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M. B. Afonso · SciRah

Researcher profile · Semantic Scholar

M. B. Afonso

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M. B. Afonso — researcher profile on SciRah

h-index: 22
Works: 80
Citations: 2,219

Most-cited papers

miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease.
R. Castro, D. M. S. Ferreira, M. B. Afonso, P. Borralho +3 more
2013Journal of Hepatology347 citations
Semantic Scholar
Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis.
M. B. Afonso, P. Rodrigues, T. Carvalho, M. Caridade +4 more
2015Clinical science207 citations
Semantic Scholar
An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD)
M. Vacca, Ioannis Kamzolas, L. M. Harder, Fiona Oakley +55 more
2024Nature Metabolism201 citations Open access
Semantic Scholar
Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease.
Amine Majdi, L. Aoudjehane, V. Ratziu, T. Islam +19 more
2019Journal of Hepatology140 citations Open access
Semantic Scholar
Activation of necroptosis in human and experimental cholestasis
M. B. Afonso, P. Rodrigues, A. Simão, D. Ofengeim +7 more
2016Cell Death and Disease125 citations Open access
Semantic Scholar
miRNA-21 ablation protects against liver injury and necroptosis in cholestasis
M. B. Afonso, P. Rodrigues, A. Simão, M. M. Gaspar +5 more
2018Cell Death and Differentiation105 citations Open access
Semantic Scholar
miR-21 ablation and obeticholic acid ameliorate nonalcoholic steatohepatitis in mice
P. Rodrigues, M. B. Afonso, A. Simão, C. Carvalho +7 more
2017Cell Death and Disease104 citations Open access
Semantic Scholar
RIPK3 acts as a lipid metabolism regulator contributing to inflammation and carcinogenesis in non-alcoholic fatty liver disease
M. B. Afonso, P. Rodrigues, Miguel Mateus-Pinheiro, A. Simão +14 more
2020Gut96 citations Open access
Semantic Scholar
Circulating microRNAs as Potential Biomarkers in Non-Alcoholic Fatty Liver Disease and Hepatocellular Carcinoma
M. B. Afonso, P. Rodrigues, A. Simão, R. Castro
2016Journal of Clinical Medicine93 citations Open access
Semantic Scholar
c-Jun N-Terminal Kinase 1/c-Jun Activation of the p53/MicroRNA 34a/Sirtuin 1 Pathway Contributes to Apoptosis Induced by Deoxycholic Acid in Rat Liver
D. M. S. Ferreira, M. B. Afonso, P. Rodrigues, A. Simão +4 more
2014Molecular and Cellular Biology69 citations Open access
Semantic Scholar
Signalling networks in cholangiocarcinoma: Molecular pathogenesis, targeted therapies and drug resistance
L. Fouassier, M. Marzioni, M. B. Afonso, S. Dooley +9 more
2019Liver international (Print)66 citations Open access
Semantic Scholar
Antitumour Potential of Gigartina pistillata Carrageenans against Colorectal Cancer Stem Cell-Enriched Tumourspheres
João Cotas, Vanda Marques, M. B. Afonso, C. Rodrigues +1 more
2020Marine Drugs65 citations Open access
Semantic Scholar
Adiponectin, Leptin, and IGF-1 Are Useful Diagnostic and Stratification Biomarkers of NAFLD
Vanda Marques, M. B. Afonso, Nina Bierig, F. Duarte-Ramos +20 more
2021Frontiers in Medicine63 citations Open access
Semantic Scholar
Human liver organoids: From generation to applications
M. B. Afonso, Vanda Marques, S. V. van Mil, C. Rodrigues
2023Hepatology57 citations Open access
Semantic Scholar
Diet-dependent gut microbiota impacts on adult neurogenesis through mitochondrial stress modulation
M. F. Ribeiro, André A. Santos, M. B. Afonso, P. Rodrigues +4 more
2020Brain Communications53 citations Open access
Semantic Scholar
Host miRNA-21 promotes liver dysfunction by targeting small intestinal Lactobacillus in mice
André A. Santos, M. B. Afonso, Ricardo S. Ramiro, David Pires +3 more
2020Gut microbes52 citations Open access
Semantic Scholar
miR‐21‐5p promotes NASH‐related hepatocarcinogenesis
