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T. Kline · SciRah

Researcher profile · Semantic Scholar

T. Kline

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T. Kline — researcher profile on SciRah

h-index: 26
Works: 69
Citations: 2,199

Most-cited papers

A rhodopsin is the functional photoreceptor for phototaxis in the unicellular eukaryote Chlamydomonas
K. Foster, J. Saranak, Nayana Patel, Gerald Zarilli +3 more
1984Nature365 citations
Semantic Scholar
AN INHIBITOR OF GRAM-NEGATIVE BACTERIAL VIRULENCE PROTEIN SECRETION
Heather B. Felise, Hai V. Nguyen, R. Pfuetzner, Kathleen C Barry +5 more
2008Cell Host and Microbe156 citations Open access
Semantic Scholar
Development and properties of beta-glucuronide linkers for monoclonal antibody-drug conjugates.
S. Jeffrey, J. Andreyka, Starr X Bernhardt, K. Kissler +8 more
2006Bioconjugate chemistry148 citations
Semantic Scholar
Potent, novel in vitro inhibitors of the Pseudomonas aeruginosa deacetylase LpxC.
T. Kline, N. Andersen, Eric A. Harwood, J. Bowman +13 more
2002Journal of Medicinal Chemistry108 citations Open access
Semantic Scholar
Molecular Validation of LpxC as an Antibacterial Drug Target in Pseudomonas aeruginosa
K. Mdluli, P. Witte, T. Kline, A. Barb +8 more
2006Antimicrobial Agents and Chemotherapy83 citations
Semantic Scholar
Design, synthesis, and in vitro evaluation of dipeptide-based antibody minor groove binder conjugates.
S. Jeffrey, M. Torgov, J. Andreyka, Laura Boddington +8 more
2005Journal of Medicinal Chemistry78 citations
Semantic Scholar
Structure of the hirulog 3-thrombin complex and nature of the S' subsites of substrates and inhibitors.
Xia-Yang Qiu, K. Padmanabhan, Vasili E. Carperos, Alexander Tulinsky +3 more
1994Biochemistry73 citations
Semantic Scholar
Novel synthetic analogs of the Pseudomonas autoinducer.
T. Kline, J. Bowman, B. Iglewski, T. D. de Kievit +2 more
1999Bioorganic & Medicinal Chemistry Letters72 citations
Semantic Scholar
Development of highly potent inhibitors of Ras farnesyltransferase possessing cellular and in vivo activity.
K. Leftheris, T. Kline, G. Vite, Y. Cho +18 more
1996Journal of Medicinal Chemistry70 citations Open access
Semantic Scholar
Methods to Make Homogenous Antibody Drug Conjugates
T. Kline, Alexander R. Steiner, K. Penta, A. Sato +2 more
2014Pharmaceutical Research69 citations Open access
Semantic Scholar
Development of a CA125-mesothelin cell adhesion assay as a screening tool for biologics discovery.
N. Scholler, B. Garvik, M. Hayden-Ledbetter, T. Kline +1 more
2007Cancer Letters66 citations Open access
Semantic Scholar
Substituted 2-Imino-5-arylidenethiazolidin-4-one Inhibitors of Bacterial Type III Secretion
T. Kline, Heather B. Felise, Kathleen C Barry, Stona R. Jackson +2 more
2008Journal of Medicinal Chemistry62 citations Open access
Semantic Scholar
Novel antitumor prodrugs designed for activation by matrix metalloproteinases-2 and -9.
T. Kline, M. Torgov, B. Mendelsohn, C. Cerveny +1 more
2004Molecular Pharmaceutics57 citations
Semantic Scholar
Discovery of STRO-002, a Novel Homogeneous ADC Targeting Folate Receptor Alpha, for the Treatment of Ovarian and Endometrial Cancers
Xiaofan Li, Si-Hong Zhou, C. Abrahams, Stellanie Krimm +17 more
2022Molecular Cancer Therapeutics56 citations Open access
Semantic Scholar
Targeting colorectal cancer with small-molecule inhibitors of ALDH1B1
Zhi-Ping Feng, Marisa E. Hom, Thomas E. Bearrood, Zachary C. Rosenthal +11 more
2022Nature Chemical Biology55 citations Open access
Semantic Scholar
Biomimetic total synthesis of (−)-codeine
James D. White, G. Caravatti, T. Kline, E. Edstrom +2 more
198355 citations
Semantic Scholar
Targeting CD74 in multiple myeloma with the novel, site-specific antibody-drug conjugate STRO-001
