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E. Duysen · SciRah

Researcher profile · Semantic Scholar

E. Duysen

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E. Duysen — researcher profile on SciRah

h-index: 30
Works: 81
Citations: 3,606

Most-cited papers

Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholine.
Marsel Mesulam, Angela L. Guillozet, Pamela L. Shaw, A. Levey +2 more
2002Neuroscience617 citations
Semantic Scholar
Butyrylcholinesterase, paraoxonase, and albumin esterase, but not carboxylesterase, are present in human plasma.
Bin Li, M. Sedlacek, Indumathi Manoharan, R. Boopathy +3 more
2005Biochemical Pharmacology528 citations
Semantic Scholar
Albumin, a new biomarker of organophosphorus toxicant exposure, identified by mass spectrometry.
Eric S. Peeples, L. Schopfer, E. Duysen, R. Spaulding +3 more
2004Toxicological Sciences154 citations Open access
Semantic Scholar
Excessive hippocampal acetylcholine levels in acetylcholinesterase‐deficient mice are moderated by butyrylcholinesterase activity
J. Hartmann, C. Kiewert, E. Duysen, O. Lockridge +2 more
2007Journal of Neurochemistry144 citations
Semantic Scholar
Evidence for nonacetylcholinesterase targets of organophosphorus nerve agent: supersensitivity of acetylcholinesterase knockout mouse to VX lethality.
E. Duysen, Bin Li, Wei-Hua Xie, L. Schopfer +3 more
2001Journal of Pharmacology and Experimental Therapeutics143 citations Open access
Semantic Scholar
Rescue of the acetylcholinesterase knockout mouse by feeding a liquid diet; phenotype of the adult acetylcholinesterase deficient mouse.
E. Duysen, J. Stribley, D. L. Fry, S. Hinrichs +1 more
2002Brain research. Developmental brain research130 citations
Semantic Scholar
The Butyrylcholinesterase Knockout Mouse as a Model for Human Butyrylcholinesterase Deficiency
Bin Li, E. Duysen, Michaela Carlson, O. Lockridge
2008Journal of Pharmacology and Experimental Therapeutics102 citations
Semantic Scholar
Sensitivity of butyrylcholinesterase knockout mice to (--)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmission.
E. Duysen, Bin Li, S. Darvesh, O. Lockridge
2007Toxicology98 citations
Semantic Scholar
Wild-Type and A328W Mutant Human Butyrylcholinesterase Tetramers Expressed in Chinese Hamster Ovary Cells Have a 16-Hour Half-Life in the Circulation and Protect Mice from Cocaine Toxicity
E. Duysen, C. Bartels, O. Lockridge
2002Journal of Pharmacology and Experimental Therapeutics94 citations
Semantic Scholar
Mice treated with chlorpyrifos or chlorpyrifos oxon have organophosphorylated tubulin in the brain and disrupted microtubule structures, suggesting a role for tubulin in neurotoxicity associated with exposure to organophosphorus agents.
Wei Jiang, E. Duysen, Heidi Hansen, L. Shlyakhtenko +2 more
2010Toxicological Sciences87 citations Open access
Semantic Scholar
Regulation of muscarinic acetylcholine receptor function in acetylcholinesterase knockout mice.
Bin Li, E. Duysen, L. Volpicelli-Daley, A. Levey +1 more
2003Pharmacology, Biochemistry and Behavior80 citations
Semantic Scholar
The butyrylcholinesterase knockout mouse is obese on a high-fat diet.
Bin Li, E. Duysen, O. Lockridge
2008Chemico-Biological Interactions77 citations
Semantic Scholar
Altered striatal function and muscarinic cholinergic receptors in acetylcholinesterase knockout mice.
L. Volpicelli-Daley, A. Hrabovská, E. Duysen, S. Ferguson +3 more
2003Molecular Pharmacology68 citations
Semantic Scholar
Production of ES1 Plasma Carboxylesterase Knockout Mice for Toxicity Studies
E. Duysen, Frank Koentgen, Gareth R. Williams, C. Timperley +3 more
2011Chemical Research in Toxicology59 citations Open access
Semantic Scholar
Reduced acetylcholine receptor density, morphological remodeling, and butyrylcholinesterase activity can sustain muscle function in acetylcholinesterase knockout mice
M. Adler, H. Manley, Angela L. Purcell, S. Deshpande +6 more
2004Muscle and Nerve58 citations
Semantic Scholar
Effects of rivastigmine and donepezil on brain acetylcholine levels in acetylcholinesterase-deficient mice.
