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Alice Giustacchini · SciRah

Researcher profile · Semantic Scholar

Alice Giustacchini

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Alice Giustacchini — researcher profile on SciRah

h-index: 19
Works: 45
Citations: 2,926

Most-cited papers

Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia
Alice Giustacchini, S. Thongjuea, Nikolaos Barkas, P. Woll +16 more
2017Nature Medicine381 citations Open access
Semantic Scholar
Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo.
P. Woll, Una Kjällquist, Onima Chowdhury, H. Doolittle +44 more
2014Cancer Cell333 citations Open access
Semantic Scholar
Stable knockdown of microRNA in vivo by lentiviral vectors
B. Gentner, Giulia Schira, Alice Giustacchini, Mario Amendola +3 more
2009Nature Methods324 citations
Semantic Scholar
Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells
A. Grover, A. Sanjuan-Pla, S. Thongjuea, J. Carrelha +8 more
2016Nature Communications298 citations Open access
Semantic Scholar
Unravelling Intratumoral Heterogeneity through High-Sensitivity Single-Cell Mutational Analysis and Parallel RNA Sequencing
A. Rodriguez-Meira, Gemma Buck, Sally-Ann Clark, B. Povinelli +11 more
2019Molecules and Cells284 citations Open access
Semantic Scholar
Distinct myeloid progenitor differentiation pathways identified through single cell RNA sequencing
Roy Drissen, Natalija Buza-Vidas, P. Woll, S. Thongjuea +10 more
2016Nature Immunology215 citations Open access
Semantic Scholar
Attenuation of miR-126 Activity Expands HSC In Vivo without Exhaustion
Eric R. Lechman, B. Gentner, P. van Galen, Alice Giustacchini +9 more
2012Cell Stem Cell215 citations Open access
Semantic Scholar
Identification of Hematopoietic Stem Cell–Specific miRNAs Enables Gene Therapy of Globoid Cell Leukodystrophy
B. Gentner, I. Visigalli, H. Hiramatsu, Eric R. Lechman +10 more
2010Science Translational Medicine214 citations
Semantic Scholar
Systemic and Targeted Delivery of Semaphorin 3A Inhibits Tumor Angiogenesis and Progression in Mouse Tumor Models
Andrea Casazza, Xi Fu, I. Johansson, L. Capparuccia +11 more
2011Arteriosclerosis, Thrombosis and Vascular Biology120 citations Open access
Semantic Scholar
Assessing similarity to primary tissue and cortical layer identity in induced pluripotent stem cell-derived cortical neurons through single-cell transcriptomics
A. Handel, Satyan Chintawar, T. Lalic, Emma S. Whiteley +11 more
2016Human Molecular Genetics101 citations Open access
Semantic Scholar
A dynamic niche provides Kit ligand in a stage-specific manner to the earliest thymocyte progenitors
Mario Buono, R. Facchini, Sahoko Matsuoka, S. Thongjuea +7 more
2016Nature Cell Biology72 citations Open access
Semantic Scholar
miRNA-126 Orchestrates an Oncogenic Program in B Cell Precursor Acute Lymphoblastic Leukemia.
Silvia Nucera, Alice Giustacchini, F. Boccalatte, A. Calabria +13 more
2016Cancer Cell58 citations Open access
Semantic Scholar
Initial seeding of embryonic thymus by immune-restricted lympho-myeloid progenitors
T. Luis, Sidinh Luc, Takuo Mizukami, Hanane Boukarabila +20 more
2016Nature Immunology57 citations Open access
Semantic Scholar
Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors.
Christopher A. G. Booth, Nikolaos Barkas, Wen Hao Neo, Hanane Boukarabila +16 more
2018Cancer Cell55 citations Open access
Semantic Scholar
Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD–induced myeloproliferation
A. Mead, Wen Hao Neo, Nikolaos Barkas, Sahoko Matsuoka +18 more
2017Journal of Experimental Medicine50 citations Open access
