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T. Dekhtyar · SciRah

Researcher profile · Semantic Scholar

T. Dekhtyar

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T. Dekhtyar — researcher profile on SciRah

h-index: 21
Works: 50
Citations: 1,534

Most-cited papers

Identification of host genes involved in hepatitis C virus replication by small interfering RNA technology
T. Ng, H. Mo, T. Pilot-Matias, Yupeng He +9 more
2007Hepatology143 citations Open access
Semantic Scholar
In Vitro Antiviral Activity and Resistance Profile of the Next-Generation Hepatitis C Virus NS5A Inhibitor Pibrentasvir
T. Ng, Preethi Krishnan, T. Pilot-Matias, W. Kati +11 more
2017Antimicrobial Agents and Chemotherapy136 citations Open access
Semantic Scholar
Mutations Conferring Resistance to a Hepatitis C Virus (HCV) RNA-Dependent RNA Polymerase Inhibitor Alone or in Combination with an HCV Serine Protease Inhibitor In Vitro
H. Mo, Liangjun Lu, T. Pilot-Matias, R. Pithawalla +12 more
2005Antimicrobial Agents and Chemotherapy132 citations Open access
Semantic Scholar
In Vitro and In Vivo Antiviral Activity and Resistance Profile of the Hepatitis C Virus NS3/4A Protease Inhibitor ABT-450
T. Pilot-Matias, Rakesh L. Tripathi, D. Cohen, I. Gaultier +14 more
2014Antimicrobial Agents and Chemotherapy116 citations Open access
Semantic Scholar
Pooled resistance analysis in HCV genotype 1–6-infected patients treated with glecaprevir/pibrentasvir in phase 2 and 3 clinical trials
Preethi Krishnan, G. Schnell, Rakesh L. Tripathi, T. Ng +9 more
2017110 citations
Semantic Scholar
In Vitro Antiviral Activity and Resistance Profile of the Next-Generation Hepatitis C Virus NS3/4A Protease Inhibitor Glecaprevir
T. Ng, Rakesh L. Tripathi, T. Reisch, Liangjun Lu +16 more
2017Antimicrobial Agents and Chemotherapy94 citations Open access
Semantic Scholar
O057 : Long-term follow-up of treatment-emergent resistance-associated variants in NS3, NS5A and NS5B with paritaprevir/r-, ombitasvir- and dasabuvir-based regimens
Preethi Krishnan, Rakesh L. Tripathi, G. Schnell, T. Reisch +8 more
201586 citations
Semantic Scholar
Resistance selection using glecaprevir and pibrentasvir in replicons of major hepatitis C virus genotypes
T. Ng, Liangjun Lu, T. Reisch, Preethi Krishnan +7 more
201773 citations
Semantic Scholar
Pooled Resistance Analysis in Patients with Hepatitis C Virus Genotype 1 to 6 Infection Treated with Glecaprevir-Pibrentasvir in Phase 2 and 3 Clinical Trials
Preethi Krishnan, T. Pilot-Matias, G. Schnell, Rakesh L. Tripathi +9 more
2018Antimicrobial Agents and Chemotherapy68 citations Open access
Semantic Scholar
Highlights of the Structure-Activity Relationships of Benzimidazole Linked Pyrrolidines Leading to the Discovery of the Hepatitis C Virus NS5A Inhibitor Pibrentasvir (ABT-530).
R. Wagner, J. Randolph, Sachin Patel, L. Nelson +24 more
2018Journal of Medicinal Chemistry47 citations Open access
Semantic Scholar
Hepatitis C Virus Genotype 4 Resistance and Subtype Demographic Characterization of Patients Treated with Ombitasvir plus Paritaprevir/Ritonavir
G. Schnell, Rakesh L. Tripathi, J. Beyer, T. Reisch +7 more
2015Antimicrobial Agents and Chemotherapy44 citations Open access
Semantic Scholar
Integrated Resistance Analysis of CERTAIN-1 and CERTAIN-2 Studies in Hepatitis C Virus-Infected Patients Receiving Glecaprevir and Pibrentasvir in Japan
Preethi Krishnan, G. Schnell, Rakesh L. Tripathi, J. Beyer +11 more
