R. Klausner

Most-cited papers

The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma.
A. Rosenwald, G. Wright, W. Chan, J. Connors +36 more
2002New England Journal of Medicine3,875 citations Open access
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Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences
R. Strausberg, E. Feingold, L. Grouse, J. G. Derge +79 more
2002Proceedings of the National Academy of Sciences of the United States of America1,896 citations Open access
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Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA
M.-C. Liu, G. Oxnard, E. Klein, C. Swanton +153 more
2020Annals of Oncology1,215 citations Open access
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Molecular Diagnosis of Primary Mediastinal B Cell Lymphoma Identifies a Clinically Favorable Subgroup of Diffuse Large B Cell Lymphoma Related to Hodgkin Lymphoma
A. Rosenwald, G. Wright, K. Leroy, Xin Yu +34 more
2003Journal of Experimental Medicine1,128 citations Open access
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The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma.
A. Rosenwald, G. Wright, A. Wiestner, Wing C. Chan +35 more
2003Cancer Cell971 citations Open access
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Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex.
K. Iwai, Koji Yamanaka, T. Kamura, N. Minato +4 more
1999Proceedings of the National Academy of Sciences of the United States of America515 citations Open access
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The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins.
A. Pause, S. Lee, R. Worrell, D.-Y.-T. Chen +3 more
1997Proceedings of the National Academy of Sciences of the United States of America510 citations Open access
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Improved detection of germline mutations in the von Hippel‐Lindau disease tumor suppressor gene
C. Stolle, G. Glenn, B. Zbar, Jeffrey S. Humphrey +7 more
1998Human Mutation479 citations Open access
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The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma.
J. Maranchie, J. Vasselli, J. Riss, J. Bonifacino +2 more
2002Cancer Cell470 citations Open access
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Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice.
J. Gnarra, Jerrold M. Ward, F. Porter, J. Wagner +6 more
1997Proceedings of the National Academy of Sciences of the United States of America390 citations Open access
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Identification and Functional Expression of HAH1, a Novel Human Gene Involved in Copper Homeostasis*
L. Klomp, Su-Ju Lin, Daniel S.Yuan, R. Klausner +2 more
1997Journal of Biological Chemistry380 citations Open access
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Next-Generation Sequencing of Circulating Tumor DNA for Early Cancer Detection.
A. Aravanis, Mark Lee, R. Klausner
2017Cell338 citations Open access
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Biochemical Characterization of the Wilson Disease Protein and Functional Expression in the Yeast Saccharomyces cerevisiae *
Irene H. Hung, Mariko Suzuki, Yukitoshi Yamaguchi, Daniel S. Yuan +2 more
1997Journal of Biological Chemistry329 citations Open access
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Iron-dependent oxidation, ubiquitination, and degradation of iron regulatory protein 2: implications for degradation of oxidized proteins.
K. Iwai, S. Drake, N. Wehr, A. Weissman +5 more
1998Proceedings of the National Academy of Sciences of the United States of America302 citations Open access
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The mammalian gene collection.
R. Strausberg, E. Feingold, R. Klausner, Francis S. Collins
1999Science293 citations
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Grand Challenges in Global Health
H. Varmus, R. Klausner, E. Zerhouni, T. Acharya +2 more
2003Science270 citations Open access
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Regulation of iron metabolism in eukaryotes.
T. Rouault, R. Klausner
1997Current Topics in Cellular Regulation254 citations
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The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal.
A. Pause, Stephen Lee, K. Lonergan, R. Klausner
1998Proceedings of the National Academy of Sciences of the United States of America239 citations Open access
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Iron-sulfur clusters as biosensors of oxidants and iron.
T. Rouault, R. Klausner
1996TIBS -Trends in Biochemical Sciences. Regular ed234 citations
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Intramembrane Bis-Heme Motif for Transmembrane Electron Transport Conserved in a Yeast Iron Reductase and the Human NADPH Oxidase*
A. A. Finegold, K. P. Shatwell, A. Segal, R. Klausner +1 more
1996Journal of Biological Chemistry223 citations Open access
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Role of transforming growth factor-alpha in von Hippel--Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis.
Natalie de Paulsen, Alexander Brychzy, Marie-Christine Fournier, R. Klausner +3 more
2001Proceedings of the National Academy of Sciences of the United States of America213 citations Open access
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The von Hippel-Lindau Tumor Suppressor Gene Inhibits Hepatocyte Growth Factor/Scatter Factor-Induced Invasion and Branching Morphogenesis in Renal Carcinoma Cells
S. Koochekpour, M. Jeffers, Paul H. Wang, Changning Gong +10 more
1999Molecular and Cellular Biology208 citations Open access
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Homeostatic Regulation of Copper Uptake in Yeast via Direct Binding of MAC1 Protein to Upstream Regulatory Sequences ofFRE1 and CTR1 *
Y. Yamaguchi-Iwai, M. Serpe, D. Haile, Wei-Min Yang +3 more
1997Journal of Biological Chemistry198 citations Open access
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The yeast CLC chloride channel functions in cation homeostasis.
Roberto A. Gaxiola, Daniel S. Yuan, R. Klausner, Gerald R. Fink
1998Proceedings of the National Academy of Sciences of the United States of America192 citations Open access
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Identification of a putative alpha-glucan synthase essential for cell wall construction and morphogenesis in fission yeast.
