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V. Manne · SciRah

Researcher profile · Semantic Scholar

V. Manne

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V. Manne — researcher profile on SciRah

h-index: 27
Works: 45
Citations: 2,286

Most-cited papers

Discovery of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a selective and orally efficacious inhibitor of the Met kinase superfamily.
Gretchen M. Schroeder, Yong-Mi An, Zhen-Wei Cai, Xiao-Tao Chen +27 more
2009Journal of Medicinal Chemistry285 citations Open access
Semantic Scholar
Ha-ras proteins exhibit GTPase activity: point mutations that activate Ha-ras gene products result in decreased GTPase activity.
V. Manne, E. Bekesi, Hsiang-Fu Kung
1985Proceedings of the National Academy of Sciences of the United States of America152 citations Open access
Semantic Scholar
Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors.
M. Lackner, R. Kindt, P. Carroll, K. Brown +21 more
2005Cancer Cell147 citations Open access
Semantic Scholar
Bisubstrate inhibitors of farnesyltransferase: a novel class of specific inhibitors of ras transformed cells.
V. Manne, N. Yan, J. Carboni, A. Tuomari +6 more
1995Oncogene138 citations
Semantic Scholar
Farnesyltransferase inhibitors block the neurofibromatosis type I (NF1) malignant phenotype.
N. Yan, C. Ricca, Jonathan A. Fletcher, Thomas W. Glover +2 more
1995Cancer Research122 citations
Semantic Scholar
Apoptotic and Novel Farnesyltransferase Inhibitor Preclinical Antitumor Activity of BMS-214662 , a Highly Updated Version
W. Rose, F. Lee, C. Fairchild, M. Lynch +3 more
2001120 citations
Semantic Scholar
Discovery of (R)-7-cyano-2,3,4, 5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3- (phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine (BMS-214662), a farnesyltransferase inhibitor with potent preclinical antitumor activity.
J. T. Hunt, Charles Z. Ding, R. Batorsky, M. Bednarz +19 more
2000Journal of Medicinal Chemistry120 citations Open access
Semantic Scholar
Discovery of pyrrolopyridine-pyridone based inhibitors of Met kinase: synthesis, X-ray crystallographic analysis, and biological activities.
K. Kim, Li-Ping Zhang, R. Schmidt, Zhen-Wei Cai +22 more
2008Journal of Medicinal Chemistry117 citations Open access
Semantic Scholar
Contribution of Ras GTPase/MAP kinase and cytochrome P450 metabolites to deoxycorticosterone-salt-induced hypertension.
M. Muthalif, Ibrahim F. Benter, Zinat Khandekar, Lillian Gaber +5 more
2000HYPERTENSION76 citations Open access
Semantic Scholar
Potent, cell active, non-thiol tetrapeptide inhibitors of farnesyltransferase.
J. T. Hunt, V. Lee, K. Leftheris, B. R. Seizinger +5 more
1996Journal of Medicinal Chemistry75 citations Open access
Semantic Scholar
Phosphinyl acid-based bisubstrate analog inhibitors of Ras farnesyl protein transferase.
D. Patel, E. Gordon, R. Schmidt, H. Weller +11 more
1995Journal of Medicinal Chemistry71 citations Open access
Semantic Scholar
Development of highly potent inhibitors of Ras farnesyltransferase possessing cellular and in vivo activity.
K. Leftheris, T. Kline, G. Vite, Y. Cho +18 more
1996Journal of Medicinal Chemistry70 citations Open access
Semantic Scholar
Farnesyl diphosphate-based inhibitors of Ras farnesyl protein transferase.
Dinesh V. Patel, R. Schmidt, S. Biller, Eric M. Gordon +2 more
1995Journal of Medicinal Chemistry67 citations Open access
Semantic Scholar
Reversal of transformed phenotype by monoclonal antibodies against Ha-ras p21 proteins.
Hsiang-Fu Kung, Mark R. Smith, E. Bekesi, V. Manne +1 more
1986Experimental Cell Research62 citations
Semantic Scholar
Ras farnesylation as a target for novel antitumor agents: Potent and selective farnesyl diphosphate analog inhibitors of farnesyltransferase
