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M. Cookson · SciRah

Researcher profile · Semantic Scholar

M. Cookson

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M. Cookson — researcher profile on SciRah

h-index: 84
Works: 268
Citations: 35K

Most-cited papers

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
D. Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, M. Abdellatif +496 more
2021Autophagy4,016 citations Open access
Semantic Scholar
Converging pathways in neurodegeneration, from genetics to mechanisms
L. Gan, M. Cookson, L. Petrucelli, A. La Spada
2018Nature Neuroscience414 citations Open access
Semantic Scholar
Major Shifts in Glial Regional Identity Are a Transcriptional Hallmark of Human Brain Aging
Lilach Soreq, J. Rose, E. Soreq, J. Hardy +6 more
2017Cell Reports387 citations Open access
Semantic Scholar
Caspase-1 causes truncation and aggregation of the Parkinson’s disease-associated protein α-synuclein
Wei Wang, L. Nguyen, C. Burlak, F. Chegini +17 more
2016Proceedings of the National Academy of Sciences of the United States of America254 citations Open access
Semantic Scholar
LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network
Zhi-Yong Liu, Nicole Bryant, R. Kumaran, A. Beilina +3 more
2018Human Molecular Genetics246 citations Open access
Semantic Scholar
LRRK2 mediates tubulation and vesicle sorting from lysosomes
L. Bonet-Ponce, A. Beilina, Chad D. Williamson, Eric Lindberg +8 more
2020Science Advances229 citations Open access
Semantic Scholar
Genetic modifiers of risk and age at onset in GBA associated Parkinson’s disease and Lewy body dementia
C. Blauwendraat, X. Reed, L. Krohn, K. Heilbron +59 more
2019bioRxiv216 citations Open access
Semantic Scholar
LRRK2 links genetic and sporadic Parkinson’s disease
Jillian H. Kluss, A. Mamais, M. Cookson
2019Biochemical Society Transactions188 citations Open access
Semantic Scholar
Glial phagocytic clearance in Parkinson’s disease
M. Tremblay, M. Cookson, L. Civiero
2019Molecular Neurodegeneration154 citations Open access
Semantic Scholar
LRRK2 promotes the activation of NLRC4 inflammasome during Salmonella Typhimurium infection
Weiwei Liu, Xia’nan Liu, Yu Li, Jun-Jie Zhao +9 more
2017Journal of Experimental Medicine150 citations Open access
Semantic Scholar
Finding Useful Biomarkers for Parkinson’s Disease
A. Chen-Plotkin, R. Albin, R. Alcalay, D. Babcock +36 more
2018Science Translational Medicine132 citations Open access
Semantic Scholar
The role of monogenic genes in idiopathic Parkinson’s disease
X. Reed, S. Bandres-Ciga, C. Blauwendraat, M. Cookson
2018Neurobiology of Disease120 citations Open access
Semantic Scholar
The Endosomal–Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo
Tal Nuriel, Katherine Y. Peng, A. Ashok, A. Dillman +7 more
2017Frontiers in Neuroscience118 citations Open access
Semantic Scholar
Large-scale pathway specific polygenic risk and transcriptomic community network analysis identifies novel functional pathways in Parkinson disease
S. Bandres-Ciga, S. Saez-Atienzar, Jj Kim, M. Makarious +24 more
2020Acta Neuropathologica103 citations Open access
Semantic Scholar
Genetic determinants of survival in progressive supranuclear palsy: a genome-wide association study
E. Jabbari, Shunsuke Koga, Rebecca R. Valentino, R. Reynolds +52 more
2020Lancet Neurology98 citations Open access
Semantic Scholar
Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation
Jesus Madero-Pérez, Elena Fdez, B. Fernández, A. J. Lara Ordóñez +18 more
2018Molecular Neurodegeneration87 citations Open access
Semantic Scholar
Tackling neurodegenerative diseases with genomic engineering: A new stem cell initiative from the NIH
Daniel M. Ramos, W. Skarnes, A. Singleton, M. Cookson +1 more
2021Neuron86 citations Open access
Semantic Scholar
mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1