R. S. Naik, J. Hartmann, C. Kiewert, E. Duysen +2 more
2009Journal of Pharmacy & Pharmaceutical Sciences47 citations Open access
Semantic Scholar
Gene-Delivered Butyrylcholinesterase Is Prophylactic against the Toxicity of Chemical Warfare Nerve Agents and Organophosphorus Compounds
Kalpana Parikh, E. Duysen, B. Snow, N. Jensen +3 more
2011Journal of Pharmacology and Experimental Therapeutics46 citations
Semantic Scholar
Glucocorticoid mediation of dietary energy restriction inhibition of mouse skin carcinogenesis.
D. Birt, Ann L. Yaktine, E. Duysen
1999Journal of NutriLife45 citations Open access
Semantic Scholar
Impaired formation of the inner retina in an AChE knockout mouse results in degeneration of all photoreceptors
A. Bytyqi, O. Lockridge, E. Duysen, Yuxia Wang +2 more
2004European Journal of Neuroscience44 citations
Semantic Scholar
Visualization of exogenous delivery of nanoformulated butyrylcholinesterase to the central nervous system
Andrea Gaydess, E. Duysen, Yuan Li, Vladimir Gilman +3 more
2010Chemico-Biological Interactions43 citations Open access
Semantic Scholar
Altered hippocampal muscarinic receptors in acetylcholinesterase‐deficient mice
L. Volpicelli-Daley, E. Duysen, O. Lockridge, A. Levey
2003Annals of Neurology43 citations
Semantic Scholar
Mass spectrometry identifies multiple organophosphorylated sites on tubulin
Hasmik Grigoryan, L. Schopfer, Eric S. Peeples, E. Duysen +3 more
2009Toxicology and Applied Pharmacology42 citations Open access
Semantic Scholar
The butyrylcholinesterase knockout mouse a research tool in the study of drug sensitivity, bio-distribution, obesity and Alzheimer's disease
E. Duysen, Bin Li, O. Lockridge
2009Expert Opinion on Drug Metabolism & Toxicology38 citations
Semantic Scholar
Production of the butyrylcholinesterase knockout mouse
Blin Li, E. Duysen, T. Saunders, O. Lockridge
2007Journal of Molecular Neuroscience38 citations
Semantic Scholar
Occupational stress among farm and ranch operators in the midwestern United States
Sabrine Chengane, C. Beseler, E. Duysen, R. Rautiainen
2021BMC Public Health37 citations Open access
Semantic Scholar
Differential sensitivity of plasma carboxylesterase-null mice to parathion, chlorpyrifos and chlorpyrifos oxon, but not to diazinon, dichlorvos, diisopropylfluorophosphate, cresyl saligenin phosphate, cyclosarin thiocholine, tabun thiocholine, and carbofuran
E. Duysen, J. Cashman, L. Schopfer, F. Nachon +2 more
2011Chemico-Biological Interactions37 citations Open access
Semantic Scholar
Resistance to organophosphorus agent toxicity in transgenic mice expressing the G117H mutant of human butyrylcholinesterase.
Yuxia Wang, A. Boeck, E. Duysen, M. V. Van Keuren +2 more
2004Toxicology and Applied Pharmacology35 citations
Semantic Scholar
Adenovirus-mediated human paraoxonase1 gene transfer to provide protection against the toxicity of the organophosphorus pesticide toxicant diazoxon
E. Duysen, Kalpana Parikh, V. Aleti, V. Manne +2 more
2011Gene Therapy33 citations Open access
Semantic Scholar
Study of acetylcholinesterase activity and apoptosis in SH-SY5Y cells and mice exposed to ethanol.
Wen-Jun Sun, Liang-Jing Chen, Wei Zheng, Xiaoan Wei +3 more
2017Toxicology32 citations
Semantic Scholar
Choline availability and acetylcholine synthesis in the hippocampus of acetylcholinesterase-deficient mice.
J. Hartmann, C. Kiewert, E. Duysen, O. Lockridge +1 more
2008Neurochemistry International32 citations
Semantic Scholar
Increased hepatotoxicity and cardiac fibrosis in cocaine-treated butyrylcholinesterase knockout mice.
E. Duysen, Bin Li, Michaela Carlson, Yi-Fan Li +3 more
2008Basic & Clinical Pharmacology & Toxicology30 citations
Semantic Scholar
Dietary energy restriction inhibits ERK but not JNK or p38 activity in the epidermis of SENCAR mice.
Yinghui Liu, E. Duysen, Ann L. Yaktine, Angela Au +2 more
2001Carcinogenesis29 citations
Semantic Scholar
Inhibition of phorbol ester-induced AP-1-DNA binding, c-Jun protein and c-jun mRNA by dietary energy restriction is reversed by adrenalectomy in SENCAR mouse epidermis.
