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G. Koev · SciRah

Researcher profile · Semantic Scholar

G. Koev

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G. Koev — researcher profile on SciRah

h-index: 21
Works: 42
Citations: 2,033

Most-cited papers

Exploratory study of oral combination antiviral therapy for hepatitis C.
F. Poordad, E. Lawitz, K. Kowdley, D. Cohen +9 more
2013New England Journal of Medicine298 citations Open access
Semantic Scholar
Synthesis of subgenomic RNAs by positive-strand RNA viruses.
W. Miller, G. Koev
2000Virology221 citations Open access
Semantic Scholar
Identification of host genes involved in hepatitis C virus replication by small interfering RNA technology
T. Ng, H. Mo, T. Pilot-Matias, Yupeng He +9 more
2007Hepatology143 citations Open access
Semantic Scholar
Mutations Conferring Resistance to a Hepatitis C Virus (HCV) RNA-Dependent RNA Polymerase Inhibitor Alone or in Combination with an HCV Serine Protease Inhibitor In Vitro
H. Mo, Liangjun Lu, T. Pilot-Matias, R. Pithawalla +12 more
2005Antimicrobial Agents and Chemotherapy132 citations Open access
Semantic Scholar
In Vitro and In Vivo Antiviral Activity and Resistance Profile of Ombitasvir, an Inhibitor of Hepatitis C Virus NS5A
Preethi Krishnan, J. Beyer, Neeta Mistry, G. Koev +10 more
2014Antimicrobial Agents and Chemotherapy131 citations Open access
Semantic Scholar
Discovery of ABT-267, a pan-genotypic inhibitor of HCV NS5A.
D. Degoey, J. Randolph, Da-Chun Liu, J. Pratt +26 more
2014Journal of Medicinal Chemistry129 citations
Semantic Scholar
In Vitro Activity and Resistance Profile of Dasabuvir, a Nonnucleoside Hepatitis C Virus Polymerase Inhibitor
W. Kati, G. Koev, Michelle L Irvin, J. Beyer +8 more
2014Antimicrobial Agents and Chemotherapy110 citations Open access
Semantic Scholar
A Positive-Strand RNA Virus with Three Very Different Subgenomic RNA Promoters
G. Koev, W. Miller
2000Journal of Virology87 citations Open access
Semantic Scholar
A phase 2a trial of 12-week interferon-free therapy with two direct-acting antivirals (ABT-450/r, ABT-072) and ribavirin in IL28B C/C patients with chronic hepatitis C genotype 1.
E. Lawitz, F. Poordad, K. Kowdley, D. Cohen +8 more
2013Journal of Hepatology71 citations
Semantic Scholar
The 3′-Terminal Structure Required for Replication of Barley Yellow Dwarf Virus RNA Contains an Embedded 3′ End
G. Koev, Sijun Liu, Randy J. Beckett, W. Miller
200270 citations Open access
Semantic Scholar
Plant Pathology and Microbiology Publications Plant Pathology and Microbiology Primary and Secondary Structural Elements Required for Synthesis of Barley Yellow Dwarf Virus Subgenomic Rna1
G. Koev, B. R. Mohan, W. Miller
70 citations
Semantic Scholar
Are There Risks Associated with Transgenic Resistance to Luteoviruses?
W. Miller, G. Koev, B. R. Mohan
1997Plant Disease49 citations
Semantic Scholar
Hepatitis C virus IRES-dependent translation is insensitive to an eIF2alpha-independent mechanism of inhibition by interferon in hepatocyte cell lines.
G. Koev, R. Duncan, M. Lai
2002Virology44 citations Open access
Semantic Scholar
Identification and characterization of mutations conferring resistance to an HCV RNA-dependent RNA polymerase inhibitor in vitro.
