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A. Szyk · SciRah

Researcher profile · Semantic Scholar

A. Szyk

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A. Szyk — researcher profile on SciRah

h-index: 19
Works: 59
Citations: 1,874

Most-cited papers

Evidence for Pore Formation in Host Cell Membranes by ESX-1-Secreted ESAT-6 and Its Role in Mycobacterium marinum Escape from the Vacuole
Jennifer Smith, Joanna Manoranjan, Miao Pan, A. Bohsali +6 more
2008Infection and Immunity306 citations Open access
Semantic Scholar
Molecular basis for age-dependent microtubule acetylation by tubulin acetyltransferase
A. Szyk, A. Deaconescu, Jeffrey O. Spector, B. Goodman +5 more
2014Cell214 citations Open access
Semantic Scholar
Crystal structures of human α‐defensins HNP4, HD5, and HD6
A. Szyk, Zhibin Wu, K. Tucker, De Yang +2 more
2006Protein Science181 citations Open access
Semantic Scholar
Tubulin tyrosine ligase structure reveals adaptation of an ancient fold to bind and modify tubulin
A. Szyk, A. Deaconescu, G. Piszczek, A. Roll-Mecak
2011Nature Structural &Molecular Biology129 citations Open access
Semantic Scholar
Structure and Dynamics of Single-isoform Recombinant Neuronal Human Tubulin
Annapurna Vemu, J. Atherton, Jeffrey O. Spector, A. Szyk +2 more
2016Journal of Biological Chemistry117 citations Open access
Semantic Scholar
Multivalent Microtubule Recognition by Tubulin Tyrosine Ligase-Like Family Glutamylases
C. P. Garnham, Annapurna Vemu, E. Wilson-Kubalek, Ian Yu +4 more
2015Cell104 citations Open access
Semantic Scholar
Crystal structure at 1.9A of E. coli ClpP with a peptide covalently bound at the active site.
A. Szyk, M. Maurizi
2006Journal of Structural Biology101 citations
Semantic Scholar
Katanin spiral and ring structures shed light on power stroke for microtubule severing
E. Zehr, A. Szyk, G. Piszczek, Ewa Szczęsna +2 more
2017Nature Structural &Molecular Biology92 citations Open access
Semantic Scholar
α-Tubulin Tail Modifications Regulate Microtubule Stability Through Selective Effector Recruitment, not Changes in Intrinsic Polymer Dynamics
Jiayi Chen, E. Kholina, A. Szyk, V. Fedorov +3 more
2021Developmental Cell85 citations Open access
Semantic Scholar
The Structure of the Extracellular Domain of Triggering Receptor Expressed on Myeloid Cells Like Transcript-1 and Evidence for a Naturally Occurring Soluble Fragment*
James L. Gattis, A. Washington, M. Chisholm, L. Quigley +3 more
2006Journal of Biological Chemistry74 citations Open access
Semantic Scholar
Katanin grips the β-tubulin tail through an electropositive double spiral to sever microtubules
E. Zehr, A. Szyk, Ewa Szczęsna, A. Roll-Mecak
2019Developmental Cell65 citations Open access
Semantic Scholar
Structural insight into the functional mechanism of Nep1/Emg1 N1-specific pseudouridine methyltransferase in ribosome biogenesis
Seth Thomas, Christopher Keller, A. Szyk, Joe R. Cannon +1 more
2010Nucleic Acids Research65 citations Open access
Semantic Scholar
An allosteric network in spastin couples multiple activities required for microtubule severing
C. Sandate, A. Szyk, E. Zehr, G. Lander +1 more
2019Nature Structural & Molecular Biology59 citations Open access
Semantic Scholar
Combinatorial and antagonistic effects of tubulin glutamylation and glycylation on katanin microtubule severing
Ewa Szczęsna, E. Zehr, Steven W Cummings, A. Szyk +3 more
2022Developmental Cell37 citations Open access
Semantic Scholar
Crystal Structures of Tubulin Acetyltransferase Reveal a Conserved Catalytic Core and the Plasticity of the Essential N Terminus*
