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D. Michaelson · SciRah

Researcher profile · Semantic Scholar

D. Michaelson

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D. Michaelson — researcher profile on SciRah

h-index: 37
Works: 141
Citations: 4,529

Most-cited papers

ApoE4: an emerging therapeutic target for Alzheimer’s disease
M. Safieh, A. Korczyn, D. Michaelson
2019BMC Medicine389 citations Open access
Semantic Scholar
Apolipoprotein E4 enhances brain inflammation by modulation of the NF-kappaB signaling cascade.
G. Ophir, N. Amariglio, J. Jacob-Hirsch, Ran Elkon +2 more
2005Neurobiology of Disease165 citations Open access
Semantic Scholar
ApoE4 impairs hippocampal plasticity isoform-specifically and blocks the environmental stimulation of synaptogenesis and memory.
O. Levi, A. Jongen-Rêlo, J. Feldon, A. Roses +1 more
2003Neurobiology of Disease150 citations Open access
Semantic Scholar
ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice
Ori Liraz, Anat Boehm-Cagan, D. Michaelson
2013Molecular Neurodegeneration126 citations Open access
Semantic Scholar
ApoE4 Alters ABCA1 Membrane Trafficking in Astrocytes
V. Rawat, Shaowei Wang, Jian Sima, R. Bar +10 more
2019Journal of Neuroscience121 citations Open access
Semantic Scholar
Impaired Autophagy in APOE4 Astrocytes
S. Simonovitch, Eran Schmukler, Alina Bespalko, T. Iram +5 more
2016Journal of Alzheimer's Disease119 citations
Semantic Scholar
Reversal of apoE4-Driven Brain Pathology and Behavioral Deficits by Bexarotene
Anat Boehm-Cagan, D. Michaelson
2014Journal of Neuroscience119 citations Open access
Semantic Scholar
Altered mitochondrial dynamics and function in APOE4-expressing astrocytes
Eran Schmukler, Shira R. Solomon, S. Simonovitch, Y. Goldshmit +3 more
2020Cell Death and Disease110 citations Open access
Semantic Scholar
Activation of the Amyloid Cascade in Apolipoprotein E4 Transgenic Mice Induces Lysosomal Activation and Neurodegeneration Resulting in Marked Cognitive Deficits
H. Belinson, D. Lev, E. Masliah, D. Michaelson
2008Journal of Neuroscience107 citations Open access
Semantic Scholar
Environmental enrichment stimulates neurogenesis in apolipoprotein E3 and neuronal apoptosis in apolipoprotein E4 transgenic mice
O. Levi, D. Michaelson
2007Journal of Neurochemistry98 citations
Semantic Scholar
ABCA1 Agonist Reverses the ApoE4-Driven Cognitive and Brain Pathologies
Anat Boehm-Cagan, R. Bar, Ori Liraz, J. Bielicki +2 more
2016Journal of Alzheimer's Disease97 citations
Semantic Scholar
Omega-3 fatty acids, lipids, and apoE lipidation in Alzheimer’s disease: a rationale for multi-nutrient dementia prevention
M. Grimm, D. Michaelson, T. Hartmann
2017Journal of Lipid Research94 citations Open access
Semantic Scholar
A nontransgenic mouse model shows inducible amyloid-β (Aβ) peptide deposition and elucidates the role of apolipoprotein E in the amyloid cascade
I. Dolev, D. Michaelson
200491 citations Open access
Semantic Scholar
Reduced levels of antioxidants in brains of apolipoprotein E-deficient mice following closed head injury.
L. Lomnitski, R. Kohen, Yun Chen, E. Shohami +3 more
1997Pharmacology, Biochemistry and Behavior75 citations
Semantic Scholar
Opposing actions of environmental enrichment and Alzheimer's disease on the expression of hippocampal microRNAs in mouse models
Boaz Barak, I. Shvarts-Serebro, S. Modai, A. Gilam +5 more
2013Translational Psychiatry70 citations Open access
Semantic Scholar
The Isoform-Specific Pathological Effects of ApoE4 in vivo are Prevented by a Fish Oil (DHA) Diet and are Modified by Cholesterol
Z. Kariv-Inbal, S. Yacobson, R. Berkecz, M. Péter +5 more
2012Journal of Alzheimer's Disease70 citations
Semantic Scholar
M1 Muscarinic Agonist Treatment Reverses Cognitive and Cholinergic Impairments of Apolipoprotein E‐Deficient Mice
