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M. Damha · SciRah

Researcher profile · Semantic Scholar

M. Damha

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M. Damha — researcher profile on SciRah

h-index: 49
Works: 288
Citations: 8,198

Most-cited papers

i-Motif DNA: structural features and significance to cell biology
Hala Abou Assi, M. Garavís, C. González, M. Damha
2018Nucleic Acids Research348 citations Open access
Semantic Scholar
Inborn errors of RNA lariat metabolism in humans with brainstem viral infection
Shen-Ying Zhang, N. E. Clark, C. Freije, Elodie Pauwels +45 more
2018Cell128 citations Open access
Semantic Scholar
Recent progress in non-native nucleic acid modifications.
Luke K McKenzie, Roberto El-Khoury, James D. Thorpe, M. Damha +1 more
2021Chemical Society Reviews127 citations Open access
Semantic Scholar
Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2′-O methylations
Y. Abbas, B. Laudenbach, Saúl Martínez-Montero, R. Cencic +5 more
2017Proceedings of the National Academy of Sciences of the United States of America121 citations Open access
Semantic Scholar
Challenges and Opportunities for Nucleic Acid Therapeutics
D. Corey, M. Damha, M. Manoharan
2021Nucleic Acid Therapeutics71 citations Open access
Semantic Scholar
Antibody-Antisense Oligonucleotide Conjugate Downregulates a Key Gene in Glioblastoma Stem Cells
Amy E. Arnold, Elise Malek-Adamian, P. Le, Anika Meng +4 more
2018Molecular Therapy: Nucleic Acids64 citations Open access
Semantic Scholar
Extensive CRISPR RNA modification reveals chemical compatibility and structure-activity relationships for Cas9 biochemical activity
D. O'reilly, Zachary J. Kartje, Eman A Ageely, Elise Malek-Adamian +8 more
2018Nucleic Acids Research63 citations Open access
Semantic Scholar
4'-C-Methoxy-2'-deoxy-2'-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing.
Elise Malek-Adamian, Dale C. Guenther, S. Matsuda, Saúl Martínez-Montero +16 more
2017Journal of the American Chemical Society62 citations
Semantic Scholar
Stabilization of i-motif structures by 2′-β-fluorination of DNA
H. Assi, Robert W. Harkness, N. Martín-Pintado, C. Wilds +4 more
2016Nucleic Acids Research59 citations Open access
Semantic Scholar
In-cell NMR suggests that DNA i-motif levels are strongly depleted in living human cells
Pavlína Víšková, Eva Ištvánková, Jan Ryneš, Š. Džatko +10 more
2024Nature Communications52 citations Open access
Semantic Scholar
Mapping the affinity landscape of Thrombin-binding aptamers on 2΄F-ANA/DNA chimeric G-Quadruplex microarrays
Jory Lietard, Hala Abou Assi, I. Gómez-Pìnto, C. González +2 more
2017Nucleic Acids Research52 citations Open access
Semantic Scholar
2'-Fluoro-arabinonucleic Acid (FANA): A Versatile Tool for Probing Biomolecular Interactions.
Roberto El-Khoury, M. Damha
2021Accounts of Chemical Research51 citations
Semantic Scholar
Dual Mechanisms of Action of Self-Delivering, Anti-HIV-1 FANA Oligonucleotides as a Potential New Approach to HIV Therapy
Mayumi M. Takahashi, Hai-Tang Li, Jie-Hua Zhou, P. Chomchan +3 more
2019Molecular Therapy: Nucleic Acids45 citations Open access
Semantic Scholar
Chemical engineering of CRISPR–Cas systems for therapeutic application
Halle M. Barber, Adrian A. Pater, Keith T. Gagnon, M. Damha +1 more
2024Nature reviews. Drug discovery42 citations Open access
Semantic Scholar
Adjusting the Structure of 2'-Modified Nucleosides and Oligonucleotides via C4'-α-F or C4'-α-OMe Substitution: Synthesis and Conformational Analysis.
Elise Malek-Adamian, Mihai Burai Patrascu, S. Jana, Saúl Martínez-Montero +2 more
2018Journal of Organic Chemistry42 citations
Semantic Scholar
Small Molecule‐Templated DNA Hydrogel with Record Stiffness Integrates and Releases DNA Nanostructures and Gene Silencing Nucleic Acids
Christophe Lachance-Brais, Mostafa Rammal, Jathavan Asohan, A. Katolik +6 more
2023Advancement of science39 citations Open access
Semantic Scholar
Activation of Frataxin Protein Expression by Antisense Oligonucleotides Targeting the Mutant Expanded Repeat