Vasilisa Kormendi, A. Szyk, G. Piszczek, A. Roll-Mecak
2012Journal of Biological Chemistry34 citations Open access
Semantic Scholar
Structural requirements for conserved Arg52 residue for interaction of the human immunodeficiency virus type 1 trans-activation responsive element with trans-activator of transcription protein (49-57). Capillary electrophoresis mobility shift assay.
P. Mucha, A. Szyk, P. Rekowski, J. Barciszewski
2002Journal of Chromatography A30 citations
Semantic Scholar
Experimental Models of Protein–RNA Interaction: Isolation and Analyses of tRNAPhe and U1 snRNA-Binding Peptides from Bacteriophage Display Libraries
P. Agris, M. T. Marchbank, Winnell H. Newman, R. Guenther +7 more
1999Journal of Protein Chemistry26 citations
Semantic Scholar
Anticodon domain methylated nucleosides of yeast tRNA(Phe) are significant recognition determinants in the binding of a phage display selected peptide.
P. Mucha, A. Szyk, P. Rekowski, Patrick A. Weiss +1 more
2001Biochemistry23 citations
Semantic Scholar
Effects of Diabetes mellitus on the Contractile Activity of Carbachol and Galanin in Isolated Gastric Fundus Strips of Rats
R. Korolkiewicz, P. Rekowski, A. Szyk, S. Kato +4 more
1998Pharmacology19 citations
Semantic Scholar
Tubulin tyrosine ligase and stathmin compete for tubulin binding in vitro
A. Szyk, G. Piszczek, A. Roll-Mecak
2013Journal of Molecular Biology17 citations Open access
Semantic Scholar
Interaction of RNA with phage display selected peptides analyzed by capillary electrophoresis mobility shift assay.
P. Mucha, A. Szyk, P. Rekowski, R. Guenther +1 more
2002RNA: A publication of the RNA Society14 citations Open access
Semantic Scholar
Tubulin code eraser CCP5 binds branch glutamates by substrate deformation
Jiayi Chen, E. Zehr, J. Gruschus, A. Szyk +4 more
2024Nature13 citations
Semantic Scholar
Inhibition of gastric acid secretion by galanin in rats. Relation to endogenous histamine release.
S. Kato, R. Korolkiewicz, P. Rekowski, A. Szyk +2 more
1998Regulatory Peptides12 citations
Semantic Scholar
Structure of the scorpion toxin BmBKTtx1 solved from single wavelength anomalous scattering of sulfur.
A. Szyk, Wu-Yuan Lu, Chenqi Xu, J. Lubkowski
2004Journal of Structural Biology11 citations
Semantic Scholar
Conformation of Systemin, a Polypeptide Activator of Proteinase Inhibitor Synthesis in Plants
P. Mucha, A. Szyk, P. Rekowski, G. Kupryszewski +2 more
19998 citations
Semantic Scholar
Using capillary electrophoresis to study methylation effect on RNA-peptide interaction.
P. Mucha, A. Szyk, P. Rekowski, P. Agris
2003Acta Biochimica Polonica6 citations Open access
Semantic Scholar
Sequence-Altered Peptide Adopts Optimum Conformation for Modification-Dependent Binding of the Yeast tRNAPhe Anticodon Domain
P. Mucha, A. Szyk, P. Rekowski, P. Agris
2004The Protein Journal5 citations
Semantic Scholar
Specific induction of Z-DNA conformation by a nuclear localization signal peptide of lupin glutaminyl tRNA synthetase
A. Krzyżaniak, M. Siatecka, A. Szyk, P. Mucha +3 more
2000Molecular Biology Reports5 citations
Semantic Scholar
Lysine14galanin(1-15)-NH2: a partial agonist at galanin receptors in rat isolated gastric fundus.
R. Korolkiewicz, W. Sliwiński, P. Rekowski, A. Szyk +3 more
1997Pharmacology5 citations
Semantic Scholar
Spastin hexamer in complex with substrate
C. Sandate, A. Szyk, E. Zehr, G. Lander +1 more
20193 citations
Semantic Scholar
Mechanism of the contractile effects of galantide and Galanin(1-14) [alpha-aminobutyric acid]scyliorhinin-I in rat isolated fundus strips.
R. Korolkiewicz, Z. Konstański, P. Rekowski, A. Szyk +5 more
