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F. Manfredsson · SciRah

Researcher profile · Semantic Scholar

F. Manfredsson

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F. Manfredsson — researcher profile on SciRah

h-index: 39
Works: 157
Citations: 5,341

Most-cited papers

Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer’s Disease
Zhi-Hao Wang, Jie Xiang, Xia Liu, Shan P. Yu +5 more
2019Cell Reports216 citations Open access
Semantic Scholar
Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson’s disease
Zhen-Tao Zhang, S. Kang, Xia Liu, E. Ahn +11 more
2017Nature Structural &Molecular Biology186 citations Open access
Semantic Scholar
Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology
F. Manfredsson, Kelvin C. Luk, Matthew J Benskey, Aysegul Gezer +7 more
2018Neurobiology of Disease175 citations Open access
Semantic Scholar
C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer’s disease
Zhi-Hao Wang, Ke-Qin Gong, Xia Liu, Zhen-Tao Zhang +9 more
2018Nature Communications132 citations Open access
Semantic Scholar
TrkB neurotrophic activities are blocked by α-synuclein, triggering dopaminergic cell death in Parkinson’s disease
S. Kang, Zhen-Tao Zhang, Xia Liu, F. Manfredsson +5 more
2017Proceedings of the National Academy of Sciences of the United States of America125 citations Open access
Semantic Scholar
High cerebrospinal amyloid-β 42 is associated with normal cognition in individuals with brain amyloidosis
Andrea Sturchio, A. Dwivedi, C. Young, T. Malm +10 more
2021EClinicalMedicine106 citations Open access
Semantic Scholar
Norepinephrine metabolite DOPEGAL activates AEP and pathological Tau aggregation in locus coeruleus.
S. Kang, Xia Liu, E. Ahn, Jie Xiang +6 more
2019Journal of Clinical Investigation102 citations Open access
Semantic Scholar
Silencing Alpha Synuclein in Mature Nigral Neurons Results in Rapid Neuroinflammation and Subsequent Toxicity
Matthew J Benskey, Rhyomi C. Sellnow, I. Sandoval, C. Sortwell +2 more
2018Frontiers in Molecular Neuroscience97 citations Open access
Semantic Scholar
α‐Synuclein stimulation of monoamine oxidase‐B and legumain protease mediates the pathology of Parkinson's disease
S. Kang, E. Ahn, Zhen-Tao Zhang, Xia Liu +6 more
2018EMBO Journal93 citations Open access
Semantic Scholar
Long-term post-mortem studies following neurturin gene therapy in patients with advanced Parkinson’s disease
Y. Chu, R. Bartus, F. Manfredsson, C. Olanow +1 more
2020Brain : a journal of neurology74 citations Open access
Semantic Scholar
Rationally Engineered AAV Capsids Improve Transduction and Volumetric Spread in the CNS
N. Kanaan, Rhyomi C. Sellnow, Sanford L. Boye, Ben Coberly +6 more
2017Molecular Therapy: Nucleic Acids67 citations Open access
Semantic Scholar
Delta-secretase-cleaved Tau antagonizes TrkB neurotrophic signalings, mediating Alzheimer’s disease pathologies
Jie Xiang, Zhi-Hao Wang, E. Ahn, Xia Liu +6 more
2019Proceedings of the National Academy of Sciences of the United States of America64 citations Open access
Semantic Scholar
Delta-secretase Phosphorylation by SRPK2 Enhances its Enzymatic Activity, Provoking the Pathogenesis in Alzheimer’s Disease
Zhi-Hao Wang, Pai Liu, Xia Liu, F. Manfredsson +4 more
2017Molecules and Cells63 citations Open access
Semantic Scholar
Regulation of dopamine neurotransmission from serotonergic neurons by ectopic expression of the dopamine D2 autoreceptor blocks levodopa-induced dyskinesia
Rhyomi C. Sellnow, J. Newman, Nicole E. Chambers, A. R. West +5 more
2019Acta Neuropathologica Communications61 citations Open access
Semantic Scholar
BDNF inhibits neurodegenerative disease-associated asparaginyl endopeptidase activity via phosphorylation by AKT.
Zhi-Hao Wang, Wan-Qiang Wu, S. Kang, Xia Liu +8 more
2018JCI Insight56 citations Open access
Semantic Scholar
Enhanced CNS transduction from AAV.PHP.eB infusion into the cisterna magna of older adult rats compared to AAV9
Diptaman Chatterjee, David J. Marmion, J. McBride, F. Manfredsson +3 more
2021Gene Therapy45 citations Open access
Semantic Scholar
Netrin-1 receptor UNC5C cleavage by active δ-secretase enhances neurodegeneration, promoting Alzheimer’s disease pathologies
