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Todd Hager · SciRah

Researcher profile · Semantic Scholar

Todd Hager

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Todd Hager — researcher profile on SciRah

h-index: 15
Works: 18
Citations: 2,087

Most-cited papers

Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models--association with liver and adipose tissue effects.
Jing Xu, Shanaka Stanislaus, N. Chinookoswong, Yvonne Y. Lau +12 more
2009American Journal of Physiology. Endocrinology and Metabolism340 citations
Semantic Scholar
Treating Diabetes and Obesity with an FGF21-Mimetic Antibody Activating the βKlotho/FGFR1c Receptor Complex
I. Foltz, S. Hu, C. King, Xinle Wu +22 more
2012Science Translational Medicine215 citations
Semantic Scholar
Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models
Elizabeth A. Killion, Jing-Hong Wang, J. Yie, S. Shi +22 more
2018Science Translational Medicine207 citations
Semantic Scholar
Lack of overt FGF21 resistance in two mouse models of obesity and insulin resistance.
C. Hale, Michelle M. Chen, Shanaka Stanislaus, N. Chinookoswong +4 more
2012Endocrinology194 citations Open access
Semantic Scholar
FGF19-induced Hepatocyte Proliferation Is Mediated through FGFR4 Activation
Xinle Wu, Hongfei Ge, B. Lemon, S. Vonderfecht +7 more
2009Journal of Biological Chemistry184 citations Open access
Semantic Scholar
A GIPR antagonist conjugated to GLP-1 analogues promotes weight loss with improved metabolic parameters in preclinical and phase 1 settings
M. Véniant, Shu-Chen Lu, Larissa I. Atangan, R. Komorowski +16 more
2024Nature Metabolism178 citations Open access
Semantic Scholar
Rationale-Based Engineering of a Potent Long-Acting FGF21 Analog for the Treatment of Type 2 Diabetes
R. Hecht, Yue-sheng Li, Jeonghoon Sun, Ed Belouski +17 more
2012PLoS ONE168 citations Open access
Semantic Scholar
Long-acting FGF21 has enhanced efficacy in diet-induced obese mice and in obese rhesus monkeys.
M. Véniant, R. Komorowski, Ping Chen, Shanaka Stanislaus +6 more
2012Endocrinology144 citations
Semantic Scholar
Chronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism
Elizabeth A. Killion, Michelle M. Chen, James R. Falsey, Glenn Sivits +9 more
2020Nature Communications129 citations Open access
Semantic Scholar
A Novel Fc-FGF21 With Improved Resistance to Proteolysis, Increased Affinity Toward &bgr;-Klotho, and Enhanced Efficacy in Mice and Cynomolgus Monkeys
Shanaka Stanislaus, R. Hecht, J. Yie, Todd Hager +12 more
2017Endocrinology98 citations
Semantic Scholar
GIPR antagonist antibodies conjugated to GLP-1 peptide are bispecific molecules that decrease weight in obese mice and monkeys
Shu-Chen Lu, Michelle M. Chen, Larissa I. Atangan, Elizabeth A. Killion +13 more
2021Cell Reports Medicine84 citations Open access
Semantic Scholar
Differential enzyme-linked immunosorbent assay and ligand-binding mass spectrometry for analysis of biotransformation of protein therapeutics: application to various FGF21 modalities.
Todd Hager, Chris Spahr, Jing Xu, H. Salimi-Moosavi +1 more
2013Analytical Chemistry63 citations
Semantic Scholar
Coal liquefaction and catalysis
F. Derbyshire, Todd Hager
199339 citations
Semantic Scholar
Lack of Overt FGF 21 Resistance in Two Mouse Models of Obesity and Insulin Resistance
C. Hale, Michelle M. Chen, Shanaka Stanislaus, N. Chinookoswong +4 more
201118 citations
Semantic Scholar
Implementation of a universal analytical method in early-stage development of human antibody therapeutics: application to pharmacokinetic assessment for candidate selection.
Judy Y Shih, Vimal Patel, Andrew Watson, Todd Hager +3 more
2012Bioanalysis17 citations
Semantic Scholar
Discovery of Selective Pituitary Adenylate Cyclase 1 Receptor (PAC1R) Antagonist Peptides Potent in a Maxadilan/PACAP38-Induced Increase in Blood Flow Pharmacodynamic Model.
E. Hu, Fang-Tsao Hong, Jennifer Aral, J. Long +13 more
2021Journal of Medicinal Chemistry6 citations Open access
Semantic Scholar
A multifactorial screening strategy to identify anti-idiotypic reagents for bioanalytical support of antibody therapeutics.
H. Salimi-Moosavi, A. Winters, Christina M. Abbott, Jennifer Patel +5 more
2015Analytical Biochemistry5 citations
Semantic Scholar
Discovery of AMG 133, a Glucose-Dependent Insulinotropic Polypeptide Receptor Antagonist and Glucagon-Like Peptide 1 Receptor Agonist Antibody-Drug Conjugate for the Treatment of Obesity
Bin Wu, James R. Falsey, Chawita Netirojjanakul, B. Herberich +16 more
2026Journal of Medicinal Chemistry3 citations
Semantic Scholar

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Shanaka Stanislaus×9
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Jing Xu×6
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Shu-Chen Lu — researcher profile on SciRah

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Jennifer Weiszmann×4

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