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R. Di Fabio · SciRah

Researcher profile · Semantic Scholar

R. Di Fabio

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R. Di Fabio — researcher profile on SciRah

h-index: 23
Works: 125
Citations: 1,543

Most-cited papers

1,2,4-Triazol-3-yl-thiopropyl-tetrahydrobenzazepines: A Series of Potent and Selective Dopamine D3 Receptor Antagonists
F. Micheli, G. Bonanomi, F. Blaney, S. Braggio +36 more
200775 citations Open access
Semantic Scholar
6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane: a new potent and selective triple reuptake inhibitor.
F. Micheli, P. Cavanni, D. Andreotti, R. Arban +27 more
2010Journal of Medicinal Chemistry62 citations Open access
Semantic Scholar
Neurokinin 1 receptor antagonists--current prospects.
Giuseppe S. Alvaro, R. Di Fabio
2007Current opinion in drug discovery & development55 citations
Semantic Scholar
Discovery process and pharmacological characterization of a novel dual orexin 1 and orexin 2 receptor antagonist useful for treatment of sleep disorders.
R. Di Fabio, A. Pellacani, S. Faedo, A. Roth +19 more
2011Bioorganic & Medicinal Chemistry Letters53 citations Open access
Semantic Scholar
Discovery process and pharmacological characterization of 2-(S)-(4-fluoro-2-methylphenyl)piperazine-1-carboxylic acid [1-(R)-(3,5-bis-trifluoromethylphenyl)ethyl]methylamide (vestipitant) as a potent, selective, and orally active NK1 receptor antagonist.
R. Di Fabio, Cristiana Griffante, Giuseppe S. Alvaro, G. Pentassuglia +15 more
2009Journal of Medicinal Chemistry51 citations Open access
Semantic Scholar
Pyrrolo[1,2-a]pyrazine and pyrazolo[1,5-a]pyrazine: novel, potent, and selective series of Vasopressin 1b receptor antagonists.
R. Arban, Federica Bianchi, A. Buson, Susanna Cremonesi +8 more
2010Bioorganic & Medicinal Chemistry Letters42 citations Open access
Semantic Scholar
Synthesis and SAR of substituted tetrahydrocarbazole derivatives as new NPY-1 antagonists.
R. Di Fabio, R. Giovannini, Barbara Bertani, Manuela Borriello +8 more
2006Bioorganic & Medicinal Chemistry Letters42 citations Open access
Semantic Scholar
1-(Aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes and 6-(aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes: a new series of potent and selective triple reuptake inhibitors.
F. Micheli, P. Cavanni, R. Arban, Roberto Benedetti +22 more
2010Journal of Medicinal Chemistry40 citations Open access
Semantic Scholar
Phenylethynyl-pyrrolo[1,2-a]pyrazine: a new potent and selective tool in the mGluR5 antagonists arena.
F. Micheli, Barbara Bertani, Andrea Bozzoli, Luca Crippa +8 more
2008Bioorganic & Medicinal Chemistry Letters35 citations Open access
Semantic Scholar
Synthesis and pharmacological characterisation of 2,4-dicarboxy-pyrroles as selective non-competitive mGluR1 antagonists.
F. Micheli, R. Di Fabio, P. Cavanni, J. Rimland +18 more
2003Bioorganic & Medicinal Chemistry34 citations Open access
Semantic Scholar
Discovery of NBI-77860/GSK561679, a potent corticotropin-releasing factor (CRF1) receptor antagonist with improved pharmacokinetic properties.
John E. Tellew, M. Lanier, M. Moorjani, E. Lin +10 more
2010Bioorganic & Medicinal Chemistry Letters33 citations Open access
Semantic Scholar
Synthesis and pharmacological characterization of novel druglike corticotropin-releasing factor 1 antagonists.
R. Di Fabio, Y. St‐Denis, F. Sabbatini, D. Andreotti +24 more
2008Journal of Medicinal Chemistry33 citations Open access
Semantic Scholar
Discovery and biological characterization of (2R,4S)-1'-acetyl-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4,4'-bipiperidine-1-carboxamide as a new potent and selective neurokinin 1 (NK1) receptor antagonist clinical candidate.