2017Antimicrobial Agents and Chemotherapy43 citations Open access
Semantic Scholar
Conserved residues in the coiled-coil pocket of human immunodeficiency virus type 1 gp41 are essential for viral replication and interhelical interaction.
H. Mo, A. K. Konstantinidis, K. Stewart, T. Dekhtyar +6 more
2004Virology43 citations Open access
Semantic Scholar
Identification and characterization of mutations conferring resistance to an HCV RNA-dependent RNA polymerase inhibitor in vitro.
Liangjun Lu, T. Dekhtyar, Sherie V. Masse, R. Pithawalla +11 more
2007Antiviral Research41 citations
Semantic Scholar
Antiviral interactions of an HCV polymerase inhibitor with an HCV protease inhibitor or interferon in vitro.
G. Koev, T. Dekhtyar, Lixin Han, P. Yan +4 more
2007Antiviral Research38 citations
Semantic Scholar
A replicon-based shuttle vector system for assessing the phenotype of HCV NS5B polymerase genes isolated from patient populations.
T. Middleton, Yupeng He, T. Pilot-Matias, Rakesh L. Tripathi +13 more
2007Journal of Virological Methods31 citations
Semantic Scholar
Characterization of resistant HIV variants generated by in vitro passage with lopinavir/ritonavir.
H. Mo, Liangjun Lu, T. Dekhtyar, K. Stewart +3 more
2003Antiviral Research31 citations
Semantic Scholar
In Vitro Selection and Characterization of Human Immunodeficiency Virus Type 2 with Decreased Susceptibility to Lopinavir
Sherie V. Masse, Xiao-Zhi Lu, T. Dekhtyar, Liangjun Lu +7 more
2007Antimicrobial Agents and Chemotherapy29 citations Open access
Semantic Scholar
2-Pyridyl P1'-substituted symmetry-based human immunodeficiency virus protease inhibitors (A-792611 and A-790742) with potential for convenient dosing and reduced side effects.
D. Degoey, D. Grampovnik, C. Flentge, W. J. Flosi +17 more
2009Journal of Medicinal Chemistry28 citations Open access
Semantic Scholar
Oximinoarylsulfonamides as potent HIV protease inhibitors.
Clinton M. Yeung, L. L. Klein, C. Flentge, J. Randolph +5 more
2005Bioorganic & Medicinal Chemistry Letters25 citations Open access
Semantic Scholar
Discovery of imidazolidine-2,4-dione-linked HIV protease inhibitors with activity against lopinavir-resistant mutant HIV.
W. J. Flosi, D. Degoey, D. Grampovnik, Hui-Ju Chen +6 more
2006Bioorganic & Medicinal Chemistry24 citations
Semantic Scholar
Identification and Structural Characterization of I84C and I84A Mutations That Are Associated with High-Level Resistance to Human Immunodeficiency Virus Protease Inhibitors and Impair Viral Replication
H. Mo, N. Parkin, K. Stewart, Liangjun Lu +3 more
2006Antimicrobial Agents and Chemotherapy16 citations Open access
Semantic Scholar
Resistance characterization of hepatitis C virus genotype 2 from Japanese patients treated with ombitasvir and paritaprevir/ritonavir
G. Schnell, Rakesh L. Tripathi, Preethi Krishnan, J. Beyer +12 more
2017Journal of Medical Virology14 citations Open access
Semantic Scholar
1229 GENOTYPIC AND PHENOTYPIC CHARACTERIZATION OF NS3 VARIANTS SELECTED IN HCV-INFECTED PATIENTS TREATED WITH ABT-450
T. Pilot-Matias, Rakesh L. Tripathi, T. Dekhtyar, R. Menon +5 more
201114 citations Open access
Semantic Scholar
Hepatitis C virus genetic diversity by geographic region within genotype 1-6 subtypes among patients treated with glecaprevir and pibrentasvir
G. Schnell, Preethi Krishnan, Rakesh L. Tripathi, J. Beyer +8 more
2018PLoS ONE13 citations Open access
Semantic Scholar
