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Y. Chu · SciRah

Researcher profile · Semantic Scholar

Y. Chu

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Y. Chu — researcher profile on SciRah

h-index: 45
Works: 80
Citations: 9,812

Most-cited papers

Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease
J. Kordower, Y. Chu, R. Hauser, T. B. Freeman +1 more
2008Nature Medicine1,687 citations
Semantic Scholar
Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease.
J. Kordower, M. Emborg, J. Bloch, S.-Y. Ma +16 more
2000Science1,277 citations Open access
Semantic Scholar
Loss and atrophy of layer II entorhinal cortex neurons in elderly people with mild cognitive impairment
J. Kordower, Y. Chu, G. Stebbins, S. DeKosky +3 more
2001Annals of Neurology457 citations
Semantic Scholar
Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions.
Y. Chu, Hemraj B. Dodiya, P. Aebischer, C. Olanow +1 more
2009Neurobiology of Disease423 citations Open access
Semantic Scholar
Age-associated increases of α-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease?
Y. Chu, J. Kordower
2007413 citations Open access
Semantic Scholar
Protective effect of encapsulated cells producing neurotrophic factor CNTF in a monkey model of Huntington's disease
Dwaine F. Emerich, S. Winn, P. Hantraye, M. Peschanski +5 more
1997Nature324 citations
Semantic Scholar
Alterations in axonal transport motor proteins in sporadic and experimental Parkinson's disease.
Y. Chu, G. Morfini, Lori B Langhamer, Yinzhen He +2 more
2012Brain : a journal of neurology304 citations Open access
Semantic Scholar
Transplanted dopaminergic neurons develop PD pathologic changes: A second case report
J. Kordower, Y. Chu, R. Hauser, C. Olanow +1 more
2008Movement Disorders287 citations
Semantic Scholar
Endocytic vesicle rupture is a conserved mechanism of cellular invasion by amyloid proteins
W. Flavin, L. Bousset, Z. Green, Y. Chu +5 more
2017Acta Neuropathologica239 citations
Semantic Scholar
Lentivirally Delivered Glial Cell Line-Derived Neurotrophic Factor Increases the Number of Striatal Dopaminergic Neurons in Primate Models of Nigrostriatal Degeneration
S. Palfi, L. Leventhal, Y. Chu, Shuang Y. Ma +6 more
2002Journal of Neuroscience228 citations Open access
Semantic Scholar
Nurr1 in Parkinson's disease and related disorders
Y. Chu, W. Le, K. Kompoliti, J. Jankovic +2 more
2006The Journal of comparative neurology220 citations Open access
Semantic Scholar
A phase1 study of stereotactic gene delivery of AAV2‐NGF for Alzheimer's disease
M. Rafii, Tiffany L. Baumann, Roy A. E. Bakay, J. Ostrove +12 more
2014Alzheimer's & Dementia216 citations
Semantic Scholar
Age‐related decreases in Nurr1 immunoreactivity in the human substantia nigra
Y. Chu, K. Kompoliti, E. Cochran, E. Mufson +1 more
2002The Journal of comparative neurology202 citations
Semantic Scholar
Lentiviral gene transfer to the nonhuman primate brain.
J. Kordower, J. Bloch, Shuang Y. Ma, Y. Chu +6 more
1999Experimental Neurology201 citations
Semantic Scholar
Neural transplants in patients with Huntington's disease undergo disease-like neuronal degeneration
F. Cicchetti, S. Saporta, R. Hauser, M. Parent +8 more
2009Proceedings of the National Academy of Sciences of the United States of America193 citations Open access
Semantic Scholar
Bioactivity of AAV2-Neurturin Gene Therapy (CERE-120): Differences Between Parkinson’s Disease and Nonhuman Primate Brains
R. Bartus, C. Herzog, Y. Chu, Alistair Z. Wilson +6 more
2010Movement Disorders175 citations Open access
Semantic Scholar
Aging-related changes in the nigrostriatal dopamine system and the response to MPTP in nonhuman primates: diminished compensatory mechanisms as a prelude to parkinsonism.
T. Collier, J. Lipton, B. Daley, S. Palfi +5 more
