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H. Keun · SciRah

Researcher profile · Semantic Scholar

H. Keun

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H. Keun — researcher profile on SciRah

h-index: 60
Works: 208
Citations: 13K

Most-cited papers

A Phase I Dose-Escalation Study of AZD3965, an Oral Monocarboxylate Transporter 1 Inhibitor, in Patients with Advanced Cancer
S. Halford, G. Veal, S. Wedge, G. Payne +17 more
2023Clinical Cancer Research255 citations Open access
Semantic Scholar
Inter-laboratory reproducibility of a targeted metabolomics platform for analysis of human serum and plasma
Alexandros P. Siskos, Pooja Jain, W. Römisch-Margl, M. Bennett +11 more
2016Analytical Chemistry237 citations Open access
Semantic Scholar
Human Early Life Exposome (HELIX) study: a European population-based exposome cohort
L. Maitre, J. de Bont, M. Casas, O. Robinson +58 more
2018BMJ Open234 citations Open access
Semantic Scholar
Multi-omics signatures of the human early life exposome
L. Maitre, M. Bustamante, C. Hernández-Ferrer, Denise Thiel +33 more
2021Nature Communications184 citations Open access
Semantic Scholar
In-utero and childhood chemical exposome in six European mother-child cohorts.
L. Haug, A. Sakhi, E. Cequier, M. Casas +25 more
2018Environment International159 citations Open access
Semantic Scholar
Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and Burkitt lymphoma
R. A. Noble, N. Bell, H. Blair, Arti Sikka +13 more
2017Haematologica150 citations Open access
Semantic Scholar
Diurnal rhythms in the human urine metabolome during sleep and total sleep deprivation
G. Giskeødegård, Sarah K. Davies, V. Revell, H. Keun +1 more
2015Scientific Reports128 citations Open access
Semantic Scholar
Determinants of the urinary and serum metabolome in children from six European populations
Chung-Ho E. Lau, Alexandros P. Siskos, L. Maitre, O. Robinson +20 more
2018BMC Medicine123 citations Open access
Semantic Scholar
The early-life exposome and epigenetic age acceleration in children.
P. de Prado-Bert, C. Ruiz-Arenas, M. Vives-Usano, S. Andrušaitytė +22 more
2021Environment International101 citations Open access
Semantic Scholar
Identification of genomic biomarkers for anthracycline-induced cardiotoxicity in human iPSC-derived cardiomyocytes: an in vitro repeated exposure toxicity approach for safety assessment
U. Chaudhari, Harshal Nemade, V. Wagh, J. A. Gaspar +10 more
2015Archives of Toxicology99 citations Open access
Semantic Scholar
Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis
Scott P. Allen, Benjamin J. Hall, L. Castelli, Laura Francis +19 more
2019Brain : a journal of neurology98 citations Open access
Semantic Scholar
RNA‐binding motif protein 39 (RBM39): An emerging cancer target
Yue-Wei Xu, A. Nijhuis, H. Keun
2020British Journal of Pharmacology86 citations Open access
Semantic Scholar
Intracellular Staphylococcus aureus Modulates Host Central Carbon Metabolism To Activate Autophagy
Natalia Bravo-Santano, J. K. Ellis, Luís M. Mateos, Y. Calle +3 more
2018Msphere86 citations Open access
Semantic Scholar
Metabolomic Analysis Reveals Increased Aerobic Glycolysis and Amino Acid Deficit in a Cellular Model of Amyotrophic Lateral Sclerosis
G. Valbuena, M. Rizzardini, S. Cimini, Alexandros P. Siskos +3 more
2015Molecular Neurobiology79 citations Open access
Semantic Scholar
Lipid degradation promotes prostate cancer cell survival
H. Itkonen, Michael D Brown, A. Urbanucci, Gregory D. Tredwell +17 more
2017OncoTarget71 citations Open access
Semantic Scholar
MicroRNAs as biomarkers for prostate cancer prognosis: a systematic review and a systematic reanalysis of public data
S. Rana, G. Valbuena, E. Curry, C. Bevan +1 more
2022British Journal of Cancer70 citations Open access
Semantic Scholar
Urine Metabolic Signatures of Multiple Environmental Pollutants in Pregnant Women: An Exposome Approach.
L. Maitre, O. Robinson, D. Martínez, M. Toledano +7 more
