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P. Borralho · SciRah

Researcher profile · Semantic Scholar

P. Borralho

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P. Borralho — researcher profile on SciRah

h-index: 34
Works: 73
Citations: 3,343

Most-cited papers

miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease.
R. Castro, D. M. S. Ferreira, M. B. Afonso, P. Borralho +3 more
2013Journal of Hepatology347 citations
Semantic Scholar
Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states
A. Sarver, A. French, P. Borralho, V. Thayanithy +12 more
2009BMC Cancer326 citations Open access
Semantic Scholar
Delivering the promise of miRNA cancer therapeutics.
Diane M. Pereira, P. Rodrigues, P. Borralho, C. Rodrigues
2013Drug Discovery Today292 citations
Semantic Scholar
MicroRNA‐143 reduces viability and increases sensitivity to 5‐fluorouracil in HCT116 human colorectal cancer cells
P. Borralho, B. Kren, R. Castro, I. B. Moreira da Silva +2 more
2009The FEBS Journal206 citations
Semantic Scholar
miRNA Expression in Colon Polyps Provides Evidence for a Multihit Model of Colon Cancer
A. Oberg, A. French, A. Sarver, S. Subramanian +10 more
2011PLoS ONE152 citations Open access
Semantic Scholar
Efficient recovery of proteins from multiple source samples after trizol® or trizol®LS RNA extraction and long-term storage
A. Simões, Diane M. Pereira, Joana D. Amaral, A. Nunes +8 more
2013BMC Genomics113 citations Open access
Semantic Scholar
miR-143 Overexpression Impairs Growth of Human Colon Carcinoma Xenografts in Mice with Induction of Apoptosis and Inhibition of Proliferation
P. Borralho, A. Simões, Sofia E. Gomes, R. Lima +5 more
2011PLoS ONE110 citations Open access
Semantic Scholar
miR-21 ablation and obeticholic acid ameliorate nonalcoholic steatohepatitis in mice
P. Rodrigues, M. B. Afonso, A. Simão, C. Carvalho +7 more
2017Cell Death and Disease104 citations Open access
Semantic Scholar
Identification of microRNAs during rat liver regeneration after partial hepatectomy and modulation by ursodeoxycholic acid.
R. Castro, D. M. S. Ferreira, Xiao-Xiao Zhang, P. Borralho +5 more
2010American Journal of Physiology - Gastrointestinal and Liver Physiology95 citations Open access
Semantic Scholar
Cobalt complexes bearing scorpionate ligands: synthesis, characterization, cytotoxicity and DNA cleavage.
T. F. S. Silva, L. Martins, M. F. C. Guedes da Silva, A. R. Fernandes +5 more
2012Dalton Transactions84 citations
Semantic Scholar
Tauroursodeoxycholic acid modulates p53‐mediated apoptosis in Alzheimer's disease mutant neuroblastoma cells
R. Ramalho, P. Borralho, R. Castro, S. Solá +2 more
2006Journal of Neurochemistry83 citations
Semantic Scholar
The MEK5/ERK5 signalling pathway in cancer: a promising novel therapeutic target.
A. Simões, C. Rodrigues, P. Borralho
2016Drug Discovery Today79 citations
Semantic Scholar
KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines
J. Lavrado, Hugo Brito, P. Borralho, S. Ohnmacht +8 more
2015Scientific Reports79 citations Open access
Semantic Scholar
Cyclopentadienyl-ruthenium(II) and iron(II) organometallic compounds with carbohydrate derivative ligands as good colorectal anticancer agents.
Pedro R. Florindo, Diane M. Pereira, P. Borralho, C. Rodrigues +2 more
2015Journal of Medicinal Chemistry78 citations
Semantic Scholar
Nuclear translocation of UDCA by the glucocorticoid receptor is required to reduce TGF‐β1–induced apoptosis in rat hepatocytes
S. Solá, Joana D. Amaral, R. Castro, R. Ramalho +5 more
2005Hepatology71 citations Open access
Semantic Scholar
c-Jun N-Terminal Kinase 1/c-Jun Activation of the p53/MicroRNA 34a/Sirtuin 1 Pathway Contributes to Apoptosis Induced by Deoxycholic Acid in Rat Liver
D. M. S. Ferreira, M. B. Afonso, P. Rodrigues, A. Simão +4 more
2014Molecular and Cellular Biology69 citations Open access
Semantic Scholar
MEK5/ERK5 signaling inhibition increases colon cancer cell sensitivity to 5-fluorouracil through a p53-dependent mechanism
Diane M. Pereira, A. Simões, Sofia E. Gomes, R. Castro +3 more
