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Timothy Y. Huang · SciRah

Researcher profile · Semantic Scholar

Timothy Y. Huang

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Timothy Y. Huang — researcher profile on SciRah

h-index: 31
Works: 60
Citations: 4,511

Most-cited papers

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease
Tiantian Guo, Deng-Hong Zhang, Yu-Zhe Zeng, Timothy Y. Huang +2 more
2020Molecular Neurodegeneration803 citations Open access
Semantic Scholar
TREM2 is a receptor for β-amyloid which mediates microglial function
Yingjun Zhao, Xi-Lin Wu, Xiaoguang Li, Lu-Lin Jiang +12 more
2018Neuron662 citations Open access
Semantic Scholar
Cofilin phosphatases and regulation of actin dynamics.
Timothy Y. Huang, C. Dermardirossian, G. Bokoch
2006Current Opinion in Cell Biology363 citations
Semantic Scholar
Dysregulation of Ubiquitin-Proteasome System in Neurodegenerative Diseases
Qiuyang Zheng, Timothy Y. Huang, Lishan Zhang, Ying Zhou +3 more
2016Frontiers in Aging Neuroscience280 citations Open access
Semantic Scholar
Menin Deficiency Leads to Depressive-like Behaviors in Mice by Modulating Astrocyte-Mediated Neuroinflammation.
Lige Leng, Kai Zhuang, Ze-Yue Liu, Changquan Huang +20 more
2018Neuron223 citations Open access
Semantic Scholar
Reactive oxygen species regulate a slingshot-cofilin activation pathway.
Jun-Sub Kim, Timothy Y. Huang, G. Bokoch
2009Molecular Biology of the Cell188 citations Open access
Semantic Scholar
Dysregulation of protein trafficking in neurodegeneration
Xin Wang, Timothy Y. Huang, Guo-Jun Bu, Hua-Xi Xu
2014Molecular Neurodegeneration123 citations Open access
Semantic Scholar
Trem2 deletion enhances tau dispersion and pathology through microglia exosomes
Bing Zhu, Yan Liu, S. Hwang, Kailey J. Archuleta +6 more
2022Molecular Neurodegeneration111 citations Open access
Semantic Scholar
Pnk1, a DNA Kinase/Phosphatase Required for Normal Response to DNA Damage by γ-Radiation or Camptothecin inSchizosaccharomyces pombe *
M. Meijer, Feridoun Karimi-Busheri, Timothy Y. Huang, M. Weinfeld +1 more
2002Journal of Biological Chemistry106 citations Open access
Semantic Scholar
Chronophin mediates an ATP-sensing mechanism for cofilin dephosphorylation and neuronal cofilin-actin rod formation
Timothy Y. Huang, L. Minamide, J. Bamburg, G. Bokoch
2008Developmental Cell100 citations Open access
Semantic Scholar
Amyloid, tau, pathogen infection and antimicrobial protection in Alzheimer’s disease –conformist, nonconformist, and realistic prospects for AD pathogenesis
Hongmei Li, Chia-Chen Liu, Hui Zheng, Timothy Y. Huang
2018Translational Neurodegeneration99 citations Open access
Semantic Scholar
Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis
Yingjun Zhao, I-Chu Tseng, C. Heyser, E. Rockenstein +15 more
2015Neuron96 citations Open access
Semantic Scholar
The Retromer Complex and Sorting Nexins in Neurodegenerative Diseases
Hongfeng Zhang, Timothy Y. Huang, Yujuan Hong, Weijie Yang +4 more
2018Frontiers in Aging Neuroscience79 citations Open access
Semantic Scholar
Isolation and Characterization of Cytoplasmic Cofilin-Actin Rods*
L. Minamide, S. Maiti, Judith A. Boyle, Richard C. Davis +6 more
2009Journal of Biological Chemistry77 citations Open access
Semantic Scholar
β-Arrestins Scaffold Cofilin with Chronophin to Direct Localized Actin Filament Severing and Membrane Protrusions Downstream of Protease-activated Receptor-2*
M. Zoudilova, Jungah Min, Heddie L. Richards, David R F Carter +2 more
2010Journal of Biological Chemistry75 citations Open access
Semantic Scholar
Sorting Nexin 27 Regulates Aβ Production through Modulating γ-secretase Activity
Xin Wang, Timothy Y. Huang, Yingjun Zhao, Qiuyang Zheng +5 more
