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Charles Vadnais · SciRah

Researcher profile · Semantic Scholar

Charles Vadnais

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Charles Vadnais — researcher profile on SciRah

h-index: 19
Works: 44
Citations: 1,526

Most-cited papers

MicroRNA122 is a key regulator of α-fetoprotein expression and influences the aggressiveness of hepatocellular carcinoma.
Kentaro Kojima, Akemi Takata, Charles Vadnais, Motoyuki Otsuka +12 more
2011Nature Communications717 citations Open access
Semantic Scholar
RAS Transformation Requires CUX1-Dependent Repair of Oxidative DNA Damage
Z. Ramdzan, Charles Vadnais, Ranjana Pal, G. Vandal +9 more
2014PLoS Biology61 citations Open access
Semantic Scholar
GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1
Charles Vadnais, Riyan Chen, J. Fraszczak, Zhen-Bao Yu +11 more
2018Nature Communications57 citations Open access
Semantic Scholar
Genome-wide location analysis and expression studies reveal a role for p110 CUX1 in the activation of DNA replication genes
Ryoko Harada, Charles Vadnais, Laurent Sansregret, L. Leduy +3 more
2007Nucleic Acids Research56 citations Open access
Semantic Scholar
CUX1 transcription factor is required for optimal ATM/ATR-mediated responses to DNA damage
Charles Vadnais, Sayeh Davoudi, Mojdeh Afshin, Ryoko Harada +4 more
2012Nucleic Acids Research55 citations Open access
Semantic Scholar
p110 CUX1 Homeodomain Protein Stimulates Cell Migration and Invasion in Part through a Regulatory Cascade Culminating in the Repression of E-cadherin and Occludin*
V. Kedinger, Laurent Sansregret, Ryoko Harada, Charles Vadnais +4 more
2009Journal of Biological Chemistry52 citations Open access
Semantic Scholar
Mouse mammary tumor virus p75 and p110 CUX1 transgenic mice develop mammary tumors of various histologic types.
Chantal Cadieux, V. Kedinger, Lu Yao, Charles Vadnais +3 more
2009Cancer Research47 citations Open access
Semantic Scholar
Autocrine Activation of the Wnt/β-Catenin Pathway by CUX1 and GLIS1 in Breast Cancers
Charles Vadnais, P. Shooshtarizadeh, C. Rajadurai, R. Lesurf +6 more
2014Biology Open45 citations Open access
Semantic Scholar
GFI1 as a novel prognostic and therapeutic factor for AML/MDS
J. Hönes, L. Botezatu, Anne Helness, Charles Vadnais +23 more
2016Leukemia43 citations
Semantic Scholar
Cut homeobox 1 causes chromosomal instability by promoting bipolar division after cytokinesis failure
Laurent Sansregret, Charles Vadnais, J. Livingstone, Nicholas Kwiatkowski +5 more
2011Proceedings of the National Academy of Sciences of the United States of America43 citations Open access
Semantic Scholar
p110 CUX1 Cooperates with E2F Transcription Factors in the Transcriptional Activation of Cell Cycle-Regulated Genes
M. Truscott, Ryoko Harada, Charles Vadnais, François Robert +1 more
2008Molecular and Cellular Biology41 citations Open access
Semantic Scholar
Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes
P. Shooshtarizadeh, Anne Helness, Charles Vadnais, Nelleke Brouwer +6 more
2019Nature Communications36 citations Open access
Semantic Scholar
Miz-1 regulates translation of Trp53 via ribosomal protein L22 in cells undergoing V(D)J recombination
Marissa Rashkovan, Charles Vadnais, Julie Ross, M. Gigoux +4 more
2014Proceedings of the National Academy of Sciences of the United States of America35 citations Open access
Semantic Scholar
Long-range transcriptional regulation by the p110 CUX1 homeodomain protein on the ENCODE array
