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T. Rockway · SciRah

Researcher profile · Semantic Scholar

T. Rockway

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T. Rockway — researcher profile on SciRah

h-index: 21
Works: 68
Citations: 1,185

Most-cited papers

Mutations Conferring Resistance to a Hepatitis C Virus (HCV) RNA-Dependent RNA Polymerase Inhibitor Alone or in Combination with an HCV Serine Protease Inhibitor In Vitro
H. Mo, Liangjun Lu, T. Pilot-Matias, R. Pithawalla +12 more
2005Antimicrobial Agents and Chemotherapy132 citations Open access
Semantic Scholar
Identification of novel inhibitors of urokinase via NMR-based screening.
P. Hajduk, S. Boyd, D. Nettesheim, V. Nienaber +5 more
2000Journal of Medicinal Chemistry69 citations Open access
Semantic Scholar
Pyridone-containing farnesyltransferase inhibitors: synthesis and biological evaluation.
Lisa A. Hasvold, Wei-Bo Wang, S. L. Gwaltney, T. Rockway +14 more
2003Bioorganic & Medicinal Chemistry Letters67 citations Open access
Semantic Scholar
Identification of novel binding interactions in the development of potent, selective 2-naphthamidine inhibitors of urokinase. Synthesis, structural analysis, and SAR of N-phenyl amide 6-substitution.
M. Wendt, T. Rockway, A. Geyer, W. Mcclellan +7 more
2004Journal of Medicinal Chemistry65 citations Open access
Semantic Scholar
Inhibitors of the protease domain of urokinase-type plasminogen activator.
T. Rockway, Vicki L. Nienaber, V. Giranda
2002Current pharmaceutical design52 citations
Semantic Scholar
Application of isotope-filtered 2D NOE experiments in the conformational analysis of atrial natriuretic factor(7–23)
S. Fesik, Robert T. Gampe, T. Rockway
198750 citations
Semantic Scholar
Highlights of the Structure-Activity Relationships of Benzimidazole Linked Pyrrolidines Leading to the Discovery of the Hepatitis C Virus NS5A Inhibitor Pibrentasvir (ABT-530).
R. Wagner, J. Randolph, Sachin Patel, L. Nelson +24 more
2018Journal of Medicinal Chemistry47 citations Open access
Semantic Scholar
Structure-directed discovery of potent non-peptidic inhibitors of human urokinase that access a novel binding subsite.
V. Nienaber, D. Davidson, R. Edalji, V. Giranda +14 more
2000Structure47 citations Open access
Semantic Scholar
Mechanistic study of HCV polymerase inhibitors at individual steps of the polymerization reaction.
Ya-Ya Liu, Wen W. Jiang, J. Pratt, T. Rockway +5 more
2006Biochemistry45 citations
Semantic Scholar
Divergence of ANF analogs in smooth muscle cell cGMP response and aorta vasorelaxation: evidence for receptor subtypes.
G. Budzik, Susan L. Firestone, E. Bush, P. Connolly +3 more
1987Biochemical and Biophysical Research Communications - BBRC45 citations
Semantic Scholar
Atrial natriuretic peptide antagonists: biological evaluation and structural correlations.
T. V. von Geldern, G. Budzik, Terry P. Dillon, W. Holleman +6 more
1990Molecular Pharmacology43 citations
Semantic Scholar
Inhibitors of the proteolytic activity of urokinase type plasminogen activator.
T. Rockway, V. Giranda
2003Current pharmaceutical design38 citations
Semantic Scholar
Inhibition of human immunodeficiency virus type I integrase by naphthamidines and 2-aminobenzimidazoles.
T. Middleton, H. B. Lim, D. Montgomery, T. Rockway +7 more
2004Antiviral Research34 citations
Semantic Scholar
Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-alkyl-4-hydroxyquinolon-3-yl-benzothiadiazine sulfamides.
A. C. Krueger, Darold L. Madigan, Wen W. Jiang, W. Kati +13 more
2006Bioorganic & Medicinal Chemistry Letters33 citations Open access
Semantic Scholar
Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-1-benzyl and N-1-[3-methylbutyl]-4-hydroxy-1,8-naphthyridon-3-yl benzothiadiazine analogs containing substituents on the aromatic ring.
