Nencioni, M. Cea, A. Garuti, M. Passalacqua +7 more
2010PLoS ONE42 citations Open access
Semantic Scholar
SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects.
P. Damonte, Giovanna Sociali, M. Parenti, D. Soncini +15 more
2017Bioorganic & Medicinal Chemistry41 citations Open access
Semantic Scholar
APO866 Increases Antitumor Activity of Cyclosporin-A by Inducing Mitochondrial and Endoplasmic Reticulum Stress in Leukemia Cells
A. Cagnetta, I. Caffa, C. Acharya, D. Soncini +18 more
2015Clinical Cancer Research37 citations Open access
Semantic Scholar
Synthesis and biological characterization of 3-(imidazol-1-ylmethyl)piperidine sulfonamides as aromatase inhibitors.
Mauro Di Matteo, Alessandra Ammazzalorso, Federico Andreoli, I. Caffa +9 more
2016Bioorganic & Medicinal Chemistry Letters32 citations Open access
Semantic Scholar
Ras-induced resistance to lapatinib is overcome by MEK inhibition.
G. Zoppoli, Eva Moran, D. Soncini, M. Cea +11 more
2010Current Cancer Drug Targets30 citations
Semantic Scholar
Dual NAMPT and BTK Targeting Leads to Synergistic Killing of Waldenstrom's Macroglobulinemia Cells Regardless of MYD88 and CXCR4 Somatic Mutations Status
M. Cea, A. Cagnetta, C. Acharya, P. Acharya +18 more
2016Clinical Cancer Research27 citations Open access
Semantic Scholar
Amino acid depletion triggered by ʟ-asparaginase sensitizes MM cells to carfilzomib by inducing mitochondria ROS-mediated cell death.
D. Soncini, P. Minetto, C. Martinuzzi, P. Becherini +18 more
2020Blood Advances26 citations Open access
Semantic Scholar
EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition
C. Zucal, V. D'Agostino, A. Casini, B. Mantelli +9 more
2015BMC Cancer17 citations Open access
Semantic Scholar
CD38-Induced Metabolic Dysfunction Primes Multiple Myeloma Cells for NAD+-Lowering Agents
P. Becherini, D. Soncini, S. Ravera, Elisa Gelli +19 more
2023Antioxidants16 citations Open access
Semantic Scholar
Targeting the immune microenvironment in Waldenström Macroglobulinemia via halting the CD40/CD40-ligand axis.
A. Sacco, V. Desantis, J. Celay, V. Giustini +20 more
2023Blood14 citations
Semantic Scholar
Therapeutic activation of G protein-coupled estrogen receptor 1 in Waldenström Macroglobulinemia
E. Morelli, Z. Hunter, M. Fulciniti, A. Gullà +19 more
2022Experimental Hematology & Oncology12 citations Open access
Semantic Scholar
The new small tyrosine-kinase inhibitor ARQ531 targets acute myeloid leukemia cells by disrupting multiple tumor-addicted programs.
D. Soncini, S. Orecchioni, Samantha Ruberti, P. Minetto +21 more
2019Haematologica11 citations Open access
Semantic Scholar
Synthetic lethality-based therapeutics: perspectives for applications in colorectal cancer.
D. Soncini, I. Caffa, Franco Patrone, A. Ballestrero +1 more
2012Current Cancer Drug Targets11 citations
Semantic Scholar
Apoptosis reprogramming triggered by splicing inhibitors sensitizes multiple myeloma cells to Venetoclax treatment
D. Soncini, C. Martinuzzi, P. Becherini, Elisa Gelli +21 more
2021Haematologica10 citations Open access
Semantic Scholar
Bone marrow-derived extracellular vesicles from multiple myeloma patients promote adaptive immune dysfunction via HLA-G, PD-1, and PD-L1
D. Soncini, D. Marimpietri, Francesco Ladisa, Francesco Lai +4 more
2025Frontiers in Immunology9 citations
Semantic Scholar
Dynamic simulations of pathways downstream of ERBB-family, including mutations and treatments: concordance with experimental results.
