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L. Vassen · SciRah

Researcher profile · Semantic Scholar

L. Vassen

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L. Vassen — researcher profile on SciRah

h-index: 22
Works: 50
Citations: 1,301

Most-cited papers

From cytopenia to leukemia: the role of Gfi1 and Gfi1b in blood formation.
T. Moroy, L. Vassen, B. Wilkes, C. Khandanpour
2015Blood109 citations Open access
Semantic Scholar
Gfi1 and Gfi1b act equivalently in haematopoiesis, but have distinct, non‐overlapping functions in inner ear development
Katharina Fiolka, R. Hertzano, L. Vassen, H. Zeng +4 more
2006EMBO Reports93 citations Open access
Semantic Scholar
Gfi1b:green fluorescent protein knock-in mice reveal a dynamic expression pattern of Gfi1b during hematopoiesis that is largely complementary to Gfi1.
L. Vassen, T. Okayama, T. Moroy
2007Blood91 citations Open access
Semantic Scholar
Evidence that growth factor independence 1b regulates dormancy and peripheral blood mobilization of hematopoietic stem cells.
C. Khandanpour, E. Sharif-Askari, L. Vassen, M. Gaudreau +5 more
2010Blood85 citations Open access
Semantic Scholar
Direct transcriptional repression of the genes encoding the zinc-finger proteins Gfi1b and Gfi1 by Gfi1b
L. Vassen, Katharina Fiolka, S. Mahlmann, T. Moroy
2005Nucleic Acids Research85 citations Open access
Semantic Scholar
Growth factor independence-1 antagonizes a p53-induced DNA damage response pathway in lymphoblastic leukemia
C. Khandanpour, James D. Phelan, L. Vassen, Judith Schütte +10 more
2013Cancer Cell71 citations Open access
Semantic Scholar
Gfi1b alters histone methylation at target gene promoters and sites of γ‐satellite containing heterochromatin
L. Vassen, Katharina Fiolka, T. Moroy
2006EMBO Journal68 citations Open access
Semantic Scholar
LSD1 inhibition by tranylcypromine derivatives interferes with GFI1-mediated repression of PU.1 target genes and induces differentiation in AML
J. Barth, K. Abou-El-Ardat, Denis Dalic, Nina Kurrle +17 more
2019Leukemia62 citations
Semantic Scholar
Human insulin receptor substrate-2 (IRS-2) is a primary progesterone response gene.
L. Vassen, W. Węgrzyn, L. Klein-Hitpass
1999Molecular Endocrinology61 citations Open access
Semantic Scholar
Growth factor independent 1b (Gfi1b) and a new splice variant of Gfi1b are highly expressed in patients with acute and chronic leukemia
L. Vassen, C. Khandanpour, P. Ebeling, B. van der Reijden +4 more
2009International journal of hematology53 citations
Semantic Scholar
IL-7R-dependent survival and differentiation of early T-lineage progenitors is regulated by the BTB/POZ domain transcription factor Miz-1.
I. Saba, C. Kosan, L. Vassen, T. Moroy
2011Blood50 citations
Semantic Scholar
The human GFI136N variant induces epigenetic changes at the Hoxa9 locus and accelerates K-RAS driven myeloproliferative disorder in mice.
C. Khandanpour, Joseph Krongold, Judith Schütte, Frédérique C. M. Bouwman +16 more
2012Blood44 citations Open access
Semantic Scholar
GFI1 as a novel prognostic and therapeutic factor for AML/MDS
J. Hönes, L. Botezatu, Anne Helness, Charles Vadnais +23 more
2016Leukemia43 citations
Semantic Scholar
Growth Factor Independence 1b (Gfi1b) Is Important for the Maturation of Erythroid Cells and the Regulation of Embryonic Globin Expression
L. Vassen, H. Beauchemin, Wafaâ Lemsaddek, Joseph Krongold +2 more
2014PLoS ONE40 citations Open access
Semantic Scholar
Targets of activated steroid hormone receptors: basal transcription factors and receptor interacting proteins
Ludger Klein-Hitpass, C. Schwerk, S. Kahmann, L. Vassen
1998Journal of molecular medicine38 citations
Semantic Scholar
Identification of a Novel Krüppel-associated Box Domain Protein, Krim-1, That Interacts with c-Myc and Inhibits Its Oncogenic Activity*