2007Neurobiology of Disease155 citations Open access
Semantic Scholar
Failure of proteasome inhibitor administration to provide a model of Parkinson's disease in rats and monkeys
J. Kordower, N. Kanaan, Y. Chu, Rangasamy Suresh Babu +5 more
2006Annals of Neurology146 citations
Semantic Scholar
Proteasome inhibition and Parkinson's disease modeling
J. Bové, Chun Zhou, V. Jackson-Lewis, Julie Taylor +6 more
2006Annals of Neurology144 citations
Semantic Scholar
Nigrostriatal tau pathology in parkinsonism and Parkinson’s disease
Y. Chu, Warren D. Hirst, H. J. Federoff, A. Harms +2 more
2023Brain : a journal of neurology133 citations Open access
Semantic Scholar
PGC−1α Promoter Methylation in Parkinson’s Disease
Xiaomin Su, Y. Chu, J. Kordower, Bin Li +6 more
2015PLoS ONE117 citations Open access
Semantic Scholar
Doublecortin expression in adult cat and primate cerebral cortex relates to immature neurons that develop into GABAergic subgroups
Yan Cai, K. Xiong, Y. Chu, Duan-Wu Luo +9 more
2008Experimental Neurology114 citations Open access
Semantic Scholar
Lewy body pathology in fetal grafts
Y. Chu, J. Kordower
2010Annals of the New York Academy of Sciences104 citations
Semantic Scholar
Focal not widespread grafts induce novel dyskinetic behavior in parkinsonian rats.
Eleonora Maries, J. Kordower, Y. Chu, T. Collier +4 more
2006Neurobiology of Disease100 citations Open access
Semantic Scholar
Intrastriatal alpha-synuclein fibrils in monkeys: spreading, imaging and neuropathological changes.
Y. Chu, Scott Muller, A. Tavares, O. Barret +8 more
2019Brain : a journal of neurology96 citations Open access
Semantic Scholar
Temporal evolution of microglia and α-synuclein accumulation following foetal grafting in Parkinson's disease.
C. Olanow, Mari H. Savolainen, Y. Chu, G. Halliday +1 more
2019Brain : a journal of neurology96 citations
Semantic Scholar
Doublecortin-Expressing Cells Persist in the Associative Cerebral Cortex and Amygdala in Aged Nonhuman Primates
Xue-Mei Zhang, Yan Cai, Y. Chu, Er-Yun Chen +8 more
2009Frontiers in Neuroanatomy95 citations Open access
Semantic Scholar
Extensive neuroprotection by choroid plexus transplants in excitotoxin lesioned monkeys.
D. Emerich, C. Thanos, M. Goddard, S. Skinner +11 more
2006Neurobiology of Disease85 citations Open access
Semantic Scholar
Robust Graft Survival and Normalized Dopaminergic Innervation Do Not Obligate Recovery in a Parkinson Disease Patient
J. Kordower, C. Goetz, Y. Chu, G. Halliday +7 more
2016Annals of Neurology83 citations Open access
Semantic Scholar
Distribution of high affinity choline transporter immunoreactivity in the primate central nervous system
L. Kus, E. Borys, Y. Chu, Shawn M. Ferguson +5 more
2003The Journal of comparative neurology75 citations
Semantic Scholar
Long-term post-mortem studies following neurturin gene therapy in patients with advanced Parkinson’s disease
Y. Chu, R. Bartus, F. Manfredsson, C. Olanow +1 more
2020Brain : a journal of neurology74 citations Open access
Semantic Scholar
The Prion Hypothesis of Parkinson’s Disease
Y. Chu, J. Kordower
2015Current Neurology and Neuroscience Reports74 citations
Semantic Scholar
Chronic ischemic stroke model in cynomolgus monkeys: Behavioral, neuroimaging and anatomical study
B. Roitberg, Naimath Khan, E. Tuccar, K. Kompoliti +4 more
2003Neurological Research74 citations
Semantic Scholar
Post-mortem assessment of the short and long-term effects of the trophic factor neurturin in patients with α-synucleinopathies.
R. Bartus, J. Kordower, E. M. Johnson, Lamar Brown +6 more
2015Neurobiology of Disease73 citations Open access
Semantic Scholar
Role of heparin binding growth factors in nigrostriatal dopamine system development and Parkinson's disease.
Deanna M. Marchionini, E. Lehrmann, Y. Chu, Bin He +5 more
2007Brain Research71 citations