A. Fisher, R. Brandeis, S. Chapman, Z. Pittel +1 more
1998Journal of Neurochemistry70 citations
Semantic Scholar
ApoE ε4 is associated with eIF2α phosphorylation and impaired learning in young mice.
Y. Segev, D. Michaelson, K. Rosenblum
2013Neurobiology of Aging66 citations
Semantic Scholar
The effects of APOE genotype on age at onset and progression of neurodegenerative diseases
J. Chapman, A. Korczyn, D. Karussis, D. Michaelson
2001Neurology66 citations
Semantic Scholar
Specific Neurochemical Derangements of Brain Projecting Neurons in Apolipoprotein E‐Deficient Mice
S. Chapman, D. Michaelson
1997Journal of Neurochemistry56 citations Open access
Semantic Scholar
The Effects of APOE4 on Mitochondrial Dynamics and Proteins in vivo
S. Simonovitch, Eran Schmukler, E. Masliah, R. Pinkas-Kramarski +1 more
2019Journal of Alzheimer's Disease54 citations Open access
Semantic Scholar
Human apoE3 but not apoE4 rescues impaired astrocyte activation in apoE null mice.
G. Ophir, S. Meilin, M. Efrati, J. Chapman +3 more
2003Neurobiology of Disease53 citations Open access
Semantic Scholar
A nontransgenic mouse model shows inducible amyloid-beta (Abeta) peptide deposition and elucidates the role of apolipoprotein E in the amyloid cascade.
I. Dolev, D. Michaelson
2004Proceedings of the National Academy of Sciences of the United States of America48 citations
Semantic Scholar
Biochemical and cognitive studies of apolipoprotein-E-deficient mice
I. Gordon, I. Genis, E. Grauer, E. Sehayek +1 more
1996Molecular and Chemical Neuropathology48 citations
Semantic Scholar
Site‐Specific Dephosphorylation of Tau of Apolipoprotein E‐Deficient and Control Mice by M1 Muscarinic Agonist Treatment
I. Genis, A. Fisher, D. Michaelson
1999Journal of Neurochemistry46 citations
Semantic Scholar
ApoE4-dependent Aβ-mediated neurodegeneration is associated with inflammatory activation in the hippocampus but not the septum
H. Belinson, D. Michaelson
2009Journal of neural transmission39 citations
Semantic Scholar
Anatomical localization of protease‐activated receptor‐1 and protease‐mediated neuroglilal crosstalk on peri‐synaptic astrocytic endfeet
Efrat Shavit, D. Michaelson, J. Chapman
2011Journal of Neurochemistry36 citations
Semantic Scholar
Regulation of hippocampal cholesterol metabolism by apoE and environmental stimulation
O. Levi, D. Lütjohann, A. Devir, K. von Bergmann +2 more
2005Journal of Neurochemistry36 citations
Semantic Scholar
Hippocampus-Related Cognitive Impairments in Young apoE4 Targeted Replacement Mice
Shiran Salomon-Zimri, Anat Boehm-Cagan, Ori Liraz, D. Michaelson
2013Neurodegenerative Diseases35 citations
Semantic Scholar
Reversal of ApoE4-Driven Brain Pathology by Vascular Endothelial Growth Factor Treatment
Shiran Salomon-Zimri, M. Glat, Y. Barhum, Ishai Luz +5 more
2016Journal of Alzheimer's Disease32 citations
Semantic Scholar
An Anti-apoE4 Specific Monoclonal Antibody Counteracts the Pathological Effects of apoE4 In Vivo.
Ishai Luz, Ori Liraz, D. Michaelson
2016Current Alzheimer Research31 citations
Semantic Scholar
ApoE4 Induces Synaptic and ERG Impairments in the Retina of Young Targeted Replacement ApoE4 Mice
R. Antes, R. Ezra‐Elia, D. Weinberger, A. Solomon +2 more
2013PLoS ONE29 citations Open access
Semantic Scholar
Involvement of the Apoer2 and Lrp1 receptors in mediating the pathological effects of ApoE4 in vivo
Moran Gilat-Frenkel, Anat Boehm-Cagan, Ori Liraz, X. Xian +2 more
2014Current Alzheimer Research28 citations Open access
Semantic Scholar
Central and Peripheral Mechanisms in ApoE4-Driven Diabetic Pathology
Amit Koren-Iton, Shiran Salomon-Zimri, A. Smolar, E. Shavit-Stein +3 more
2020International Journal of Molecular Sciences26 citations Open access
