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L. Sheiner · SciRah

Researcher profile · Semantic Scholar

L. Sheiner

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L. Sheiner — researcher profile on SciRah

h-index: 72
Works: 257
Citations: 22K

Most-cited papers

Adherence to protease inhibitors, HIV-1 viral load, and development of drug resistance in an indigent population
D. Bangsberg, F. Hecht, E. Charlebois, A. Zolopa +5 more
2000AIDS (London)1,131 citations Open access
Semantic Scholar
Learning versus confirming in clinical drug development
L. Sheiner
1997Clinical pharmacology and therapy620 citations
Semantic Scholar
The importance of modeling interoccasion variability in population pharmacokinetic analyses
M. Karlsson, L. Sheiner
1993Journal of pharmacokinetics and biopharmaceutics448 citations
Semantic Scholar
Population pharmacokinetics/pharmacodynamics of docetaxel in phase II studies in patients with cancer.
R. Bruno, D. Hille, A. Riva, N. Vivier +13 more
1998Journal of Clinical Oncology434 citations
Semantic Scholar
Building population pharmacokineticpharmacodynamic models. I. Models for covariate effects
J. Mandema, D. Verotta, L. Sheiner
1992Journal of pharmacokinetics and biopharmaceutics433 citations
Semantic Scholar
Evaluating Pharmacokinetic/Pharmacodynamic Models Using the Posterior Predictive Check
Y. Yano, S. L. Beal, L. Sheiner
2001Journal of Pharmacokinetics and Pharmacodynamics424 citations
Semantic Scholar
Simultaneous vs. Sequential Analysis for Population PK/PD Data I: Best-Case Performance
Li-Ping Zhang, S. L. Beal, L. Sheiner
2003Journal of Pharmacokinetics and Pharmacodynamics362 citations
Semantic Scholar
Pharmacokinetic/pharmacodynamic modeling in drug development.
L. Sheiner, J. Steimer
2000Annual Review of Pharmacology and Toxicology328 citations
Semantic Scholar
Intention‐to‐treat analysis and the goals of clinical trials
L. Sheiner, D. Rubin
1995Clinical pharmacology and therapy327 citations
Semantic Scholar
Comparison of the Akaike Information Criterion, the Schwarz criterion and the F test as guides to model selection
T. Ludden, S. L. Beal, L. Sheiner
1994Journal of pharmacokinetics and biopharmaceutics271 citations
Semantic Scholar
A population pharmacokinetic model for docetaxel (Taxotere®): Model building and validation
R. Bruno, N. Vivier, J. C. Vergniol, Susan L. De Phillips +2 more
1996Journal of pharmacokinetics and biopharmaceutics212 citations
Semantic Scholar
Dual vs single protease inhibitor therapy following antiretroviral treatment failure: a randomized trial.
S. Hammer, F. Vaida, K. Bennett, M. K. Holohan +15 more
2002Journal of the American Medical Association (JAMA)195 citations
Semantic Scholar
Opportunities for Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development
C. Peck, W. H. Barr, L. Benet, J. Collins +16 more
1992Clinical pharmacology and therapy181 citations
Semantic Scholar
Population Pharmacokinetics and Pharmacodynamics of Efavirenz, Nelfinavir, and Indinavir: Adult AIDS Clinical Trial Group Study 398
M. Pfister, L. Labbé, S. Hammer, J. Mellors +3 more
2003Antimicrobial Agents and Chemotherapy148 citations Open access
Semantic Scholar
A pharmacodynamic model of erythropoietin therapy for uremic anemia
D. Uehlinger, F. Gotch, L. Sheiner
1992Clinical pharmacology and therapy143 citations
Semantic Scholar
Characterizing patterns of drug‐taking behavior with a multiple drug regimen in an AIDS clinical trial