Semantic Scholar
Down‐regulation of trkA mRNA within nucleus basalis neurons in individuals with mild cognitive impairment and Alzheimer's disease
Y. Chu, E. J. Cochran, David A. Bennett, Elliott J. Mufson +1 more
2001The Journal of comparative neurology71 citations
Semantic Scholar
Abnormal alpha-synuclein reduces nigral voltage-dependent anion channel 1 in sporadic and experimental Parkinson's disease.
Y. Chu, Jennifer G. Goldman, L. Kelly, Yinzhen He +2 more
2014Neurobiology of Disease70 citations Open access
Semantic Scholar
Transgene expression, bioactivity, and safety of CERE-120 (AAV2-neurturin) following delivery to the monkey striatum.
C. Herzog, Biplob Dass, Mehdi Gasmi, R. Bakay +8 more
2008Molecular Therapy69 citations Open access
Semantic Scholar
β-Secretase-1 elevation in aged monkey and Alzheimer's disease human cerebral cortex occurs around vasculature in partnership with multisystem axon terminal pathogenesis and β-amyloid accumulation
Yan Cai, K. Xiong, Xue-Mei Zhang, H. Cai +8 more
2010European Journal of Neuroscience62 citations Open access
Semantic Scholar
Analysis of YFP(J16)-R6/2 reporter mice and postmortem brains reveals early pathology and increased vulnerability of callosal axons in Huntington's disease.
Rodolfo Gabriel Gatto, Y. Chu, Allen Q. Ye, Steven D. Price +6 more
2015Human Molecular Genetics53 citations Open access
Semantic Scholar
Systemic administration of the immunophilin ligand GPI 1046 in MPTP-treated monkeys.
M. Emborg, P. Shin, B. Roitberg, J. Sramek +6 more
2001Experimental Neurology53 citations
Semantic Scholar
In situ proximity labeling identifies Lewy pathology molecular interactions in the human brain
B. Killinger, Lee L. Marshall, Diptaman Chatterjee, Y. Chu +3 more
2022Proceedings of the National Academy of Sciences of the United States of America47 citations Open access
Semantic Scholar
Detecting Alpha Synuclein Seeding Activity in Formaldehyde-Fixed MSA Patient Tissue by PMCA
K. Becker, Xin-He Wang, Kayla Vander Stel, Y. Chu +2 more
2018Molecular Neurobiology47 citations Open access
Semantic Scholar
Novel oligodendroglial alpha synuclein viral vector models of multiple system atrophy: studies in rodents and nonhuman primates
R. Mandel, David J. Marmion, D. Kirik, Y. Chu +4 more
2017Acta Neuropathologica Communications46 citations Open access
Semantic Scholar
Postmortem study of deep brain stimulation of the anterior thalamus: case report.
Julie G. Pilitsis, Y. Chu, J. Kordower, D. Bergen +2 more
2008Neurosurgery45 citations
Semantic Scholar
Cellular delivery of CNTF but not NT-4/5 prevents degeneration of striatal neurons in a rodent model of Huntington's disease.
Dwaine F. Emerich, Suzanne L. Bruhn, Y. Chu, J. Kordower
1998Cell Transplantation45 citations Open access
Semantic Scholar
α-synuclein aggregation reduces nigral myocyte enhancer factor-2D in idiopathic and experimental Parkinson's disease.
Y. Chu, Amanda L. Mickiewicz, J. Kordower
2011Neurobiology of Disease43 citations Open access
Semantic Scholar
DO SUBJECTS WITH MINIMAL MOTOR FEATURES HAVE PRODROMAL PD?
Y. Chu, A. Buchman, C. Olanow, J. Kordower
2018Annals of Neurology41 citations Open access
Semantic Scholar
Effects of estrogen replacement therapy on cholinergic basal forebrain neurons and cortical cholinergic innervation in young and aged ovariectomized rhesus monkeys
K. Kompoliti, Y. Chu, Ari Polish, Jeffrey A. Roberts +5 more
2004The Journal of comparative neurology37 citations
Semantic Scholar
Generation and transplantation of EGF-responsive neural stem cells derived from GFAP-hNGF transgenic mice.
Melissa K. Carpenter, C. Winkler, R. Fricker, Dwaine F. Emerich +8 more
1997Experimental Neurology35 citations
Semantic Scholar

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R. Hauser — researcher profile on SciRah