Synthesis and antiviral activity of P1' arylsulfonamide azacyclic urea HIV protease inhibitors.
Peggy P. Huang, J. Randolph, L. L. Klein, S. Vasavanonda +3 more
2004Bioorganic & Medicinal Chemistry Letters11 citations Open access
Semantic Scholar
P1-substituted symmetry-based human immunodeficiency virus protease inhibitors with potent antiviral activity against drug-resistant viruses.
D. Degoey, D. Grampovnik, Hui-Ju Chen, W. J. Flosi +6 more
2011Journal of Medicinal Chemistry10 citations Open access
Semantic Scholar
Design and synthesis of pseudo-symmetric HIV protease inhibitors containing a novel hydroxymethylcarbonyl (HMC)-hydrazide isostere.
K. Hidaka, T. Kimura, Y. Hayashi, K. F. McDaniel +3 more
2003Bioorganic & Medicinal Chemistry Letters10 citations Open access
Semantic Scholar
Resistance analysis in the MAGELLAN-1 Study (Part 2): glecaprevir/pibrentasvir therapy in HCV-infected patients who had failed prior DAA regimens containing NS3/4A protease and/or NS5A inhibitors
T. Pilot-Matias, Preethi Krishnan, G. Schnell, Rakesh L. Tripathi +9 more
20179 citations
Semantic Scholar
Synthesis, antiviral activity, and pharmacokinetic evaluation of P3 pyridylmethyl analogs of oximinoarylsulfonyl HIV-1 protease inhibitors.
J. Randolph, Peggy P. Huang, W. J. Flosi, D. Degoey +12 more
2006Bioorganic & Medicinal Chemistry9 citations
Semantic Scholar
Analysis of HCV Genotype 2 and 3 Variants in Patients Treated with Combination Therapy of Next Generation HCV Direct-Acting Antiviral Agents ABT-493 and ABT-530
T. Ng, T. Pilot-Matias, Rakesh L. Tripathi, G. Schnell +7 more
20168 citations
Semantic Scholar
Discovery of 2-aminoisobutyric acid ethyl ester (AIBEE) phosphoramidate prodrugs for delivering nucleoside HCV NS5B polymerase inhibitors.
J. Randolph, Tongmei Li, A. C. Krueger, H. Heyman +11 more
2020Bioorganic & Medicinal Chemistry Letters6 citations Open access
Semantic Scholar
Medicinal Chemistry and Drug Design
S. Khanna, M. Madan, A. Vangoori, R. Banerjee +14 more
6 citations
Semantic Scholar
Synthesis and evaluation of 2'-dihalo ribonucleotide prodrugs with activity against hepatitis C virus.
A. C. Krueger, Hui-Ju Chen, J. Randolph, B. Brown +17 more
2019Bioorganic & Medicinal Chemistry5 citations
Semantic Scholar
Characterization of a Novel Human Immunodeficiency Virus Type 1 Protease Inhibitor, A-790742
T. Dekhtyar, T. Ng, Liangjun Lu, Sherie V. Masse +6 more
2008Antimicrobial Agents and Chemotherapy5 citations Open access
Semantic Scholar
Characterization of demographics and NS5A genetic diversity for hepatitis C virus genotype 4‐infected patients with or without cirrhosis treated with ombitasvir/paritaprevir/ritonavir
G. Schnell, Rakesh L. Tripathi, J. Beyer, Thomas Reisch +9 more
2018Journal of Viral Hepatitis4 citations Open access
Semantic Scholar
Discovery of fluorobenzimidazole HCV NS5A inhibitors.
J. Randolph, C. Flentge, Pamela L. Donner, T. Rockway +14 more
2016Bioorganic & Medicinal Chemistry Letters4 citations
Semantic Scholar
Reaction of 2-Mono- and 2,2-Disubstituted 1,3-Dioxolanes with 1-Ethyl-3-hexylaluminacyclopentane
T. Dekhtyar, E. F. Dekhtyar, O. S. Vostrikova, Yu. T. Gafarova +3 more
20043 citations
Semantic Scholar
Resistance Analysis of a 3-Day Monotherapy Study with Glecaprevir or Pibrentasvir in Patients with Chronic Hepatitis C Virus Genotype 1 Infection
T. Ng, T. Pilot-Matias, Rakesh L. Tripathi, G. Schnell +14 more
2018Viruses2 citations Open access
Semantic Scholar
Synthesis and properties of quaternary ammonium salts on the basis of piperidine