2018Environmental Science and Technology61 citations Open access
Semantic Scholar
A first-in-human first-in-class (FIC) trial of the monocarboxylate transporter 1 (MCT1) inhibitor AZD3965 in patients with advanced solid tumours.
Ruth Plummer, S. Halford, Paul S. Jones, S. Wedge +6 more
201761 citations Open access
Semantic Scholar
Advancing tools for human early lifecourse exposome research and translation (ATHLETE)
M. Vrijheid, X. Basagaña, J. González, V. Jaddoe +75 more
2021Environmental Epidemiology56 citations Open access
Semantic Scholar
Metabolic profiling in human exposome studies.
T. Athersuch, H. Keun
2015Mutagenesis51 citations
Semantic Scholar
Simultaneous targeting of glycolysis and oxidative phosphorylation as a therapeutic strategy to treat diffuse large B-cell lymphoma
R. A. Noble, H. Thomas, Yan Zhao, Lili Herendi +6 more
2022British Journal of Cancer47 citations Open access
Semantic Scholar
Enhanced triacylglycerol catabolism by Carboxylesterase 1 promotes aggressive colorectal carcinoma.
D. Capece, D. D'Andrea, Federica Begalli, Laura Goracci +23 more
2021Journal of Clinical Investigation47 citations Open access
Semantic Scholar
Lactic acidosis induces resistance to the pan-Akt inhibitor uprosertib in colon cancer cells
Emily M. E. Barnes, Yi-Tao Xu, A. Benito, Lili Herendi +4 more
2020British Journal of Cancer45 citations Open access
Semantic Scholar
The coordinated action of VCP/p97 and GCN2 regulates cancer cell metabolism and proteostasis during nutrient limitation
K. Parzych, P. Saavedra-García, G. Valbuena, Hibah A. Al-Sadah +15 more
2019Oncogene45 citations Open access
Semantic Scholar
Suppression of MTHFD2 in MCF-7 Breast Cancer Cells Increases Glycolysis, Dependency on Exogenous Glycine, and Sensitivity to Folate Depletion.
C. Koufaris, S. Gallage, Tianlai Yang, Chung-Ho E. Lau +2 more
2016Journal of Proteome Research45 citations Open access
Semantic Scholar
Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition
M. Breeur, P. Ferrari, L. Dossus, M. Jenab +43 more
2022BMC Medicine43 citations Open access
Semantic Scholar
Acetaminophen cytotoxicity in HepG2 cells is associated with a decoupling of glycolysis from the TCA cycle, loss of NADPH production, and suppression of anabolism
V. Behrends, G. Giskeødegård, Natalia Bravo-Santano, Michal Letek +1 more
2018Archives of Toxicology42 citations Open access
Semantic Scholar
Metabolite signatures of doxorubicin induced toxicity in human induced pluripotent stem cell-derived cardiomyocytes
U. Chaudhari, J. K. Ellis, V. Wagh, Harshal Nemade +3 more
2017Amino Acids41 citations Open access
Semantic Scholar
Prospective analysis of circulating metabolites and endometrial cancer risk
L. Dossus, Eirini Kouloura, C. Biessy, V. Viallon +32 more
2021Gynecologic Oncology40 citations Open access
Semantic Scholar
Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures
R. Rodrigues, L. Kollipara, U. Chaudhari, A. Sachinidis +14 more
2018Archives of Toxicology40 citations Open access
Semantic Scholar
Pharmacological depletion of RNA splicing factor RBM39 by indisulam synergizes with PARP inhibitors in high-grade serous ovarian carcinoma
Yue-Wei Xu, S. Spear, Yurui Ma, Marc P. Lorentzen +8 more
2023bioRxiv38 citations Open access
Semantic Scholar
Metabolic signatures of greater body size and their associations with risk of colorectal and endometrial cancers in the European Prospective Investigation into Cancer and Nutrition
Nathalie Kliemann, V. Viallon, N. Murphy, R. Beeken +32 more
2021BMC Medicine38 citations Open access
Semantic Scholar
p53 Loss in MYC-Driven Neuroblastoma Leads to Metabolic Adaptations Supporting Radioresistance.
O. Yogev, K. Barker, Arti Sikka, G. S. Almeida +13 more
2016Cancer Research36 citations
Semantic Scholar
Metabonomic analysis of ovarian tumour cyst fluid by proton nuclear magnetic resonance spectroscopy
M. Kyriakides, N. Rama, J. Sidhu, H. Gabra +2 more
2016OncoTarget36 citations Open access
Semantic Scholar
