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J. Zhan · SciRah

Researcher profile · Semantic Scholar

J. Zhan

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J. Zhan — researcher profile on SciRah

h-index: 8
Works: 23
Citations: 461

Most-cited papers

AMG 757, a Half-Life Extended, DLL3-Targeted Bispecific T-Cell Engager, Shows High Potency and Sensitivity in Preclinical Models of Small-Cell Lung Cancer
M. Giffin, K. Cooke, E. Lobenhofer, Juan Estrada +19 more
2020Clinical Cancer Research209 citations Open access
Semantic Scholar
Local Delivery of OncoVEXmGM-CSF Generates Systemic Antitumor Immune Responses Enhanced by Cytotoxic T-Lymphocyte–Associated Protein Blockade
Achim K. Moesta, K. Cooke, J. Piasecki, Petia Mitchell +15 more
2017Clinical Cancer Research96 citations Open access
Semantic Scholar
AMG 509 (Xaluritamig), an Anti-STEAP1 XmAb 2+1 T-cell Redirecting Immune Therapy with Avidity-Dependent Activity Against Prostate Cancer.
Olivier Nolan-Stevaux, Cong Li, Lingming Liang, J. Zhan +20 more
2023Cancer Discovery48 citations
Semantic Scholar
Tumor-specific intravenous gene delivery using oncolytic adenoviruses
J. Zhan, Yi Gao, Wensheng Wang, Annie Shen +5 more
2005Cancer Gene Therapy31 citations Open access
Semantic Scholar
Oxopyrido[2,3-d]pyrimidines as Covalent L858R/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors.
Ryan P. Wurz, L. Pettus, K. Ashton, James Brown +30 more
2015ACS Medicinal Chemistry Letters21 citations Open access
Semantic Scholar
OncoVEXmGM-CSFexpands tumor antigen-specific CD8+ T-cell response in preclinical models
Juan Estrada, J. Zhan, Petia Mitchell, J. Werner +4 more
2023Journal for ImmunoTherapy of Cancer15 citations Open access
Semantic Scholar
Characterization of an Anti-CD70 Half-Life Extended Bispecific T Cell Engager (HLE-BiTE) and Associated On-Target Toxicity in Cynomolgus Monkeys.
Tod A. Harper, Amy M. Sharma, Sarav Kaliyaperumal, F. Fajardo +13 more
2022Toxicological Sciences12 citations Open access
Semantic Scholar
Oncovex MGM-CSF –mediated regression of contralateral (non-injected) tumors in the A20 murine lymphoma model does not involve direct viral oncolysis
K. Cooke, J. Rottman, J. Zhan, Petia Mitchell +6 more
2015Journal of Immunotherapy for Cancer8 citations Open access
Semantic Scholar
Abstract 2351: Development of a B16F10 cell line expressing mNectin1 to study the activity of OncoVEXmGM-CSF in murine syngeneic melanoma models
K. Cooke, Juan Estrada, J. Zhan, Petia Mitchell +2 more
20164 citations
Semantic Scholar
P15.01 AMG 757, a Half-Life Extended Bispecific T-Cell Engager (HLE BiTE® Immune Therapy) Targeting DLL3, for the Treatment of Small Cell Lung Cancer
K. Cooke, Juan Estrada, J. Zhan, J. Werner +5 more
20213 citations Open access
Semantic Scholar
627 The DLL3-targeted half-life extended bispecific T cell engager (HLE BiTE®) immune-oncology therapy AMG 757 has potent antitumor activity in neuroendocrine cancer
K. Cooke, Juan Estrada, J. Zhan, J. Werner +5 more
2020Journal for ImmunoTherapy of Cancer3 citations Open access
Semantic Scholar
Potency and Selectivity Assessment of Small Molecules Against Janus Kinase (JAK) 2: Widely Used AG490 Inhibitor Is Neither Potent Nor Selective for JAK2
A. Sinclair, I. Archibeque, J. Zhan, Liqin Liu +3 more
20113 citations
Semantic Scholar
Generation and Characterization of Monoclonal Antibodies to Human Keratinocyte Growth Factor Receptor
P. Wei, J. Zhan, Shu-Ying Liu, D. Chang +10 more
2006Hybridoma3 citations
Semantic Scholar
1189 Elucidating the effects of chemotherapy and immune checkpoint blockade on the activity of tarlatamab, a DLL3-targeting bispecific T cell engager molecule, in small cell lung cancer preclinical models
R. You, Juan Estrada, J. Zhan, Petra Deegen +3 more
2023Regular and Young Investigator Award Abstracts2 citations Open access
Semantic Scholar
Novel Anti-c-Mpl Monoclonal Antibodies Identified Multiple Differentially Glycosylated Human c-Mpl Proteins in Megakaryocytic Cells But Not in Human Solid Tumors
J. Zhan, B. Felder, A. Ellison, A. Winters +4 more
2013Monoclonal antibodies in immunodiagnosis and immunotherapy2 citations
Semantic Scholar
Abstract 1586: Oncolytic virus HSV-1/ICP34.5-/ICP47-/mFLT3L/mIL12 promotes systemic anti-tumor responses and cooperates with immuno-modulatory agents in multiple mouse syngeneic tumor models
K. Cooke, Walter H. Meisen, Petia Mitchell, Juan Estrada +6 more
2021Immunology1 citations
Semantic Scholar
Abstract 4558: Antitumor activity of AMG757, a half-life extended (HLE) bispecific T-cell engager (BiTE®) immune therapy targeting DLL3, in human PDX and orthotopic mouse models of small cell lung cancer (SCLC)
K. Cooke, Juan Estrada, J. Zhan, J. Werner +6 more
2020Immunology1 citations
Semantic Scholar
Triazolone/alginate-zinc (II)-montmorillonite sustained release system with improved adsorption capacity and pH-sensitivity
Hua-Yao Chen, J. Zhan, Hong-Jun Zhou, Li Hao +3 more
2020SN Applied Sciences1 citations Open access
Semantic Scholar
A comparison of potency of and intracellular signaling events provoked by, small molecule and protein-based mpl agonists.
C. Hartley, G. Dyas, Ivonne Archibeque, A. Al-Assaad +5 more
2009Journal of Clinical Oncology1 citations
Semantic Scholar
Listeria monocytogenes personalized cancer vaccines drive therapeutic immune responses to cancer derived neoantigens
Brandon D. Coder, O. Pryshchep, D. Kelkar, Elena V. Filippova +20 more
2020bioRxiv0 citations Open access
Semantic Scholar
Abstract LB-150: Neoantigens that fail to elicit measurable T cell responses following peptide immunization can control tumor growth when delivered using a Listeria-based immunotherapy platform
Brandon D. Coder, H. Phee, Cristina Mottershead, D. Kelkar +16 more
2018Clinical research0 citations
Semantic Scholar
Abstract 4566: OncoVEXmGM-CSF(HSV-1 modified similarly to Talimogene Laherparepvec) in combination with CTLA-4 blockade leads to both local and systemic efficacy in a murine syngeneic model of metastatic melanoma
K. Cooke, Juan Estrada, J. Zhan, David Hill +3 more
20170 citations
Semantic Scholar
Abstract 2587: A novel covalent inhibitor of mutant but not wild-type (WT) epidermal growth factor receptor (EGFR) has activity in vitro and in vivo in non-small cell lung cancer (NSCLC) models
P. Beltran, J. Zhan, Petia Mitchell, Ryan P. Wurz +7 more
20150 citations
Semantic Scholar

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