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N. Furnham · SciRah

Researcher profile · Semantic Scholar

N. Furnham

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N. Furnham — researcher profile on SciRah

h-index: 30
Works: 69
Citations: 3,735

Most-cited papers

CATH: comprehensive structural and functional annotations for genome sequences
I. Sillitoe, Tony E. Lewis, Alison L. Cuff, Sayoni Das +10 more
2014Nucleic Acids Res.440 citations Open access
Semantic Scholar
Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis
F. Coll, J. Phelan, G. Hill-Cawthorne, Mridul B. Nair +47 more
2018Nature Genetics327 citations Open access
Semantic Scholar
New functional families (FunFams) in CATH to improve the mapping of conserved functional sites to 3D structures
I. Sillitoe, Alison L. Cuff, B. H. Dessailly, N. Dawson +9 more
2012Nucleic Acids Res.229 citations Open access
Semantic Scholar
Mechanism and Catalytic Site Atlas (M-CSA): a database of enzyme reaction mechanisms and active sites
António J. M. Ribeiro, G. Holliday, N. Furnham, Jonathan D. Tyzack +2 more
2017Nucleic Acids Res.215 citations Open access
Semantic Scholar
In silico Strategies to Support Fragment-to-Lead Optimization in Drug Discovery
Lauro Ribeiro de Souza, J. T. Moreira-Filho, B. Neves, Rocío L. B. R. Maidana +4 more
2020Frontiers in Chemistry189 citations Open access
Semantic Scholar
Assembly and Channel Opening in a Bacterial Drug Efflux Machine
Vassiliy N. Bavro, Z. Pietras, N. Furnham, Laura Perez-Cano +4 more
2008Molecules and Cells174 citations Open access
Semantic Scholar
The Catalytic Site Atlas 2.0: cataloging catalytic sites and residues identified in enzymes
N. Furnham, G. Holliday, T. D. de Beer, Julius O. B. Jacobsen +2 more
2013Nucleic Acids Res.170 citations Open access
Semantic Scholar
Extending CATH: increasing coverage of the protein structure universe and linking structure with function
Alison L. Cuff, I. Sillitoe, Tony E. Lewis, Andrew B. Clegg +6 more
2010Nucleic Acids Res.139 citations Open access
Semantic Scholar
EC-BLAST: A Tool to Automatically Search and Compare Enzyme Reactions
S. A. Rahman, S. M. Cuesta, N. Furnham, G. Holliday +1 more
2014Nature Methods131 citations Open access
Semantic Scholar
The Classification and Evolution of Enzyme Function.
Sergio Martínez Cuesta, S. A. Rahman, N. Furnham, J. Thornton
2015Biophysical Journal120 citations Open access
Semantic Scholar
Is one solution good enough?
N. Furnham, T. Blundell, M. DePristo, T. Terwilliger
2006Nature Structural &Molecular Biology114 citations
Semantic Scholar
Mycobacterium tuberculosis whole genome sequencing and protein structure modelling provides insights into anti-tuberculosis drug resistance
J. Phelan, F. Coll, R. McNerney, D. Ascher +12 more
2016BMC Medicine110 citations Open access
Semantic Scholar
Chopping and Changing: the Evolution of the Flavin-dependent Monooxygenases
M. L. Mascotti, Maximiliano Juri Ayub, N. Furnham, J. Thornton +1 more
2016Journal of Molecular Biology94 citations Open access
Semantic Scholar
Exploring the Evolution of Novel Enzyme Functions within Structurally Defined Protein Superfamilies
N. Furnham, I. Sillitoe, G. Holliday, Alison L. Cuff +3 more
2012PLoS Comput. Biol.85 citations Open access
Semantic Scholar
Discovery of New Anti-Schistosomal Hits by Integration of QSAR-Based Virtual Screening and High Content Screening
B. Neves, R. Dantas, M. R. Senger, C. Melo-Filho +12 more
2016Journal of Medicinal Chemistry74 citations Open access
Semantic Scholar
To what extent do structural changes in catalytic metal sites affect enzyme function?
Yana Valasatava, A. Rosato, N. Furnham, J. Thornton +1 more
2018Journal of Inorganic Biochemistry72 citations Open access
Semantic Scholar
Understanding molecular consequences of putative drug resistant mutations in Mycobacterium tuberculosis
