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Christina Lamers · SciRah

Researcher profile · Semantic Scholar

Christina Lamers

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Christina Lamers — researcher profile on SciRah

h-index: 18
Works: 51
Citations: 1,213

Most-cited papers

Overcoming the shortcomings of peptide-based therapeutics
Christina Lamers
2022Future Drug Discovery125 citations Open access
Semantic Scholar
Revealing the macromolecular targets of complex natural products.
D. Reker, A. Perna, Tiago Rodrigues, P. Schneider +10 more
2014Nature Chemistry121 citations
Semantic Scholar
Molecular tuning of farnesoid X receptor partial agonism
D. Merk, S. Sreeramulu, D. Kudlinzki, K. Saxena +11 more
2019Nature Communications94 citations Open access
Semantic Scholar
Macrocyclization strategies for cyclic peptides and peptidomimetics
Clément Bechtler, Christina Lamers
2021RSC Medicinal Chemistry87 citations Open access
Semantic Scholar
Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs
Jonas Wilbs, Xu-Dong Kong, S. Middendorp, Raja Prince +12 more
2020Nature Communications76 citations Open access
Semantic Scholar
Nonacidic Farnesoid X Receptor Modulators.
D. Flesch, S. Cheung, Jurema Schmidt, Matthias Gabler +13 more
2017Journal of Medicinal Chemistry72 citations Open access
Semantic Scholar
The Promiscuous Profile of Complement Receptor 3 in Ligand Binding, Immune Modulation, and Pathophysiology
Christina Lamers, Carla Johanna Plüss, D. Ricklin
2021Frontiers in Immunology65 citations Open access
Semantic Scholar
Therapeutic modulators of peroxisome proliferator-activated receptors (PPAR): a patent review (2008–present)
Christina Lamers, M. Schubert-Zsilavecz, D. Merk
2012Expert Opinion on Therapeutic Patents61 citations
Semantic Scholar
Compstatins: The dawn of clinical C3-targeted complement inhibition
Christina Lamers, D. Mastellos, D. Ricklin, John D Lambris
2022TIPS - Trends in Pharmacological Sciences60 citations Open access
Semantic Scholar
Extending the structure-activity relationship of anthranilic acid derivatives as farnesoid X receptor modulators: development of a highly potent partial farnesoid X receptor agonist.
D. Merk, Christina Lamers, K. Ahmad, Roberto Carrasco Gomez +3 more
2014Journal of Medicinal Chemistry50 citations Open access
Semantic Scholar
N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase/Peroxisome Proliferator-Activated Receptor γ Modulators.
René Blöcher, Christina Lamers, Sandra K. Wittmann, D. Merk +19 more
2016Journal of Medicinal Chemistry49 citations Open access
Semantic Scholar
Insight into mode-of-action and structural determinants of the compstatin family of clinical complement inhibitors
Christina Lamers, X. Xue, M. Smieško, Henri van Son +6 more
2022Nature Communications38 citations Open access
Semantic Scholar
Anthranilic acid derivatives as novel ligands for farnesoid X receptor (FXR).
D. Merk, Matthias Gabler, R. Gomez, D. Flesch +6 more
2014Bioorganic & Medicinal Chemistry32 citations Open access
Semantic Scholar
Medicinal chemistry and pharmacological effects of Farnesoid X Receptor (FXR) antagonists.
Christina Lamers, M. Schubert-Zsilavecz, D. Merk
2014Current Topics in Medicinal Chemistry30 citations
Semantic Scholar
Anthranilic acid derivatives as nuclear receptor modulators--development of novel PPAR selective and dual PPAR/FXR ligands.
D. Merk, Christina Lamers, J. Weber, D. Flesch +3 more
2015Bioorganic & Medicinal Chemistry29 citations Open access
Semantic Scholar
Factor XII signaling via uPAR-integrin β1 axis promotes tubular senescence in diabetic kidney disease
Ahmed Elwakiel, Dheerendra Gupta, Rajiv Rana, Jayakumar Manoharan +23 more
2024Nature Communications24 citations Open access
Semantic Scholar
Complement‐targeted therapeutics: An emerging field enabled by academic drug discovery
Christina Lamers, D. Ricklin, John D Lambris
2023American journal of hematology/oncology24 citations Open access
Semantic Scholar
Design and synthesis of dual modulators of soluble epoxide hydrolase and peroxisome proliferator-activated receptors.
