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R. Wahl · SciRah

Researcher profile · Semantic Scholar

R. Wahl

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R. Wahl — researcher profile on SciRah

h-index: 20
Works: 39
Citations: 1,629

Most-cited papers

Towards defining the urinary proteome using liquid chromatography‐tandem mass spectrometry I.Profiling an unfractionated tryptic digest
Chris Spahr, M. T. Davis, M. Mcginley, John H. Robinson +9 more
2001Proteomics270 citations
Semantic Scholar
Structure of human neutrophil collagenase reveals large S1′ specificity pocket
T. Stams, J. Spurlino, D. L. Smith, R. Wahl +4 more
1994Nature Structural Biology149 citations
Semantic Scholar
1.56 Å structure of mature truncated human fibroblast collagenase
John C. Spurlino, A. Smallwood, D. Carlton, Tracey M. Banks +8 more
1994Proteins: Structure, Function, and Bioinformatics148 citations
Semantic Scholar
From fragment screening to in vivo efficacy: optimization of a series of 2-aminoquinolines as potent inhibitors of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1).
Yuan Cheng, T. Judd, M. Bartberger, James Brown +18 more
2011Journal of Medicinal Chemistry134 citations Open access
Semantic Scholar
Discovery and optimization of a series of benzothiazole phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors.
Noel D. D'Angelo, Tae-Seong Kim, Kristin L. Andrews, S. Booker +24 more
2011Journal of Medicinal Chemistry114 citations Open access
Semantic Scholar
Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors
D. Lloyd, D. S. St Jean, R. Kurzeja, R. Wahl +25 more
2013Nature96 citations
Semantic Scholar
Discovery and in vivo evaluation of (S)-N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and related PI3Kδ inhibitors for inflammation and autoimmune disease.
Timothy D. Cushing, Xiao-Lin Hao, Y. Shin, Kristin L. Andrews +32 more
2015Journal of Medicinal Chemistry86 citations
Semantic Scholar
Structure- and property-based design of aminooxazoline xanthenes as selective, orally efficacious, and CNS penetrable BACE inhibitors for the treatment of Alzheimer's disease.
Hong-Bing Huang, Daniel S. La, Alan C. Cheng, D. Whittington +13 more
2012Journal of Medicinal Chemistry57 citations Open access
Semantic Scholar
Design and preparation of a potent series of hydroxyethylamine containing β-secretase inhibitors that demonstrate robust reduction of central β-amyloid.
M. Weiss, Toni L. Williamson, S. Babu-Khan, M. Bartberger +34 more
2012Journal of Medicinal Chemistry56 citations Open access
Semantic Scholar
Inhibitors of β-site amyloid precursor protein cleaving enzyme (BACE1): identification of (S)-7-(2-fluoropyridin-3-yl)-3-((3-methyloxetan-3-yl)ethynyl)-5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine (AMG-8718).
Thomas A. Dineen, Kui Chen, Alan C. Cheng, K. Derakhchan +13 more
2014Journal of Medicinal Chemistry54 citations Open access
Semantic Scholar
Inhibition of matrix metalloproteinases by hydroxamates containing heteroatom-based modifications of the P1' group.
Madhusudhan R. Gowravaram, Jeffrey S. Johnson, D. Delecki, E. Cook +8 more
1995Journal of Medicinal Chemistry46 citations Open access
Semantic Scholar
Lead optimization and modulation of hERG activity in a series of aminooxazoline xanthene β-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors.
O. Epstein, M. Bryan, Alan C. Cheng, K. Derakhchan +15 more
2014Journal of Medicinal Chemistry40 citations Open access
Semantic Scholar
Design and synthesis of potent, orally efficacious hydroxyethylamine derived β-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors.
Thomas A. Dineen, M. Weiss, Toni L. Williamson, Paul D. Acton +37 more
2012Journal of Medicinal Chemistry40 citations Open access
Semantic Scholar
Determination of Pharmacophoric Geometry for Collagenase Inhibitors Using a Novel Computational Method and Its Verification Using Molecular Dynamics, NMR, and X-ray Crystallography
A. Ghose, M. Logan, A. Treasurywala, Hsin Wang +5 more
199537 citations
Semantic Scholar
Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 1. Discovery of a novel tool compound for in vivo proof-of-concept.
K. Ashton, Kristin L. Andrews, M. Bryan, Jie Chen +20 more
2014Journal of Medicinal Chemistry33 citations Open access
Semantic Scholar
An Orally Available BACE1 Inhibitor That Affords Robust CNS Aβ Reduction without Cardiovascular Liabilities.
Yuan Cheng, James Brown, T. Judd, Patricia Lopez +22 more
2015ACS Medicinal Chemistry Letters29 citations Open access
Semantic Scholar
Relationship between structure and bioavailability in a series of hydroxamate based metalloprotease inhibitors
Jasbir Singh, P. Conzentino, K. Cundy, J. Gainor +7 more
199526 citations
Semantic Scholar
A Potent and Orally Efficacious, Hydroxyethylamine-Based Inhibitor of β-Secretase.