2002Medical Science Monitor3 citations
Semantic Scholar
Synthesis and Circular Dichroism Studies of HIV-1 Tat Arginine Rich Domain Analoques Substituted in Arg 52 Position
A. Szyk, P. Mucha, P. Rekowski, M. Giel-Pietraszuk +1 more
19993 citations
Semantic Scholar
Circular dichroism studies of the interaction of Tat analogues substituted in the Arg52 position with TAR RNA HIV-1
P. Mucha, P. Rekowski, A. Szyk, G. Kupryszewski +2 more
1998Letters in peptide science3 citations
Semantic Scholar
Increased potency of some substituted short peptide analogues in comparison to galanin(1-15)-NH(2)in rat fundus strips.
R. Korolkiewicz, Z. Konstański, P. Rekowski, J. Ruczyński +5 more
2001Pharmacological Research2 citations
Semantic Scholar
[Capillary electrophoresis: a new tool for biomolecule separation].
P. Mucha, P. Rekowski, A. Szyk, G. Kupryszewski +1 more
1997Postepy biochemii2 citations
Semantic Scholar
Pharmacological characterization of the contractile effects of galanin(l‐29)‐NH2, galantide and galanin(l‐14)‐(α‐aminobutyric acid8)scyliorhinin‐I in the rat gastric fundus †
R. Korolkiewicz, W. Sliwiński, Z. Konstański, P. Rekowski +4 more
1997Fundamental & Clinical Pharmacology2 citations
Semantic Scholar
Tubulin flux at spastin-induced nanodamage sites regulates microtubule rescue frequency and EB1 lifetimes
Ewa Szczęsna, Jeffrey O. Spector, Stephanie L. Sarbanes, Jiayi Chen +2 more
2026Proceedings of the National Academy of Sciences of the United States of America1 citations Open access
Semantic Scholar
Author Correction: An allosteric network in spastin couples multiple activities required for microtubule severing
C. Sandate, A. Szyk, E. Zehr, G. Lander +1 more
2020Nature Structural & Molecular Biology1 citations Open access
Semantic Scholar
Molecular Basis for Age-Dependent Microtubule Acetylation
A. Roll-Mecak, A. Szyk, A. Deaconescu, Jeffrey O. Spector +2 more
20151 citations Open access
Semantic Scholar
BPS2025 - Tubulin code eraser CCP5 binds branch glutamates by substrate deformation
Jiayi Chen, E. Zehr, J. Gruschus, A. Szyk +4 more
2025Biophysical Journal0 citations Open access
Semantic Scholar
Katanin hexamer in the ring conformation
E. Zehr, A. Szyk, G. Piszczek, E. Szczesna +2 more
20170 citations
Semantic Scholar
katanin hexamer in spiral conformation
E. Zehr, A. Szyk, G. Piszczek, E. Szczesna +2 more
20170 citations
Semantic Scholar
katanin AAA ATPase domain
A. Szyk, A. Roll-Mecak
20170 citations
Semantic Scholar
X-Ray Diffraction data from Human Tubulin Acetyltransferase in complex with bisubstrate analog, source of 4PK2 structure
A. Szyk, A. Roll-Mecak
20150 citations
Semantic Scholar
Molecular Basis for Age-Dependent Acetylation by Tubulin Acetyltransferase
Jeffrey O. Spector, A. Szyk, A. Deaconescu, Max L. Valenstein +4 more
20150 citations Open access
Semantic Scholar
Tubulin tyrosine ligase - structural and functional studies
A. Szyk, A. Deaconescu, G. Piszczek, A. Roll-Mecak
20140 citations Open access
Semantic Scholar
Microtubule chemical complexity: mechanism of tubulin modification enzymes
A. Roll-Mecak, A. Szyk, Vasilisa Kormendi
20140 citations Open access
Semantic Scholar
tubulin acetyltransferase complex with bisubstrate analog
A. Szyk, A. Roll-Mecak
20140 citations
Semantic Scholar
Tubulin acetyltransferase mutant
A. Roll-Mecak, V. Kizub, A. Szyk
20120 citations
Semantic Scholar
Crystal structure of Saccharomyces Cerevisiae Nep1/Emg1 bound to S-adenosylhomocysteine
S. Thomas, A. Szyk, N. Laronde-Leblanc
20100 citations
Semantic Scholar

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