R. Di Fabio, Giuseppe S. Alvaro, Cristiana Griffante, D. A. Pizzi +13 more
2011Journal of Medicinal Chemistry31 citations Open access
Semantic Scholar
From pyrroles to 1-oxo-2,3,4,9-tetrahydro-1H-beta-carbolines: a new class of orally bioavailable mGluR1 antagonists.
R. Di Fabio, F. Micheli, Giuseppe S. Alvaro, P. Cavanni +8 more
2007Bioorganic & Medicinal Chemistry Letters31 citations Open access
Semantic Scholar
Novel stereocontrolled addition of allylmetal reagents to alpha-imino esters: efficient synthesis of chiral tetrahydroquinoline derivatives.
R. Di Fabio, Giuseppe S. Alvaro, Barbara Bertani, D. Donati +4 more
2002Journal of Organic Chemistry30 citations
Semantic Scholar
1,2,4-triazol-3-yl-thiopropyl-tetrahydrobenzazepines: a series of potent and selective dopamine D(3) receptor antagonists.
F. Micheli, G. Bonanomi, F. Blaney, S. Braggio +36 more
2007Journal of Medicinal Chemistry28 citations
Semantic Scholar
Enantiomerically pure tetrahydroquinoline derivatives as in vivo potent antagonists of the glycine binding site associated to the NMDA receptor.
R. Di Fabio, E. Tranquillini, Barbara Bertani, Giuseppe S. Alvaro +12 more
2003Bioorganic & Medicinal Chemistry Letters25 citations
Semantic Scholar
Discovery Process and Characterization of Novel Carbohydrazide Derivatives as Potent and Selective GHSR1a Antagonists
F. Sabbatini, R. Di Fabio, M. Corsi, P. Cavanni +19 more
2010ChemMedChem24 citations
Semantic Scholar
Asymmetric synthesis of 2-(2-pyridyl)aziridines from 2-pyridineimines bearing stereogenic N-alkyl substituents and regioselective opening of the aziridine ring.
D. Savoia, Giuseppe S. Alvaro, R. Di Fabio, A. Gualandi +1 more
2006Journal of Organic Chemistry24 citations
Semantic Scholar
Synthesis and structure-activity relationship of N-(3-azabicyclo[3.1.0]hex-6-ylmethyl)-5-(2-pyridinyl)-1,3-thiazol-2-amines derivatives as NPY Y5 antagonists.
M. Biagetti, C. Leslie, Angelica Mazzali, Catia Seri +6 more
2010Bioorganic & Medicinal Chemistry Letters23 citations Open access
Semantic Scholar
2,4-Dicarboxy-pyrroles as selective non-competitive mGluR1 antagonists: further characterization of 3,5-dimethyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2-trimethyl-propyl) ester and structure-activity relationships.
F. Micheli, R. Di Fabio, F. Bordi, Palmina Cavallini +7 more
2003Bioorganic & Medicinal Chemistry Letters22 citations Open access
Semantic Scholar
Identification, biological characterization and pharmacophoric analysis of a new potent and selective NK1 receptor antagonist clinical candidate.
R. Di Fabio, Giuseppe S. Alvaro, S. Braggio, R. Carletti +12 more
2013Bioorganic & Medicinal Chemistry20 citations Open access
Semantic Scholar
Functional and binding kinetic studies make a distinction between OX1 and OX2 orexin receptor antagonists.
S. Faedo, E. Perdona', Marinella Antolini, R. Di Fabio +2 more
2012European Journal of Pharmacology19 citations
Semantic Scholar
Novel carbazole derivatives as NPY Y1 antagonists.
C. Leslie, R. Di Fabio, Francesca Bonetti, Manuela Borriello +12 more
2007Bioorganic & Medicinal Chemistry Letters19 citations Open access
Semantic Scholar
Chiral tetrahydroquinoline derivatives as potent anti-hyperalgesic agents in animal models of sustained inflammation and chronic neuropathic pain.
R. Di Fabio, Giuseppe S. Alvaro, Barbara Bertani, D. Donati +10 more
2007Bioorganic & Medicinal Chemistry Letters19 citations
Semantic Scholar
Highly Diastereoselective Synthesis of 2,6‐Di[1‐(2‐alkylaziridin‐1‐yl)alkyl]pyridines, Useful Ligands in Palladium‐Catalyzed Asymmetric Allylic Alkylation