C. Manzoni, A. Mamais, Dorien A. Roosen, S. Dihanich +7 more
2016Scientific Reports84 citations Open access
Semantic Scholar
RNA sequencing of whole blood reveals early alterations in immune cells and gene expression in Parkinson’s disease
D. Craig, E. Hutchins, Ivo Violich, Eric B. Alsop +18 more
2021Nature Aging81 citations
Semantic Scholar
Genetic analysis of amyotrophic lateral sclerosis identifies contributing pathways and cell types
S. Saez-Atienzar, S. Bandres-Ciga, R. Langston, J. J. Kim +12 more
2020Science Advances81 citations Open access
Semantic Scholar
The endocytic membrane trafficking pathway plays a major role in the risk of Parkinson disease
S. Bandres-Ciga, S. Saez-Atienzar, L. Bonet-Ponce, K. Billingsley +8 more
2019Movement Disorders80 citations Open access
Semantic Scholar
LAG3 is not expressed in human and murine neurons and does not modulate α‐synucleinopathies
Marc Emmenegger, Elena de Cecco, M. Hruska-Plochan, Timo Eninger +25 more
2021bioRxiv76 citations Open access
Semantic Scholar
Frequency of Loss of Function Variants in LRRK2 in Parkinson Disease
C. Blauwendraat, X. Reed, D. Kia, Z. Gan-or +25 more
2018JAMA Neurology73 citations Open access
Semantic Scholar
Transcriptome analysis of LRRK2 knock-out microglia cells reveals alterations of inflammatory- and oxidative stress-related pathways upon treatment with α-synuclein fibrils
Isabella Russo, A. Kaganovich, Jinhui Ding, N. Landeck +7 more
2019Neurobiology of Disease70 citations Open access
Semantic Scholar
LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies
Changyoun Kim, A. Beilina, Nathan Smith, Yan Li +15 more
2020Science Translational Medicine69 citations Open access
Semantic Scholar
LRRK2 recruitment, activity, and function in organelles
L. Bonet-Ponce, M. Cookson
2021The FEBS Journal67 citations Open access
Semantic Scholar
The Parkinson’s Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network
A. Beilina, L. Bonet-Ponce, R. Kumaran, Jennifer J. Kordich +13 more
2020Cell Reports66 citations Open access
Semantic Scholar
AKT signalling selectively regulates PINK1 mitophagy in SHSY5Y cells and human iPSC-derived neurons
Marc P. M. Soutar, Liam Kempthorne, Shuichi Miyakawa, Emily Annuario +9 more
2018Scientific Reports63 citations Open access
Semantic Scholar
Detection of endogenous S1292 LRRK2 autophosphorylation in mouse tissue as a readout for kinase activity
Jillian H. Kluss, M. Conti, A. Kaganovich, A. Beilina +3 more
2018npj Parkinson's Disease62 citations Open access
Semantic Scholar
Preclinical modeling of chronic inhibition of the Parkinson’s disease associated kinase LRRK2 reveals altered function of the endolysosomal system in vivo
Jillian H. Kluss, Melissa Conti Mazza, Yan Li, C. Manzoni +3 more
2020Molecular Neurodegeneration56 citations Open access
Semantic Scholar
PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2
L. Civiero, S. Cogo, A. Kiekens, Claudia Morganti +13 more
2017Frontiers in Molecular Neuroscience56 citations Open access
Semantic Scholar
Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice
L. Pellegrini, D. Hauser, Yan Li, A. Mamais +11 more
2018Human Molecular Genetics55 citations Open access
Semantic Scholar
Hexokinases link DJ-1 to the PINK1/parkin pathway
D. Hauser, A. Mamais, M. Conti, C. Primiani +13 more
2017Molecular Neurodegeneration54 citations Open access
Semantic Scholar
The DYT6 Dystonia Protein THAP1 Regulates Myelination Within The Oligodendrocyte Lineage
Dhananjay Yellajoshyula, Chun-Chi Liang, Samuel S. Pappas, S. Penati +6 more
2017Developmental Cell53 citations Open access
Semantic Scholar
APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice
E. Area‐Gomez, D. Larrea, Marta Pera, R. Agrawal +13 more
2018Scientific Reports52 citations Open access
Semantic Scholar