T. Rockway, Rong-hong Zhang, Da-Chun Liu, D. Betebenner +11 more
2006Bioorganic & Medicinal Chemistry Letters29 citations Open access
Semantic Scholar
NMR study of the solution conformation of rat atrial natriuretic factor 7-23 in sodium dodecyl sulfate micelles.
E. Olejniczak, Robert T. Gampe, T. Rockway, Stephen W. Fesik
1988Biochemistry28 citations
Semantic Scholar
Naphthamidine urokinase plasminogen activator inhibitors with improved pharmacokinetic properties.
M. Bruncko, W. Mcclellan, M. Wendt, D. Sauer +14 more
2005Bioorganic & Medicinal Chemistry Letters27 citations Open access
Semantic Scholar
Design of oxytocin antagonists with prolonged action: potential tocolytic agents for the treatment of preterm labor.
W. Chan, V. Hruby, T. Rockway, J. Hlaváček
1986Journal of Pharmacology and Experimental Therapeutics25 citations
Semantic Scholar
Species specificity of amidine-based urokinase inhibitors.
V. Klinghofer, Kent D. Stewart, Tom Mcgonigal, Richard D. Smith +11 more
2001Biochemistry24 citations
Semantic Scholar
Diastereoselectivity in the osmium-catalyzed dihydroxylation of allylic amides and carbamates
Damian J. Krysan, T. Rockway, A. Haight
199424 citations
Semantic Scholar
Interaction with the S1 beta-pocket of urokinase: 8-heterocycle substituted and 6,8-disubstituted 2-naphthamidine urokinase inhibitors.
M. Wendt, A. Geyer, W. Mcclellan, T. Rockway +7 more
2004Bioorganic & Medicinal Chemistry Letters22 citations Open access
Semantic Scholar
Synthesis and SAR of novel 1,1-dialkyl-2(1H)-naphthalenones as potent HCV polymerase inhibitors.
Todd D. Bosse, D. Larson, R. Wagner, D. Hutchinson +11 more
2008Bioorganic & Medicinal Chemistry Letters21 citations
Semantic Scholar
Small atrial natriuretic peptide analogues: design, synthesis, and structural requirements for guanylate cyclase activation.
T. V. von Geldern, T. Rockway, S. Davidsen, G. Budzik +6 more
1992Journal of Medicinal Chemistry20 citations
Semantic Scholar
Probing inhibitors binding to human urokinase crystals by Raman microscopy: implications for compound screening.
Jian Dong, K. Swift, E. Matayoshi, Vicki L. Nienaber +3 more
2001Biochemistry19 citations
Semantic Scholar
Conformational and dynamic considerations in the design of peptide hormone analogs
V. J. Hruby, H. Mosberg, T. K. Sawyer, J. Knittel +5 more
1983Biopolymers19 citations
Semantic Scholar
Long-Acting Oxytocin Antagonists: Effects of 2-D-Stereoisomer Substitution on Antagonistic Potency and Duration of Action 1
W. Chan, T. Rockway, V. Hruby
1987Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine18 citations
Semantic Scholar
Two‐Dimensional NMR studies of [Pro‐10] atrial natriuretic factor [7‐23]
Robert T. Gampe, P. Connolly, T. Rockway, Stephen W. Fesik
1988Biopolymers16 citations
Semantic Scholar
Synthesis and Biological Characterization of Aryl Uracil Inhibitors of Hepatitis C Virus NS5B Polymerase: Discovery of ABT-072, a trans-Stilbene Analog with Good Oral Bioavailability.
J. Randolph, A. C. Krueger, Pamela L. Donner, J. Pratt +20 more
2018Journal of Medicinal Chemistry15 citations Open access
Semantic Scholar
Pharmacological, conformational and dynamic properties of cycloleucine-2 analogues of oxytocin and [1-penicillamine]oxytocin.
V. J. Hruby, T. Rockway, V. Viswanatha, W. Chan
2009International journal of peptide & protein research13 citations
Semantic Scholar
Aryl uracil inhibitors of hepatitis C virus NS5B polymerase: synthesis and characterization of analogs with a fused 5,6-bicyclic ring motif.
A. C. Krueger, J. Randolph, D. Degoey, Pamela L. Donner +17 more
2013Bioorganic & Medicinal Chemistry Letters11 citations