Lian-De Li, Xiulong Shen, Zhong-Tian Liu, Michaela Norrbom +7 more
2018Nucleic Acid Therapeutics38 citations Open access
Semantic Scholar
High‐Density RNA Microarrays Synthesized In Situ by Photolithography
Jory Lietard, Dominik Ameur, M. Damha, M. Somoza
2018Angewandte Chemie37 citations Open access
Semantic Scholar
A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution
B. Paudel, Aaron L. Moye, Hala Abou Assi, Roberto El-Khoury +12 more
2020bioRxiv36 citations Open access
Semantic Scholar
Gene editing with CRISPR-Cas12a guides possessing ribose-modified pseudoknot handles
Eman A Ageely, Ramadevi Chilamkurthy, S. Jana, Leonora Abdullahu +4 more
2021Nature Communications34 citations Open access
Semantic Scholar
Rationally Designed Anti-CRISPR Nucleic Acid Inhibitors of CRISPR-Cas9
Christopher L. Barkau, D. O'reilly, Kushal J. Rohilla, M. Damha +1 more
2019Nucleic Acid Therapeutics32 citations Open access
Semantic Scholar
2′-Fluoroarabinonucleic acid modification traps G-quadruplex and i-motif structures in human telomeric DNA
Hala Abou Assi, Roberto El-Khoury, C. González, M. Damha
2017Nucleic Acids Research30 citations Open access
Semantic Scholar
Structure of tRNA splicing enzyme Tpt1 illuminates the mechanism of RNA 2′-PO4 recognition and ADP-ribosylation
A. Banerjee, Annum Munir, Leonora Abdullahu, M. Damha +2 more
2019Nature Communications28 citations Open access
Semantic Scholar
Accurately Modeling the Conformational Preferences of Nucleosides.
Mihai Burai Patrascu, Elise Malek-Adamian, M. Damha, N. Moitessier
2017Journal of the American Chemical Society26 citations Open access
Semantic Scholar
Metal dependence and branched RNA cocrystal structures of the RNA lariat debranching enzyme Dbr1
N. E. Clark, A. Katolik, K. M. Roberts, A. B. Taylor +7 more
2016Proceedings of the National Academy of Sciences of the United States of America26 citations Open access
Semantic Scholar
Effect of Sugar 2′,4′-Modifications on Gene Silencing Activity of siRNA Duplexes
Elise Malek-Adamian, Johans F Fakhoury, Amy E. Arnold, Saúl Martínez-Montero +2 more
2019Nucleic Acid Therapeutics25 citations Open access
Semantic Scholar
Telomeric i-motifs and C-strands inhibit parallel G-quadruplex extension by telomerase
Roberto El-Khoury, Morgane Roman, H. Assi, Aaron L. Moye +2 more
2023Nucleic Acids Research23 citations Open access
Semantic Scholar
Two-step mechanism and step-arrest mutants of Runella slithyformis NAD+-dependent tRNA 2′-phosphotransferase Tpt1
Annum Munir, Leonora Abdullahu, M. Damha, S. Shuman
2018RNA: A publication of the RNA Society23 citations Open access
Semantic Scholar
Effect of 2′-5′/3′-5′ phosphodiester linkage heterogeneity on RNA interference
Maryam Habibian, S. Harikrishna, Johans F Fakhoury, M. Barton +10 more
2020Nucleic Acids Research20 citations Open access
Semantic Scholar
The debranching enzyme Dbr1 regulates lariat turnover and intron splicing
Luke Buerer, Nathaniel E. Clark, Anastasia Welch, Chao-Rui Duan +12 more
2024Nature Communications17 citations Open access
Semantic Scholar
Activating frataxin expression by single-stranded siRNAs targeting the GAA repeat expansion
Xiulong Shen, Audrius Kilikevicius, D. O'reilly, T. P. Prakash +3 more
2018Bioorganic & Medicinal Chemistry Letters17 citations Open access
Semantic Scholar
Exploring Atypical Fluorine-Hydrogen Bonds and Their Effects on Nucleoside Conformations.
D. O'reilly, R. Stein, Mihai Burai Patrascu, S. Jana +3 more
2018Chemistry17 citations
Semantic Scholar
Mechanochemical synthesis of short DNA fragments.
James D. Thorpe, D. O'reilly, T. Friščić, M. Damha
2020Chemistry16 citations Open access
Semantic Scholar
Large-Scale Photolithographic Synthesis of Chimeric DNA/RNA Hairpin Microarrays To Explore Sequence Specificity Landscapes of RNase HII Cleavage
Jory Lietard, M. Damha, M. Somoza
2019Biochemistry16 citations Open access
Semantic Scholar
Probing Synergistic Effects of DNA Methylation and 2'-β-Fluorination on i-Motif Stability.