Charles Vadnais, A. Awan, Ryoko Harada, Pier-Luc Clermont +3 more
2013BMC Genomics30 citations Open access
Semantic Scholar
The function of cux1 in oxidative dna damage repair is needed to prevent premature senescence of mouse embryo fibroblasts
Z. Ramdzan, Ranjana Pal, Simran Kaur, L. Leduy +4 more
2015OncoTarget28 citations Open access
Semantic Scholar
Heterogeneous Nuclear Ribonucleoprotein L is required for the survival and functional integrity of murine hematopoietic stem cells
M. Gaudreau, Damien Grapton, Anne Helness, Charles Vadnais +6 more
2016Scientific Reports24 citations Open access
Semantic Scholar
Gfi1b controls integrin signaling-dependent cytoskeleton dynamics and organization in megakaryocytes
H. Beauchemin, P. Shooshtarizadeh, Charles Vadnais, L. Vassen +2 more
2017Haematologica23 citations Open access
Semantic Scholar
Reduced expression but not deficiency of GFI1 causes a fatal myeloproliferative disease in mice
J. Fraszczak, Charles Vadnais, Marissa Rashkovan, Julie Ross +5 more
2018Leukemia22 citations Open access
Semantic Scholar
Implementing DPYD*2A genotyping in clinical practice: The Quebec (Canada) experience.
Catherine Jolivet, R. Nassabein, D. Soulières, X. Weng +16 more
2020The Oncologist19 citations Open access
Semantic Scholar
Transcriptional activation of the Lats1 tumor suppressor gene in tumors of CUX1 transgenic mice
R. Siam, Ryoko Harada, Chantal Cadieux, R. Battat +2 more
2009Molecular Cancer19 citations Open access
Semantic Scholar
Deletion of the Miz-1 POZ domain increases efficacy of cytarabine treatment in T- and B-ALL/lymphoma mouse models.
Julie Ross, Marissa Rashkovan, J. Fraszczak, Charles Joly Beauparlant +5 more
2019Cancer Research18 citations Open access
Semantic Scholar
Epigenetic therapy as a novel approach for GFI136N-associated murine/human AML.
L. Botezatu, L. Michel, Anne Helness, Charles Vadnais +16 more
2016Experimental Hematology16 citations Open access
Semantic Scholar
Threshold Levels of Gfi1 Maintain E2A Activity for B Cell Commitment via Repression of Id1
J. Fraszczak, Anne Helness, Riyan Chen, Charles Vadnais +3 more
2016PLoS ONE15 citations Open access
Semantic Scholar
A novel regulatory circuit between p53 and GFI1 controls induction of apoptosis in T cells
Charles Vadnais, Riyan Chen, J. Fraszczak, Pierre-Jacques Hamard +2 more
2019Scientific Reports13 citations Open access
Semantic Scholar
Upfront DPYD Genotyping and Toxicity Associated with Fluoropyrimidine-Based Concurrent Chemoradiotherapy for Oropharyngeal Carcinomas: A Work in Progress
A. Désilets, W. Mccarvill, F. Aubin, H. Bahig +9 more
2022Current Oncology8 citations Open access
Semantic Scholar
Severe Inflammatory Reactions in Mice Expressing a GFI1P2A Mutant Defective in Binding to the Histone Demethylase KDM1A (LSD1)
J. Fraszczak, K. Arman, M. Lacroix, Charles Vadnais +2 more
2021Journal of Immunology1 citations Open access
Semantic Scholar
Loss of heterogeneous nuclear ribonucleoprotein L (HNRNP L) leads to mitochondrial dysfunction, DNA damage response and caspase-dependent cell death in hematopoietic stem cells
Anne Helness, M. Gaudreau, Damien Grapton, Charles Vadnais +5 more
20161 citations Open access
Semantic Scholar
Low GFI1 expression level drive the development of acute myeloid leukemia and fatal myeloproliferative neoplasia by blocking differentiation and P53-mediated apoptosis
J. Fraszczak, Riyan Chen, Marissa Rashkovan, Charles Vadnais +2 more
20161 citations Open access
Semantic Scholar
Primary Paget-like intraepithelial glandular lesion of the bronchus: report of a first case.