H. Kastrissios, José-Ramón Suárez, D. Katzenstein, P. Girard +2 more
1998AIDS (London)122 citations Open access
Semantic Scholar
Three new residual error models for population PK/PD analyses
M. Karlsson, S. L. Beal, L. Sheiner
1995Journal of pharmacokinetics and biopharmaceutics122 citations
Semantic Scholar
A new approach to the analysis of analgesic drug trials, illustrated with bromfenac data
L. Sheiner
1994Clinical pharmacology and therapy114 citations
Semantic Scholar
Simultaneous vs. Sequential Analysis for Population PK/PD Data II: Robustness of Methods
Li-Ping Zhang, S. L. Beal, L. Sheiner
2003Journal of Pharmacokinetics and Pharmacodynamics100 citations
Semantic Scholar
Population Pharmacokinetics of Nevirapine, Zidovudine, and Didanosine in Human Immunodeficiency Virus-Infected Patients
Xiao-Jian Zhou, L. Sheiner, R. D'Aquila, M. Hughes +5 more
1999Antimicrobial Agents and Chemotherapy99 citations Open access
Semantic Scholar
Pharmacokinetic‐pharmacodynamic modeling of caffeine: Tolerance to pressor effects
Jun Shi, Neal L. Benowitz, C. Denaro, L. Sheiner
1993Clinical pharmacology and therapy98 citations
Semantic Scholar
Population modelling in drug development
L. Sheiner, J. Wakefield
1999Statistical Methods in Medical Research95 citations
Semantic Scholar
A Markov mixed effect regression model for drug compliance.
Pascal Girard, Terrence F. Blaschke, Helen Kastrissios, L. Sheiner
1998Statistics in Medicine93 citations
Semantic Scholar
Analysis of Nonrandomly Censored Ordered Categorical Longitudinal Data from Analgesic Trials
L. Sheiner, S. L. Beal, A. Dunne
199785 citations
Semantic Scholar
The design and implementation of a ventilator-management advisor
Geoffrey W. Rutledge, G. Thomsen, B. Farr, M. A. Tovar +4 more
1993Artif. Intell. Medicine78 citations
Semantic Scholar
A population model for the leukopenic effect of etoposide
M. O. Karlsson, R. Port, M. Ratain, L. Sheiner
1995Clinical pharmacology and therapy77 citations
Semantic Scholar
Comparison of Twitch Depression of the Adductor Pollicis and the Respiratory Muscles Pharmacodynamic Modeling without Plasma Concentrations
P. Bragg, D. Fisher, Jun Shi, F. Donati +3 more
1994Anesthesiology72 citations Open access
Semantic Scholar
Hypothesis: A single clinical trial plus causal evidence of effectiveness is sufficient for drug approval
Carl C. Peck, D. Rubin, L. Sheiner
2003Clinical pharmacology and therapy70 citations
Semantic Scholar
Bioequivalence revisited.
L. Sheiner
1992Statistics in Medicine70 citations
Semantic Scholar
A Population Pharmacokinetic–Pharmacodynamic Analysis of Repeated Measures Time-to-Event Pharmacodynamic Responses: The Antiemetic Effect of Ondansetron
E. Cox, C. Veyrat-Follet, S. L. Beal, E. Fuseau +2 more
1999Journal of pharmacokinetics and biopharmaceutics68 citations
Semantic Scholar
Quantitative characterization of therapeutic index: Application of mixed‐effects modeling to evaluate oxybutynin dose–efficacy and dose–side effect relationships
Suneel K. Gupta, G. Sathyan, Elizabeth A. Lindemulder, Pai‐ling Ho +2 more
1999Clinical pharmacology and therapy67 citations
Semantic Scholar
More efficient clinical trials through use of scientific model‐based statistical tests
E. Jonsson, L. Sheiner
2002Clinical pharmacology and therapy59 citations
Semantic Scholar
Do we need full compliance data for population pharmacokinetic analysis?
P. Girard, L. Sheiner, H. Kastrissios, T. Blaschke
1996Journal of pharmacokinetics and biopharmaceutics58 citations
Semantic Scholar
