M. Fuxreiter

Most-cited papers

Classification of Intrinsically Disordered Regions and Proteins
R. van der Lee, M. Buljan, Benjamin Lang, Robert J. Weatheritt +14 more
2014Chemical Reviews2,010 citations Open access
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Protein Phase Separation: A New Phase in Cell Biology
S. Boeynaems, S. Alberti, N. L. Fawzi, T. Mittag +8 more
2018Trends in Cell Biology1,777 citations Open access
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Fuzzy complexes: polymorphism and structural disorder in protein-protein interactions.
P. Tompa, M. Fuxreiter
2008TIBS -Trends in Biochemical Sciences. Regular ed1,055 citations Open access
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Preformed structural elements feature in partner recognition by intrinsically unstructured proteins.
M. Fuxreiter, I. Simon, P. Friedrich, P. Tompa
2004Journal of Molecular Biology526 citations Open access
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Type II restriction endonucleases: structure and mechanism
A. Pingoud, M. Fuxreiter, V. Pingoud, W. Wende
2005Cellular and Molecular Life Sciences488 citations Open access
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Tissue-Specific Splicing of Disordered Segments that Embed Binding Motifs Rewires Protein Interaction Networks
M. Buljan, G. Chalancon, S. Eustermann, Günter P. Wagner +3 more
2012Molecules and Cells381 citations Open access
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Widespread occurrence of the droplet state of proteins in the human proteome
M. Hardenberg, Attila Horváth, V. Ambrus, M. Fuxreiter +1 more
2020Proceedings of the National Academy of Sciences of the United States of America335 citations Open access
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A Structure and Dynamics Continuum of Higher-Order Assemblies: Amyloids, Signalosomes and Granules
Hao Wu, M. Fuxreiter
2016Cell317 citations Open access
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What’s in a name? Why these proteins are intrinsically disordered
A. Dunker, M. Babu, E. Barbar, M. Blackledge +20 more
2013Intrinsically Disordered Proteins263 citations Open access
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Close encounters of the third kind: disordered domains and the interactions of proteins
P. Tompa, M. Fuxreiter, C. Oldfield, I. Simon +2 more
2009Bioessays242 citations
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Intrinsically Disordered Segments Affect Protein Half-Life in the Cell and during Evolution
R. van der Lee, Benjamin Lang, Kai Kruse, Jörg Gsponer +5 more
2014Cell Reports228 citations Open access
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Fuzzy complexes: a more stochastic view of protein function.
M. Fuxreiter, P. Tompa
2012Advances in Experimental Medicine and Biology218 citations
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Malleable machines take shape in eukaryotic transcriptional regulation
M. Fuxreiter, P. Tompa, I. Simon, V. Uversky +2 more
2008Nature Chemical Biology218 citations Open access
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Fuzzy complexes: Specific binding without complete folding
Rashmi Sharma, Zsolt Ráduly, M. Miskei, M. Fuxreiter
2015FEBS Letters205 citations Open access
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MobiDB: intrinsically disordered proteins in 2021
D. Piovesan, M. Necci, Nahuel Escobedo, A. Monzon +11 more
2020Nucleic Acids Res.192 citations Open access
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Alternative splicing of intrinsically disordered regions and rewiring of protein interactions.
M. Buljan, G. Chalancon, A. Dunker, A. Bateman +3 more
2013Current Opinion in Structural Biology182 citations Open access
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Fuzziness: linking regulation to protein dynamics.
M. Fuxreiter
2012Molecular Biosystems163 citations Open access
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Observation of an α-synuclein liquid droplet state and its maturation into Lewy body-like assemblies
M. Hardenberg, T. Sinnige, Sam Casford, Samuel T Dada +8 more
2020bioRxiv162 citations Open access
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FuzDrop on AlphaFold: visualizing the sequence-dependent propensity of liquid–liquid phase separation and aggregation of proteins
András Hatos, S. Tosatto, M. Vendruscolo, M. Fuxreiter
2022Nucleic Acids Res.143 citations Open access
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Malleable Machines in Transcription Regulation: The Mediator Complex
Ágnes Tóth-Petróczy, C. Oldfield, I. Simon, Y. Takagi +3 more
2008PLoS Comput. Biol.141 citations Open access
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Fuzziness and Frustration in the Energy Landscape of Protein Folding, Function, and Assembly
S. Gianni, M. Freiberger, P. Jemth, D. Ferreiro +2 more
2021Accounts of Chemical Research139 citations Open access
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Fuzziness in Protein Interactions-A Historical Perspective.
M. Fuxreiter
2018Journal of Molecular Biology137 citations Open access
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Sequence determinants of the aggregation of proteins within condensates generated by liquid-liquid phase separation
M. Vendruscolo, M. Fuxreiter
2020bioRxiv130 citations Open access
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Generic nature of the condensed states of proteins
M. Fuxreiter, M. Vendruscolo
2021Nature Cell Biology126 citations
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Disordered Proteinaceous Machines
M. Fuxreiter, Ágnes Tóth-Petróczy, D. Kraut, A. Matouschek +4 more
2014Chemical Reviews124 citations Open access
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Simultaneous quantification of protein order and disorder.
