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R. Cencic · SciRah

Researcher profile · Semantic Scholar

R. Cencic

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R. Cencic — researcher profile on SciRah

h-index: 32
Works: 79
Citations: 3,562

Most-cited papers

Antitumor Activity and Mechanism of Action of the Cyclopenta[b]benzofuran, Silvestrol
R. Cencic, M. Carrier, Gabriela Galicia-Vázquez, Marie-Ève Bordeleau +8 more
2009PLoS ONE289 citations Open access
Semantic Scholar
Structural conservation of druggable hot spots in protein–protein interfaces
D. Kozakov, D. Hall, G. Chuang, R. Cencic +6 more
2011Proceedings of the National Academy of Sciences of the United States of America231 citations Open access
Semantic Scholar
Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F
R. Cencic, D. Hall, F. Robert, Yu-Hong Du +10 more
2010Proceedings of the National Academy of Sciences of the United States of America181 citations Open access
Semantic Scholar
c-Myc and eIF4F are components of a feedforward loop that links transcription and translation.
Chen-ju Lin, R. Cencic, J. Mills, F. Robert +1 more
2008Cancer Research179 citations Open access
Semantic Scholar
RNA-mediated sequestration of the RNA helicase eIF4A by Pateamine A inhibits translation initiation.
Marie-Ève Bordeleau, R. Cencic, L. Lindqvist, M. Oberer +3 more
2006Chemistry and Biology153 citations Open access
Semantic Scholar
Repurposing CRISPR/Cas9 for in situ functional assays
A. Malina, J. Mills, R. Cencic, Yifei Yan +5 more
2013Genes & Development134 citations Open access
Semantic Scholar
Selective Pharmacological Targeting of a DEAD Box RNA Helicase
L. Lindqvist, M. Oberer, M. Reibarkh, R. Cencic +8 more
2008PLoS ONE124 citations Open access
Semantic Scholar
Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2′-O methylations
Y. Abbas, B. Laudenbach, Saúl Martínez-Montero, R. Cencic +5 more
2017Proceedings of the National Academy of Sciences of the United States of America121 citations Open access
Semantic Scholar
Protospacer Adjacent Motif (PAM)-Distal Sequences Engage CRISPR Cas9 DNA Target Cleavage
R. Cencic, Hisashi Miura, A. Malina, F. Robert +4 more
2014PLoS ONE112 citations Open access
Semantic Scholar
A cellular response linking eIF4AI activity to eIF4AII transcription.
Gabriela Galicia-Vázquez, R. Cencic, F. Robert, Aouod Agenor +1 more
2012RNA: A publication of the RNA Society108 citations Open access
Semantic Scholar
Blocking eIF4E-eIF4G Interaction as a Strategy To Impair Coronavirus Replication
R. Cencic, M. Desforges, D. Hall, D. Kozakov +7 more
2011Journal of Virology105 citations Open access
Semantic Scholar
Enantioselective synthesis of the complex rocaglate (-)-silvestrol.
B. Gerard, R. Cencic, J. Pelletier, John A. Jr. Porco
2007Angewandte Chemie105 citations
Semantic Scholar
CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary
Yibo Xue, B. Meehan, E. Macdonald, S. Venneti +32 more
2019Nature Communications104 citations Open access
Semantic Scholar
Synthesis of Rocaglamide Hydroxamates and Related Compounds as Eukaryotic Translation Inhibitors: Synthetic and Biological Studies
C. M. Rodrigo, R. Cencic, Stéphane P. Roche, J. Pelletier +1 more
2011Journal of Medicinal Chemistry92 citations Open access
Semantic Scholar
CRISPR-Mediated Drug-Target Validation Reveals Selective Pharmacological Inhibition of the RNA Helicase, eIF4A
J. Chu, Gabriela Galicia-Vázquez, R. Cencic, J. Mills +3 more
2016Cell Reports87 citations Open access
Semantic Scholar
Amidino-Rocaglates – A potent class of eIF4A inhibitors
J. Chu, Wenhan Zhang, R. Cencic, William G Devine +6 more
2019Cell Chemical Biology70 citations Open access
Semantic Scholar
Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F