Estel.la Buscató, René Blöcher, Christina Lamers, Franca-Maria Klingler +4 more
2012Journal of Medicinal Chemistry23 citations Open access
Semantic Scholar
Aberrant Complement Activation Is Associated With Structural Brain Damage in Multiple Sclerosis
J. Oechtering, S. Schaedelin, Kerstin Stein, Aleksandra Maleska Maceski +34 more
2025Neurology(R) neuroimmunology & neuroinflammation18 citations Open access
Semantic Scholar
SAR studies on FXR modulators led to the discovery of the first combined FXR antagonistic/TGR5 agonistic compound.
Christina Lamers, D. Merk, Matthias Gabler, D. Flesch +2 more
2016Future Medicinal Chemistry18 citations
Semantic Scholar
Complement-regulatory biomaterial coatings: activity and selectivity profile of the factor H-binding peptide 5C6.
Clément Bechtler, S. Koutsogiannaki, E. Umnyakova, A. Hamid +8 more
2022Acta Biomaterialia15 citations Open access
Semantic Scholar
Glomerular-tubular crosstalk via cold shock Y-box binding protein-1 in the kidney.
Rajiv Rana, Jayakumar Manoharan, Ahmed Elwakiel, Silke Zimmermann +18 more
2023Kidney International14 citations Open access
Semantic Scholar
Identification of pirinixic acid derivatives bearing a 2-aminothiazole moiety combines dual PPARα/γ activation and dual 5-LO/mPGES-1 inhibition.
T. Hanke, Christina Lamers, R. Gomez, G. Schneider +2 more
2014Bioorganic & Medicinal Chemistry Letters13 citations Open access
Semantic Scholar
Novel prostaglandin receptor modulators: a patent review (2002 – 2012) – part I: non-EP receptor modulators
Christina Lamers, D. Flesch, M. Schubert-Zsilavecz, D. Merk
2013Expert Opinion on Therapeutic Patents13 citations
Semantic Scholar
Design and synthesis of fused soluble epoxide hydrolase/peroxisome proliferator-activated receptor modulators
René Blöcher, Christina Lamers, Sandra K. Wittmann, O. Diehl +6 more
201611 citations Open access
Semantic Scholar
Complement inhibition can decrease the haemostatic response in a microvascular bleeding model at multiple levels
M. Golomingi, J. Kohler, Christina Lamers, R. Pouw +10 more
2023Frontiers in Immunology10 citations Open access
Semantic Scholar
Novel prostaglandin receptor modulators – Part II: EP receptor modulators; a patent review (2002 – 2012)
D. Flesch, D. Merk, Christina Lamers, M. Schubert-Zsilavecz
2013Expert Opinion on Therapeutic Patents10 citations
Semantic Scholar
Crossing Barriers: Advancements in Macromolecular Therapeutics for Neurodegenerative Diseases and Strategies to Overcome the Blood–Brain Barrier
Bekas Alo, Christina Lamers
2025ACS Pharmacology & Translational Science7 citations
Semantic Scholar
Development of Selective FXIa Inhibitors Based on Cyclic Peptides and Their Application for Safe Anticoagulation.
Vanessa Carle, Yu-Teng Wu, Rakesh Mukherjee, Xu-Dong Kong +12 more
2021Journal of Medicinal Chemistry7 citations Open access
Semantic Scholar
Molecular determinants for improved activity at PPARα: structure-activity relationship of pirinixic acid derivatives, docking study and site-directed mutagenesis of PPARα.
Christina Lamers, M. Dittrich, R. Steri, E. Proschak +1 more
2014Bioorganic & Medicinal Chemistry Letters7 citations Open access
Semantic Scholar
Praziquantel and factor H recruitment differentially affect the susceptibility of Schistosoma mansoni to complement-mediated damage
A. V. van Beek, Hannah Jeanguenat, Cécile Häberli, R. Pouw +6 more
2024Frontiers in Immunology5 citations Open access
Semantic Scholar
SAR-studies of γ-secretase modulators with PPARγ-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer's disease.
D. Flesch, Julia Ness, Christina Lamers, Friederike Dehm +8 more
2015Bioorganic & Medicinal Chemistry Letters5 citations Open access
Semantic Scholar
Determining Ligand Binding and Specificity Within the β2-Integrin Family with a Novel Assay Platform
Carla Johanna Sommer-Plüss, Céline Leiggener, Elira Nikci, R. Mancuso +3 more
2025Biomolecules2 citations Open access
Semantic Scholar
The Biggest Challenge for Prediction of Membrane Permeability of Cyclic Peptides: Scarce Data Availability