P. Rodrigues, M. B. Afonso, A. Simão, T. Islam +16 more
2023Liver international (Print)48 citations Open access
Semantic Scholar
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease
M. B. Afonso, T. Islam, Julie Magusto, R. Amorim +13 more
2022Hepatology48 citations Open access
Semantic Scholar
Skeletal muscle miR-34a/SIRT1:AMPK axis is activated in experimental and human non-alcoholic steatohepatitis
A. Simão, M. B. Afonso, P. Rodrigues, Margarida Gama-Carvalho +4 more
2019Journal of molecular medicine36 citations
Semantic Scholar
Inhibition of NF-κB by deoxycholic acid induces miR-21/PDCD4-dependent hepatocellular apoptosis
P. Rodrigues, M. B. Afonso, A. Simão, P. Borralho +2 more
2015Scientific Reports34 citations Open access
Semantic Scholar
Polyoxazoline‐Based Nanovaccine Synergizes with Tumor‐Associated Macrophage Targeting and Anti‐PD‐1 Immunotherapy against Solid Tumors
Ana I. Matos, C. Peres, B. Carreira, Liane I. F. Moura +16 more
2023Advancement of science26 citations Open access
Semantic Scholar
Processes exacerbating apoptosis in non-alcoholic steatohepatitis.
M. B. Afonso, R. Castro, C. Rodrigues
2019Clinical science23 citations
Semantic Scholar
Intricate interplay between cell metabolism and necroptosis regulation in metabolic dysfunction-associated steatotic liver disease: A narrative review.
M. B. Afonso, J. David, M. I. Alves, André Santos +4 more
2024Metabolism: Clinical and Experimental17 citations Open access
Semantic Scholar
The role of RIPK3 in liver mitochondria bioenergetics and function
T. Islam, M. B. Afonso, C. Rodrigues
2021European Journal of Clinical Investigation17 citations
Semantic Scholar
Phenotypic high-throughput screening platform identifies novel chemotypes for necroptosis inhibition
Hugo Brito, Vanda Marques, M. B. Afonso, Dean G. Brown +9 more
2020Cell Death Discovery17 citations Open access
Semantic Scholar
The necroptosis-inducing pseudokinase mixed lineage kinase domain-like regulates the adipogenic differentiation of pre-adipocytes
Julie Magusto, C. Beaupere, M. B. Afonso, M. Auclair +10 more
2022iScience14 citations Open access
Semantic Scholar
Inhibition of lysophosphatidic acid receptor 6 upregulated by the choline‐deficient l‐amino acid‐defined diet prevents hepatocarcinogenesis in mice
D. Gnocchi, M. B. Afonso, M. Cavalluzzi, G. Lentini +4 more
2023Molecular Carcinogenesis11 citations Open access
Semantic Scholar
Combining 1,3‐Ditriazolylbenzene and Quinoline to Discover a New G‐Quadruplex‐Interactive Small Molecule Active against Cancer Stem‐Like Cells
E. Mendes, Enrico Cadoni, Filipa Carneiro, M. B. Afonso +7 more
2019ChemMedChem11 citations Open access
Semantic Scholar
miR-21 ablation and obeticholic acid ameliorate nonalcoholic steatohepatitis in mice
P. Rodrigues, M. B. Afonso, A. Simão, C. Carvalho +7 more
2017Cell Death and Disease10 citations Open access
Semantic Scholar
Disclosing the antitumour potential of the marine bromoditerpene sphaerococcenol A on distinct cancer cellular models.
Celso Alves, Joana Silva, M. B. Afonso, Romina A. Guedes +10 more
2022Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie9 citations Open access
Semantic Scholar
Decoding the role of leptin and adiponectin in obesity-related gastrointestinal cancer.
Vanda Marques, Fabiola Arella, M. B. Afonso, André A. Santos +1 more
2023Clinical science6 citations
Semantic Scholar
Role of CNNM4 in the progression of cholangiocarcinoma: implications for ferroptosis and therapeutic potential
Maria Mercado-Gómez, Naroa Goikoetxea-Usandizaga, Alvaro Eguileor Giné, M. A. Merlos Rodrigo +45 more
2025Gut5 citations Open access
Semantic Scholar
Corrigendum: Inhibition of NF-κB by deoxycholic acid induces miR-21/PDCD4-dependent hepatocellular apoptosis
