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Lingming Liang · SciRah

Researcher profile · Semantic Scholar

Lingming Liang

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Lingming Liang — researcher profile on SciRah

h-index: 13
Works: 27
Citations: 613

Most-cited papers

Identification and characterization of a melanin-concentrating hormone receptor
S. An, G. Cutler, J. Zhao, Shu-Gui Huang +8 more
2001Proceedings of the National Academy of Sciences of the United States of America192 citations Open access
Semantic Scholar
Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3.
Zhihong Li, Xiang-Hong Wang, J. Eksterowicz, Michael W. Gribble +47 more
2014Journal of Medicinal Chemistry67 citations Open access
Semantic Scholar
AMG 509 (Xaluritamig), an Anti-STEAP1 XmAb 2+1 T-cell Redirecting Immune Therapy with Avidity-Dependent Activity Against Prostate Cancer.
Olivier Nolan-Stevaux, Cong Li, Lingming Liang, J. Zhan +20 more
2023Cancer Discovery48 citations
Semantic Scholar
Discovery of potent LPA2 (EDG4) antagonists as potential anticancer agents.
Hilary P. Beck, Todd J. Kohn, Steven M. Rubenstein, C. Hedberg +13 more
2008Bioorganic & Medicinal Chemistry Letters48 citations Open access
Semantic Scholar
Cancer cell-intrinsic resistance to BiTE therapy is mediated by loss of CD58 costimulation and modulation of the extrinsic apoptotic pathway
Ye Shen, Jason S. Eng, F. Fajardo, Lingming Liang +4 more
2022Journal for ImmunoTherapy of Cancer36 citations Open access
Semantic Scholar
Preclinical Evaluation of AMG 925, a FLT3/CDK4 Dual Kinase Inhibitor for Treating Acute Myeloid Leukemia
Kathleen S. Keegan, Cong Li, Zhi-Hong Li, Ji Ma +22 more
2014Molecular Cancer Therapeutics34 citations Open access
Semantic Scholar
Identification of piperazine-bisamide GHSR antagonists for the treatment of obesity.
Ming Yu, M. Lizarzaburu, H. Beckmann, Richard V. Connors +11 more
2010Bioorganic & Medicinal Chemistry Letters28 citations Open access
Semantic Scholar
AMG 925 Is a Dual FLT3/CDK4 Inhibitor with the Potential to Overcome FLT3 Inhibitor Resistance in Acute Myeloid Leukemia
Cong Li, Liqin Liu, Lingming Liang, Zhen Xia +8 more
2014Molecular Cancer Therapeutics27 citations Open access
Semantic Scholar
Discovery of a new class of ghrelin receptor antagonists.
Jeffrey T. Mihalic, Yong-Jae Kim, M. Lizarzaburu, Xiao-Qi Chen +13 more
2012Bioorganic & Medicinal Chemistry Letters21 citations Open access
Semantic Scholar
Discovery of a novel melanin concentrating hormone receptor 1 (MCHR1) antagonist with reduced hERG inhibition.
Jeffrey T. Mihalic, Ping-Chen Fan, Xiao-Qi Chen, Xi Chen +9 more
2012Bioorganic & Medicinal Chemistry Letters21 citations Open access
Semantic Scholar
Discovery and characterization of a potent and selective antagonist of melanin-concentrating hormone receptor 2.
Xiao-Qi Chen, Jeffrey T. Mihalic, Ping-Chen Fan, Lingming Liang +8 more
2012Bioorganic & Medicinal Chemistry Letters15 citations Open access
Semantic Scholar
Preclinical Characterization of AMG 424, a Novel Humanized T Cell-Recruiting Bispecific Anti-CD3/CD38 Antibody
Christina L. Zuch de Zafra, M. Balazs, F. Fajardo, Lingming Liang +19 more
201714 citations
Semantic Scholar
Discovery of a novel series of melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity.
Jeffrey T. Mihalic, Xiao-Qi Chen, Ping-Chen Fan, Xi Chen +8 more