Pietro Sormanni, D. Piovesan, Gabriella T. Heller, Massimiliano Bonomi +12 more
2017Nature Chemical Biology113 citations Open access
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FuzDB: database of fuzzy complexes, a tool to develop stochastic structure-function relationships for protein complexes and higher-order assemblies
M. Miskei, Csaba Antal, M. Fuxreiter
2016Nucleic Acids Res.109 citations Open access
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Protein condensation diseases: therapeutic opportunities
M. Vendruscolo, M. Fuxreiter
2022Nature Communications107 citations Open access
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Sequence-based determinants and prediction of fuzzy interactions in protein complexes.
M. Miskei, Attila Horváth, M. Vendruscolo, M. Fuxreiter
2020Journal of Molecular Biology97 citations Open access
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Interactions via intrinsically disordered regions: What kind of motifs?
R. Pancsa, M. Fuxreiter
2012IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology83 citations
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QM/MM simulation of liquid water with an adaptive quantum region.
N. Bernstein, C. Várnai, I. Solt, S. Winfield +4 more
2012Physical Chemistry, Chemical Physics - PCCP83 citations Open access
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Frustration in Fuzzy Protein Complexes Leads to Interaction Versatility
M. Freiberger, P. Wolynes, D. Ferreiro, M. Fuxreiter
2021Journal of Physical Chemistry B79 citations Open access
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Fold or not to fold upon binding - does it really matter?
M. Fuxreiter
2019Current Opinion in Structural Biology75 citations Open access
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On the divalent metal ion dependence of DNA cleavage by restriction endonucleases of the EcoRI family.
V. Pingoud, W. Wende, Peter Friedhoff, M. Reuter +5 more
2009Journal of Molecular Biology72 citations Open access
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Fuzziness enables context dependence of protein interactions
M. Miskei, A. Gregus, Rashmi Sharma, Norbert Duro +2 more
2017FEBS Letters71 citations Open access
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Physiological, pathological, and structural implications of non-enzymatic protein–protein interactions of the multifunctional human transglutaminase 2
K. Kanchan, M. Fuxreiter, L. Fésüs
2015Cellular and Molecular Life Sciences66 citations
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Disordered tails of homeodomains facilitate DNA recognition by providing a trade-off between folding and specific binding.
Ágnes Tóth-Petróczy, I. Simon, M. Fuxreiter, Y. Levy
2009Journal of the American Chemical Society66 citations
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Flexibility of prolyl oligopeptidase: Molecular dynamics and molecular framework analysis of the potential substrate pathways
M. Fuxreiter, C. Magyar, Tünde Juhász, Z. Szeltner +2 more
2005Proteins: Structure, Function, and Bioinformatics59 citations
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Evaluating boundary dependent errors in QM/MM simulations.
I. Solt, P. Kulhánek, I. Simon, S. Winfield +3 more
2009Journal of Physical Chemistry B56 citations
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Classifying the Binding Modes of Disordered Proteins
M. Fuxreiter
2020International Journal of Molecular Sciences55 citations Open access
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Sequence-based prediction of protein binding mode landscapes
Attila Horváth, M. Miskei, V. Ambrus, M. Vendruscolo +1 more
2020PLoS Comput. Biol.54 citations Open access
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Flexible segments modulate co-folding of dUTPase and nucleocapsid proteins
V. Németh-Pongrácz, O. Barabas, M. Fuxreiter, I. Simon +11 more
2006Nucleic Acids Research52 citations Open access
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Interfacial water as a "hydration fingerprint" in the noncognate complex of BamHI.
M. Fuxreiter, M. Mezei, I. Simon, R. Osman
2005Biophysical Journal51 citations Open access
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Fuzzy regions in an intrinsically disordered protein impair protein–protein interactions
Antoine Gruet, Marion Dosnon, D. Blocquel, J. Brunel +7 more
2016The FEBS Journal43 citations Open access
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The energy gap as a universal reaction coordinate for the simulation of chemical reactions.
L. Mones, P. Kulhánek, I. Simon, A. Laio +1 more
2009Journal of Physical Chemistry B41 citations
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Towards sequence-based principles for protein phase separation predictions.
M. Vendruscolo, M. Fuxreiter
2023Current Opinion in Chemical Biology36 citations Open access
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Identification of a specific one amino acid change in recombinant human transglutaminase 2 that regulates its activity and calcium sensitivity.
K. Kanchan, Elvan Ergülen, R. Király, Zsófia Simon-Vecsei +2 more
2013Biochemical Journal36 citations Open access
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Phosphorylation‐induced transient intrinsic structure in the kinase‐inducible domain of CREB facilitates its recognition by the KIX domain of CBP
I. Solt, C. Magyar, I. Simon, P. Tompa +1 more
2006Proteins: Structure, Function, and Bioinformatics33 citations Open access
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Fuzzy protein theory for disordered proteins
M. Fuxreiter
2017Biochemical Society Transactions32 citations Open access
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Probing the two-metal ion mechanism in the restriction endonuclease BamHI.
L. Mones, P. Kulhánek, J. Florián, I. Simon +1 more
2007Biochemistry32 citations
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