Semantic Scholar
A double-switch vector system positively regulates transgene expression by endogenous microRNA expression (miR-ON vector).
Mario Amendola, Alice Giustacchini, B. Gentner, L. Naldini
2013Molecular Therapy32 citations Open access
Semantic Scholar
Mbd3/NuRD controls lymphoid cell fate and inhibits tumorigenesis by repressing a B cell transcriptional program
Stephen J. Loughran, F. Comoglio, F. Hamey, Alice Giustacchini +7 more
2017Journal of Experimental Medicine28 citations Open access
Semantic Scholar
Activation priming and cytokine polyfunctionality modulate the enhanced functionality of low-affinity CD19 CAR T cells
I. Michelozzi, E. Gómez-Castañeda, R. V. Pohle, Ferran Cardoso Rodriguez +14 more
2022Blood Advances25 citations Open access
Semantic Scholar
Perivascular niche cells sense thrombocytopenia and activate hematopoietic stem cells in an IL-1 dependent manner
T. Luis, Nikolaos Barkas, J. Carrelha, Alice Giustacchini +17 more
2023Nature Communications19 citations Open access
Semantic Scholar
Driving CAR T Stem Cell Targeting in Acute Myeloid Leukemia: The Roads to Success
I. Michelozzi, Efstratios Kirtsios, Alice Giustacchini
2021Cancers18 citations Open access
Semantic Scholar
High-dimensional functional phenotyping of preclinical human CAR T cells using mass cytometry
I. Michelozzi, J. Sufi, Thomas Adejumo, P. Amrolia +2 more
2022STAR Protocols7 citations Open access
Semantic Scholar
The Enhanced Functionality of Low-Affinity CD19 CAR T Cells Is Associated with Activation Priming and Polyfunctional Cytokine Phenotype
I. Michelozzi, E. Gómez-Castañeda, R. V. Pohle, Ferran Cardoso Rodriguez +11 more
20207 citations Open access
Semantic Scholar
Taming Cell-to-Cell Heterogeneity in Acute Myeloid Leukaemia With Machine Learning
Yara E. Sánchez-Corrales, R. V. Pohle, S. Castellano, Alice Giustacchini
2021Frontiers in Oncology5 citations Open access
Semantic Scholar
Single Cell Multimodal Framework Identifies CD84 As a Leukaemic Stem Cell Target in Paediatric AML
Macarena Oporto Espuelas, Sina Kanannejad, I. Michelozzi, Eduardo Gomez Castaneda +11 more
2024Blood4 citations
Semantic Scholar
Enhanced functionality of low-affinity CD19 CAR T-cells is associated with activation priming and a polyfunctional cytokine phenotype
I. Michelozzi, E. G. Castañeda, R. V. Pohle, F. C. Rodriguez +14 more
2020bioRxiv4 citations Open access
Semantic Scholar
Perivascular Niche Cells Sense Thrombocytopenia and Activate Platelet-Biased Hscs in an IL-1 Dependent Manner
T. Luis, Nikolaos Barkas, Alice Giustacchini, Bishan Wu +4 more
2018Experimental Hematology3 citations Open access
Semantic Scholar
PERIVASCULAR NICHE CELLS SENSE THROMBOCYTOPENIA AND ACTIVATE PLATELET-BIASED STEM CELLS IN AN IL-1 DEPENDENT MANNER
T. Luis, Nikolas Barkas, Alice Giustacchini, J. Guerrero +7 more
2018Experimental Hematology2 citations Open access
Semantic Scholar
Single Cell Whole Transcriptome Analysis Reveals Distinct Molecular Signatures of Therapy-Resistant Chronic Myeloid Leukemia Stem Cells
Alice Giustacchini, S. Thongjuea, P. Woll, P. Sopp +8 more
20151 citations
Semantic Scholar
A Mechanistic Role For Mir-126, a Hematopoietic Stem Cell Microrna, In Acute Leukemias
Alice Giustacchini, Silvia Nucera, Eric R. Lechman, Cristiana Fanciullo +9 more
20131 citations
Semantic Scholar
Super-resolution imaging reveals altered actin architecture at CAR-T cell immune synapses
Olivia P. L. Dalby, Efstratios Kirtsios, Hale-Seda Radoykova, C. Zaza +4 more
2026Journal of Cell Biology0 citations Open access
Semantic Scholar