Stephanie Portelli, J. Phelan, D. Ascher, T. Clark +1 more
2018Scientific Reports72 citations Open access
Semantic Scholar
THE RAMACHANDRAN PLOT AND PROTEIN STRUCTURE VALIDATION
R. Laskowski, N. Furnham, J. Thornton
201369 citations
Semantic Scholar
Structure of an Xrcc4-DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode.
A. S. Doré, N. Furnham, O. R. Davies, B. L. Sibanda +4 more
2006DNA Repair65 citations Open access
Semantic Scholar
Missing in action: enzyme functional annotations in biological databases.
N. Furnham, J. Garavelli, R. Apweiler, J. Thornton
2009Nature Chemical Biology64 citations
Semantic Scholar
Comparisons of Allergenic and Metazoan Parasite Proteins: Allergy the Price of Immunity
N. Tyagi, Edward J. Farnell, C. Fitzsimmons, S. Ryan +5 more
2015PLoS Comput. Biol.56 citations Open access
Semantic Scholar
Large-Scale Analysis Exploring Evolution of Catalytic Machineries and Mechanisms in Enzyme Superfamilies
N. Furnham, N. Dawson, S. A. Rahman, J. Thornton +1 more
2016Journal of Molecular Biology55 citations Open access
Semantic Scholar
Prediction of rifampicin resistance beyond the RRDR using structure-based machine learning approaches
Stephanie Portelli, Yoochan Myung, N. Furnham, S. Vedithi +2 more
2020Scientific Reports54 citations Open access
Semantic Scholar
QSAR-Driven Discovery of Novel Chemical Scaffolds Active Against Schistosoma mansoni
C. Melo-Filho, R. Dantas, R. Braga, B. Neves +11 more
2016Journal of Chemical Information and Modeling48 citations Open access
Semantic Scholar
FunTree: a resource for exploring the functional evolution of structurally defined enzyme superfamilies
N. Furnham, I. Sillitoe, G. Holliday, Alison L. Cuff +4 more
2011Nucleic Acids Res.44 citations Open access
Semantic Scholar
Structural basis for inhibition of homologous recombination by the RecX protein
S. Ragone, J. Maman, N. Furnham, L. Pellegrini
2008EMBO Journal43 citations Open access
Semantic Scholar
Understanding enzyme function evolution from a computational perspective.
Jonathan D. Tyzack, N. Furnham, I. Sillitoe, C. Orengo +1 more
2017Current Opinion in Structural Biology38 citations Open access
Semantic Scholar
The evolution of enzyme function in the isomerases
Sergio Martínez Cuesta, N. Furnham, S. A. Rahman, I. Sillitoe +1 more
2014Current Opinion in Structural Biology37 citations Open access
Semantic Scholar
Structure and mechanism of drug efflux machinery in Gram negative bacteria.
Z. Pietras, Vassiliy N. Bavro, N. Furnham, M. Pellegrini-Calace +2 more
2008Current Drug Targets34 citations
Semantic Scholar
Computationally-guided drug repurposing enables the discovery of kinase targets and inhibitors as new schistosomicidal agents
S. Giuliani, A. Silva, Joyce V. B. Borba, P. Ramos +4 more
2018PLoS Comput. Biol.33 citations Open access
Semantic Scholar
Novel computational models offer alternatives to animal testing for assessing eye irritation and corrosion potential of chemicals
A. Silva, Joyce V. B. Borba, Vinicius M. Alves, Steven U S Hall +5 more
2021Artificial Intelligence in the Life Sciences30 citations Open access
Semantic Scholar
PhyTB: Phylogenetic tree visualisation and sample positioning for M. tuberculosis
E. D. Benavente, F. Coll, N. Furnham, R. McNerney +5 more
2015BMC Bioinformatics30 citations Open access
Semantic Scholar
Knowledge-based real-space explorations for low-resolution structure determination.
N. Furnham, A. S. Doré, D. Chirgadze, P. D. de Bakker +2 more
2006Structure28 citations Open access
Semantic Scholar
Known Allergen Structures Predict Schistosoma mansoni IgE-Binding Antigens in Human Infection
Edward J. Farnell, N. Tyagi, S. Ryan, Iain W. Chalmers +8 more
2015Frontiers in Immunology27 citations Open access
Semantic Scholar
Conformer generation under restraints.