J. Chu, Wenhan Zhang, R. Cencic, Patrick B. F. O'Connor +9 more
2020Cell Reports67 citations Open access
Semantic Scholar
Targeting Translation Dependence in Cancer
A. Malina, R. Cencic, J. Pelletier
2011OncoTarget66 citations Open access
Semantic Scholar
Biomimetic Photocycloaddition of 3-Hydroxyflavones: Synthesis and Evaluation of Rocaglate Derivatives as Inhibitors of Eukaryotic Translation
Stéphane P. Roche, R. Cencic, J. Pelletier, J. Porco
2010Angewandte Chemie63 citations Open access
Semantic Scholar
Synergistic effect of inhibiting translation initiation in combination with cytotoxic agents in acute myelogenous leukemia cells
R. Cencic, M. Carrier, A. Trnkus, J. Porco +2 more
2009Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis63 citations Open access
Semantic Scholar
Hippuristanol - A potent steroid inhibitor of eukaryotic initiation factor 4A
R. Cencic, J. Pelletier
2016Translation57 citations Open access
Semantic Scholar
Repression of p53-target gene Bbc3/PUMA by MYSM1 is essential for the survival of hematopoietic multipotent progenitors and contributes to stem cell maintenance
Jad I. Belle, Jessica C Petrov, D. Langlais, F. Robert +5 more
2016Cell Death and Differentiation55 citations Open access
Semantic Scholar
Haploinsufficiency of the ESCRT Component HD-PTP Predisposes to Cancer.
Sanaz Manteghi, M. Gingras, Dmitri Kharitidi, L. Galarneau +8 more
2016Cell Reports48 citations Open access
Semantic Scholar
Blocking UV-Induced eIF2α Phosphorylation with Small Molecule Inhibitors of GCN2
F. Robert, Chris Williams, Yifei Yan, E. Donohue +3 more
2009Chemical Biology and Drug Design43 citations Open access
Semantic Scholar
Targeting protein synthesis in a Myc/mTOR-driven model of anorexia-cachexia syndrome delays its onset and prolongs survival.
F. Robert, J. Mills, Aouod Agenor, Dan-Tong Wang +7 more
2012Cancer Research40 citations Open access
Semantic Scholar
Synthesis of Aza-Rocaglates via ESIPT-Mediated (3+2) Photocycloaddition
Wen-Yu Wang, R. Cencic, L. Whitesell, J. Pelletier +1 more
2016Chemistry39 citations Open access
Semantic Scholar
Functional mimicry revealed by the crystal structure of an eIF4A:RNA complex bound to the interfacial inhibitor, des-methyl pateamine A
S. K. Naineni, Jason Liang, K. Hull, R. Cencic +6 more
2021Cell Chemical Biology38 citations Open access
Semantic Scholar
eIF4A Inhibitors Suppress Cell-Cycle Feedback Response and Acquired Resistance to CDK4/6 Inhibition in Cancer
Tim Kong, Yibo Xue, R. Cencic, Xianbing Zhu +10 more
2019Molecular Cancer Therapeutics38 citations Open access
Semantic Scholar
Synthesis Facilitates an Understanding of the Structural Basis for Translation Inhibition by the Lissoclimides
Zef A. Könst, A. Szklarski, S. Pellegrino, Sharon E. Michalak +11 more
2017Nature Chemistry38 citations Open access
Semantic Scholar
A CRISPR/Cas9 Functional Screen Identifies Rare Tumor Suppressors
Alexandra Katigbak, R. Cencic, F. Robert, Patrick Sénécha +2 more
2016Scientific Reports37 citations Open access
Semantic Scholar
Rocaglates as dual-targeting agents for experimental cerebral malaria
D. Langlais, R. Cencic, Neda Moradin, J. Kennedy +9 more
2018Proceedings of the National Academy of Sciences of the United States of America36 citations Open access
Semantic Scholar
Identification and characterization of hippuristanol-resistant mutants reveals eIF4A1 dependencies within mRNA 5′ leader regions
J. Steinberger, Leo Shen, Stephen J Kiniry, S. K. Naineni +10 more
2020Nucleic Acids Research33 citations Open access
Semantic Scholar
A comparative study of small molecules targeting eIF4A
S. K. Naineni, Rayelle Itoua Maïga, R. Cencic, Andrea Putnam +4 more
2020RNA: A publication of the RNA Society32 citations Open access