P. Rodrigues, M. B. Afonso, A. Simão, P. Borralho +2 more
2016Scientific Reports5 citations Open access
Semantic Scholar
On the way to understand antioxidants: chromanol and dimethoxyphenols gas-phase acidities.
P. J. Amorim Madeira, M. Faddoul, M. B. Afonso, Pedro D. Vaz +2 more
2011Journal of Mass Spectrometry5 citations
Semantic Scholar
Microfluidic Detection of Adenylate Kinase as a Cell Damage Biomarker
C. Domingues, P. M. Fontes, Pedro G. M. Condelipes, Vanda Marques +4 more
2023Chemosensors4 citations Open access
Semantic Scholar
Towards personalized antibody cancer therapy: development of a microfluidic cell culture device for antibody selection.
Pedro G. M. Condelipes, P. M. Fontes, Ana Godinho-Santos, Eduardo J. S. Brás +6 more
2022Lab on a Chip4 citations
Semantic Scholar
Modulation of rectal cancer stemness, patient outcome and therapy response by adipokines
Vanda Marques, S. Ôuro, M. B. Afonso, C. Rodrigues
2022Journal of physiology and biochemistry4 citations
Semantic Scholar
Necrosome Formation and Necroptosis in Experimental Cholestasis.
M. B. Afonso, C. Rodrigues
2019Methods in molecular biology3 citations
Semantic Scholar
The role of necroptosis in non-alcoholic fatty liver disease-related carcinogenesis
M. B. Afonso, P. Rodrigues, A. Simão, André A. Santos +3 more
20183 citations
Semantic Scholar
MicroRevolution in understanding primary biliary cholangitis pathophysiology
M. B. Afonso, C. Rodrigues
2018Hepatology2 citations Open access
Semantic Scholar
miRNA-21 ablation protects against liver injury and necroptosis in cholestasis
M. B. Afonso, P. Rodrigues, A. Simão, M. M. Gaspar +5 more
2017Cell Death and Differentiation2 citations Open access
Semantic Scholar
P0951 : MIR-21 inhibition and FXR activation synergistically ameliorate disease pathogenesis in a mouse model of NAFLD
P. Rodrigues, M. B. Afonso, A. Simão, M. Caridade +8 more
20152 citations
Semantic Scholar
Is there a murine model that fully recapitulates human NASH? An unbiased bioinformatics approach to rank pre-clinical models based on proximity to human disease
M. Vacca, Ioannis Kamzolas, L. M. Harder, F. Oakley +43 more
2022Journal of Hepatology1 citations
Semantic Scholar
mIR-21 is increased in patients with NASH-associated HCC and contributes to hepatocarcinogenesis in mice with NAFLD
P. Rodrigues, M. B. Afonso, A. Simão, T. Islam +12 more
2020Journal of Hepatology1 citations Open access
Semantic Scholar
Development Of a Microfluidic Colorectal Cancer Cell Culture System with Integrated Optical Sensors for Rapid Phage Selection
Pedro G. M. Condelipes, P. M. Fontes, K. Nikolaidou, Vanda Marques +6 more
2020Italian National Conference on Sensors1 citations
Semantic Scholar
Administration of lactobacillus alleviates experimental NASH by reducing miR-21 in the liver
André A. Santos, M. B. Afonso, A. Simão, R. Castro +1 more
2020Journal of Hepatology1 citations Open access
Semantic Scholar
PS-003-Activation of the miR-34a/SIRT1:AMPK axis contributes for insulin resistance and mitochondrial dysfunction in the NAFLD muscle
A. Simão, M. B. Afonso, P. Rodrigues, Margarida Gama-Carvalho +4 more
2019Journal of Hepatology1 citations
Semantic Scholar
Role of mitofusin-2 in NAFLD and targeting by miRNAs
A. Simão, M. B. Afonso, P. Rodrigues, A. Amaral +4 more
20181 citations
Semantic Scholar
miRNA-21-deficiency reduces liver injury, fibrosis and necroptosis in cholestatic bile duct-ligated mice
M. B. Afonso, P. Rodrigues, A. Simão, M. M. Gaspar +2 more
20171 citations
Semantic Scholar
Activation of miR-34a contributes to liver and muscle insulin resistance in experimental and human non-alcoholic fatty liver disease
A. Simão, M. B. Afonso, P. Rodrigues, A. Amaral +4 more
20171 citations
Semantic Scholar

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