D. Savoia, Giuseppe S. Alvaro, R. Di Fabio, C. Fiorelli +3 more
200619 citations
Semantic Scholar
New fused benzazepine as selective D3 receptor antagonists. Synthesis and biological evaluation. Part one: [h]-fused tricyclic systems.
F. Micheli, G. Bonanomi, S. Braggio, A. Capelli +13 more
2008Bioorganic & Medicinal Chemistry Letters18 citations Open access
Semantic Scholar
Benzoazepine derivative as potent antagonists of the glycine binding site associated to the NMDA receptor.
R. Di Fabio, F. Micheli, Davide Baraldi, Barbara Bertani +13 more
2003Il Farmaco17 citations
Semantic Scholar
Triazolyl Azabicyclo[3.1.0]hexanes: a Class of Potent and Selective Dopamine D3 Receptor Antagonists
G. Bonanomi, S. Braggio, A. Capelli, Anna Checchia +8 more
2010ChemMedChem16 citations
Semantic Scholar
Novel substituted tetrahydrotriazaacenaphthylene derivatives as potent CRF1 receptor antagonists.
G. Gentile, R. Di Fabio, F. Pavone, F. Sabbatini +4 more
2007Bioorganic & Medicinal Chemistry Letters16 citations Open access
Semantic Scholar
3-Methyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2-trimethyl-propyl) ester: an exploration of the C-2 position. Part I.
F. Micheli, R. Di Fabio, Roberto Benedetti, A. Capelli +11 more
2004Il Farmaco16 citations
Semantic Scholar
Novel imidazobenzazepine derivatives as dual H1/5-HT2A antagonists for the treatment of sleep disorders.
M. Gianotti, C. Corti, Sonia Delle Fratte, R. Di Fabio +5 more
2010Bioorganic & Medicinal Chemistry Letters15 citations Open access
Semantic Scholar
Asymmetric route to pyridines bearing a highly functionalized 2-alkyl substituent by aziridine ring-opening reactions.
D. Savoia, Giuseppe S. Alvaro, R. Di Fabio, A. Gualandi
2007Journal of Organic Chemistry13 citations Open access
Semantic Scholar
Efficient synthesis of novel benzo-[e]-[1,4]-diazepine derivatives
T. Messeri, G. Pentassuglia, R. Di Fabio
200113 citations
Semantic Scholar
Cyclopenta[d]pyrimidines and Dihydropyrrolo[2,3‐d]pyrimidines as Potent and Selective Corticotropin‐Releasing Factor 1 Receptor Antagonists
R. Arban, Roberto Benedetti, G. Bonanomi, A. Capelli +21 more
2007ChemMedChem12 citations
Semantic Scholar
Substituted tetraazaacenaphthylenes as potent CRF1 receptor antagonists for the treatment of depression and anxiety.
Y. St‐Denis, R. Di Fabio, G. Bernasconi, E. Castiglioni +14 more
2005Bioorganic & Medicinal Chemistry Letters12 citations
Semantic Scholar
Synthesis and pharmacological characterization of constrained analogues of Vestipitant as in vitro potent and orally active NK(1) receptor antagonists.
F. Sabbatini, R. Di Fabio, Cristiana Griffante, G. Pentassuglia +9 more
2010Bioorganic & Medicinal Chemistry Letters11 citations Open access
Semantic Scholar
Discovery of 1-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone (GSK163090), a Potent, selective, and orally active 5-HT1A/B/D receptor antagonist.
C. Leslie, M. Biagetti, Silvia Bison, S. Bromidge +13 more
2010Journal of Medicinal Chemistry11 citations Open access
Semantic Scholar
Synthesis and pharmacological characterization of 5-phenyl-2-[2-(1-piperidinylcarbonyl)phenyl]-2,3-dihydro-1H-pyrrolo[1,2-c]imidazol-1-ones: a new class of Neuropeptide S antagonists.
F. Micheli, R. Di Fabio, A. Giacometti, A. Roth +9 more
2010Bioorganic & Medicinal Chemistry Letters11 citations Open access
Semantic Scholar
New fused benzazepine as selective D3 receptor antagonists. Synthesis and biological evaluation. Part 2: [g]-fused and hetero-fused systems.
F. Micheli, G. Bonanomi, S. Braggio, A. Capelli +11 more
2008Bioorganic & Medicinal Chemistry Letters11 citations Open access
Semantic Scholar