2014Cell Reports71 citations Open access
Semantic Scholar
β_2-Microglobulin coaggregates with Aβ and contributes to amyloid pathology and cognitive deficits in Alzheimer’s disease model mice
Yini Zhao, Qiuyang Zheng, Yujuan Hong, Yue Gao +13 more
2023Nature Neuroscience70 citations
Semantic Scholar
ER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity
Bing Zhu, Lu-Lin Jiang, Timothy Y. Huang, Yingjun Zhao +8 more
2017Nature Communications70 citations Open access
Semantic Scholar
P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting p-tau217 with immunotherapy ameliorates murine tauopathy.
Deng-Hong Zhang, Wei Zhang, Ming Chen, Xu-Heng Gao +15 more
2024Neuron68 citations
Semantic Scholar
Inhibition of PKCδ reduces amyloid-β levels and reverses Alzheimer disease phenotypes
Ying Du, Yingjun Zhao, Chuan-Bo Li, Qiuyang Zheng +5 more
2018Journal of Experimental Medicine66 citations Open access
Semantic Scholar
β2-microglobulin functions as an endogenous NMDAR antagonist to impair synaptic function.
Yue Gao, Yujuan Hong, Lihong Huang, Shuang Zheng +21 more
2023Cell63 citations Open access
Semantic Scholar
Multi-omic comparison of Alzheimer’s variants in human ESC–derived microglia reveals convergence at APOE
Tongfei Liu, Bing Zhu, Yan Liu, Xiaoming Zhang +12 more
2020Journal of Experimental Medicine58 citations Open access
Semantic Scholar
USP25 inhibition ameliorates Alzheimer’s pathology through the regulation of APP processing and Aβ generation
Qiuyang Zheng, Beibei Song, Guilin Li, Fang Cai +26 more
2022Journal of Clinical Investigation56 citations Open access
Semantic Scholar
SNX27 and SORLA Interact to Reduce Amyloidogenic Subcellular Distribution and Processing of Amyloid Precursor Protein
Timothy Y. Huang, Yingjun Zhao, Xiaoguang Li, Xin Wang +6 more
2016Journal of Neuroscience56 citations Open access
Semantic Scholar
LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions
Penghui Zhao, Yuanzhong Xu, Lu-Lin Jiang, Xuejun Fan +13 more
2022Molecular Neurodegeneration51 citations Open access
Semantic Scholar
Membralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment.
Lu-Lin Jiang, Bing Zhu, Yingjun Zhao, Xiaoguang Li +13 more
2019Journal of Clinical Investigation39 citations Open access
Semantic Scholar
SORLA attenuates EphA4 signaling and amyloid β–induced neurodegeneration
Timothy Y. Huang, Yingjun Zhao, Lu-Lin Jiang, Xiaoguang Li +8 more
2017Journal of Experimental Medicine38 citations Open access
Semantic Scholar
Cyclin-Dependent Kinase 5-Dependent BAG3 Degradation Modulates Synaptic Protein Turnover.
Jie-Chao Zhou, Hei-Man Chow, Yan Liu, Di Wu +23 more
2019Biological Psychiatry36 citations Open access
Semantic Scholar
SNX27 Deletion Causes Hydrocephalus by Impairing Ependymal Cell Differentiation and Ciliogenesis
Xin Wang, Ying Zhou, Jian Wang, I-Chu Tseng +9 more
2016Journal of Neuroscience34 citations Open access
Semantic Scholar
The deubiquitinase USP6 affects memory and synaptic plasticity through modulating NMDA receptor stability
Fan-Wei Zeng, Xue-Fei Ma, Lin Zhu, Qiang Xu +27 more
2019PLoS Biology32 citations Open access
Semantic Scholar
Role of Rab GTPases in Alzheimer's Disease.
Xian Zhang, Timothy Y. Huang, Joel Yancey, Hong Luo +1 more
2018ACS Chemical Neuroscience32 citations
Semantic Scholar
RPS23RG1 is Required for Synaptic Integrity and Rescues Alzheimer’s Associated Cognitive Deficits
Dongdong Zhao, Jian Meng, Yingjun Zhao, Y. Huo +20 more
2018Biological Psychiatry31 citations Open access
Semantic Scholar
Nak1, an Essential Germinal Center (GC) Kinase Regulates Cell Morphology and Growth in Schizosaccharomyces pombe *
Timothy Y. Huang, N. Markley, D. Young
