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D. Steinhilber · SciRah

Researcher profile · Semantic Scholar

D. Steinhilber

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D. Steinhilber — researcher profile on SciRah

h-index: 51
Works: 318
Citations: 11K

Most-cited papers

5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease.
O. Rådmark, O. Werz, D. Steinhilber, B. Samuelsson
2015Biochimica et Biophysica Acta486 citations
Semantic Scholar
Formation, Signaling and Occurrence of Specialized Pro-Resolving Lipid Mediators—What is the Evidence so far?
N. Schebb, Hartmut Kühn, A. Kahnt, K. Rund +14 more
2022Frontiers in Pharmacology180 citations Open access
Semantic Scholar
Aspirin prevents colorectal cancer metastasis in mice by splitting the crosstalk between platelets and tumor cells
P. Guillem-Llobat, M. Dovizio, Annalisa Bruno, E. Ricciotti +11 more
2016OncoTarget167 citations Open access
Semantic Scholar
Lipoxin and resolvin biosynthesis is dependent on 5‐lipoxygenase activating protein
Christoph Lehmann, Julia Homann, A. Ball, René Blöcher +12 more
2015The FASEB Journal83 citations Open access
Semantic Scholar
Mitochondrial Reactive Oxygen Species Formation Determines ACSL4/LPCAT2-Mediated Ferroptosis
M. Merkel, Bjarne Goebel, Moritz Boll, Aasha Adhikari +3 more
2023Antioxidants74 citations Open access
Semantic Scholar
A Dual Modulator of Farnesoid X Receptor and Soluble Epoxide Hydrolase To Counter Nonalcoholic Steatohepatitis.
Jurema Schmidt, Marco J. Rotter, T. Weiser, Sandra K. Wittmann +12 more
2017Journal of Medicinal Chemistry72 citations Open access
Semantic Scholar
Failure to apply standard limit-of-detection or limit-of-quantitation criteria to specialized pro-resolving mediator analysis incorrectly characterizes their presence in biological samples
V. O'Donnell, N. Schebb, Ginger L. Milne, M. P. Murphy +11 more
2023Nature Communications69 citations Open access
Semantic Scholar
Two‐pronged approach to anti‐inflammatory therapy through the modulation of the arachidonic acid cascade
A. Sala, E. Proschak, D. Steinhilber, Enrico G. Rovati
2018Biochemical Pharmacology63 citations
Semantic Scholar
S1PR4 ablation reduces tumor growth and improves chemotherapy via CD8+ T cell expansion.
C. Olesch, Evelyn Sirait-Fischer, M. Berkefeld, Annika F. Fink +9 more
2020Journal of Clinical Investigation59 citations Open access
Semantic Scholar
Iron-Dependent Trafficking of 5-Lipoxygenase and Impact on Human Macrophage Activation
B. Dufrusine, Andrea Di Francesco, S. Oddi, L. Scipioni +7 more
2019Frontiers in Immunology57 citations Open access
Semantic Scholar
Long-term stimulation of toll-like receptor-2 and -4 upregulates 5-LO and 15-LO-2 expression thereby inducing a lipid mediator shift in human monocyte-derived macrophages.
Roland Ebert, Rivelino Cumbana, Christoph Lehmann, Laura Kutzner +6 more
2020Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids51 citations Open access
Semantic Scholar
Challenges in the Development of a Thiol-Based Broad-Spectrum Inhibitor for Metallo-β-Lactamases.
Dominik Büttner, J. Kramer, Franca-Maria Klingler, Sandra K. Wittmann +10 more
2017ACS Infectious Diseases51 citations
Semantic Scholar
Small molecules with anti-inflammatory properties in clinical development.
T. Hanke, D. Merk, D. Steinhilber, G. Geisslinger +1 more
2016Pharmacology and Therapeutics51 citations
Semantic Scholar
N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase/Peroxisome Proliferator-Activated Receptor γ Modulators.
René Blöcher, Christina Lamers, Sandra K. Wittmann, D. Merk +19 more
2016Journal of Medicinal Chemistry49 citations Open access
Semantic Scholar
Formation of Lipoxins and Resolvins in Human Leukocytes.
A. Kahnt, N. Schebb, D. Steinhilber
2023Prostaglandins & other lipid mediators46 citations Open access
Semantic Scholar
The Emerging Therapeutic Potential of Nitro Fatty Acids and Other Michael Acceptor-Containing Drugs for the Treatment of Inflammation and Cancer