Nicoletta Castagnino, Lorenzo Tortolina, Alessandro Balbi, R. Pesenti +6 more
2010Current Cancer Drug Targets9 citations
Semantic Scholar
Clonal hematopoiesis impacts frailty in newly diagnosed multiple myeloma patients: a retrospective multicenter analysis
Elisa Gelli, C. Martinuzzi, D. Soncini, C. Conticello +15 more
2024Scientific Reports7 citations Open access
Semantic Scholar
NAD+ metabolism restriction boosts high-dose melphalan efficacy in patients with multiple myeloma
D. Soncini, P. Becherini, Francesco Ladisa, S. Ravera +24 more
2024Blood Advances6 citations Open access
Semantic Scholar
Sirtuin 6 Regulates the Activation of the ATP/Purinergic Axis in Endothelial Cells
C. Astigiano, Francesco Piacente, Maria Elena Laugieri, A. Benzi +9 more
2023International Journal of Molecular Sciences6 citations Open access
Semantic Scholar
The new small molecule tyrosine-kinase inhibitor ARQ531 targets acute myeloid leukemia cells by disrupting multiple tumor-addicted programs
D. Soncini, S. Orecchioni, Samantha Ruberti, P. Minetto +22 more
20196 citations
Semantic Scholar
Monoclonal gammopathy of renal significance (MGRS): retrospective monocentric analysis of clinical outcomes and treatment strategies
P. Esposito, Lucia Macciò, A. Cagnetta, F. Costigliolo +7 more
2025Clinical and Experimental Medicine (Testo stampato)4 citations Open access
Semantic Scholar
CD56 expression modulates NAD+ metabolic landscape and predicts sensitivity to anti-CD38 therapies in multiple myeloma
Giulia Giorgetti, Elena Maroto-Martin, D. Soncini, Daniela Fenoglio +20 more
2025Blood Cancer Journal3 citations Open access
Semantic Scholar
Higher CD56 Expression on Multiple Myeloma Cells Increases CD38 Expression, Reduces Intracellular NAD+ Levels, and Enhances the Efficacy of Daratumumab-Based Treatment Strategies
Giulia Giorgetti, P. Becherini, Elena Maroto-Martin, Daniela Fenoglio +12 more
2023Blood2 citations Open access
Semantic Scholar
Melflufen in Multiple Myeloma: Clinical Limitations, Biological Rationale, and Future Perspectives
Matteo Garibotto, D. Soncini, R. Lemoli, Antonia Cagnetta +1 more
2026Cancers1 citations Open access
Semantic Scholar
Clonal Hematopoiesis: Exploiting Molecular Landscape of Multiple Myeloma Patients for Choosing the Most Appropriate Therapeutic Strategy
Elisa Gelli, Antonella Laudisi, C. Martinuzzi, D. Soncini +9 more
2022Blood1 citations Open access
Semantic Scholar
SIRT6 Inhibition As a Novel Approach for Treating Acute Myeloid Leukemia
M. Cea, A. Cagnetta, D. Soncini, P. Minetto +8 more
20161 citations
Semantic Scholar
CRISPR application in hematological disorders: from bench to bedside
Francesco Ladisa, Eugenio Morelli, D. Soncini, Matteo Garibotto +3 more
2026Blood Advances0 citations Open access
Semantic Scholar
The immunosuppressive role of HLA-G+ extracellular vesicles in bone marrow of infiltrating tumors: The lesson learned from neuroblastoma and multiple myeloma.
I. Airoldi, D. Soncini, D. Marimpietri, Michele Cea +1 more
2026Human Immunology0 citations Open access
Semantic Scholar
CO32 | ARQ531 targets MAPK–S6K1 signaling and synergizes with lenalidomide in RAS-mutant and wild-type multiple myeloma
D. Soncini
2026Haematologica0 citations Open access
Semantic Scholar
PA-269 Investigating Vγ9Vδ2 T-Cell Cytotoxicity in Multiple Myeloma in Combination With BCMA Targeting
Irini Xhuveli, Randa Yacoub, Serena Matis, F. Loiacono +4 more
2026Clinical Lymphoma, Myeloma & Leukemia0 citations
Semantic Scholar
Immunoregulatory extracellular vesicles in multiple myeloma patients’ peripheral blood
I. Airoldi, D. Soncini, Danilo Marimpietri, Fabio Malavasi +4 more
2026Extracellular Vesicles and Circulating Nucleic Acids0 citations Open access
Semantic Scholar
P104 | Soluble BCMA mirrors bone marrow disease burden and predicts outcome in multiple myeloma patients
D. Soncini
2026Haematologica0 citations Open access
Semantic Scholar
The NAD + Metabolic Dependency Restriction Overcomes Drug-Resistance Phenotype of Multiple Myeloma CELLS
D. Soncini, P. Becherini, S. Ravera, C. Martinuzzi +9 more
2023Blood0 citations Open access
Semantic Scholar
Deciphering the Immune Microenvironment in Waldenstrom's Macroglobulinemia
A. Sacco, V. Desantis, Jon Celay, V. Giustini +20 more
2023Blood0 citations Open access
Semantic Scholar
Targeting the deacetylase SIRT6 unveils spliceosome deregulation as exploitable vulnerability for aggressive myeloma
Elisa Gelli, D. Soncini, P. Becherini, C. Martinuzzi +10 more
2023Blood Advances0 citations Open access
Semantic Scholar
The Multi-Kinases Inhibitor ARQ531 Enhanches Anti-MM Activity of Imids By Dual Deregulation of MAP- and Cyclin-Dependent Kinases Activities
D. Soncini, P. Becherini, Elisa Gelli, C. Martinuzzi +5 more
2022Blood0 citations Open access
Semantic Scholar
The new small tyrosine kinase inhibitor ARQ531 targets acute myeloid leukemia cells by disrupting multiple tumor-addicted programs.
D. Soncini, Stefania Orecchioni, Samantha Ruberti, P. Minetto +21 more
2019Haematologica0 citations Open access
Semantic Scholar

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