Skip to content

Home Search Authors Pakistan News Saved

SciRah

SciRah does not host or store research papers. Results come live from free, official scholarly APIs, and every paper links back to its original source.

Data sources

OpenAlex
Semantic Scholar
Crossref
CORE
arXiv
PubMed

Privacy policy Terms of service

Xiao-Ling Xu · SciRah

Researcher profile · Semantic Scholar

Xiao-Ling Xu

Share profile

Xiao-Ling Xu — researcher profile on SciRah

h-index: 54
Works: 108
Citations: 17K

Most-cited papers

53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks
S. Bunting, E. Callen, N. Wong, Hua-Tang Chen +12 more
2010Cell1,695 citations Open access
Semantic Scholar
Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells.
Xiao-Ling Xu, Z. Weaver, S. Linke, Cui-ling Li +5 more
1999Molecules and Cells861 citations Open access
Semantic Scholar
Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice
Rui-Hong Wang, K. Sengupta, Cui-ling Li, Hyun-Seok Kim +12 more
2008Cancer Cell807 citations Open access
Semantic Scholar
Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation
Xiao-Ling Xu, Kay-Uwe Wagner, Denise Larson, Z. Weaver +5 more
1999Nature Genetics805 citations
Semantic Scholar
TGF-β/Smad3 Signals Repress Chondrocyte Hypertrophic Differentiation and Are Required for Maintaining Articular Cartilage
Xiao Yang, Lin Chen, Xiao-Ling Xu, Cui-ling Li +2 more
2001Journal of Cell Biology681 citations Open access
Semantic Scholar
A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression.
Rui-Hong Wang, Cui-ling Li, Xiao-Ling Xu, Yin Zheng +7 more
2005Cell Metabolism650 citations Open access
Semantic Scholar
Silencing of unsynapsed meiotic chromosomes in the mouse
J. M. Turner, S. Mahadevaiah, O. Fernández-Capetillo, A. Nussenzweig +3 more
2005Nature Genetics558 citations
Semantic Scholar
SIRT2 Maintains Genome Integrity and Suppresses Tumorigenesis through Regulating APC/C Activity
Hyun-Seok Kim, A. Vassilopoulos, Rui-Hong Wang, T. Lahusen +12 more
2011Cancer Cell533 citations Open access
Semantic Scholar
Hepatic specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis
Hyun-Seok Kim, C. Xiao, Rui-Hong Wang, T. Lahusen +8 more
2010Cell Metabolism496 citations Open access
Semantic Scholar
Bmi1 regulates mitochondrial function and the DNA damage response pathway
Jie Liu, Liu Cao, Ji-Chun Chen, Shiwei Song +14 more
2009Nature488 citations Open access
Semantic Scholar
SIRT4 has tumor suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism
S. Jeong, C. Xiao, Lydia W. S. Finley, T. Lahusen +17 more
2013Cancer Cell448 citations Open access
Semantic Scholar
BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation.
J. M. Turner, O. Aprelikova, Xiao-Ling Xu, Rui-Hong Wang +5 more
2004Current Biology419 citations Open access
Semantic Scholar
Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis
Xiao-Ling Xu, W. Qiao, S. Linke, Liu Cao +4 more
2001Nature Genetics385 citations
Semantic Scholar
Interplay among BRCA1, SIRT1 and Survivin during BRCA1-Associated Tumorigenesis
Rui-Hong Wang, Yin Zheng, Hyun-Seok Kim, Xiao-Ling Xu +11 more
2008Molecules and Cells369 citations Open access
Semantic Scholar
Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance.
Rui-Hong Wang, Hyun-Seok Kim, C. Xiao, Xiao-Ling Xu +2 more
2011Journal of Clinical Investigation294 citations Open access
Semantic Scholar
Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice
Xiao-Ling Xu, S. Brodie, X. Yang, Y. Im +6 more
2000Oncogene267 citations Open access
Semantic Scholar
A Pro250Arg substitution in mouse Fgfr1 causes increased expression of Cbfa1 and premature fusion of calvarial sutures.
Yong-Xing Zhou, Xiao-Ling Xu, Lin Chen, Cui-Ling Li +2 more
2000Human Molecular Genetics240 citations
Semantic Scholar
Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice.
Xiao-Ling Xu, Shogo Kobayashi, W. Qiao, Cui-ling Li +12 more
2006Journal of Clinical Investigation217 citations Open access
Semantic Scholar
SIRT6 Deficiency Results in Severe Hypoglycemia by Enhancing Both Basal and Insulin-stimulated Glucose Uptake in Mice*
C. Xiao, Hyun-Seok Kim, T. Lahusen, Rui-Hong Wang +5 more
2010Journal of Biological Chemistry201 citations Open access
Semantic Scholar
Patient‐Derived Organoids Can Guide Personalized‐Therapies for Patients with Advanced Breast Cancer
Ping Chen, Xu Zhang, Renbo Ding, Linglin Yang +30 more
2021Advancement of science198 citations Open access
Semantic Scholar
Multiple genetic changes are associated with mammary tumorigenesis in Brca1 conditional knockout mice
S. Brodie, Xiao-Ling Xu, W. Qiao, Wen-Mei Li +2 more
2001Oncogene198 citations Open access
Semantic Scholar