Is intent-to-treat analysis always (ever) enough?
L. Sheiner
2002British Journal of Clinical Pharmacology51 citations Open access
Semantic Scholar
Exposure-response relationships for saquinavir, zidovudine, and zalcitabine in combination therapy
G. Vanhove, J. Gries, D. Verotta, L. Sheiner +3 more
1997Antimicrobial Agents and Chemotherapy47 citations Open access
Semantic Scholar
Prediction Methods for Nicotine Clearance Using Cotinine and 3-Hydroxy-Cotinine Spot Saliva Samples II. Model Application
M. Levi, D. Dempsey, N. Benowitz, L. Sheiner
2007Journal of Pharmacokinetics and Pharmacodynamics41 citations
Semantic Scholar
Pharmacokinetics of saquinavir, zidovudine, and zalcitabine in combination therapy
G. Vanhove, H. Kastrissios, J. Gries, D. Verotta +5 more
1997Antimicrobial Agents and Chemotherapy40 citations Open access
Semantic Scholar
An introduction to mixed effect modeling: Concepts, definitions, and justification
L. Sheiner, T. Grasela
2005Journal of pharmacokinetics and biopharmaceutics39 citations
Semantic Scholar
Time and Theophylline Concentration Help Explain the Recovery of Peak Flow Following Acute Airways Obstruction
N. Holford, Y. Hashimoto, L. Sheiner
1993Clinical Pharmacokinetics37 citations
Semantic Scholar
Diagnostics for confounding in PK/PD models for oxcarbazepine
J. Nedelman, D. Rubin, L. Sheiner
2007Statistics in Medicine32 citations
Semantic Scholar
The Need for Mixed-Effects Modeling with Population Dichotomous Data
I. Yano, S. L. Beal, L. Sheiner
2001Journal of Pharmacokinetics and Pharmacodynamics30 citations
Semantic Scholar
Use of a Pharmacokinetic/Pharmacodynamic Model to Design an Optimal Dose Input Profile
Kyungsoo Park, D. Verotta, Suneel Gupta, L. Sheiner
1998Journal of pharmacokinetics and biopharmaceutics30 citations
Semantic Scholar
Zidovudine response relationships in early human immunodeficiency virus infection
Mark Sale, L. Sheiner, P. Volberding, T. Blaschke
1993Clinical pharmacology and therapy30 citations
Semantic Scholar
Modeling a bivariate control system: LH and testosterone response to the GnRH antagonist antide.
K. Fattinger, D. Verotta, H. Porchet, A. Munafo +2 more
1996American Journal of Physiology29 citations
Semantic Scholar
Population one‐compartment pharmacokinetic analysis with missing dosage data
D. Soy, S. L. Beal, L. Sheiner
2004Clinical pharmacology and therapy28 citations
Semantic Scholar
Effect of coadministration of nelfinavir, indinavir, and saquinavir on the pharmacokinetics of amprenavir
M. Pfister, L. Labbé, Jian-Feng Lu, S. Hammer +4 more
2002Clinical pharmacology and therapy27 citations
Semantic Scholar
A general conceptual model for non-steady state pharmacokinetic/Pharmacodynamic data
D. Verotta, L. Sheiner
1995Journal of pharmacokinetics and biopharmaceutics26 citations
Semantic Scholar
A new method to explore the distribution of interindividual random effects in non-linear mixed effects models.
K. Fattinger, L. Sheiner, D. Verotta
1995Biometrics26 citations
Semantic Scholar
Effect of simultaneous versus staggered dosing on pharmacokinetic interactions of protease inhibitors
Carla B. Washington, C. Flexner, L. Sheiner, S. Rosenkranz +3 more
2003Clinical pharmacology and therapy25 citations
Semantic Scholar
Case-mix adjustment using objective measures of severity: the case for laboratory data.
B. Mozes, M. Easterling, L. Sheiner, K. Melmon +3 more
1994Health Services Research24 citations
Semantic Scholar

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