Gui-Qin Chen, S. Kang, Zhi-Hao Wang, E. Ahn +6 more
2021Science Advances44 citations Open access
Semantic Scholar
α-synuclein aggregates induce c-Abl activation and dopaminergic neuronal loss by a feed-forward redox stress mechanism
Soumitra S. Ghosh, S. Won, Jie-jie Wang, Rebecca Fong +9 more
2021Progress in neurobiology39 citations Open access
Semantic Scholar
The Future of GDNF in Parkinson's Disease
F. Manfredsson, N. Polinski, T. Subramanian, N. Boulis +2 more
2020Frontiers in Aging Neuroscience38 citations Open access
Semantic Scholar
α-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation
S. Kang, Zhen-Tao Zhang, Xia Liu, F. Manfredsson +6 more
2017Proceedings of the National Academy of Sciences of the United States of America37 citations Open access
Semantic Scholar
Neonatal Nicotine Exposure Primes Midbrain Neurons to a Dopaminergic Phenotype and Increases Adult Drug Consumption
B. Romoli, A. Lozada, I. Sandoval, F. Manfredsson +3 more
2019Biological Psychiatry34 citations Open access
Semantic Scholar
Glycomic and Proteomic Changes in Aging Brain Nigrostriatal Pathway*
Rekha Raghunathan, N. Polinski, J. Klein, John D. Hogan +7 more
2018Molecular & Cellular Proteomics33 citations Open access
Semantic Scholar
Epigenetic inactivation of the autophagy–lysosomal system in appendix in Parkinson’s disease
Juozas Gordevičius, Pei-Pei Li, Lee L. Marshall, B. Killinger +14 more
2021Nature Communications32 citations Open access
Semantic Scholar
Subthalamic Nucleus Deep Brain Stimulation Does Not Modify the Functional Deficits or Axonopathy Induced by Nigrostriatal α-Synuclein Overexpression
D. L. Fischer, F. Manfredsson, Christopher J. Kemp, Allyson Cole-Strauss +8 more
2017Scientific Reports32 citations Open access
Semantic Scholar
"Advanced" Parkinson's disease: A review.
Sana Aslam, F. Manfredsson, Ashley Stokes, H. Shill
2024Parkinsonism & Related Disorders31 citations
Semantic Scholar
Genetic silencing of striatal CaV1.3 prevents and ameliorates levodopa dyskinesia
K. Steece-Collier, Jennifer A. Stancati, N. Collier, I. Sandoval +4 more
2019Movement Disorders31 citations Open access
Semantic Scholar
Multimodal Production of Adeno-Associated Virus.
I. Sandoval, N. Kuhn, F. Manfredsson
2019Methods in molecular biology28 citations
Semantic Scholar
A comparison of AAV-vector production methods for gene therapy and preclinical assessment
M. Davidsson, M. Negrini, Swantje Hauser, A. Svanbergsson +4 more
2020Scientific Reports27 citations Open access
Semantic Scholar
Striatal Nurr1 Facilitates the Dyskinetic State and Exacerbates Levodopa-Induced Dyskinesia in a Rat Model of Parkinson's Disease
Rhyomi C. Sellnow, K. Steece-Collier, F. Altwal, I. Sandoval +5 more
2019Journal of Neuroscience26 citations Open access
Semantic Scholar
The α-synuclein seed amplification assay: Interpreting a test of Parkinson's pathology.
A. Espay, A. J. Lees, F. Cardoso, S. Frucht +10 more
2024Parkinsonism & Related Disorders25 citations Open access
Semantic Scholar
The BDNF Val66Met polymorphism (rs6265) enhances dopamine neuron graft efficacy and side-effect liability in rs6265 knock-in rats
Natosha M. Mercado, Jennifer A. Stancati, C. Sortwell, Rebecca L. Mueller +7 more
2020Neurobiology of Disease22 citations Open access
Semantic Scholar
Sequential or Simultaneous Injection of Preformed Fibrils and AAV Overexpression of Alpha-Synuclein Are Equipotent in Producing Relevant Pathology and Behavioral Deficits
M. Negrini, G. Tomasello, M. Davidsson, Alexis Fenyi +7 more
2022Journal of Parkinson's Disease20 citations Open access
Semantic Scholar
IFNγ drives neuroinflammation, demyelination, and neurodegeneration in a mouse model of multiple system atrophy
Nicole J. Corbin-Stein, Gabrielle M. Childers, Jhodi M. Webster, Asta Zane +6 more
2024Acta Neuropathologica Communications19 citations Open access
Semantic Scholar
Oxytocin receptors in the midbrain dorsal raphe are essential for postpartum maternal social and affective behaviors
Z. Grieb, Emma Ford, Mahircan Yagan, B. Lau +3 more
2021Psychoneuroendocrinology18 citations Open access
Semantic Scholar