Hala Abou Assi, Yu-Chen Lin, I. Serrano, C. González +1 more
2018Chemistry16 citations
Semantic Scholar
Structural Studies and Gene Silencing Activity of siRNAs Containing Cationic Phosphoramidate Linkages
Danielle Vlaho, Johans F Fakhoury, M. Damha
2017Nucleic Acid Therapeutics15 citations
Semantic Scholar
Challenges of Assessing Exon 53 Skipping of the Human DMD Transcript with Locked Nucleic Acid-Modified Antisense Oligonucleotides in a Mouse Model for Duchenne Muscular Dystrophy
S. Engelbeen, Daniel O'Reilly, Davy Van De Vijver, I. Verhaart +6 more
2023Nucleic Acid Therapeutics13 citations Open access
Semantic Scholar
i-Motif folding intermediates with zero-nucleotide loops are trapped by 2′-fluoroarabinocytidine via F···H and O···H hydrogen bonds
Roberto El-Khoury, Veronica Macaluso, Christopher D Hennecker, Anthony K. Mittermaier +4 more
2023Communications Chemistry12 citations Open access
Semantic Scholar
Fluorescent Branched RNAs for High-Throughput Analysis of Dbr1 Enzyme Kinetics and Inhibition.
A. Katolik, N. E. Clark, Nobuhiro Tago, E. Montemayor +2 more
2017ACS Chemical Biology12 citations
Semantic Scholar
Carrier-free Gene Silencing by Amphiphilic Nucleic Acid Conjugates in Differentiated Intestinal Cells
Elena V. Moroz, S. Lee, Ken Yamada, François Halloy +6 more
2016Molecular Therapy: Nucleic Acids12 citations Open access
Semantic Scholar
A Complex Network of Interactions between S282 and G283 of Hepatitis C Virus Nonstructural Protein 5B and the Template Strand Affects Susceptibility to Sofosbuvir and Ribavirin
Anupriya S Kulkarni, M. Damha, R. Schinazi, H. Mo +3 more
2016Antimicrobial Agents and Chemotherapy12 citations Open access
Semantic Scholar
Nucleoside Analogues with a Seven-Membered Sugar Ring: Synthesis and Structural Compatibility in DNA-RNA Hybrids.
S. Jana, S. Harikrishna, Sruthi Sudhakar, Roberto El-Khoury +2 more
2022Journal of Organic Chemistry11 citations
Semantic Scholar
Compatibility of 5-ethynyl-2'F-ANA UTP with in vitro selection for the generation of base-modified, nuclease resistant aptamers.
F. Levi-Acobas, A. Katolik, Pascal Röthlisberger, T. Cokelaer +4 more
2019Organic and biomolecular chemistry11 citations Open access
Semantic Scholar
Small Nucleic Acids and the Path to the Clinic for Anti-CRISPR
Christopher L. Barkau, D. O'reilly, Seth B. Eddington, M. Damha +1 more
2021Biochemical Pharmacology10 citations Open access
Semantic Scholar
Activity and substrate specificity of Candida, Aspergillus, and Coccidioides Tpt1: essential tRNA splicing enzymes and potential antifungal targets
S. Dantuluri, Beate Schwer, Leonora Abdullahu, M. Damha +1 more
2021RNA: A publication of the RNA Society10 citations Open access
Semantic Scholar
2′-Fluoroarabinonucleic acid modification traps G-quadruplex and i-motif structures in human telomeric DNA
H. Assi, Roberto El-Khoury, C. González, M. Damha
2017Nucleic Acids Research10 citations Open access
Semantic Scholar
Formation of left-handed helices by C2′-fluorinated nucleic acids under physiological salt conditions
Roberto El-Khoury, C. Cabrero, Santiago Movilla, Harneesh Kaur +7 more
2024Nucleic Acids Research9 citations Open access
Semantic Scholar
Binding to the conserved and stably folded guide RNA pseudoknot induces Cas12a conformational changes during ribonucleoprotein assembly
Sruthi Sudhakar, Christopher L. Barkau, Ramadevi Chilamkurthy, Halle M. Barber +5 more
2023Journal of Biological Chemistry8 citations Open access
Semantic Scholar
Metal content and kinetic properties of yeast RNA lariat debranching enzyme Dbr1
N. E. Clark, A. Katolik, A. Taggart, Luke Buerer +6 more
2022RNA: A publication of the RNA Society8 citations Open access
Semantic Scholar
A modified X10-23 DNAzyme that can better access large, structured RNA targets
Connor Nurmi, Halle M. Barber, Harneesh Kaur, John D. Brennan +2 more
2026Nucleic Acids Research7 citations
Semantic Scholar

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