From pyrroles to pyrrolo[1,2-a]pyrazinones: a new class of mGluR1 antagonists.
F. Micheli, P. Cavanni, R. Di Fabio, C. Marchioro +5 more
2006Bioorganic & Medicinal Chemistry Letters11 citations Open access
Semantic Scholar
Azabicyclo[3.1.0]hexane‐1‐carbohydrazides as Potent and Selective GHSR1a Ligands Presenting a Specific in vivo Behavior
F. Sabbatini, S. Melotto, G. Bernasconi, Steve M. Bromidge +14 more
2011ChemMedChem10 citations
Semantic Scholar
Stereospecific synthesis and structure-activity relationships of unsymmetrical 4,4-diphenylbut-3-enyl derivatives of nipecotic acid as GAT-1 inhibitors.
D. A. Pizzi, C. Leslie, R. Di Fabio, Catia Seri +7 more
2011Bioorganic & Medicinal Chemistry Letters10 citations Open access
Semantic Scholar
Oxa‐azaspiro Derivatives: a Novel Class of Triple Re‐uptake Inhibitors
Michela Bettati, P. Cavanni, R. Di Fabio, B. Oliosi +5 more
2010ChemMedChem10 citations
Semantic Scholar
Dopamine D(3) receptor antagonists: The quest for a potentially selective PET ligand. Part two: Lead optimization.
F. Micheli, I. Holmes, Luca Arista, G. Bonanomi +11 more
2009Bioorganic & Medicinal Chemistry Letters10 citations
Semantic Scholar
Dihydropyrrole[2,3-d]pyridine derivatives as novel corticotropin-releasing factor-1 antagonists: mapping of the receptor binding pocket by in silico docking studies.
R. Di Fabio, R. Arban, G. Bernasconi, S. Braggio +16 more
2008Journal of Medicinal Chemistry9 citations Open access
Semantic Scholar
Versatile assembly of the 2-carboxybenzo[b]azepine ring system
S. Giacobbe, R. Di Fabio
20019 citations
Semantic Scholar
Stereocontrolled synthesis of 5-azaspiro[2.3]hexane derivatives as conformationally “frozen” analogues of L-glutamic acid
Beatrice Bechi, D. Amantini, C. Tintori, M. Botta +1 more
2014Beilstein Journal of Organic Chemistry8 citations Open access
Semantic Scholar
Stereoselective synthesis of substituted 2,5-diazabicyclo[2.2.1]heptanes by iodine-mediated cyclization of optically pure compounds containing the 4,5-diamino-1,7-octadiene and 1,2-diamino-4-alkene moieties.
Giuseppe S. Alvaro, R. Di Fabio, A. Gualandi, C. Fiorelli +3 more
20078 citations Open access
Semantic Scholar
Asymmetric Synthesis of 1‐(2‐Pyrrolyl)alkylamines by the Addition of Organometallic Reagents to Chiral 2‐Pyrroleimines
Giuseppe S. Alvaro, R. Di Fabio, A. Gualandi, D. Savoia
20078 citations
Semantic Scholar

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D. Donati×25
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D. Donati — researcher profile on SciRah
F. Micheli×21
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F. Micheli — researcher profile on SciRah
Giuseppe S. Alvaro×14
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Giuseppe S. Alvaro — researcher profile on SciRah
F. Sabbatini×14
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F. Sabbatini — researcher profile on SciRah

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S. Braggio — researcher profile on SciRah

C. Marchioro×13

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C. Marchioro — researcher profile on SciRah

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A. Capelli — researcher profile on SciRah

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G. Gentile — researcher profile on SciRah

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M. Corsi — researcher profile on SciRah

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P. Cavanni — researcher profile on SciRah

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E. Ratti — researcher profile on SciRah

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Laura Zonzini — researcher profile on SciRah