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Shanaka Stanislaus · SciRah

Researcher profile · Semantic Scholar

Shanaka Stanislaus

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Shanaka Stanislaus — researcher profile on SciRah

h-index: 17
Works: 27
Citations: 2,897

Most-cited papers

Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice
Jing Xu, D. Lloyd, C. Hale, Shanaka Stanislaus +12 more
2009Diabetes1,105 citations Open access
Semantic Scholar
Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models--association with liver and adipose tissue effects.
Jing Xu, Shanaka Stanislaus, N. Chinookoswong, Yvonne Y. Lau +12 more
2009American Journal of Physiology. Endocrinology and Metabolism340 citations
Semantic Scholar
Lack of overt FGF21 resistance in two mouse models of obesity and insulin resistance.
C. Hale, Michelle M. Chen, Shanaka Stanislaus, N. Chinookoswong +4 more
2012Endocrinology194 citations Open access
Semantic Scholar
A GIPR antagonist conjugated to GLP-1 analogues promotes weight loss with improved metabolic parameters in preclinical and phase 1 settings
M. Véniant, Shu-Chen Lu, Larissa I. Atangan, R. Komorowski +16 more
2024Nature Metabolism178 citations Open access
Semantic Scholar
Rationale-Based Engineering of a Potent Long-Acting FGF21 Analog for the Treatment of Type 2 Diabetes
R. Hecht, Yue-sheng Li, Jeonghoon Sun, Ed Belouski +17 more
2012PLoS ONE168 citations Open access
Semantic Scholar
Long-acting FGF21 has enhanced efficacy in diet-induced obese mice and in obese rhesus monkeys.
M. Véniant, R. Komorowski, Ping Chen, Shanaka Stanislaus +6 more
2012Endocrinology144 citations
Semantic Scholar
FGF21 Promotes Metabolic Homeostasis via White Adipose and Leptin in Mice
M. Véniant, C. Hale, Joan Helmering, Michelle M. Chen +5 more
2012PLoS ONE141 citations Open access
Semantic Scholar
A Novel Fc-FGF21 With Improved Resistance to Proteolysis, Increased Affinity Toward &bgr;-Klotho, and Enhanced Efficacy in Mice and Cynomolgus Monkeys
Shanaka Stanislaus, R. Hecht, J. Yie, Todd Hager +12 more
2017Endocrinology98 citations
Semantic Scholar
GIPR antagonist antibodies conjugated to GLP-1 peptide are bispecific molecules that decrease weight in obese mice and monkeys
Shu-Chen Lu, Michelle M. Chen, Larissa I. Atangan, Elizabeth A. Killion +13 more
2021Cell Reports Medicine84 citations Open access
Semantic Scholar
Design and synthesis of conformationally constrained glucagon-like peptide-1 derivatives with increased plasma stability and prolonged in vivo activity.
L. Miranda, K. Winters, C. Gegg, Ankit Patel +11 more
2008Journal of Medicinal Chemistry78 citations Open access
Semantic Scholar
Nicotinic acetylcholine receptor distribution in relation to spinal neurotransmission pathways
I. Khan, H. Osaka, Shanaka Stanislaus, R. M. Calvo +3 more
2003The Journal of comparative neurology69 citations Open access
Semantic Scholar
Polyethylene glycol modified FGF21 engineered to maximize potency and minimize vacuole formation.
Jing Xu, J. Bussiere, J. Yie, A. Sickmier +4 more
2013Bioconjugate chemistry59 citations
Semantic Scholar
FGF21 Is Not a Major Mediator for Bone Homeostasis or Metabolic Actions of PPARα and PPARγ Agonists
Xiao-Dong Li, Shanaka Stanislaus, F. Asuncion, Qing-Tian Niu +14 more
2017Journal of Bone and Mineral Research58 citations Open access