Frans Hochstenbach, F. Klis, H. van den Ende, E. V. van Donselaar +2 more
1998Proceedings of the National Academy of Sciences of the United States of America190 citations Open access
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Predicting survival in patients with metastatic kidney cancer by gene-expression profiling in the primary tumor
J. Vasselli, J. Shih, S. Iyengar, J. Maranchie +11 more
2003Proceedings of the National Academy of Sciences of the United States of America189 citations Open access
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Structure and dynamics of the iron responsive element RNA: implications for binding of the RNA by iron regulatory binding proteins.
K. J. Addess, J. Basilion, R. Klausner, Tracey A. Rouault +1 more
1997Journal of Molecular Biology184 citations
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Restriction of Copper Export in Saccharomyces cerevisiae to a Late Golgi or Post-Golgi Compartment in the Secretory Pathway*
Daniel S. Yuan, A. Dancis, R. Klausner
1997Journal of Biological Chemistry181 citations Open access
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Enhanced: The Need for a Global HIV Vaccine Enterprise
R. Klausner, A. Fauci, L. Corey, G. Nabel +20 more
2003Science168 citations
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Reductive iron uptake by Candida albicans: role of copper, iron and the TUP1 regulator.
S. Knight, E. Lesuisse, R. Stearman, R. Klausner +1 more
2002Microbiology159 citations Open access
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Transcription-Dependent Nuclear-Cytoplasmic Trafficking Is Required for the Function of the von Hippel-Lindau Tumor Suppressor Protein
Stephen Lee, M. Neumann, R. Stearman, R. Stauber +3 more
1999Molecular and Cellular Biology146 citations Open access
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The FRE1 Ferric Reductase of Saccharomyces cerevisiae Is a Cytochrome b Similar to That of NADPH Oxidase*
K. P. Shatwell, A. Dancis, A. Cross, R. Klausner +1 more
1996Journal of Biological Chemistry144 citations Open access
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VHL-mediated hypoxia regulation of cyclin D1 in renal carcinoma cells.
R. Bindra, J. Vasselli, R. Stearman, W. Linehan +1 more
2002Cancer Research132 citations
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The cancer genome anatomy project: building an annotated gene index.
R. Strausberg, K. Buetow, M. Emmert-Buck, R. Klausner
2000Trends in Genetics128 citations
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New opportunities for uncovering the molecular basis of cancer
R. Strausberg, C. A. Dahl, R. Klausner
1997Nature Genetics125 citations
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Cancers as wounds that do not heal: differences and similarities between renal regeneration/repair and renal cell carcinoma.
J. Riss, C. Khanna, S. Koo, G. Chandramouli +21 more
2006Cancer Research124 citations Open access
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Human BRCA1 inhibits growth in yeast: potential use in diagnostic testing.
Jeffrey S. Humphrey, Ali Salim, M. Erdos, F. Collins +2 more
1997Proceedings of the National Academy of Sciences of the United States of America119 citations Open access
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Studying interactions of four proteins in the yeast two-hybrid system: structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box protein.
A. Pause, B. Peterson, G. Schaffar, R. Stearman +1 more
1999Proceedings of the National Academy of Sciences of the United States of America102 citations Open access
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Molecular profiling of clinical tissues specimens: feasibility and applications.
M. Emmert-Buck, R. Strausberg, D. Krizman, M. Bonaldo +29 more
2000Journal of Molecular Diagnostics100 citations Open access
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Solid renal tumor severity in von Hippel Lindau disease is related to germline deletion length and location
J. Maranchie, A. Afonso, P. Albert, S. Kalyandrug +13 more
2004Human Mutation94 citations Open access
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Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase
Christopher S. Brower, S. Sato, C. Tomomori-Sato, T. Kamura +9 more
2002Proceedings of the National Academy of Sciences of the United States of America92 citations Open access
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Molecular profiling of clinical tissue specimens: feasibility and applications.
M. Emmert-buck, R. Strausberg, David B. Krizman, M. Bonaldo +29 more
2000American Journal of Pathology90 citations Open access
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Studying cancer families to identify kidney cancer genes.
B. Zbar, R. Klausner, W. M. Linehan
2003Annual Review of Medicine72 citations
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The need for a global HIV vaccine enterprise. Policy forum.
R. Klausner, A. Fauci, L. Corey, G. Nabel +1 more
200372 citations
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Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface
U. Shigdel, Seung-Joo Lee, M. Sowa, B. R. Bowman +22 more
2020Proceedings of the National Academy of Sciences of the United States of America65 citations Open access
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The fabric of cancer cell biology-Weaving together the strands.
R. Klausner
2002Cancer Cell59 citations Open access
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Cell‐cycle arrest and inhibition of G1 cyclin translation by iron in AFT1‐1up yeast
C. Philpott, Jared Rashford, Y. Yamaguchi-Iwai, Tracey A. Rouault +2 more
1998EMBO Journal59 citations Open access
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Constitutional von Hippel-Lindau (VHL) gene deletions detected in VHL families by fluorescence in situ hybridization.
Svetlana D. Pack, B. Zbar, Evgenia Pak, David O. Ault +13 more
1999Cancer Research54 citations
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A systematic, high-resolution linkage of the cytogenetic and physical maps of the human genome
I. Kirsch, Eric D. Green, R. Yonescu, R. Strausberg +13 more
2000Nature Genetics43 citations
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Post-transcriptional regulation of genes of iron metabolism in mammalian cells
Tracey A. Rouault, R. Klausner
1996JBIC Journal of Biological Inorganic Chemistry42 citations
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