C. Abrahams, Xiaofan Li, M. Embry, Abigail S. Yu +15 more
2018OncoTarget50 citations Open access
Semantic Scholar
Synthesis of and evaluation of lipid A modification by 4-substituted 4-deoxy arabinose analogs as potential inhibitors of bacterial polymyxin resistance.
T. Kline, M. Trent, Christopher M. Stead, M. Lee +4 more
2008Bioorganic & Medicinal Chemistry Letters47 citations Open access
Semantic Scholar
Tethered Thiazolidinone Dimers as Inhibitors of the Bacterial Type III Secretion System
T. Kline, Kathleen C Barry, Stona R. Jackson, Heather B. Felise +2 more
2009Bioorganic & Medicinal Chemistry Letters40 citations Open access
Semantic Scholar
Exploration of the Carmaphycins as Payloads in Antibody Drug Conjugate Anticancer Agents
J. Almaliti, Bailey W. Miller, Halina Pietraszkiewicz, Evgenia Glukhov +7 more
2018European journal of medicinal chemistry38 citations Open access
Semantic Scholar
Chloramphenicol Is a Substrate for a Novel Nitroreductase Pathway in Haemophilus influenzae
A. Smith, A. L. Erwin, T. Kline, William C. T. Unrath +3 more
2007Antimicrobial Agents and Chemotherapy38 citations Open access
Semantic Scholar
Hirulog peptides with scissile bond replacements resistant to thrombin cleavage.
T. Kline, Charles Hammond, P. Bourdon, John M. Maraganore
1991Biochemical and Biophysical Research Communications - BBRC38 citations
Semantic Scholar
Lophotoxin and related coral toxins covalently label the alpha-subunit of the nicotinic acetylcholine receptor.
S. N. Abramson, P. Culver, T. Kline, Ying Li +3 more
1988Journal of Biological Chemistry38 citations
Semantic Scholar
Antimicrobial effects of novel siderophores linked to β-lactam antibiotics
T. Kline, M. Fromhold, T. Mckennon, S. Cai +18 more
200033 citations
Semantic Scholar
Synthesis and characterization of the colistin peptide polymyxin E1 and related antimicrobial peptides.
T. Kline, D. Holub, J. Therrien, T. Leung +1 more
2001Journal of Peptide Research30 citations
Semantic Scholar
Peptide based P21RAS farnesyl transferase inhibitors: systematic modification of the tetrapeptide CA1A2X motif
K. Leftheris, T. Kline, S. Natarajan, M. DeVirgilio +7 more
199427 citations
Semantic Scholar
The type III secretion system as a source of novel antibacterial drug targets.
T. Kline, Heather B. Felise, Sarah Sanowar, S. Miller
2012Current Drug Targets25 citations
Semantic Scholar
Design and Synthesis of bis-carbamate Analogs of Cyclic bis-(3′-5′)-Diguanylic Acid (c-di-GMP) and the Acyclic Dimer PGPG
T. Kline, Stona R. Jackson, Wei Deng, C. Verlinde +1 more
2008Nucleosides, Nucleotides & Nucleic Acids23 citations
Semantic Scholar
Preparation of 2‐iodotryptamine and 2‐iodo‐5‐methoxytryptamine
T. Kline
198522 citations
Semantic Scholar
Handbook of Affinity Chromatography
T. Kline
199319 citations
Semantic Scholar
Toward a Ferrous Iron-Cleavable Linker for Antibody-Drug Conjugates.
B. Spangler, T. Kline, J. Hanson, Xiaofan Li +4 more
2018Molecular Pharmaceutics18 citations
Semantic Scholar
Targeting CD74 in B-cell non-Hodgkin lymphoma with the antibody-drug conjugate STRO-001
Xiaofan Li, C. Abrahams, Abigail S. Yu, M. Embry +9 more
2023OncoTarget13 citations Open access
Semantic Scholar
Identification of Small Molecule Modulators of Diguanylate Cyclase by FRET-based High-Throughput-Screening
M. Christen, Cassandra Kamischke, H. Kulasekara, Kathleen C. Olivas +4 more
2018bioRxiv13 citations Open access
Semantic Scholar
1,4-Benzodioxane Lignans: An Efficient, Asymmetric Synthesis of Flavonolignans and Study of Neolignan Cytotoxicity and Antiviral Profiles.
L. Pilkington, J. Wagoner, T. Kline, S. Polyak +1 more
2018Journal of Natural Products12 citations Open access