V. Manne, C. Ricca, Johnni Gullo Brown, A. Tuomari +11 more
199557 citations
Semantic Scholar
Discovery of orally active pyrrolopyridine- and aminopyridine-based Met kinase inhibitors.
Zhen-Wei Cai, Donna D. Wei, Gretchen M. Schroeder, Lyndon A. M. Cornelius +15 more
2008Bioorganic & Medicinal Chemistry Letters54 citations Open access
Semantic Scholar
Identification of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of Met kinase.
Gretchen M. Schroeder, Xiao-Tao Chen, David K. Williams, David S. Nirschl +18 more
2008Bioorganic & Medicinal Chemistry Letters49 citations Open access
Semantic Scholar
Gene-Delivered Butyrylcholinesterase Is Prophylactic against the Toxicity of Chemical Warfare Nerve Agents and Organophosphorus Compounds
Kalpana Parikh, E. Duysen, B. Snow, N. Jensen +3 more
2011Journal of Pharmacology and Experimental Therapeutics46 citations
Semantic Scholar
Purified yeast protein farnesyltransferase is structurally and functionally similar to its mammalian counterpart.
R. Gomez, Laurie E. Goodman, S. K. Tripathy, E. O'Rourke +2 more
1993Biochemical Journal46 citations Open access
Semantic Scholar
Guanosine nucleotide binding by highly purified Ha-ras-encoded p21 protein produced in Escherichia coli.
V. Manne, S. Yamazaki, Hsiang-Fu Kung
1984Proceedings of the National Academy of Sciences of the United States of America46 citations Open access
Semantic Scholar
Discovery and structure-activity relationships of imidazole-containing tetrahydrobenzodiazepine inhibitors of farnesyltransferase
Charles Z. Ding, R. Batorsky, R. Bhide, Hannguang J. Chao +19 more
1999Journal of Medicinal Chemistry37 citations Open access
Semantic Scholar
Phase I pharmacokinetic and pharmacodynamic study of weekly 1-hour and 24-hour infusion BMS-214662, a farnesyltransferase inhibitor, in patients with advanced solid tumors.
J. Tabernero, F. Rojo, I. Marimón, M. Voi +16 more
2005Journal of Clinical Oncology36 citations
Semantic Scholar
10'-Desmethoxystreptonigrin, a novel analog of streptonigrin.
W.-C. Liu, M. Barbacid, M. Bulgar, J. M. Clark +6 more
1992Journal of antibiotics (Tokyo. 1968)34 citations Open access
Semantic Scholar
Senescence Marker Protein 30 (SMP30) Expression in Eukaryotic Cells: Existence of Multiple Species and Membrane Localization
Peethambaran Arun, V. Aleti, Kalpana Parikh, V. Manne +1 more
2011PLoS ONE33 citations Open access
Semantic Scholar
Adenovirus-mediated human paraoxonase1 gene transfer to provide protection against the toxicity of the organophosphorus pesticide toxicant diazoxon
E. Duysen, Kalpana Parikh, V. Aleti, V. Manne +2 more
2011Gene Therapy33 citations Open access
Semantic Scholar
Apoptotic and Cytostatic Farnesyltransferase Inhibitors Have Distinct Pharmacology and Efficacy Profiles in Tumor Models
V. Manne, F. Lee, D. Bol, J. Gullo-Brown +8 more
2004Cancer Research28 citations
Semantic Scholar
Peptide based P21RAS farnesyl transferase inhibitors: systematic modification of the tetrapeptide CA1A2X motif
K. Leftheris, T. Kline, S. Natarajan, M. DeVirgilio +7 more
199427 citations
Semantic Scholar
Characterization of phosphoinositide-specific phospholipase C from human platelets.
V. Manne, Hsiang-Fu Kung
1987Biochemical Journal26 citations Open access
Semantic Scholar
3-Imidazolylmethylaminophenylsulfonyltetrahydroquinolines, a novel series of farnesyltransferase inhibitors.
Charles Z. Ding, J. T. Hunt, C. Ricca, V. Manne
2000Bioorganic & Medicinal Chemistry Letters24 citations Open access
Semantic Scholar
Design, synthesis, and structure-activity relationships of tetrahydroquinoline-based farnesyltransferase inhibitors.
L. Lombardo, Amy Camuso, J. Clark, Krista Fager +17 more
2005Bioorganic & Medicinal Chemistry Letters21 citations Open access
Semantic Scholar
Pyrrolopyridazine MEK inhibitors.