High-frequency head impact causes chronic synaptic adaptation and long-term cognitive impairment in mice
S. Sloley, B. Main, Charisse N. Winston, Alex C Harvey +9 more
2021Nature Communications51 citations Open access
Semantic Scholar
Molecular mechanism of olesoxime-mediated neuroprotection through targeting α-synuclein interaction with mitochondrial VDAC
A. Rovini, P. Gurnev, A. Beilina, M. Queralt-Martín +4 more
2019Cellular and Molecular Life Sciences51 citations Open access
Semantic Scholar
The role of Rab GTPases in the pathobiology of Parkinson’ disease
L. Bonet-Ponce, M. Cookson
2019Current Opinion in Cell Biology51 citations Open access
Semantic Scholar
In Vitro CRISPR/Cas9-Directed Gene Editing to Model LRRK2 G2019S Parkinson’s Disease in Common Marmosets
S. Vermilyea, Alex P. Babinski, N. Tran, Samantha To +9 more
2020Scientific Reports47 citations Open access
Semantic Scholar
Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues
Lucia Iannotta, Alice Biosa, Jillian H. Kluss, Giulia Tombesi +8 more
2020Cells47 citations Open access
Semantic Scholar
Cellular functions of LRRK2 implicate vesicular trafficking pathways in Parkinson's disease.
M. Cookson
2016Biochemical Society Transactions45 citations
Semantic Scholar
Extracellular clusterin limits the uptake of α‐synuclein fibrils by murine and human astrocytes
Alice Filippini, Veronica Mutti, G. Faustini, F. Longhena +16 more
2020Glia44 citations Open access
Semantic Scholar
GENETIC ANALYSIS OF NEURODEGENERATIVE DISEASES IN A PATHOLOGY COHORT
C. Blauwendraat, O. Pletnikova, Joshua T. Geiger, N. Murphy +21 more
2018Neurobiology of Aging44 citations Open access
Semantic Scholar
Leucine-rich repeat kinase 2 controls protein kinase A activation state through phosphodiesterase 4
Isabella Russo, G. Di Benedetto, A. Kaganovich, Jinhui Ding +5 more
2018Journal of Neuroinflammation43 citations Open access
Semantic Scholar
Genomewide Association Studies of LRRK2 Modifiers of Parkinson's Disease
Dong-Bing Lai, Babak Alipanahi, P. Fontanillas, Tae-Hwi Schwantes-An +57 more
2021Annals of Neurology42 citations Open access
Semantic Scholar
Reduction of PINK1 or DJ‐1 impair mitochondrial motility in neurites and alter ER‐mitochondria contacts
Cristina Parrado-Fernández, Bernadette Schneider, M. Ankarcrona, M. Conti +4 more
2018Journal of Cellular and Molecular Medicine41 citations Open access
Semantic Scholar
Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis
George R. Heaton, N. Landeck, A. Mamais, M. Nalls +7 more
2020bioRxiv40 citations Open access
Semantic Scholar
Mechanisms of Mutant LRRK2 Neurodegeneration.
M. Cookson
2017Advances in neurobiology39 citations
Semantic Scholar
The LRRK2 signalling system
A. Price, C. Manzoni, M. Cookson, P. Lewis
2018Cell and Tissue Research38 citations Open access
Semantic Scholar
Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins
James E. Tomkins, S. Dihanich, A. Beilina, R. Ferrari +4 more
2018Proteomics37 citations Open access
Semantic Scholar

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A. Mamais×12
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A. Mamais — researcher profile on SciRah
A. Beilina×10
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R. Kumaran×9
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A. Kaganovich×9
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C. Blauwendraat

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M. Nalls — researcher profile on SciRah

L. Bonet-Ponce×6

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Jillian H. Kluss×6

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Yan Li — researcher profile on SciRah

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E. Greggio — researcher profile on SciRah

S. Saez-Atienzar×5

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S. Saez-Atienzar — researcher profile on SciRah