Semantic Scholar
FGF21 acts as a negative regulator of bile acid synthesis.
Michelle M. Chen, C. Hale, Shanaka Stanislaus, Jing Xu +1 more
2018Journal of Endocrinology49 citations Open access
Semantic Scholar
A-85380 and epibatidine each interact with disparate spinal nicotinic receptor subtypes to achieve analgesia and nociception.
I. Khan, Shanaka Stanislaus, Limin Zhang, Palmer Taylor +1 more
2001Journal of Pharmacology and Experimental Therapeutics48 citations
Semantic Scholar
A Novel Approach to Improve the Function of FGF21
Richard Smith, Amy N. Duguay, Jennifer Weiszmann, Shanaka Stanislaus +7 more
2013BioDrugs22 citations
Semantic Scholar
Lack of Overt FGF 21 Resistance in Two Mouse Models of Obesity and Insulin Resistance
C. Hale, Michelle M. Chen, Shanaka Stanislaus, N. Chinookoswong +4 more
201118 citations
Semantic Scholar
FGF21 Reverses Hepatic Steatosis, Increases Energy Expenditure and Improves Insulin Sensitivity in Diet-induced Obese Mice
Jing Xu, D. Lloyd, C. Hale, Shanaka Stanislaus +13 more
200813 citations
Semantic Scholar
Elimination of rat spinal substance P receptor bearing neurons dissociates cardiovascular and nocifensive responses to nicotinic agonists.
I. Khan, Chris V. Wart, Erin A. Singletary, Shanaka Stanislaus +3 more
2008Neuropharmacology10 citations Open access
Semantic Scholar
Nicotinic receptor gene cluster on rat chromosome 8 in nociceptive and blood pressure hyperresponsiveness.
I. Khan, Erin A. Singletary, A. Alemayehu, Shanaka Stanislaus +3 more
2002Physiological Genomics10 citations
Semantic Scholar
SPINAL NICOTINIC RECEPTOR ACTIVITY IN A GENETIC MODEL OF HYPERTENSION
I. Khan, Shanaka Stanislaus, Limin Zhang, D. A. Vaughn +3 more
2001Clinical and experimental hypertension7 citations
Semantic Scholar
Th-P16:329 The effect of leptin versus food restriction on lipid metabolism and atherosclerosis in ApoE-/-ApoB100/100OB-/- and LDLR-/-ApoB100/100 OB-/- mice
J. Mccormick, Stephen A. Kaufman, J. Witkosky, Shanaka Stanislaus +3 more
20064 citations
Semantic Scholar
Discovery of AMG 133, a Glucose-Dependent Insulinotropic Polypeptide Receptor Antagonist and Glucagon-Like Peptide 1 Receptor Agonist Antibody-Drug Conjugate for the Treatment of Obesity
Bin Wu, James R. Falsey, Chawita Netirojjanakul, B. Herberich +16 more
2026Journal of Medicinal Chemistry3 citations
Semantic Scholar
Method of treating or ameliorating metabolic disorders using antagonistic binding proteins for gastric inhibitory peptide receptor (gipr)/glp-1 receptor agonist fusion proteins
K. Walker, J. R. Holder, D. Lloyd, Shu-Chen Lu +2 more
20180 citations
Semantic Scholar
Traitement de troubles liés à l'acide biliaire
Jing Xu, Shanaka Stanislaus, Meicui Chen, C. Hale +1 more
20160 citations
Semantic Scholar
FGF 21 is not a major mediator for bone homeostasis or metabolic actions of PPAR and PPAR agonists † Running Title : FGF 21 on bone and actions of PPAR PPAR
Xiao-Dong Li, Shanaka Stanislaus, F. Asuncion, Qing-Tian Niu +16 more
20160 citations
Semantic Scholar
association with liver and adipose tissue effects -- of FGF21 in insulin-resistant mouse models Acute glucose-lowering and insulin-sensitizing action
James Busby, R. Hecht, Yue-sheng Li, Yang Li +19 more
20110 citations
Semantic Scholar

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