Zhong Chen, Soong-Hoon Kim, Stephanie A. Barbosa, T. Huynh +9 more
2006Bioorganic & Medicinal Chemistry Letters20 citations Open access
Semantic Scholar
Design, synthesis and structure-activity relationships of novel biarylamine-based Met kinase inhibitors.
David K. Williams, Xiao-Tao Chen, C. Tarby, R. Kaltenbach +14 more
2010Bioorganic & Medicinal Chemistry Letters18 citations Open access
Semantic Scholar
Effects of phospholipids and ADP-ribosylation on GTP hydrolysis by Escherichia coli-synthesized Ha-ras-encoded p21.
Su-Chen Tsai, R. Adamik, Joel Moss, M. Vaughan +2 more
1985Proceedings of the National Academy of Sciences of the United States of America15 citations Open access
Semantic Scholar
Effect of divalent metal ions and glycerol on the GTPase activity of H-ras proteins.
V. Manne, Hsiang-Fu Kung
1985Biochemical and Biophysical Research Communications - BBRC8 citations
Semantic Scholar
Quiescent Chronic Myelogenous Leukemia (CML) Cells Are Resistant to BCR-ABL Inhibitors but Preferentially Sensitive to BMS-214662, a Farnesyltransferase Inhibitor (FTI) with Unique Quiescent-Cell Selective Cytotoxicity.
F. Lee, Mei-Li Wen, Amy Camuso, Stephen Castenada +10 more
20055 citations
Semantic Scholar
A phase Ib study of troriluzole (BHV-4157) in combination with nivolumab.
A. Silk, B. Saraiya, R. Groisberg, N. Chan +11 more
20203 citations
Semantic Scholar
Development of Farnesyltransferase Inhibitors as Potential Antitumor Agents
V. Manne, F. Lee, N. Yan, C. Fairchild +1 more
20011 citations Open access
Semantic Scholar
Increased occurrence of malignancy before and after chemoradiation for anal squamous cell carcinoma: a multi-institutional analysis
Ritesh Kumar, C. Hallemeier, Daniel T. Chang, Shou-En Lu +13 more
2024Journal of the National Cancer Institute0 citations Open access
Semantic Scholar
Overexpression of Human Senescence Marker Protein 30 in Mice Fails to Offer Protection Against Challenge with Organophosphorus Compounds
Peethambaran Arun, V. Aleti, N. Jensen, V. Manne +2 more
20110 citations Open access
Semantic Scholar
3-Imidazolylmethylaminophenylsulfonyltetrahydroquinolines, a Novel Series of Farnesyltransferase Inhibitors
Charles Z. Ding, J. T. Hunt, C. Ricca, V. Manne
20000 citations
Semantic Scholar
Discovery and structure-activity relationships of imidazole-containing tetrahydrobenzodiazepine inhibitors of farnesyltransferase.
C.-Z. Ding, R. Batorsky, R. Bhide, Hannguang J. Chao +19 more
1999Journal of Medicinal Chemistry0 citations
Semantic Scholar
Tetrapeptide based inhibitors of p21 ras protein farnesyl transferase
K. Leftheris, T. Kline, W. Lau, L. Mueller +7 more
19940 citations
Semantic Scholar
Use of biphosphonates for the manufacture of a medicament for blocking neoplastic cell transformation caused by the Ras-Oncogene.
S. Biller, M. Barbacid, E. Gordon, D. Magnin +2 more
19920 citations
Semantic Scholar
Bisphosphonate use for the manufacture of a medicament for blocking neoplastic cell transformation induced by ras oncogenes.
S. Biller, M. Barbacid, E. Gordon, D. Magnin +2 more
19920 citations
Semantic Scholar
Bacterial gene expression and biotechnology.
Hsiang-Fu Kung, Miloslav Boublik, V. Manne, S. Yamazaki +1 more
1985Current Topics in Cellular Regulation0 citations
Semantic Scholar

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C. Ricca×15
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C. Ricca — researcher profile on SciRah
J. T. Hunt×13
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J. Gullo-Brown×12
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L. Lombardo×7
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K. Leftheris×7

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David K. Williams×6

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