Liangjun Lu, T. Dekhtyar, Sherie V. Masse, R. Pithawalla +11 more
2007Antiviral Research41 citations
Semantic Scholar
Antiviral interactions of an HCV polymerase inhibitor with an HCV protease inhibitor or interferon in vitro.
G. Koev, T. Dekhtyar, Lixin Han, P. Yan +4 more
2007Antiviral Research38 citations
Semantic Scholar
Synthesis and biological characterization of B-ring amino analogues of potent benzothiadiazine hepatitis C virus polymerase inhibitors.
J. Randolph, C. Flentge, Peggy P. Huang, D. Hutchinson +16 more
2009Journal of Medicinal Chemistry32 citations Open access
Semantic Scholar
A replicon-based shuttle vector system for assessing the phenotype of HCV NS5B polymerase genes isolated from patient populations.
T. Middleton, Yupeng He, T. Pilot-Matias, Rakesh L. Tripathi +13 more
2007Journal of Virological Methods31 citations
Semantic Scholar
In Vitro Selection and Characterization of Human Immunodeficiency Virus Type 2 with Decreased Susceptibility to Lopinavir
Sherie V. Masse, Xiao-Zhi Lu, T. Dekhtyar, Liangjun Lu +7 more
2007Antimicrobial Agents and Chemotherapy29 citations Open access
Semantic Scholar
Methods to measure the intracellular concentration of unlabeled compounds within cultured cells using liquid chromatography/tandem mass spectrometry.
Lynn Colletti, Ya-Ya Liu, G. Koev, Paul L. Richardson +2 more
2008Analytical Biochemistry25 citations
Semantic Scholar
The emerging field of HCV drug resistance
G. Koev, W. Kati
200824 citations
Semantic Scholar
The emerging field of HCV drug resistance.
G. Koev, W. Kati
2008Expert Opinion on Investigational Drugs23 citations
Semantic Scholar
Synthesis and SAR of novel 1,1-dialkyl-2(1H)-naphthalenones as potent HCV polymerase inhibitors.
Todd D. Bosse, D. Larson, R. Wagner, D. Hutchinson +11 more
2008Bioorganic & Medicinal Chemistry Letters21 citations
Semantic Scholar
1206 ABT-072 OR ABT-333 COMBINED WITH PEGYLATED INTERFERON/RIBAVIRIN AFTER 3-DAY MONOTHERAPY IN HCV GENOTYPE 1 (GT1)-INFECTED TREATMENT-NAIVE SUBJECTS: 12-WEEK SUSTAINED VIROLOGIC RESPONSE (SVR12) AND SAFETY RESULTS
F. Poordad, E. Lawitz, E. Dejesus, K. Kowdley +9 more
201220 citations
Semantic Scholar
Inhibitors of hepatitis C virus polymerase: synthesis and biological characterization of unsymmetrical dialkyl-hydroxynaphthalenoyl-benzothiadiazines.
R. Wagner, D. Larson, D. Beno, Todd D. Bosse +24 more
2009Journal of Medicinal Chemistry20 citations
Semantic Scholar
In Vitro and In Vivo Antiviral Activity and Resistance Profile of Ombitasvir , an Inhibitor of Hepatitis C Virus NS 5 A
Preethi Krishnan, J. Beyer, Neeta Mistry, G. Koev +10 more
201518 citations
Semantic Scholar
Des-A-ring benzothiadiazines: inhibitors of HCV genotype 1 NS5B RNA-dependent RNA polymerase.
Pamela L. Donner, Qing-Hua Xie, J. Pratt, C. Maring +8 more
2008Bioorganic & Medicinal Chemistry Letters18 citations
Semantic Scholar
955 PRECLINICAL POTENCY, PHARMACOKINETIC AND ADME CHARACTERIZATION OF ABT-333, A NOVEL NON-NUCLEOSIDE HCV POLYMERASE INHIBITOR
C. Maring, R. Wagner, D. Hutchinson, C. Flentge +13 more
200916 citations
Semantic Scholar