2002Journal of Biological Chemistry31 citations Open access
Semantic Scholar
GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer’s disease
Peng Xu, Jerry C. Chang, Xiao-Pu Zhou, Wei Wang +12 more
2021Journal of Experimental Medicine30 citations Open access
Semantic Scholar
Neuron-specific menin deletion leads to synaptic dysfunction and cognitive impairment by modulating p35 expression
Kai Zhuang, Changquan Huang, Lige Leng, Hong-Hua Zheng +15 more
2018Cell Reports26 citations Open access
Semantic Scholar
Oncogene regulation of tumor suppressor genes in tumorigenesis.
Jimmy C. Sung, J. Turner, S. McCarthy, Steven Enkemann +4 more
2004Carcinogenesis25 citations Open access
Semantic Scholar
Intracellular trafficking of TREM2 is regulated by presenilin 1
Yingjun Zhao, Xiaoguang Li, Timothy Y. Huang, Lu-Lin Jiang +8 more
2017Experimental and Molecular Medicine23 citations Open access
Semantic Scholar
Nak1 interacts with Hob1 and Wsp1 to regulate cell growth and polarity in Schizosaccharomyces pombe
Timothy Y. Huang, M. Renaud-Young, D. Young
2005Journal of Cell Science23 citations
Semantic Scholar
Soluble SORLA Enhances Neurite Outgrowth and Regeneration through Activation of the EGF Receptor/ERK Signaling Axis
Jessica Stupack, Xiao-Peng Xiong, Lu-Lin Jiang, Tong-Mei Zhang +7 more
2020Journal of Neuroscience19 citations Open access
Semantic Scholar
RPS23RG1 modulates tau phosphorylation and axon outgrowth through regulating p35 proteasomal degradation
Dongdong Zhao, Yunqiang Zhou, Y. Huo, Jian Meng +12 more
2020Cell Death and Differentiation18 citations Open access
Semantic Scholar
A novel Rac1 GAP splice variant relays poly-Ub accumulation signals to mediate Rac1 inactivation
Timothy Y. Huang, Sarah Michael, Tao Xu, Ali Sarkeshik +5 more
2013Molecular Biology of the Cell18 citations Open access
Semantic Scholar
SNX8 Enhances Non-amyloidogenic APP Trafficking and Attenuates Aβ Accumulation and Memory Deficits in an AD Mouse
Yongzhuang Xie, Mengxi Niu, Chengxiang Ji, Timothy Y. Huang +10 more
2019Frontiers in Cellular Neuroscience12 citations Open access
Semantic Scholar
RPS23RG1 reduces Aβ oligomer-induced synaptic and cognitive deficits
Li Yan, Yao-Min Chen, Wu-Bo Li, Xiumei Huang +10 more
2016Scientific Reports12 citations Open access
Semantic Scholar
Appoptosin Mediates Lesions Induced by Oxidative Stress Through the JNK-FoxO1 Pathway
Cui-Lin Zhang, Zhenqiu Tan, Yongzhuang Xie, Yingjun Zhao +7 more
2019Frontiers in Aging Neuroscience11 citations Open access
Semantic Scholar
Bringing Order Out of Chaos: Establishing an Epistatic Relationship Between CD33 and TREM2
Timothy Y. Huang, Hua-Xi Xu
2019Neuron6 citations Open access
Semantic Scholar
SNX17 Mediates Dendritic Spine Maturation via p140Cap
Qi Cui, Shiqi Liang, Hao Li, Yi-Qing Guo +8 more
2023Molecular Neurobiology4 citations
Semantic Scholar
GSAP regulates mitochondrial function through the Mitochondria-associated ER membrane in the pathogenesis of Alzheimer’s disease
Peng Xu, Jerry C. Chang, Xiao-Pu Zhou, Wei Wang +12 more
2020bioRxiv1 citations Open access
Semantic Scholar
Neurobiology of Disease SNX 27 and SORLA Interact to Reduce Amyloidogenic Subcellular Distribution and Processing of Amyloid Precursor Protein
Timothy Y. Huang, Yingjun Zhao, Xiaoguang Li, Xin Wang +6 more
20171 citations
Semantic Scholar
Dysregulation of protein trafficking in neurodegeneration
Xin Wang, Timothy Y. Huang, Guo-Jun Bu, Hua-Xi Xu
2014Molecular Neurodegeneration1 citations Open access
Semantic Scholar
Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis.
Yingjun Zhao, I. Tseng, C. Heyser, E. Rockenstein +15 more
2024Neuron0 citations Open access
Semantic Scholar

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