Semantic Scholar
Structure-activity relationships in potentially hallucinogenic N,N-dialkyltryptamines substituted in the benzene moiety.
T. Kline, Frederick Benington, R. Morin, J. M. Beaton
1982Journal of Medicinal Chemistry11 citations Open access
Semantic Scholar
Antimicrobial effects of novel siderophores linked to beta-lactam antibiotics.
T. Kline, M. Fromhold, T. Mckennon, S. Cai +18 more
2000Bioorganic & Medicinal Chemistry10 citations
Semantic Scholar
Side chain modified sterols as probes into insect molting hormone metabolism. I: synthesis of monofluorophytosterols
T. Kline, G. Prestwich
198210 citations
Semantic Scholar
Novel [(diazomethyl)carbonyl]-1,2,3,4-tetrahydronaphthalene derivatives as potential photoaffinity ligands for the 5-HT1A receptor.
T. Kline, David L. Nelson, K. Namboodiri
1990Journal of Medicinal Chemistry9 citations Open access
Semantic Scholar
29–Fluorophytosterols: Novel Pro–Insecticides which Cause Death by Dealkylation
G. Prestwich, A. K. Gayen, S. Phirwa, T. Kline
1983Bio/Technology9 citations
Semantic Scholar
Abstract NT-090: PRECLINICAL ACTIVITY AND SAFETY OF STRO-002, A NOVEL ADC TARGETING FOLATE RECEPTOR ALPHA FOR OVARIAN AND ENDOMETRIAL CANCER
C. Abrahams, Stellanie Krimm, Xiaofan Li, Si-Hong Zhou +21 more
20198 citations
Semantic Scholar
Targeting CD74 with Novel Antibody Drug Conjugates (ADCs) for the Treatment of B-Cell Non-Hodgkin's Lymphoma (NHL)
Xiaofan Li, C. Abrahams, M. Embry, Abigail S. Yu +24 more
20168 citations
Semantic Scholar
A pseudopeptide incorporating the tetrahydrophthalazine nucleus, a constrained aza analog of phenylalanine.
T. Kline, L. Mueller, Ellen SIEBER-McMaster, W. Lau +1 more
2009International journal of peptide & protein research8 citations
Semantic Scholar
Abstract 1782: Discovery and activity of STRO-002, a novel ADC targeting folate receptor alpha for ovarian and endometrial cancer
Xiaofan Li, C. Abrahams, Si-Hong Zhou, Stellanie Krimm +21 more
2018Immunology7 citations
Semantic Scholar
Measurement of imidazoleacetic acid in urine by gas chromatography-mass spectrometry.
J. Khandelwal, T. Kline, J. P. Green
1985Journal of Chromatography A5 citations
Semantic Scholar
Structure-activity relationships for hallucinogenic N,N-dialkyltryptamines: photoelectron spectra and serotonin receptor affinities of methylthio and methylenedioxy derivatives.
T. Kline, Frederick Benington, R. Morin, J. M. Beaton +4 more
1982Journal of Medicinal Chemistry5 citations
Semantic Scholar
Discovery and Preclinical Development of Novel CD74-Targeting Antibody-Drug Conjugates (ADCs) with Significant Activity in Multiple Myeloma (MM) Cell Lines and Xenograft Models
C. Abrahams, Xiaofan Li, Abigail S. Yu, Stellanie Krimm +22 more
20163 citations
Semantic Scholar
Intracellular metabolism of antibody-drug conjugates: identification and quantitation of released drugs
S. Alley, N. Okeley, R. Sanderson, V. Nanayakkara +6 more
20063 citations
Semantic Scholar
3,7-functionalized-10-methyl phenothiazine: A potential turn scaffold in peptidomimetics
T. Kline, E. Sieber-McMaster, W. Lau, S. Natarajan
19973 citations
Semantic Scholar
Preclinical activity and safety of STRO-002, a novel ADC targeting folate receptor alpha for ovarian cancer
V. D. De Almeida, C. Abrahams, W. Solis, Xiaofan Li +6 more
2018Gynecologic Oncology2 citations
Semantic Scholar
High Frequency of CD74 Expression in B-Cell Non-Hodgkin's Lymphoma (NHL) and Targeting with SΤRO-001, a Novel Anti-CD74 Antibody Drug Conjugate (ADC) with Potent I n Vitro Cytotoxicty and In Vivo Anti-Tumor Activity
Abigail S. Yu, C. Abrahams, M. Embry, Xiao-Fan Li +11 more
20172 citations
Semantic Scholar

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