Semantic Scholar
Foot-and-Mouth Disease Virus Leader Proteinase
Walter Glaser, R. Cencic, T. Skern
2001Journal of Biological Chemistry31 citations Open access
Semantic Scholar
RNA-tethering assay and eIF4G:eIF4A obligate dimer design uncovers multiple eIF4F functional complexes
F. Robert, R. Cencic, Renying Cai, T. M. Schmeing +1 more
2020Nucleic Acids Research28 citations Open access
Semantic Scholar
Huwe1 Regulates the Establishment and Maintenance of Spermatogonia by Suppressing DNA Damage Response
Kin L. Fok, R. Bose, Kai Sheng, Ching-Wen Chang +13 more
2017Endocrinology28 citations
Semantic Scholar
Inhibitors of translation targeting eukaryotic translation initiation factor 4A.
R. Cencic, Gabriela Galicia-Vázquez, J. Pelletier
2012Methods in Enzymology26 citations
Semantic Scholar
The binding of foot‐and‐mouth disease virus leader proteinase to eIF4GI involves conserved ionic interactions
Nicole Foeger, E. Kuehnel, R. Cencic, T. Skern
2005The FEBS Journal26 citations
Semantic Scholar
Obatoclax is a direct and potent antagonist of membrane-restricted Mcl-1 and is synthetic lethal with treatment that induces Bim
M. Nguyen, R. Cencic, F. Ertel, Cynthia Bernier +4 more
2015BMC Cancer25 citations Open access
Semantic Scholar
Translation Inhibition by Rocaglates is Independent of eIF4E Phosphorylation Status
J. Chu, R. Cencic, Wen-Yu Wang, J. Porco +1 more
2015Molecular Cancer Therapeutics23 citations Open access
Semantic Scholar
A second-generation eIF4A RNA helicase inhibitor exploits translational reprogramming as a vulnerability in triple-negative breast cancer
R. Cencic, Y. Im, S. K. Naineni, M. Moustafa-Kamal +13 more
2024Proceedings of the National Academy of Sciences of the United States of America22 citations Open access
Semantic Scholar
Identifying small molecule inhibitors of eukaryotic translation initiation.
R. Cencic, F. Robert, J. Pelletier
2007Methods in Enzymology22 citations
Semantic Scholar
Assessing eukaryotic initiation factor 4F subunit essentiality by CRISPR-induced gene ablation in the mouse
P. Sénéchal, F. Robert, R. Cencic, Akiko Yanagiya +4 more
2021Cellular and Molecular Life Sciences21 citations Open access
Semantic Scholar
Effect of 2′-5′/3′-5′ phosphodiester linkage heterogeneity on RNA interference
Maryam Habibian, S. Harikrishna, Johans F Fakhoury, M. Barton +10 more
2020Nucleic Acids Research20 citations Open access
Semantic Scholar
Adapting CRISPR/Cas9 for functional genomics screens.
A. Malina, Alexandra Katigbak, R. Cencic, Rayelle I. Maiga +3 more
2014Methods in Enzymology20 citations
Semantic Scholar
Kaiso mediates human ICR1 methylation maintenance and H19 transcriptional fine regulation
F. Bohne, D. Langer, U. Martiné, Claudia S. Eider +10 more
2016Clinical Epigenetics19 citations Open access
Semantic Scholar
An Antiviral Peptide Inhibitor That Is Active against Picornavirus 2A Proteinases but Not Cellular Caspases
L. Deszcz, R. Cencic, Carla Sousa, E. Kuechler +1 more
2006Journal of Virology19 citations Open access
Semantic Scholar
Oxo-aglaiastatin-Mediated Inhibition of Translation Initiation
Rayelle Itoua Maïga, R. Cencic, J. Chu, Daniel D. Waller +6 more
2019Scientific Reports18 citations Open access
Semantic Scholar
5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells
S. Henry, Ria Q. Kidner, M. R. Reisenauer, I. Magedov +16 more
2016European journal of medicinal chemistry18 citations Open access
Semantic Scholar
Residue L143 of the Foot-and-Mouth Disease Virus Leader Proteinase Is a Determinant of Cleavage Specificity
C. Mayer, D. Neubauer, Aloysius T. Nchinda, R. Cencic +2 more
2008Journal of Virology18 citations Open access
Semantic Scholar

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