Semantic Scholar
Direct observation of diastereomers with opposite Mo configurations by 95Mo NMR
M. Minelli, T. Rockway, J. Enemark, H. Brunner +1 more
198111 citations
Semantic Scholar
Effects of conformational constraint in 2- and 8-cycloleucine analogues of oxytocin and [1-penicillamine] oxytocin examined by circular dichroism and biosassay
I. Frič, J. Hlaváček, T. Rockway, W. Chan +1 more
1990Journal of Protein Chemistry8 citations
Semantic Scholar
970 PRECLINICAL CHARACTERIZATION OF ABT-072: A NOVEL NON-NUCLEOSIDE HCV POLYMERASE INHIBITOR
R. Wagner, C. Maring, Pamela L. Donner, J. Randolph +18 more
20097 citations Open access
Semantic Scholar
Small molecule inhibitors of urokinase-type plasminogen activator
T. Rockway
20037 citations
Semantic Scholar
Atrial natriuretic factor: Structural requirements of the peptide for receptor binding, biological activity, and cGMP stimulation
W. Holleman, E. Bush, E. Devine, Susan L. Firestone +3 more
19887 citations
Semantic Scholar
Active and inactive L-prolyl-L-leucyl glycinamide synthetic analogs in rat models of levodopa-treated Parkinson's disease.
T. Case, S. R. Snider, V. J. Hruby, T. Rockway
1985Life Science7 citations
Semantic Scholar
Conformational Considerations in the Design of Highly Potent and Long-Acting Peptide Hormone Agonists and Antagonists
V. Hruby, J. Knittel, H. Mosberg, T. Rockway +2 more
19837 citations
Semantic Scholar
AN IMPROVED PREPARATION OF (S)-N-(BOC)-CYCLOHEXYLALANINAL. THE MOFFAT-SWERN OXIDATION OF α-AMINOALCOHOLS
Damian J. Krysan, A. Haight, J. E. Lallaman, Denton C. Langridge +7 more
19935 citations
Semantic Scholar
Truncated atrial natriuretic factor analogs retain full agonist activity.
W. Holleman, G. Budzik, E. Devine, D. Pollock +4 more
1991Canadian Journal of Physiology and Pharmacology5 citations
Semantic Scholar
Discovery of fluorobenzimidazole HCV NS5A inhibitors.
J. Randolph, C. Flentge, Pamela L. Donner, T. Rockway +14 more
2016Bioorganic & Medicinal Chemistry Letters4 citations
Semantic Scholar
Azapteridine Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase
T. Middleton, H. B. Lim, D. Montgomery, T. Rockway +6 more
20074 citations
Semantic Scholar
An Efficient Process for the Synthesis of Renin Inhibitor, ABT-517
P. R. Singam, C. Bradshaw, Jerome A. Menzia, B. Narayanan +3 more
19963 citations
Semantic Scholar
The Design and Synthesis of Long-Acting Oxytocin Antagonists Substituted in Positions 2, 7, and 8
V. Hruby, W. Chan, T. Rockway, J. Hlaváček +1 more
19943 citations
Semantic Scholar
Antiviral Agents, DNA
T. Middleton, T. Rockway
20032 citations
Semantic Scholar
Structure-activity relationships of atrial natriuretic factor (ANF) receptor agonists
T. Rockway, P. Connolly, E. Devine, G. Budzik +3 more
19902 citations
Semantic Scholar
95Mo NMR spectra of dioxomolybdenum(VI) complexes
K. A. Christensen, P. Miller, M. Minelli, T. Rockway +1 more
19812 citations
Semantic Scholar
Small atrial natriuretic factor (ANF) peptide analogs maintaining agonist activity
T. Rockway, G. Budzik, E. Bush, P. Connolly +5 more
19901 citations
Semantic Scholar
Isotope-filtered proton NMR experiments for the conformational determination of peptides in solution and bound to biomacromolecules
S. Fesik, R. Gampe, E. Olejniczak, J. Luly +2 more
19881 citations
Semantic Scholar
MOLYBDENUM-95 NMR SPECTRA OF DIOXOMOLYBDENUM(VI) COMPLEXES
K. A. Christensen, P. Miller, M. Minelli, T. Rockway +1 more
19811 citations
Semantic Scholar
An Efficient Process for the Synthesis of Renin Inhibitor, ABT-517.
P. R. Singam, C. Bradshaw, Jerome A. Menzia, B. Narayanan +3 more
20100 citations
Semantic Scholar

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