Synthesis and Biological Characterization of Aryl Uracil Inhibitors of Hepatitis C Virus NS5B Polymerase: Discovery of ABT-072, a trans-Stilbene Analog with Good Oral Bioavailability.
J. Randolph, A. C. Krueger, Pamela L. Donner, J. Pratt +20 more
2018Journal of Medicinal Chemistry15 citations Open access
Semantic Scholar
Development of a cell-based assay for high-throughput screening of inhibitors against HCV genotypes 1a and 1b in a single well.
Rubina Mondal, G. Koev, T. Pilot-Matias, Yupeng He +3 more
2009Antiviral Research15 citations
Semantic Scholar
953 CHARACTERIZATION OF RESISTANCE MUTATIONS SELECTED IN VITRO BY THE NON-NUCLEOSIDE HCV POLYMERASE INHIBITORS ABT-333 AND ABT-072
G. Koev, Rubina Mondal, J. Beyer, T. Reisch +12 more
200912 citations Open access
Semantic Scholar
MINIREVIEW Synthesis of Subgenomic RNAs by Positive-Strand RNA Viruses
W. Miller, G. Koev
200012 citations
Semantic Scholar
Aryl uracil inhibitors of hepatitis C virus NS5B polymerase: synthesis and characterization of analogs with a fused 5,6-bicyclic ring motif.
A. C. Krueger, J. Randolph, D. Degoey, Pamela L. Donner +17 more
2013Bioorganic & Medicinal Chemistry Letters11 citations
Semantic Scholar
867 IN VITRO COMBINATORY EFFECT OF HCV NS3/4A PROTEASE INHIBITOR ABT-450, NS5A INHIBITOR ABT-267, AND NON-NUCLEOSIDE NS5B POLYMERASE INHIBITOR ABT-333
T. Pilot-Matias, G. Koev, Preethi Krishnan, J. Beyer +8 more
201211 citations
Semantic Scholar
Hepatitis C NS5B polymerase inhibitors: functional equivalents for the benzothiadiazine moiety.
D. Hutchinson, C. Flentge, Pamela L. Donner, R. Wagner +14 more
2011Bioorganic & Medicinal Chemistry Letters9 citations
Semantic Scholar
Getting a handle on RNA virus recombination
W. Miller, G. Koev
1998Trends in Microbiology9 citations Open access
Semantic Scholar
The 3prime prime or minute-terminal structure required for replication of Barley yellow dwarf virus RNA contains an embedded 3prime prime or minute end.
G. Koev, Sijun Liu, Randy J. Beckett, W. Miller
2002Virology8 citations
Semantic Scholar
970 PRECLINICAL CHARACTERIZATION OF ABT-072: A NOVEL NON-NUCLEOSIDE HCV POLYMERASE INHIBITOR
R. Wagner, C. Maring, Pamela L. Donner, J. Randolph +18 more
20097 citations Open access
Semantic Scholar
[620] CHARACTERIZATION OF PHARMACOKINETIC/PHARMACODYNAMIC PARAMETERS FOR THE NOVEL HCV POLYMERASE INHIBITOR A-848837
A. Molla, R. Wagner, Liangjun Lu, D. He +14 more
20077 citations Open access
Semantic Scholar
High potency improvements to weak aryl uracil HCV polymerase inhibitor leads.
Pamela L. Donner, J. Randolph, Peggy P. Huang, R. Wagner +14 more
2013Bioorganic & Medicinal Chemistry Letters5 citations
Semantic Scholar
The 3 9-Terminal Structure Required for Replication of Barley Yellow Dwarf Virus RNA Contains an Embedded 3 9 End
G. Koev, Sijun Liu, Randy J. Beckett, W. Miller
20022 citations
Semantic Scholar
Original Article Protein and mRNA Levels of YKL-40 in High-Grade Glioma
M. Kazakova, D. Staneva, G. Koev, D. Staikov +4 more
20140 citations
Semantic Scholar
Interferon-Free Regimens for Chronic Hepatitis C—A Step Forward
F. Poordad, E. Lawitz, Kowdley Kv, Cohen De +7 more
20130 citations
Semantic Scholar

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