Maja Mujcin, P. Ferraro, Paul Verschelden, D. Tran‐Thanh +3 more
2026American Journal of Clinical Pathology0 citations
Semantic Scholar
Correction: Reduced expression but not deficiency of GFI1 causes a fatal myeloproliferative disease in mice.
J. Fraszczak, Charles Vadnais, Marissa Rashkovan, Julie Ross +5 more
2026Leukemia0 citations
Semantic Scholar
Upfront DPYD genotyping and toxicity associated with fluoropyrimidine-based concurrent chemoradiotherapy for oropharyngeal carcinomas.
A. Désilets, F. Aubin, H. Bahig, O. Ballivy +7 more
20200 citations
Semantic Scholar
GFI1’s role in DNA repair suggests implications for tumour cell response to treatment
Charles Vadnais, T. Moroy
2018Cell Stress0 citations Open access
Semantic Scholar
Reduced expression of Gfi1 causes a fatal myeloproliferative disease by simultaneously blocking myeloid differentiation and p53 mediated apoptosis
J. Fraszczak, Riyan Chen, Marissa Rashkovan, Charles Vadnais +2 more
20170 citations Open access
Semantic Scholar
Growth factor independence 1B (GFI1B) regulates WNT signaling in hematopoietic stem cells and megakaryocytes by recruiting LSD1 to B-CATENIN target genes
T. Moroy, P. Shooshtarizadeh, Anne Helness, H. Beauchemin +2 more
20160 citations Open access
Semantic Scholar
Notch1-induced T cell leukemogenesis requires the c-Myc cofactor and BTB-POZ domain protein MIZ-1 to control the activation of P53
Marissa Rashkovan, Charles Joly-Beauparlant, Charles Vadnais, J. Fraszczak +5 more
20160 citations Open access
Semantic Scholar
Abstract B08: Loss of functional Miz-1 impairs c-Myc-dependent B cell lymphomagenesis
Julie Ross, R. Winkler, Charles Vadnais, Marissa Rashkovan +2 more
20150 citations
Semantic Scholar
72 PERSONALIZED TREATMENT APPROACH FOR GFI136N HETEROZYGOUS OR HOMOZYGOUS MDS PATIENTS
B. Lacramioara, H. Makishima, L. Michel, J. Hoenes +18 more
20150 citations
Semantic Scholar
Abstract 997: Loss of Miz-1 increases latency of T-ALL by preventing induction of autophagy
Marissa Rashkovan, Charles Vadnais, Julie Ross, J. Fraszczak +1 more
20150 citations
Semantic Scholar
Gfi136N is a prognostic marker and possible target for the progression of MDS to AML
L. Michel, L. Botezatu, J. Hönes, Damien Grapton +13 more
20140 citations Open access
Semantic Scholar
Gfi136N As a Novel Marker and Therapeutic Target of MDS and AML
L. Michel, L. Botezatu, J. Hönes, A. Marneth +17 more
20140 citations
Semantic Scholar
The Splicing Factor Heterogeneous Nuclear Ribonucleoprotein L (hnRNPL) Restricts p53 Dependent and p53 Independent Cell Death Pathways In Hematopoietic Stem Cells
M. Gaudreau, F. Heyd, Charles Vadnais, B. Wilhelm +1 more
20130 citations
Semantic Scholar
A Single Nucleotide Polymorphism Of Growth Factor Independence 1 (GFI136N) is a Novel Prognostic Marker For The Progression Of Myelodysplastic Syndrome To Acute Myeloid Leukemia
L. Michel, L. Botezatu, J. Hönes, Damien Grapton +17 more
20130 citations
Semantic Scholar
Role Of The BTB/POZ Domain Protein Miz-1 In The Development Of c-Myc Driven B-Cell Lymphoma
Julie Ross, Marissa Rashkovan, C. Kosan, Charles Vadnais +1 more
20130 citations
Semantic Scholar
Correction: Corrigendum: MicroRNA122 is a key regulator of α-fetoprotein expression and influences the aggressiveness of hepatocellular carcinoma
Kentaro Kojima, Akemi Takata, Charles Vadnais, Motoyuki Otsuka +12 more
2012Nature Communications0 citations Open access
Semantic Scholar

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