H. Hennemann, L. Vassen, Christoph Geisen, M. Eilers +1 more
2003Journal of Biological Chemistry36 citations Open access
Semantic Scholar
Gfi1b negatively regulates Rag expression directly and via the repression of FoxO1
D. Schulz, L. Vassen, Kwan T. Chow, Sarah M. McWhirter +3 more
2012Journal of Experimental Medicine31 citations Open access
Semantic Scholar
Zinc Finger Protein Gfi1 Controls the Endotoxin-Mediated Toll-Like Receptor Inflammatory Response by Antagonizing NF-κB p65
E. Sharif-Askari, L. Vassen, C. Kosan, C. Khandanpour +8 more
2010Molecular and Cellular Biology30 citations Open access
Semantic Scholar
Miz-1 Is Required To Coordinate the Expression of TCRβ and p53 Effector Genes at the Pre-TCR “β-Selection” Checkpoint
I. Saba, C. Kosan, L. Vassen, L. Klein-Hitpass +1 more
2011Journal of Immunology27 citations Open access
Semantic Scholar
Human insulin receptor substrate-2: gene organization and promoter characterization.
L. Vassen, W. Węgrzyn, L. Klein-Hitpass
1999Diabetes24 citations
Semantic Scholar
Gfi1b: a key player in the genesis and maintenance of acute myeloid leukemia and myelodysplastic syndrome
Aniththa Thivakaran, L. Botezatu, J. Hönes, Judith Schütte +17 more
2018Haematologica23 citations Open access
Semantic Scholar
Gfi1b controls integrin signaling-dependent cytoskeleton dynamics and organization in megakaryocytes
H. Beauchemin, P. Shooshtarizadeh, Charles Vadnais, L. Vassen +2 more
2017Haematologica23 citations Open access
Semantic Scholar
Synergistic enhancement of PRB-mediated RU486 and R5020 agonist activities through cyclic adenosine 3',5'-monophosphate represents a delayed primary response.
S. Kahmann, L. Vassen, L. Klein-Hitpass
1998Molecular Endocrinology20 citations Open access
Semantic Scholar
Enforced GFI1 expression impedes human and murine leukemic cell growth
J. Hönes, Aniththa Thivakaran, L. Botezatu, P. Patnana +9 more
2017Scientific Reports18 citations Open access
Semantic Scholar
Epigenetic therapy as a novel approach for GFI136N-associated murine/human AML.
L. Botezatu, L. Michel, Anne Helness, Charles Vadnais +16 more
2016Experimental Hematology16 citations Open access
Semantic Scholar
GFI1 is required for RUNX1/ETO positive acute myeloid leukemia
A. Marneth, L. Botezatu, J. Hönes, J.-M. Israël +17 more
2018Haematologica15 citations Open access
Semantic Scholar
Growth factor independence 1 (Gfi1) regulates cell-fate decision of a bipotential granulocytic-monocytic precursor defined by expression of Gfi1 and CD48.
L. Vassen, U. Duhrsen, C. Kosan, H. Zeng +1 more
2012American Journal of Blood Research15 citations
Semantic Scholar
Gene expression of the POU factor Brn-3a is regulated by two different promoters.
Beate Frass, L. Vassen, T. Moroy
2002Biochimica et Biophysica Acta10 citations
Semantic Scholar
The Growth Factor Independence 1 variant form GFI136N Predisposes to Acute Myeloid Leukemia by Inducing Epigenetic Changes in Oncogenes Such As Hoxa9
C. Khandanpour, Joseph Krongold, Judith Schütte, Frédérique C. M. Bouwman +13 more
20114 citations
Semantic Scholar
Identification of a novel KRAB box domain protein - KRIM-1 - that interacts with c-Myc and inhibits its oncogenic activity
H. Hennemann, L. Vassen, Christoph Geisen, M. Eilers +1 more
20033 citations
Semantic Scholar
Growth Factor Independence 1 (Gfi1) Regulates Cell-Fate Decision of the Bipotential Granulocytic-Monocytic Precursors Defined by Expression of CD48 As a New Marker,
L. Vassen, U. Duehrsen, C. Kosan, H. Zeng +1 more
20112 citations
Semantic Scholar
Gﬁ1b:green ﬂuorescent protein knock-in mice reveal a dynamic expression pattern of Gﬁ1b during hematopoiesis that is largely complementary to Gﬁ1
L. Vassen, T. Okayama, T. Moroy
20072 citations