Metabolic characterization of colorectal cancer cells harbouring different KRAS mutations in codon 12, 13, 61 and 146 using human SW48 isogenic cell lines
Dorna Varshavi, Dorsa Varshavi, N. McCarthy, K. Veselkov +2 more
2020Metabolomics35 citations Open access
Semantic Scholar
Systems level profiling of chemotherapy-induced stress resolution in cancer cells reveals druggable trade-offs
P. Saavedra-García, M. Román-Trufero, Hibah A. Al-Sadah, Kevin Blighe +22 more
2021Proceedings of the National Academy of Sciences of the United States of America34 citations Open access
Semantic Scholar
A case of malignant hyperlactaemic acidosis appearing upon treatment with the mono-carboxylase transporter 1 inhibitor AZD3965
Rosie McNeillis, A. Greystoke, J. Walton, C. Bacon +8 more
2020British Journal of Cancer34 citations Open access
Semantic Scholar
In utero and childhood exposure to tobacco smoke and multi-layer molecular signatures in children
M. Vives-Usano, C. Hernández-Ferrer, L. Maitre, C. Ruiz-Arenas +26 more
2020BMC Medicine34 citations Open access
Semantic Scholar
Assessment of metabolic phenotypic variability in children’s urine using 1H NMR spectroscopy
L. Maitre, Chung-Ho E. Lau, E. Vizcaíno, O. Robinson +8 more
2017Scientific Reports33 citations Open access
Semantic Scholar
Phase I expansion study of the first-in-class monocarboxylate transporter 1 (MCT1) inhibitor AZD3965 in patients with diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL).
S. Halford, H. Walter, P. McKay, W. Townsend +11 more
202132 citations Open access
Semantic Scholar
Variability of multi-omics profiles in a population-based child cohort
Marta Gallego-Paüls, C. Hernández-Ferrer, M. Bustamante, X. Basagaña +21 more
2021BMC Medicine32 citations Open access
Semantic Scholar
Influence of glutathione-S-transferase (GST) inhibition on lung epithelial cell injury: role of oxidative stress and metabolism.
M. Fletcher, P. Boshier, K. Wakabayashi, H. Keun +6 more
2015American Journal of Physiology - Lung cellular and Molecular Physiology32 citations
Semantic Scholar
A Systems Oncology Approach Identifies NT5E as a Key Metabolic Regulator in Tumor Cells and Modulator of Platinum Sensitivity.
E. Nevedomskaya, R. Perryman, S. Solanki, N. Syed +2 more
2016Journal of Proteome Research31 citations Open access
Semantic Scholar
The impact of p53 on aristolochic acid I-induced nephrotoxicity and DNA damage in vivo and in vitro
M. Sborchia, E. D. de Prez, M. Antoine, Lucie Bienfait +7 more
2019Archives of Toxicology28 citations Open access
Semantic Scholar
A model-based assay design to reproduce in vivo patterns of acute drug-induced toxicity
L. Kuepfer, O. Clayton, C. Thiel, Henrik Cordes +20 more
2017Archives of Toxicology26 citations Open access
Semantic Scholar
Intracellular Staphylococcus aureus Elicits the Production of Host Very Long-Chain Saturated Fatty Acids with Antimicrobial Activity
Natalia Bravo-Santano, J. K. Ellis, Y. Calle, H. Keun +2 more
2019Metabolites25 citations Open access
Semantic Scholar
Childhood exposure to non-persistent endocrine disrupting chemicals and multi-omic profiles: A panel study.
Lorenzo Fabbri, R. Garlantézec, K. Audouze, M. Bustamante +15 more
2023Environment International24 citations Open access
Semantic Scholar
β-Hydroxybutyrate Oxidation Promotes the Accumulation of Immunometabolites in Activated Microglia Cells
A. Benito, N. Hajji, K. O’Neill, H. Keun +1 more
2020Metabolites24 citations Open access
Semantic Scholar
Spinal Cord Metabolic Signatures in Models of Fast- and Slow-Progressing SOD1G93A Amyotrophic Lateral Sclerosis
G. Valbuena, L. Cantoni, M. Tortarolo, C. Bendotti +1 more
2019Frontiers in Neuroscience24 citations Open access
Semantic Scholar
Metabolomic characterisation of the effects of oncogenic PIK3CA transformation in a breast epithelial cell line
Chung-Ho E. Lau, Gregory D. Tredwell, J. K. Ellis, E. Lam +1 more
2017Scientific Reports24 citations Open access
Semantic Scholar

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