2016OncoTarget64 citations Open access
Semantic Scholar
Functional modulation of nuclear steroid receptors by tauroursodeoxycholic acid reduces amyloid beta-peptide-induced apoptosis.
S. Solá, Joana D. Amaral, P. Borralho, R. Ramalho +4 more
2006Molecular Endocrinology62 citations Open access
Semantic Scholar
Aberrant MEK5/ERK5 signalling contributes to human colon cancer progression via NF-κB activation
Aes Simões, Diane M. Pereira, Sofia E. Gomes, Hugo Brito +7 more
2015Cell Death and Disease56 citations Open access
Semantic Scholar
miR-143 or miR-145 overexpression increases cetuximab-mediated antibody-dependent cellular cytotoxicity in human colon cancer cells
Sofia E. Gomes, A. Simões, Diane M. Pereira, R. Castro +2 more
2016OncoTarget52 citations Open access
Semantic Scholar
Inhibition of Fas expression by RNAi modulates 5-fluorouracil-induced apoptosis in HCT116 cells expressing wild-type p53.
P. Borralho, I. B. Moreira da Silva, M. M. Aranha, C. Albuquerque +3 more
2007Biochimica et Biophysica Acta51 citations Open access
Semantic Scholar
Convergence of miR-143 overexpression, oxidative stress and cell death in HCT116 human colon cancer cells
Sofia E. Gomes, Diane M. Pereira, C. Roma-Rodrigues, A. R. Fernandes +2 more
2018PLoS ONE47 citations Open access
Semantic Scholar
Targeting KRAS Oncogene in Colon Cancer Cells with 7-Carboxylate Indolo[3,2-b]quinoline Tri-Alkylamine Derivatives
Hugo Brito, Ana Cláudia Martins, J. Lavrado, E. Mendes +9 more
2015PLoS ONE46 citations Open access
Semantic Scholar
Biological characterization of the antiproliferative potential of Co(II) and Sn(IV) coordination compounds in human cancer cell lines: a comparative proteomic approach
A. Silva, Daniel V. Luís, Susana Santos, Joana Silva +12 more
2013Drug Metabolism and Drug Interactions46 citations
Semantic Scholar
Cobalt and Zinc Compounds Bearing 1,10-Phenanthroline-5,6-dione or 1,3,5-Triaza-7-phosphaadamantane Derivatives – Synthesis, Characterization, Cytotoxicity, and Cell Selectivity Studies
T. F. S. Silva, Piotr Smoleński, L. Martins, M. F. C. Guedes da Silva +7 more
201344 citations
Semantic Scholar
MEK5/ERK5 activation regulates colon cancer stem-like cell properties
Diane M. Pereira, Sofia E. Gomes, P. Borralho, C. Rodrigues
2019Cell Death Discovery42 citations Open access
Semantic Scholar
Monoterpene bisindole alkaloids, from the African medicinal plant Tabernaemontana elegans, induce apoptosis in HCT116 human colon carcinoma cells.
T. A. Mansoor, P. Borralho, S. Dewanjee, S. Mulhovo +2 more
2013Journal of Ethnopharmacology42 citations
Semantic Scholar
In Silico HCT116 Human Colon Cancer Cell-Based Models En Route to the Discovery of Lead-Like Anticancer Drugs
S. Cruz, Sofia E. Gomes, P. Borralho, C. Rodrigues +2 more
2018Biomolecules41 citations Open access
Semantic Scholar
microRNAs in Mitochondria: An Unexplored Niche.
P. Borralho, C. Rodrigues, C. Steer
2015Advances in Experimental Medicine and Biology40 citations
Semantic Scholar
Insights into the mechanisms underlying the antiproliferative potential of a Co(II) coordination compound bearing 1,10-phenanthroline-5,6-dione: DNA and protein interaction studies
Daniel V. Luís, Joana Silva, A. Tomaz, R. D. de Almeida +9 more
2014JBIC Journal of Biological Inorganic Chemistry39 citations
Semantic Scholar
Apoptosis inducing activity of benzophenanthridine-type alkaloids and 2-arylbenzofuran neolignans in HCT116 colon carcinoma cells.
T. A. Mansoor, P. Borralho, Xuan Luo, S. Mulhovo +2 more
2013Phytomedicine38 citations
Semantic Scholar
Synthesis, G‐Quadruplex Stabilisation, Docking Studies, and Effect on Cancer Cells of Indolo[3,2‐b]quinolines with One, Two, or Three Basic Side Chains
J. Lavrado, P. Borralho, Stephan A. Ohnmacht, R. Castro +5 more
2013ChemMedChem38 citations Open access
Semantic Scholar
The Madeira Archipelago As a Significant Source of Marine-Derived Actinomycete Diversity with Anticancer and Antimicrobial Potential
A. Prieto-Davó, T. Dias, Sofia E. Gomes, S. Rodrigues +6 more