Semantic Scholar
Brain area- and isoform-specific inhibition of synaptic plasticity by apoE4.
O. Levi, A. Jongen-Rêlo, J. Feldon, D. Michaelson
2005Journal of Neurological Sciences26 citations
Semantic Scholar
Following activation of the amyloid cascade, apolipoprotein E4 drives the in vivo oligomerization of amyloid-β resulting in neurodegeneration
H. Belinson, Z. Kariv-Inbal, R. Kayed, E. Masliah +1 more
2010Journal of Alzheimer's Disease25 citations Open access
Semantic Scholar
Differential Effects of apoE4 and Activation of ABCA1 on Brain and Plasma Lipoproteins
Anat Boehm-Cagan, R. Bar, D. Harats, A. Shaish +4 more
2016PLoS ONE24 citations Open access
Semantic Scholar
Apolipoprotein E4 reduces evoked hippocampal acetylcholine release in adult mice
Eva Dolejší, Ori Liraz, V. Rudajev, P. Zimčík +2 more
2015Journal of Neurochemistry24 citations Open access
Semantic Scholar
ApoE4-Driven Accumulation of Intraneuronal Oligomerized Aβ42 following Activation of the Amyloid Cascade In Vivo Is Mediated by a Gain of Function
L. Zepa, M. Frenkel, H. Belinson, Z. Kariv-Inbal +3 more
2011International Journal of Alzheimer's Disease23 citations Open access
Semantic Scholar
Intraneuronal amyloid‐β plays a role in mediating the synergistic pathological effects of apoE4 and environmental stimulation
O. Levi, I. Dolev, H. Belinson, D. Michaelson
2007Journal of Neurochemistry23 citations
Semantic Scholar
APOE4: The most prevalent yet understudied risk factor for Alzheimer’s disease
D. Michaelson
201621 citations
Semantic Scholar
Antiphospholipid syndrome induction exacerbates a transgenic Alzheimer disease model on a female background.
A. Katzav, Achinoam Faust-Socher, F. Kvapil, D. Michaelson +5 more
2011Neurobiology of Aging21 citations
Semantic Scholar
Possible Role of Tau in Mediating Pathological Effects of apoE4 in vivo prior to and following Activation of the Amyloid Cascade
D. Inbar, H. Belinson, H. Rosenman, D. Michaelson
2010Neurodegenerative Diseases21 citations
Semantic Scholar
The effects of apolipoprotein E genotype, α-synuclein deficiency, and sex on brain synaptic and Alzheimer's disease–related pathology
R. Bar, Anat Boehm-Cagan, Ishai Luz, Yarden Kleper-Wall +1 more
2017Alzheimer's & Dementia20 citations Open access
Semantic Scholar
VEGF Mediates ApoE4-Induced Neovascularization and Synaptic Pathology in the Choroid and Retina.
R. Antes, Shiran Salomon-Zimri, Susanne C. Beck, M. G. Garrido +6 more
2015Current Alzheimer Research20 citations
Semantic Scholar
Pathological Synergism Between Amyloid-β and Apolipoprotein E4 – The Most Prevalent Yet Understudied Genetic Risk Factor for Alzheimer's Disease
H. Belinson, D. Michaelson
2009Journal of Alzheimer's Disease19 citations
Semantic Scholar
The effects of apolipoprotein e deficiency on braincholinergic neurons
O. Kleifeld, M. Diebler, S. Chapman, L. Oron +1 more
1998International Journal of Developmental Neuroscience18 citations
Semantic Scholar
Behavioral testing affects the phenotypic expression of APOE ε3 and APOE ε4 in targeted replacement mice and reduces the differences between them
Shiran Salomon-Zimri, Ori Liraz, D. Michaelson
2015Alzheimer's & Dementia16 citations Open access
Semantic Scholar
The Role of MAPK's Signaling in Mediating ApoE4-Driven Pathology In Vivo.
Shiran Salomon-Zimri, Ami Koren, Ariel Angel, T. Ben-Zur +2 more
2019Current Alzheimer Research15 citations
Semantic Scholar
Increased levels of intracellular iron in the brains of ApoE-deficient mice with closed head injury.
L. Lomnitski, A. Nyska, E. Shohami, Yun Chen +1 more
2000Experimental and Toxicological Pathology15 citations
Semantic Scholar

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O. Levi — researcher profile on SciRah

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