M. Piesche, J. Roos, Benjamin Kühn, Jasmin Fettel +11 more
2020Frontiers in Pharmacology44 citations Open access
Semantic Scholar
Apoptotic Cancer Cells Suppress 5-Lipoxygenase in Tumor-Associated Macrophages
Julia Ringleb, E. Strack, C. Angioni, G. Geisslinger +3 more
2018Journal of Immunology41 citations
Semantic Scholar
L-thyroxin and the non-classical thyroid hormone TETRAC are potent activators of PPARγ.
L. Gellrich, Pascal Heitel, J. Heering, Whitney Kilu +15 more
2020Journal of Medicinal Chemistry39 citations Open access
Semantic Scholar
Sphingosine‐1‐phosphate (S1P) induces potent anti‐inflammatory effects in vitro and in vivo by S1P receptor 4‐mediated suppression of 5‐lipoxygenase activity
Jasmin Fettel, Benjamin Kühn, Nathalie Guillen, D. Sürün +12 more
2018The FASEB Journal37 citations
Semantic Scholar
Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain
J. Kramer, Stefano Woltersdorf, T. Duflot, Kerstin Hiesinger +22 more
2019Journal of Medicinal Chemistry36 citations Open access
Semantic Scholar
Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology.
S. Schierle, Cathrin Flauaus, Pascal Heitel, Sabine Willems +12 more
2018Journal of Medicinal Chemistry36 citations Open access
Semantic Scholar
Novel insights into the regulation of cyclooxygenase-2 expression by platelet-cancer cell cross-talk
M. Dovizio, S. Alberti, A. Sacco, P. Guillem-Llobat +4 more
2015Biochemical Society Transactions35 citations Open access
Semantic Scholar
Beyond leukotriene formation-The noncanonical functions of 5-lipoxygenase.
Ann-Kathrin Häfner, A. Kahnt, D. Steinhilber
2019Prostaglandins & other lipid mediators33 citations Open access
Semantic Scholar
Epigenetic Regulation of Angiogenesis by JARID1B-Induced Repression of HOXA5
Christian Fork, Lunda Gu, Juliane Hitzel, I. Josipovic +11 more
2015Arteriosclerosis, Thrombosis and Vascular Biology33 citations
Semantic Scholar
Regulation of tumorigenic Wnt signaling by cyclooxygenase-2, 5-lipoxygenase and their pharmacological inhibitors: A basis for novel drugs targeting cancer cells?
J. Roos, S. Grösch, O. Werz, P. Schröder +13 more
2016Pharmacology and Therapeutics31 citations
Semantic Scholar
Heterodimer formation with retinoic acid receptor RXRα modulates coactivator recruitment by peroxisome proliferator-activated receptor PPARγ
Whitney Kilu, D. Merk, D. Steinhilber, E. Proschak +1 more
2021Journal of Biological Chemistry30 citations Open access
Semantic Scholar
The Histone Demethylase PHF8 Is Essential for Endothelial Cell Migration
Lunda Gu, Juliane Hitzel, F. Moll, Christoph Kruse +7 more
2016PLoS ONE30 citations Open access
Semantic Scholar
miR‐574‐5p as RNA decoy for CUGBP1 stimulates human lung tumor growth by mPGES‐1 induction
M. J. Saul, Isabell Baumann, Annalisa Bruno, Anne C. Emmerich +18 more
2019The FASEB Journal29 citations
Semantic Scholar
How to effectively treat acute leukemia patients bearing MLL-rearrangements ?
D. Steinhilber, R. Marschalek
2018Biochemical Pharmacology29 citations Open access
Semantic Scholar
On the biosynthesis of specialized pro-resolving mediators in human neutrophils and the influence of cell integrity.
M. Mainka, S. George, C. Angioni, Roland Ebert +8 more
2021Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids28 citations Open access
Semantic Scholar
Zafirlukast Is a Dual Modulator of Human Soluble Epoxide Hydrolase and Peroxisome Proliferator-Activated Receptor γ
Tamara Göbel, O. Diehl, J. Heering, D. Merk +12 more
2019Frontiers in Pharmacology27 citations Open access
Semantic Scholar
Exploring CYP2J2: lipid mediators, inhibitors and therapeutic implications.
Marco Sisignano, D. Steinhilber, M. J. Parnham, G. Geisslinger
2020Drug Discovery Today25 citations
Semantic Scholar
The endocannabinoid anandamide has an anti-inflammatory effect on CCL2 expression in vascular smooth muscle cells
Beatrice Pflüger-Müller, James A. Oo, J. Heering, T. Warwick +12 more
2020Basic Research in Cardiology24 citations Open access
Semantic Scholar