Joseph Przybyszewski, Ann L. Yaktine, E. Duysen, D. Blackwood +3 more
2001Carcinogenesis29 citations
Semantic Scholar
Knowledge, Attitudes, and Practices for Respiratory and Hearing Health among Midwestern Farmers
M. Cramer, Mary J. Wendl, H. Sayles, E. Duysen +1 more
2017Public Health Nursing25 citations
Semantic Scholar
Life without acetylcholinesterase: the implications of cholinesterase inhibitor toxicity in AChE-knockout mice.
O. Lockridge, E. Duysen, T. Voelker, C. Thompson +1 more
2005Environmental Toxicology and Pharmacology25 citations
Semantic Scholar
Dietary energy restriction in the SENCAR mouse: Elevation of glucocorticoid hormone levels but no change in distribution of glucocorticoid receptor in epidermal cells
Ann L. Yaktine, Rick Vaughn, D. Blackwood, E. Duysen +1 more
1998Molecular Carcinogenesis25 citations
Semantic Scholar
Adenovirus-mediated gene transfer of human butyrylcholinesterase results in persistent high-level transgene expression in vivo.
N. Chilukuri, E. Duysen, Kalpana Parikh, Wei Sun +3 more
2008Chemico-Biological Interactions24 citations
Semantic Scholar
Phenotype comparison of three acetylcholinesterase knockout strains
E. Duysen, O. Lockridge
2007Journal of Molecular Neuroscience22 citations
Semantic Scholar
Virtual Outreach: Using Social Media to Reach Spanish-speaking Agricultural Workers during the COVID-19 Pandemic
Athena K. Ramos, E. Duysen, Marcela Carvajal-Suárez, Natalia Trinidad
2020Journal of Agromedicine20 citations
Semantic Scholar
Contributions of Selective Knockout Studies to Understanding Cholinesterase Disposition and Function
S. Camp, Limin Zhang, E. Krejci, A. Dobbertin +6 more
2010Chemico-Biological Interactions19 citations Open access
Semantic Scholar
Comparison of agricultural injuries reported in the media and census of fatal occupational injuries
Moses New-Aaron, Jessica N. Semin, E. Duysen, M. Madsen +2 more
2019Journal of Agromedicine18 citations
Semantic Scholar
Butyrylcholinesterase: Overview, Structure, and Function
O. Lockridge, E. Duysen, P. Masson
201118 citations
Semantic Scholar
Induction of plasma acetylcholinesterase activity in mice challenged with organophosphorus poisons.
E. Duysen, O. Lockridge
2011Toxicology and Applied Pharmacology18 citations
Semantic Scholar
Prolonged Toxic Effects After Cocaine Challenge in Butyrylcholinesterase/Plasma Carboxylesterase Double Knockout Mice: A Model for Butyrylcholinesterase-Deficient Humans
E. Duysen, O. Lockridge
2011Drug Metabolism And Disposition16 citations
Semantic Scholar
Adenovirus-Transduced Human Butyrylcholinesterase in Mouse Blood Functions as a Bioscavenger of Chemical Warfare Nerve Agents
N. Chilukuri, E. Duysen, Kalpana Parikh, Robert C. diTargiani +3 more
2009Molecular Pharmacology16 citations
Semantic Scholar
Whole body and tissue imaging of the butyrylcholinesterase knockout mouse injected with near infrared dye labeled butyrylcholinesterase.
E. Duysen, O. Lockridge
2008Chemico-Biological Interactions16 citations
Semantic Scholar
Role of Acetylcholinesterase on the Structure and Function of Cholinergic Synapses: Insights Gained from Studies on Knockout Mice
M. Adler, R. Sweeney, T. Hamilton, O. Lockridge +3 more
2011Cellular and molecular neurobiology15 citations
Semantic Scholar
Intrathecal delivery of fluorescent labeled butyrylcholinesterase to the brains of butyrylcholinesterase knock-out mice: Visualization and quantification of enzyme distribution in the brain
Noel D Johnson, E. Duysen, O. Lockridge
2009Neurotoxicology15 citations Open access
Semantic Scholar
Corticosterone supplementation reduced selective protein kinase C isoform expression in the epidermis of adrenalectomized mice.
Diane F. Birt, E. Duysen, Wei-Qun Wang, Ann L. Yaktine
2001Cancer Epidemiology, Biomarkers and Prevention14 citations
Semantic Scholar
Social Marketing Campaign Promoting the Use of Respiratory Protection Devices Among Farmers
Lea Pounds, E. Duysen, D. Romberger, M. Cramer +2 more
2014Journal of Agromedicine13 citations
Semantic Scholar

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