R. R. Rakhmatullin, V. I. Levashova, T. Dekhtyar
2013Petroleum chemistry (1991)2 citations
Semantic Scholar
Reactions of trialkylalanes with cyclic acetals and orthoformates in CH2Cl2 and ClCH2CH2Cl as solvents
Yu. T. Gafarova, E. F. Dekhtyar, T. Dekhtyar, A. A. Fatykhov +4 more
20031 citations
Semantic Scholar
Interaction of 2-Monosubstituted 1,3-Dioxolanes with Aluminacyclopentanes
T. Dekhtyar, O. S. Vostrikova, S. S. Zlotskii, A. Bogomazova +1 more
2019Petroleum chemistry (1991)0 citations
Semantic Scholar
HCV genetic diversity by geographic region within genotype 1-6 subtypes among patients treated with Glecaprevir and Pibrentasvir
G. Schnell, Rakesh L. Tripathi, Preethi Krishnan, J. Beyer +8 more
20180 citations
Semantic Scholar
Pooled Resistance Analysis in HCV Genotype 1-6 Infected Patients Treated With 1 Glecaprevir / Pibrentasvir in Phase 2 and 3 Clinical Trials 2
Preethi Krishnan, T. Pilot-Matias, G. Schnell, Rakesh L. Tripathi +9 more
20180 citations
Semantic Scholar
Analysis of Hepatitis C Virus (HCV) Genotype 2 and 3 Variants in Patients Treated With Combination Therapy of Next-Generation HCV Direct-Acting Antiviral Agents ABT-493 and ABT-530
T. Ng, T. Pilot-Matias, Rakesh L. Tripathi, G. Schnell +7 more
20160 citations Open access
Semantic Scholar
Hepatitis C Virus Genotype 4 Resistance and Subtype Demographic Characterization of 1
G. Schnell, Rakesh L. Tripathi, J. Beyer, T. Reisch +6 more
20150 citations
Semantic Scholar
Synthesis of bactericides and inhibitors of hydrogen sulfide corrosion from diethylamine and piperylene and isoprene hydrochlorides
E. Nafikova, V. I. Levashova, T. Dekhtyar
20110 citations
Semantic Scholar
HIV Protease with oximinoarylsulfonamide bound
Clinton M. Yeung, L. L. Klein, C. Flentge, J. Randolph +5 more
20050 citations
Semantic Scholar
Synthesis and Antiviral Activity of P1′ Arylsulfonamide Azacyclic Urea HIV Protease Inhibitors.
Peggy P. Huang, J. Randolph, L. L. Klein, S. Vasavanonda +3 more
20040 citations
Semantic Scholar
Reactions of Trialkylalanes with Cyclic Acetals and Orthoformates in CH2Cl2 and ClCH2CH2Cl as Solvents.
Yu. T. Gafarova, E. F. Dekhtyar, T. Dekhtyar, A. A. Fatykhov +4 more
20030 citations
Semantic Scholar

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T. Pilot-Matias×26
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T. Pilot-Matias — researcher profile on SciRah
Preethi Krishnan×23
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Preethi Krishnan — researcher profile on SciRah
Rakesh L. Tripathi×21
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Rakesh L. Tripathi — researcher profile on SciRah
Christine A. Collins×21
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Christine A. Collins — researcher profile on SciRah

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T. Ng — researcher profile on SciRah

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T. Reisch — researcher profile on SciRah

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G. Schnell — researcher profile on SciRah

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J. Beyer — researcher profile on SciRah

Michelle L Irvin×17

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Michelle L Irvin — researcher profile on SciRah

Liangjun Lu×15

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Liangjun Lu — researcher profile on SciRah

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