Inhibitors of Human 5-Lipoxygenase Potently Interfere With Prostaglandin Transport
A. Kahnt, C. Angioni, Tamara Göbel, B. Hofmann +9 more
2022Frontiers in Pharmacology23 citations Open access
Semantic Scholar
Anti‐inflammatory nitro‐fatty acids suppress tumor growth by triggering mitochondrial dysfunction and activation of the intrinsic apoptotic pathway in colorectal cancer cells
Benjamin Kühn, Camilla Brat, Jasmin Fettel, Nadine Hellmuth +13 more
2018Biochemical Pharmacology23 citations
Semantic Scholar
Design, Synthesis and Cellular Characterization of a Dual Inhibitor of 5-Lipoxygenase and Soluble Epoxide Hydrolase
Karin Meirer, D. Glatzel, Simon B. M. Kretschmer, Sandra K. Wittmann +8 more
2016Molecules22 citations Open access
Semantic Scholar
Michael acceptor containing drugs are a novel class of 5‐lipoxygenase inhibitor targeting the surface cysteines C416 and C418
Isabelle V. Maucher, Michael Rühl, Simon B. M. Kretschmer, B. Hofmann +17 more
2017Biochemical Pharmacology21 citations
Semantic Scholar
Camptothecin and its analog SN‐38, the active metabolite of irinotecan, inhibit binding of the transcriptional regulator and oncoprotein FUBP1 to its DNA target sequence FUSE
S. K. Hosseini, S. Kolterer, Marlene Steiner, V. von Manstein +12 more
2017Biochemical Pharmacology21 citations Open access
Semantic Scholar
UPF1 regulates myeloid cell functions and S100A9 expression by the hnRNP E2/miRNA-328 balance
M. J. Saul, S. Stein, M. Grez, P. Jakobsson +2 more
2016Scientific Reports21 citations Open access
Semantic Scholar
Cellular analysis of the histamine H4 receptor in human myeloid cells.
Ricardo Capelo, Christoph Lehmann, K. Ahmad, Ryan G. Snodgrass +7 more
2016Biochemical Pharmacology21 citations
Semantic Scholar
Development of novel aminothiazole-comprising 5-LO inhibitors.
Simon B. M. Kretschmer, Stefano Woltersdorf, Carmen B. Rödl, D. Vogt +4 more
2016Future Medicinal Chemistry20 citations
Semantic Scholar
Regulation of Eicosanoid Pathways by MicroRNAs
M. J. Saul, Anne C. Emmerich, D. Steinhilber, Beatrix Suess
2019Frontiers in Pharmacology19 citations Open access
Semantic Scholar
Human 5-lipoxygenase regulates transcription by association to euchromatin.
Marius Kreiß, Julia H. Oberlis, S. Seuter, I. Bischoff-Kont +9 more
2022Biochemical Pharmacology16 citations Open access
Semantic Scholar
Analysis of proximal ALOX5 promoter binding proteins by quantitative proteomics
Katharina Schlag, D. Steinhilber, M. Karas, B. Sorg
2020The FEBS Journal16 citations Open access
Semantic Scholar
Combined Proteomic and In Silico Target Identification Reveal a Role for 5-Lipoxygenase in Developmental Signaling Pathways.
Silke Brand, Sayantani Roy, P. Schröder, Bernd Rathmer +13 more
2018Cell Chemical Biology16 citations Open access
Semantic Scholar
CarbORev‐5901: The First Carborane‐Based Inhibitor of the 5‐Lipoxygenase Pathway
R. Kuhnert, Menyhárt B. Sárosi, S. George, P. Lönnecke +6 more
2017ChemMedChem16 citations
Semantic Scholar
Design, Synthesis, and Structure-Activity Relationship Studies of Dual Inhibitors of Soluble Epoxide Hydrolase and 5-Lipoxygenase.
Kerstin Hiesinger, J. Kramer, Sandra Beyer, Timon Eckes +18 more
2020Journal of Medicinal Chemistry15 citations Open access
Semantic Scholar
Melleolides from Honey Mushroom Inhibit 5-Lipoxygenase via Cys159.
Stefanie König, Erik Romp, Verena Krauth, Michael Rühl +9 more
2019Cell Chemical Biology15 citations Open access
Semantic Scholar
AF4 and AF4N protein complexes: recruitment of P-TEFb kinase, their interactome and potential functions.
Bastian Scholz, E. Kowarz, T. Rössler, K. Ahmad +2 more
2015American Journal of Blood Research15 citations
Semantic Scholar
Development and evaluation of ST-1829 based on 5-benzylidene-2-phenylthiazolones as promising agent for anti-leukotriene therapy.
Andreas Lill, Carmen B. Rödl, D. Steinhilber, H. Stark +1 more
2015European journal of medicinal chemistry15 citations Open access
Semantic Scholar

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