Integrated in silico and in vitro approaches identify a HSP90 drug vulnerability axis in t(7;12) infant leukemia stem-like cells
Ylenia Cicirò, Denise Ragusa, Emily M. Johnson, Ayona Johns +8 more
2026bioRxiv0 citations Open access
Semantic Scholar
scINTILLA: Single-Cell Integrated Inference, Labelling, and Landscape Analysis for Cell-Type Annotation Quality Assessment
Sina Kanannejad, Noemi Bongiorni, Elisa Nordera, Sara Redaelli +4 more
2026bioRxiv0 citations Open access
Semantic Scholar
3008 – INTEGRATED IN SILICO AND IN VITRO APPROACHES MATCH DEVELOPMENTAL CELL-OF-ORIGIN TO THERAPEUTIC VULNERABILITIES IN INFANT LEUKEMIA
Denise Ragusa, Ylenia Cicirò, Emily M. Johnson, Ayona Johns +5 more
2025Experimental Hematology0 citations
Semantic Scholar
Introductions to the Community: Early-Career Researchers in the Time of COVID-19
Elphège P. Nora, Shruti Naik, Alice Giustacchini, Maria J. Rodríguez Colman +2 more
2020Cell Stem Cell0 citations Open access
Semantic Scholar
Unraveling intratumoral heterogeneity through high-sensitivity single-cell mutational analysis and parallel RNA-sequencing
A. Rodriguez-Meira, Gemma Buck, Sally-Ann Clark, B. Povinelli +11 more
2018bioRxiv0 citations Open access
Semantic Scholar
Single Cell Analysis Resolves Genetic and Transcriptional Heterogeneity in Myeloproliferative Neoplasms
A. Rodriguez-Meira, Gemma Buck, Sally-Ann Clark, E. Louka +9 more
2018Experimental Hematology0 citations Open access
Semantic Scholar
Mbd3/NuRD-mediated chromatin remodelling controls lymphoid cell fate and inhibits tumorigenesis by opposing transcriptional pioneering during B cell programming
Stephen J. Loughran, F. Comoglio, Alice Giustacchini, Y. Errami +7 more
20170 citations Open access
Semantic Scholar
Embryonic thymopoiesis is initiated by an immune-restricted lympho-myeloid progenitor, independently of notch signaling: 46th Annual Scientific Meeting of the ISEH - International Society for Experimental Hematology46th Annual Scientific Meeting of the ISEH - International Society for Experimental H
T. Luis, Sidinh Luc, Takuo Mizukami, Hanane Boukarabila +20 more
20170 citations Open access
Semantic Scholar
DISRUPTION OF HAEMATOPOIETIC STEM CELL HETEROGENEITY IN A MOUSE MODEL OF MYELOPROLIFERATIVE NEOPLASM
Ruggiero Norfo, C. Di Genua, Christopher A. G. Booth, Alice Giustacchini +9 more
20170 citations
Semantic Scholar
Initial seeding of embryonic thymus by immune-restricted lympho-myeloid progenitors
T. Luis, Sidinh Luc, Takuo Mizukami, Hanane Boukarabila +23 more
20160 citations
Semantic Scholar
Ezh2 and Runx1 Mutations Targeted to Early Lymphoid Progenitors Collaborate to Promote Early Thymic Progenitor Leukemia
C. Booth, Nikolas Barkas, Wen Hao Neo, E. Soilleux +10 more
20150 citations
Semantic Scholar
Erratum to Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo, [Cancer Cell, 25, 2014, 794-808]
P. Woll, Una Kjällquist, Onima Chowdhury, H. Doolittle +44 more
20140 citations Open access
Semantic Scholar
Hematopoietic Stem Cell Expansion, without Exhaustion or Transformation, by Stable Microrna Antagonism in Vivo
B. Gentner, Alice Giustacchini, Eric R. Lechman, P. van Galen +4 more
20120 citations
Semantic Scholar
Identification and Function of Hematopoietic Stem and Progenitor Cell Specific Micrornas.
B. Gentner, Alice Giustacchini, F. Boccalatte, Giulia Schira +5 more
20100 citations
Semantic Scholar
Integrated in silico and in vitro approaches identify SNX.2112 as a drug 1 vulnerability in t(7;12) AML stem-like cells
Ylenia Cicirò, Denise Ragusa, Emily M. Johnson, Ayona Johns +8 more
0 citations
Semantic Scholar

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