Genetic suppression of the dopamine D3 receptor in striatal D1 cells reduces the development of L-DOPA-induced dyskinesia.
Kathryn Lanza, Ashley Centner, Michael Coyle, I. Delpriore +2 more
2020Experimental Neurology18 citations
Semantic Scholar
Characterisation of functional deficits induced by AAV overexpression of alpha-synuclein in rats
F. Gubinelli, L. Šarauskytė, C. Venuti, I. Kulacz +8 more
2022Current Research in Neurobiology17 citations Open access
Semantic Scholar
Loss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons
D. Pathak, Amandine Berthet, Jacob T. Bendor, K. Yu +6 more
2017eNeuro16 citations Open access
Semantic Scholar
Striatal Nurr1, but not FosB Expression links a Levodopa-induced Dyskinesia Phenotype to Genotype in Fisher 344 vs. Lewis Hemiparkinsonian Rats
K. Steece-Collier, T. Collier, J. Lipton, Jennifer A. Stancati +9 more
2020Experimental Neurology15 citations Open access
Semantic Scholar
Modulation of cannabinoid receptor 2 alters neuroinflammation and reduces formation of alpha-synuclein aggregates in a rat model of nigral synucleinopathy
V. Joers, Benjamin C Murray, Caroline McLaughlin, Danielle L. Oliver +10 more
2024Journal of Neuroinflammation13 citations Open access
Semantic Scholar
2021 Workshop: Neurodegenerative Diseases in the Gut-Brain Axis - Parkinson’s Disease
G. Mawe, K. Browning, F. Manfredsson, M. Camilleri +6 more
2022Gastroenterology13 citations Open access
Semantic Scholar
Nicotine-Mediated Recruitment of GABAergic Neurons to a Dopaminergic Phenotype Attenuates Motor Deficits in an Alpha-Synuclein Parkinson’s Model
Jessica IChi Lai, A. Porcu, B. Romoli, Maria N. Keisler +3 more
2021bioRxiv13 citations Open access
Semantic Scholar
Nigral-specific increase in ser31 phosphorylation compensates for tyrosine hydroxylase protein and nigrostriatal neuron loss: Implications for delaying parkinsonian signs.
E. Kasanga, Yoonhee Han, Marla K. Shifflet, Walter Navarrete +8 more
2023Experimental Neurology12 citations Open access
Semantic Scholar
Gene Therapy to Modulate Alpha-Synuclein in Synucleinopathies
I. Sandoval, David J. Marmion, K. Meyers, F. Manfredsson
2021Journal of Parkinson's Disease11 citations Open access
Semantic Scholar
Downregulation of striatal CaV1.3 inhibits the escalation of levodopa-induced dyskinesia in male and female parkinsonian rats of advanced age
Margaret E. Caulfield, Molly J. Vander Werp, Jennifer A. Stancati, T. Collier +4 more
2023Neurobiology of Disease10 citations Open access
Semantic Scholar
The multimodal serotonin compound Vilazodone alone, but not combined with the glutamate antagonist Amantadine, reduces l-DOPA-induced dyskinesia in hemiparkinsonian rats.
Sophie R. Cohen, Michelle L. Terry, Michael Coyle, Emily Wheelis +7 more
2022Pharmacology, Biochemistry and Behavior10 citations
Semantic Scholar
GFR-α1 expression in substantia nigra increases bilaterally following unilateral striatal GDNF in aged rats and attenuates nigral tyrosine hydroxylase loss following 6-OHDA nigrostriatal lesion.
E. Kasanga, Catherine L Owens, M. Cantu, Adam D. Richard +9 more
2019ACS Chemical Neuroscience10 citations
Semantic Scholar
Alpha-synuclein in Parkinson's disease: Embracing debate, exercising skepticism.
A. Espay, A. J. Lees, F. Cardoso, S. Frucht +9 more
2025Parkinsonism & Related Disorders9 citations Open access
Semantic Scholar
Broad Serotonergic Actions of Vortioxetine as a Promising Avenue for the Treatment of L-DOPA-Induced Dyskinesia
Carla Budrow, Kayla Elder, Michael Coyle, Ashley Centner +8 more
2023Cells9 citations Open access
Semantic Scholar
Engineered AAV capsid transport mutants overcome transduction deficiencies in the aged CNS
I. Sandoval, Christy M Kelley, L. Bernal-Conde, K. Steece-Collier +6 more
2024Molecular Therapy: Nucleic Acids8 citations Open access
Semantic Scholar
Differential expression of RET and GDNF family receptor, GFR-α1, between striatum and substantia nigra following nigrostriatal lesion: A case for diminished GDNF-signaling.
E. Kasanga, Yoonhee Han, Walter Navarrete, Robert McManus +7 more
2023Experimental Neurology8 citations Open access
Semantic Scholar

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