Christina Lamers
2026Journal of Medicinal Chemistry1 citations Open access
Semantic Scholar
Computer-guided design of Z domain peptides with improved inhibition of VEGF
C. Geist, Abibe Useini, A. Kazimir, Richy Kümpfel +4 more
2024bioRxiv1 citations Open access
Semantic Scholar
Therapeutic Peptides as Emerging Options to Restore Misguided Host Defence and Homeostasis: From Teaching to Concept to Clinic.
O. Schwardt, Christina Lamers, Clément Bechtler, D. Ricklin
2021Chimia (Basel)1 citations Open access
Semantic Scholar
CHAPTER 3. Discovery, Structural Refinement and Therapeutic Potential of Farnesoid X Receptor Activators
Christina Lamers, D. Merk
20201 citations
Semantic Scholar
Medizinische Chemie der β2‐Sympathomimetika
Christina Lamers, M. Schubert-Zsilavecz
20111 citations
Semantic Scholar
Author Correction: Factor XII signaling via uPAR-integrin β1 axis promotes tubular senescence in diabetic kidney disease
Ahmed Elwakiel, Dheerendra Gupta, Rajiv Rana, Jayakumar Manoharan +23 more
2026Nature Communications0 citations
Semantic Scholar
Tearing Down Scientific Boundaries: Frontiers in Medicinal Chemistry 2026.
Pascal Heitel, Philipp Barbie, Alessia Gambardella, Marta Pinto +6 more
2026ChemMedChem0 citations Open access
Semantic Scholar
Phage Display-Derived Cyclic Peptides as Ligand-Specific Modulators for β2-Integrin Receptors
Carla Johanna Sommer-Plüss, S. Vogt, Lorella Ciullo, R. Mancuso +4 more
2026bioRxiv0 citations Open access
Semantic Scholar
From Monomers to Dendrimers: Novel Synthetic Strategies for Highly Branched Peptide Nanostructures for Next-Generation Drug Delivery
Tom Götze-Ebert, Frida Fritzsche, Christina Lamers
2026Proceedings of the 38th European Peptide Symposium0 citations Open access
Semantic Scholar
Transcending Amino Acid Limitations: Enzymatic Halogenation for Phage Display Diversification
Richard Schreiter, Leonard Kaysser, Christina Lamers
2026Proceedings of the 38th European Peptide Symposium0 citations Open access
Semantic Scholar
New Analogs of the Compstatin Family of Clinical Complement Inhibitors with Low Picomolar Target Affinity
S. Vogt, Alexander J. Lander, Karl Herbine, Ekaterina Umnyakova +9 more
2026Journal of Medicinal Chemistry0 citations Open access
Semantic Scholar
A Warm Welcome to MedChem: The Frontiers in Medicinal Chemistry 2025
Matthias Schiedel, Marta Pinto, Andrea Unzue Lopez, Philipp Barbie +6 more
2025ChemMedChem0 citations Open access
Semantic Scholar
We are MedChem: The Frontiers in Medicinal Chemistry 2024
Matthias Schiedel, Philipp Barbie, Felix Pape, Marta Pinto +6 more
2024ChemMedChem0 citations
Semantic Scholar
158 Structure-guided design of derivatives of the complement inhibitor compstatin with improved species specificity profiles
Stephanie Anita Vogt, R. Aschwanden, Christina Lamers, Alexander John Lander +7 more
2023Immunobiology0 citations Open access
Semantic Scholar
109 Investigation of complement-related integrin receptors using a screening platform and newly developed tool compounds
Christina Lamers, C. Sommer, Céline Leiggener, S. Vogt +5 more
2023Immunobiology0 citations Open access
Semantic Scholar
Biochemie: Peptide mit hoher Bindungsaffinität
C. Heinis, Christina Lamers
20170 citations
Semantic Scholar
Schilddrüsenhormone: Wissenschaftliche Fakten für die Praxis
Christina Lamers, C. Ude, M. Wurglics
20120 citations
Semantic Scholar

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M. Schubert-Zsilavecz×17
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D. Merk×12
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D. Ricklin×11
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D. Flesch×7
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E. Proschak — researcher profile on SciRah

John D Lambris×6

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John D Lambris — researcher profile on SciRah

Matthias Gabler×5

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G. Schneider×4

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Astrid Kaiser×4

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