Semantic Scholar
Regulation of Progesterone Receptor Activity in Cell Culture Systems and Cell-Free Transcription
L. Vassen, M. Klotzbücher, V. Ulber, G. Ryffel +1 more
19942 citations
Semantic Scholar
Cesarean section: antibiotic prophylaxis with ceftezole.
P. Spreafico, A. Scian, A. Epis, L. Vassen +2 more
1987Chemioterapia : international journal of the Mediterranean Society of Chemotherapy2 citations
Semantic Scholar
Correction: LSD1 inhibition by tranylcypromine derivatives interferes with GFI1-mediated repression of PU.1 target genes and induces differentiation in AML
J. Barth, K. Abou-El-Ardat, Denis Dalic, Nina Kurrle +17 more
2019Leukemia1 citations Open access
Semantic Scholar
Enforced GFI1 expression impedes human and murine leukemic cell growth
J. Hönes, Aniththa Thivakaran, L. Botezatu, P. Patnana +9 more
2017Scientific Reports1 citations Open access
Semantic Scholar
Growth Factor Independence 1b (Gfi1b) Is Required for the Regulation of Fetal Globin Genes in Both Fetal and Adult Erythroid Cells
L. Vassen, Wafaâ Lemsaddek, M. Trudel, T. Moroy
20111 citations
Semantic Scholar
Growth Factor Independence 1b (Gfi1b) Is An Essential Regulator of Late Stage Megakaryocyte Maturation and Platelet Production
L. Vassen, T. Moroy
20111 citations
Semantic Scholar
GFI1B (growth factor independent 1B transcription repressor)
L. Vassen, T. Moroy
20111 citations Open access
Semantic Scholar
A Human Variant of Growth Factor Independence 1 (GFI136N) Predisposes to Myeloid Leukemia In Mice
C. Khandanpour, L. Vassen, M. Gaudreau, Joseph Krongold +4 more
20101 citations
Semantic Scholar
Acute myeloid leukemia LSD 1 inhibition by tranylcypromine derivatives interferes with GFI 1-mediated repression of PU . 1 target genes and induces differentiation in AML
J. Barth, K. Abou-El-Ardat, Denis Dalic, Nina Kurrle +17 more
20190 citations
Semantic Scholar
CURCUMIN AS A NOVEL EPIGENETIC TREATMENT APPROACH FOR GFI1-ASSOCIATED MDS/AML
Judith Schütte, Aniththa Thivakaran, D. Heinrichs, Y. Al-Matary +6 more
2018Experimental Hematology0 citations Open access
Semantic Scholar
Gfi1b – a novel oncosuppressor, which restricts number of leukemic stem cells
C. Khandanpour, Aniththa Thivakaran, Judith Schütte, L. Vassen +2 more
20170 citations Open access
Semantic Scholar
A transgenic mouse model ubiquitously overexpressing Dnmt1s mRNA lacks increased protein levels
Christian Grosser, L. Vassen, B. Horsthemke, Nicholas Wagner
20140 citations Open access
Semantic Scholar
The Zinc Finger Transcription Factor (Growth Factor Independence 1b) Gfi1b Regulates Megakaryocyte Proliferation and Their Ability To Produce and Release Platelets
H. Beauchemin, L. Vassen, T. Moroy
20130 citations
Semantic Scholar
locus and accelerates K-RAS driven myeloproliferative disorder in mice Hoxa9 The human GFI136N variant induces epigenetic changes at the
T. Moroy, C. V. Patel, J. Peeters, B. Lowenberg +13 more
20130 citations
Semantic Scholar
Growth Factor Independent-1 (Gfi1) As a New Target for Human Leukemia Therapy
C. Khandanpour, J. Phelan, Riyan Chen, S. R. Horman +10 more
20110 citations
Semantic Scholar
Growth Factor Independence 1 b (Gfi1b) as a New Regulator of Hematopoietic Stem Cell Fate
C. Khandanpour, L. Vassen, M. Gaudreau, C. Kosan +1 more
20100 citations
Semantic Scholar
The Zinc Finger Protein Gfi1 Controls TLR4-Mediated Inflammatory Response by Directly Antagonizing NF-κB Transcription Factor
E. Sharif-Askari, H. Zeng, L. Vassen, C. Kosan +3 more
20080 citations
Semantic Scholar
Growth Factor Independent 1b (Gfi1b) Is Highly Expressed in Human CML and Accelerates p210BCR-ABL Induced Leukemia in Mice.
L. Vassen, D. Tenen, B. van der Reijden, U. Duehrsen +4 more
20070 citations
Semantic Scholar

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