P. D. de Bakker, N. Furnham, T. Blundell, M. DePristo
2006Current Opinion in Structural Biology25 citations
Semantic Scholar
Model-building strategies for low-resolution X-ray crystallographic data
Anjum M. Karmali, Tom L. Blundell, N. Furnham
2009Acta Crystallographica Section D: Biological Crystallography23 citations Open access
Semantic Scholar
Splice variants: A homology modeling approach
N. Furnham, S. Ruffle, C. Southan
2004Proteins: Structure, Function, and Bioinformatics23 citations
Semantic Scholar
Unveiling the Kinomes of Leishmania infantum and L. braziliensis Empowers the Discovery of New Kinase Targets and Antileishmanial Compounds
Joyce V. B. Borba, A. Silva, P. Ramos, Nathalia Grazzia +4 more
2019Computational and Structural Biotechnology Journal22 citations Open access
Semantic Scholar
Combining structure and genomics to understand antimicrobial resistance
Tanushree Tunstall, Stephanie Portelli, J. Phelan, T. Clark +2 more
2020Computational and Structural Biotechnology Journal19 citations Open access
Semantic Scholar
Schistosomiasis Drug Discovery in the Era of Automation and Artificial Intelligence
J. T. Moreira-Filho, A. Silva, R. Dantas, B. F. Gomes +7 more
2021Frontiers in Immunology18 citations Open access
Semantic Scholar
Current challenges in genome annotation through structural biology and bioinformatics.
N. Furnham, T. D. de Beer, J. Thornton
2012Current Opinion in Structural Biology18 citations
Semantic Scholar
Exploring the Biological and Chemical Complexity of the Ligases
G. Holliday, S. A. Rahman, N. Furnham, J. Thornton
2014Journal of Molecular Biology14 citations Open access
Semantic Scholar
FunTree: advances in a resource for exploring and contextualising protein function evolution
I. Sillitoe, N. Furnham
2015Nucleic Acids Res.12 citations Open access
Semantic Scholar
Exploring Enzyme Evolution from Changes in Sequence, Structure, and Function.
Jonathan D. Tyzack, N. Furnham, I. Sillitoe, C. Orengo +1 more
2018Methods in molecular biology9 citations
Semantic Scholar
A computational method for predicting the most likely evolutionary trajectories in the stepwise accumulation of resistance mutations
R. C. Eccleston, E. Manko, S. Campino, T. Clark +1 more
2022bioRxiv8 citations Open access
Semantic Scholar
Structural and Genomic Insights Into Pyrazinamide Resistance in Mycobacterium tuberculosis Underlie Differences Between Ancient and Modern Lineages
Tanushree Tunstall, J. Phelan, Charlotte Eccleston, T. Clark +1 more
2021Frontiers in Molecular Biosciences8 citations Open access
Semantic Scholar
Abstracting knowledge from the Protein Data Bank.
N. Furnham, R. Laskowski, J. Thornton
2013Biopolymers8 citations
Semantic Scholar
Author Correction: Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis
F. Coll, J. Phelan, G. Hill-Cawthorne, Mridul B. Nair +47 more
2018Nature Genetics7 citations Open access
Semantic Scholar
Complementary Sources of Protein Functional Information: The Far Side of GO.
N. Furnham
2017Methods in molecular biology5 citations Open access
Semantic Scholar
Editorial: Current approaches in infectious disease drug discovery
F. Silva-Jr, Siva S. Panda, C. Andrade, N. Furnham
2022Frontiers in Chemistry3 citations Open access
Semantic Scholar

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J. Thornton — researcher profile on SciRah
I. Sillitoe×9
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I. Sillitoe — researcher profile on SciRah
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R. Laskowski — researcher profile on SciRah

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G. Holliday — researcher profile on SciRah

S. A. Rahman×6

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Alison L. Cuff — researcher profile on SciRah

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