Matthew R. Kaller, Scott S. Harried, B. Albrecht, P. Amarante +33 more
2012ACS Medicinal Chemistry Letters25 citations Open access
Semantic Scholar
Chicken Macrophage Stimulating Protein Is a Ligand of the Receptor Protein-tyrosine Kinase Sea*
R. Wahl, Rou-Yin Hsu, J. Huff, M. A. Jelinek +5 more
1999Journal of Biological Chemistry21 citations Open access
Semantic Scholar
A telomerase enzymatic assay that does not use polymerase chain reaction, radioactivity, or electrophoresis.
H. Kha, Wen Zhou, Kui Chen, B. Karan-Tamir +7 more
2004Analytical Biochemistry20 citations
Semantic Scholar
Identification of incompletely processed potential Carboxypeptidase E substrates from CpEfat/CpEfat mice
E. Bures, Paul L. Courchesne, J. Douglass, Kui Chen +8 more
2001Proteomics18 citations
Semantic Scholar
Production of selenomethionine-labeled recombinant human neutrophil collagenase in Escherichia coli.
M. Qoronfleh, Thau F. Ho, Patricia G. Brake, Tracey M. Banks +6 more
1995Journal of Biotechnology17 citations
Semantic Scholar
Hydroxamate inhibitors of the matrix metallo-proteinases (MMPs) containing novel P1′ heteroatom based modifications
B. Tomczuk, Madhusudhan R. Gowravaram, Jeffrey S. Johnson, D. Delecki +8 more
199517 citations
Semantic Scholar
Hydroxyethylamine-based inhibitors of BACE1: P₁-P₃ macrocyclization can improve potency, selectivity, and cell activity.
L. Pennington, D. Whittington, M. Bartberger, S. Jordan +12 more
2013Bioorganic & Medicinal Chemistry Letters16 citations Open access
Semantic Scholar
Hydroxamate inhibitors of human gelatinase B (92 kDa)
R. Wahl, Tricia A. Pulvino, A. Mathiowetz, A. Ghose +6 more
199516 citations
Semantic Scholar
A Metalloproteinase Inhibitor from Doliocarpus verruculosus
Hao H. Sun, Paul V. Kaplita, David R. Houck, Mary B. Stawicki +4 more
199614 citations
Semantic Scholar
Gene expression, purification and characterization of recombinant human neutrophil collagenase.
Thau F. Ho, M. Qoronfleh, R. Wahl, Tricia A. Pulvino +5 more
1994Gene13 citations
Semantic Scholar
Chapter 19. Biochemistry and Inhibition of Collagenase and Stromelysin
R. Wahl, R. P. Dunlap, B. Morgan
19909 citations
Semantic Scholar
Assignments and structure determination of the catalytic domain of human fibroblast collagenase using 3D double and triple resonance NMR spectroscopy
M. Mccoy, M. J. Dellwo, D. M. Schneider, Tracey M. Banks +9 more
1997Journal of Biomolecular NMR8 citations
Semantic Scholar
Mutation of Cys672 Allows Recombinant Expression of Activatible Macrophage-stimulating Protein*
R. Wahl, V. Costigan, Jennifer Batac, Kui Chen +5 more
1997Journal of Biological Chemistry8 citations Open access
Semantic Scholar
Comparison of native matrix metalloproteinases and their recombinant catalytic domains using a novel radiometric assay.
J. Brownell, W. Earley, E. Kunec, B. Morgan +3 more
1994Archives of Biochemistry and Biophysics5 citations
Semantic Scholar
Discovery of Small-Molecule Glucokinase Regulatory Protein Modulators That Restore Glucokinase Activity
Kui Chen, Klaus Michelsen, R. Kurzeja, Joon-Hee Han +4 more
2014Journal of biomolecular screening4 citations Open access
Semantic Scholar
Mutagenesis Of Recombinant Human Fibroblast Stromelysin C-Terminus Reveals the Autodegradation Pathway
M. Qoronfleh, Thau F. Ho, Tracey M. Banks, Tricia A. Pulvino +5 more
1996Protein & Peptide Letters2 citations
Semantic Scholar
AIDS. Case for diagnosis series, 1987.
D. Anderson, M. L. De Vinatea, A. Macher, R. Moriarity +6 more
1987Military Medicine2 citations
Semantic Scholar
Examination of recombinant truncated mature human fibroblast collagenase by mass spectrometry: identification of differences with the published sequence and determination of stable isotope incorporation.
Swapan K. Chowdhury, Jamshid Eshraghi, George Gonyea, Patricia G. Brake +6 more
1995Rapid Communications in Mass Spectrometry1 citations
Semantic Scholar
P1-241 IN VIVO REDUCTION OF BETA-AMYLOID PEPTIDES IN THEBRAINOFTG2576MICEAFTER ORAL ADMINISTRATION OFA NOVEL BACE1 INHIBITOR
Juliette Jansson, Kristina Eliason, K. Kolmodin, Paul H. Wen +24 more
20190 citations
Semantic Scholar
Human GKRP bound to AMG-0696 and Sorbitol-6-phosphate
K. Ashton, Kristin L. Andrews, M. Bryan, J. Chen +20 more
20140 citations
Semantic Scholar
P1‐243: Pharmacokinetic and pharmacodynamic evaluation of orally available hydroxyethylamine‐derived beta‐secretase inhibitors in Sprague Dawley rats
Stephen Wood, Paul H. Wen, P. Amarante, Paul D. Acton +22 more
20120 citations Open access
Semantic Scholar
Hydrokseemihappo- and carboxylic acid derivatives, a process for their preparation and their use
Madhusudhan R. Gowravaram, Jeffrey S. Johnson, E. Cook, R. Wahl +3 more
19960 citations
Semantic Scholar

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