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Glenn Sivits · SciRah

Researcher profile · Semantic Scholar

Glenn Sivits

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Glenn Sivits — researcher profile on SciRah

h-index: 14
Works: 20
Citations: 2,147

Most-cited papers

Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice
Jing Xu, D. Lloyd, C. Hale, Shanaka Stanislaus +12 more
2009Diabetes1,105 citations Open access
Semantic Scholar
Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models
Elizabeth A. Killion, Jing-Hong Wang, J. Yie, S. Shi +22 more
2018Science Translational Medicine207 citations
Semantic Scholar
Pharmacologic Effects of FGF21 Are Independent of the "Browning" of White Adipose Tissue.
M. Véniant, Glenn Sivits, Joan Helmering, R. Komorowski +4 more
2015Cell Metabolism203 citations Open access
Semantic Scholar
Chronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism
Elizabeth A. Killion, Michelle M. Chen, James R. Falsey, Glenn Sivits +9 more
2020Nature Communications129 citations Open access
Semantic Scholar
Long-Term Inhibition of the Glucagon Receptor with a Monoclonal Antibody in Mice Causes Sustained Improvement in Glycemic Control, with Reversible α-Cell Hyperplasia and Hyperglucagonemia
W. Gu, Hai Yan, K. Winters, R. Komorowski +11 more
2009Journal of Pharmacology and Experimental Therapeutics97 citations
Semantic Scholar
Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors
D. Lloyd, D. S. St Jean, R. Kurzeja, R. Wahl +25 more
2013Nature96 citations
Semantic Scholar
Glucagon receptor antagonist-mediated improvements in glycemic control are dependent on functional pancreatic GLP-1 receptor.
W. Gu, K. Winters, A. Motani, R. Komorowski +12 more
2010American Journal of Physiology. Endocrinology and Metabolism51 citations
Semantic Scholar
Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N'-arylpiperazine series.
N. Nishimura, M. Norman, Longbin Liu, Kevin C. Yang +16 more
2014Journal of Medicinal Chemistry48 citations Open access
Semantic Scholar
GIPR-Ab/GLP-1 peptide–antibody conjugate requires brain GIPR and GLP-1R for additive weight loss in obese mice
Clarissa M. Liu, Elizabeth A. Killion, Rola Hammoud, Shu-Chen Lu +14 more
2025Nature Metabolism35 citations Open access
Semantic Scholar
Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase-Glucokinase Regulatory Protein (GK-GKRP) Binding: Strategic Use of a N → S (nN → σ*S-X) Interaction for Conformational Constraint.
L. Pennington, M. Bartberger, Michael D Croghan, Kristin L. Andrews +28 more
2015Journal of Medicinal Chemistry34 citations Open access
Semantic Scholar
Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 1. Discovery of a novel tool compound for in vivo proof-of-concept.
K. Ashton, Kristin L. Andrews, M. Bryan, Jie Chen +20 more
2014Journal of Medicinal Chemistry33 citations Open access
Semantic Scholar
Pharmacological Targeting of Glucagon and Glucagon-Like Peptide 1 Receptors Has Different Effects on Energy State and Glucose Homeostasis in Diet-Induced Obese Mice
W. Gu, D. Lloyd, Narumol Chinookswong, R. Komorowski +7 more
2011Journal of Pharmacology and Experimental Therapeutics33 citations
Semantic Scholar
Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 5. A Novel Aryl Sulfone Series, Optimization Through Conformational Analysis.
N. Tamayo, M. Norman, M. Bartberger, Fang-Tsao Hong +15 more
2015Journal of Medicinal Chemistry28 citations
Semantic Scholar
Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 2. Leveraging structure-based drug design to identify analogues with improved pharmacokinetic profiles.
D. S. St Jean, K. Ashton, M. Bartberger, Jie Chen +24 more
2014Journal of Medicinal Chemistry26 citations Open access
Semantic Scholar
FGF21 Reverses Hepatic Steatosis, Increases Energy Expenditure and Improves Insulin Sensitivity in Diet-induced Obese Mice
Jing Xu, D. Lloyd, C. Hale, Shanaka Stanislaus +13 more
200813 citations
Semantic Scholar
Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 4. Exploration of a novel binding pocket.
Fang-Tsao Hong, M. Norman, K. Ashton, M. Bartberger +10 more
2014Journal of Medicinal Chemistry10 citations Open access
Semantic Scholar
JPET # 157685 1 Long-term Inhibition of the Glucagon Receptor with a Monoclonal Antibody in Mice Causes Sustained Improvement in Glycemic Control , with Reversibility of Alpha-Cell Hyperplasia and Hyperglucagonemia
W. Gu, Hai Yan, K. Winters, R. Komorowski +10 more
20091 citations
Semantic Scholar
Human GKRP bound to AMG-5980 and S6P
D. S. St Jean, K. Ashton, M. Bartberger, J. Chen +20 more
20140 citations
Semantic Scholar
Human GKRP bound to AMG-0696 and Sorbitol-6-phosphate
K. Ashton, Kristin L. Andrews, M. Bryan, J. Chen +20 more
20140 citations
Semantic Scholar
mixed meal in type 2 diabetes Regulation of endogenous glucose production after a
P. Singhal, Andrea Caumo, Peter Carey, C. Cobelli +52 more
20020 citations
Semantic Scholar

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