2011Bioorganic & Medicinal Chemistry Letters13 citations Open access
Semantic Scholar
SAR studies on a novel series of human cytomegalovirus primase inhibitors.
Xi Chen, J. Adrian, Timothy D. Cushing, H. Dimaio +11 more
2007Bioorganic & Medicinal Chemistry Letters13 citations
Semantic Scholar
Evaluation of AMG 076, a potent and selective MCHR1 antagonist, in rodent and primate obesity models
A. Motani, Jian Luo, Lingming Liang, Jeffrey T. Mihalic +6 more
2013Pharmacology Research & Perspectives10 citations Open access
Semantic Scholar
Discovery of a novel series of inhibitors of human cytomegalovirus primase.
Timothy D. Cushing, J. Adrian, Xi Chen, H. Dimaio +14 more
2006Bioorganic & Medicinal Chemistry Letters9 citations
Semantic Scholar
Development of a time-resolved fluorescence resonance energy transfer assay for cyclin-dependent kinase 4 and identification of its ATP-noncompetitive inhibitors.
Mei-Chu Lo, R. Ngo, K. Dai, Cong Li +7 more
2012Analytical Biochemistry8 citations
Semantic Scholar
718 AMG 509, a STEAP1 x CD3 bispecific XmAb® 2+1 immune therapy, exhibits avidity-driven binding and preferential killing of high STEAP1-expressing prostate and Ewing sarcoma cancer cells
Cong Li, M. Fort, Lingming Liang, G. Moore +12 more
2020Journal for ImmunoTherapy of Cancer7 citations Open access
Semantic Scholar
Abstract 2351: CDK4/FLT3 dual inhibitors as potential therapeutics for acute myeloid leukemia.
Zhi-Hong Li, K. Dai, Kathleen S. Keegan, Ji Ma +21 more
20132 citations
Semantic Scholar
Abstract 787: FLX925 (AMG 925) is a rationally designed FLT3, CDK4/6 inhibitor that retains potency against clinically relevant secondary resistance mutations in FLT3
Cong Li, Lingming Liang, Liqin Liu, Zhen Xia +10 more
20151 citations
Semantic Scholar
Abstract LB-249: Characterization of a novel potent and selective CDK4/6 inhibitor and a resistance mechanism
K. Dai, Cong Li, Lingming Liang, M. Rong +10 more
20121 citations
Semantic Scholar
Abstract 6348: Unveiling diverse trimeric forms of STEAP1 in human prostate cancer cells: Exploring STEAP1-STEAP2 interdependence for expression and plasma membrane localization
Cong Li, Lingming Liang, Joonhee Park, Olga Pryshchep +11 more
2024Cancer Research0 citations
Semantic Scholar
Is a Dual FLT 3 / CDK 4 Inhibitor with the Potential to Overcome FLT 3 Inhibitor Resistance in Acute Myeloid Leukemia
Cong Li, Liqin Liu, Lingming Liang, Zhen Xia +8 more
20150 citations
Semantic Scholar
Small Molecule Therapeutics Preclinical Evaluation of AMG 925 , a FLT 3 / CDK 4 Dual Kinase Inhibitor for Treating Acute Myeloid Leukemia
Kathleen S. Keegan, Cong Li, Zhi-Hong Li, Ji Ma +22 more
20140 citations
Semantic Scholar
Abstract A279: Preclinical evaluation of AMG 925, a FLT3/CDK4 dual kinase inhibitor.
K. Dai, Kathleen S. Keegan, Zhi-Hong Li, M. Ji +19 more
20130 citations
Semantic Scholar
Abstract 5636: Different characteristics of drug resistance in AML cell lines between a dual Flt3/CDK4 kinase inhibitor AMG 925 and Flt3 inhibitors.
Cong Li, Lingming Liang, D. Beaupre, Katie Newhall +7 more
20130 citations
Semantic Scholar
Abstract A244: Characterization of a novel potent and selective CDK4/6 inhibitor and a resistance mechanism.
K. Dai, Cong Li, Lingming Liang, M. Rong +10 more
20110 citations
Semantic Scholar

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