2016Frontiers in Microbiology35 citations Open access
Semantic Scholar
Inhibition of NF-κB by deoxycholic acid induces miR-21/PDCD4-dependent hepatocellular apoptosis
P. Rodrigues, M. B. Afonso, A. Simão, P. Borralho +2 more
2015Scientific Reports34 citations Open access
Semantic Scholar
Monoterpene indole alkaloid hydrazone derivatives with apoptosis inducing activity in human HCT116 colon and HepG2 liver carcinoma cells.
Angela Paterna, P. Borralho, Sofia E. Gomes, S. Mulhovo +2 more
2015Bioorganic & Medicinal Chemistry Letters28 citations Open access
Semantic Scholar
Evaluation of a new high-dimensional miRNA profiling platform
J. Cunningham, A. Oberg, P. Borralho, B. Kren +12 more
2009BMC Medical Genomics27 citations Open access
Semantic Scholar
Vobasinyl-Iboga Alkaloids from Tabernaemontana elegans: Cell Cycle Arrest and Apoptosis-Inducing Activity in HCT116 Colon Cancer Cells.
Angela Paterna, Sofia E. Gomes, P. Borralho, S. Mulhovo +2 more
2016Journal of Natural Products25 citations
Semantic Scholar
(3'R)-hydroxytabernaelegantine C: A bisindole alkaloid with potent apoptosis inducing activity in colon (HCT116, SW620) and liver (HepG2) cancer cells.
Angela Paterna, Sofia E. Gomes, P. Borralho, S. Mulhovo +2 more
2016Journal of Ethnopharmacology20 citations Open access
Semantic Scholar
Mitochondrial MicroRNAs and Their Potential Role in Cell Function
P. Borralho, C. Rodrigues, C. Steer
2014Current Pathobiology Reports19 citations Open access
Semantic Scholar
New Lectins from Mediterranean Flora. Activity against HT29 Colon Cancer Cells
Isabel Oliveira, A. Nunes, Ana Lima, P. Borralho +3 more
2019International Journal of Molecular Sciences18 citations Open access
Semantic Scholar
New [(η(5)-C5H5)Ru(N-N)(PPh3)][PF6] compounds: colon anticancer activity and GLUT-mediated cellular uptake of carbohydrate-appended complexes.
Pedro R. Florindo, Diane M. Pereira, P. Borralho, Paulo J. Costa +3 more
2016Dalton Transactions18 citations
Semantic Scholar
6-Acetonyldihydrochelerythrine Is a Potent Inducer of Apoptosis in HCT116 and SW620 Colon Cancer Cells.
T. A. Mansoor, P. Borralho, Xuan Luo, S. Mulhovo +2 more
2014Journal of Natural Products14 citations
Semantic Scholar
The MEK 5 / ERK 5 signalling pathway in cancer : a promising novel therapeutic target
A. Simões, C. Rodrigues, P. Borralho
201612 citations
Semantic Scholar
Colorectal cancer: can nutrients modulate NF-kappaB and apoptosis?
P. Ravasco, M. M. Aranha, P. Borralho, I. B. Moreira da Silva +4 more
2010Clinical Nutrition12 citations
Semantic Scholar
miR-21 ablation and obeticholic acid ameliorate nonalcoholic steatohepatitis in mice
P. Rodrigues, M. B. Afonso, A. Simão, C. Carvalho +7 more
2017Cell Death and Disease10 citations Open access
Semantic Scholar
Evaluation of PIK3CA mutations in advanced ER+/HER2-breast cancer in Portugal – U-PIK Project
A. Peixoto, L. Cirnes, A. L. Carvalho, Maria João Andrade +24 more
2023Frontiers in Molecular Biosciences8 citations Open access
Semantic Scholar
Corrigendum: Inhibition of NF-κB by deoxycholic acid induces miR-21/PDCD4-dependent hepatocellular apoptosis
P. Rodrigues, M. B. Afonso, A. Simão, P. Borralho +2 more
2016Scientific Reports5 citations Open access
Semantic Scholar
Isolation of mitochondria from liver and extraction of total RNA and protein: analyses of microRNA and protein expressions.
P. Borralho, C. Steer, C. Rodrigues
2015Methods in molecular biology5 citations
Semantic Scholar
Synthesis, G‐Quadruplex Stabilization, Docking Studies, and Effect on Cancer Cells of Indolo[3,2‐b]quinolines with One, Two, or Three Basic Side Chains.
J. Lavrado, P. Borralho, S. Ohnmacht, R. Castro +5 more
20144 citations
Semantic Scholar
Isolation of Mitochondria from Liver and Extraction of Total RNA and Protein: Analyses of miRNA and Protein Expression.
A. Simão, P. Borralho, C. Steer, R. Castro +1 more
2021Methods in molecular biology3 citations
Semantic Scholar

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C. Steer×13
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