Impaired meiotic DNA-damage repair and lack of crossing-over during spermatogenesis in BRCA1 full-length isoform deficient mice
Xiao-Ling Xu, O. Aprelikova, P. Moens, Chu-Xia Deng +1 more
2003Development173 citations Open access
Semantic Scholar
A Ser(365)-->Cys mutation of fibroblast growth factor receptor 3 in mouse downregulates Ihh/PTHrP signals and causes severe achondroplasia.
Lin Chen, Cui-ling Li, W. Qiao, Xiao-Ling Xu +1 more
2001Human Molecular Genetics164 citations
Semantic Scholar
Progression of Chronic Liver Inflammation and Fibrosis Driven by Activation of c-JUN Signaling in Sirt6 Mutant Mice*
C. Xiao, Rui-Hong Wang, T. Lahusen, Ogyi Park +9 more
2012Journal of Biological Chemistry160 citations Open access
Semantic Scholar
Mammary tumors in mice conditionally mutant for Brca1 exhibit gross genomic instability and centrosome amplification yet display a recurring distribution of genomic imbalances that is similar to human breast cancer
Z. Weaver, C. Montagna, Xiao-Ling Xu, T. Howard +4 more
2002Oncogene159 citations
Semantic Scholar
Senataxin Plays an Essential Role with DNA Damage Response Proteins in Meiotic Recombination and Gene Silencing
O. Bécherel, A. Yeo, Alissa Stellati, E. Y. H. Heng +9 more
2013PLoS Genetics154 citations Open access
Semantic Scholar
A Pro253Arg mutation in fibroblast growth factor receptor 2 (Fgfr2) causes skeleton malformation mimicking human Apert syndrome by affecting both chondrogenesis and osteogenesis.
L. Yin, Xiao-Lan Du, Cui-ling Li, Xiao-Ling Xu +10 more
2008Bone139 citations
Semantic Scholar
ATM–Chk2–p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency
Liu Cao, Sangsoo Kim, C. Xiao, Rui-Hong Wang +10 more
2006EMBO Journal138 citations Open access
Semantic Scholar
Cisplatin prevents breast cancer metastasis through blocking early EMT and retards cancer growth together with paclitaxel
Hai-Tao Wang, Sen Guo, Seung-Jin Kim, Fangyuan Shao +12 more
2021Theranostics127 citations Open access
Semantic Scholar
HBsAg and HBx knocked into the p21 locus causes hepatocellular carcinoma in mice
You-Liang Wang, Fang Cui, Yaxin Lv, Cuiling Li +8 more
2004Hepatology125 citations
Semantic Scholar
BRCA1 affects global DNA methylation through regulation of DNMT1
V. Shukla, X. Coumoul, T. Lahusen, Rui-Hong Wang +8 more
2010Cell Research111 citations Open access
Semantic Scholar
Squamous cell carcinoma and mammary abscess formation through squamous metaplasia in Smad4/Dpc4 conditional knockout mice
Wen-Mei Li, W. Qiao, Lin Chen, Xiao-Ling Xu +7 more
2003Development109 citations
Semantic Scholar
NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation
Kai Miao, J. Lei, Monica V. Valecha, Aiping Zhang +18 more
2020Nature Communications97 citations Open access
Semantic Scholar
Direct removal in the mouse of a floxed neo gene from a three‐loxp conditional knockout allele by two novel approaches
Xiao-Ling Xu, Cui-ling Li, L. Garrett-Beal, Denise Larson +2 more
2001Genesis97 citations
Semantic Scholar
BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis
Qiang Chen, J. Lei, Jiao-Lin Bao, Hai-Tao Wang +8 more
2020Advancement of science90 citations Open access
Semantic Scholar
Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics
Ren Ding, Ping Chen, Barani Kumar Rajendran, Xueying Lyu +19 more
2021Nature Communications79 citations Open access
Semantic Scholar
The Inhibition and Treatment of Breast Cancer with Poly (ADP-ribose) Polymerase (PARP-1) Inhibitors
J. D. de Soto, Xian-Yan Wang, Y. Tominaga, Rui-Hong Wang +8 more
2006International Journal on Biological Sciences78 citations Open access
Semantic Scholar
FGFR1 function at the earliest stages of mouse limb development plays an indispensable role in subsequent autopod morphogenesis
Cui-ling Li, Xiao-Ling Xu, D. Nelson, T. Williams +2 more
2005Development74 citations Open access
Semantic Scholar
S100A9-CXCL12 activation in BRCA1-mutant breast cancer promotes an immunosuppressive microenvironment associated with resistance to immunotherapy
Jianjie Li, Xiaodong Shu, Jun Xu, S. Su +18 more
2022Nature Communications73 citations Open access
Semantic Scholar
SIRT6 Is Essential for Adipocyte Differentiation by Regulating Mitotic Clonal Expansion
Qiang Chen, Wen-Hui Hao, C. Xiao, Rui-Hong Wang +4 more
2017Cell Reports72 citations Open access
Semantic Scholar
Fibroblast growth factor receptor 2 (Fgfr2) plays an important role in eyelid and skin formation and patterning
Cui-ling Li, Huiming Guo, Xiao-Ling Xu, W. Weinberg +1 more
2001Developmental Dynamics72 citations Open access
Semantic Scholar
Murine fibroblast growth factor receptor 1alpha isoforms mediate node regression and are essential for posterior mesoderm development.
Xiao-Ling Xu, Cui-ling Li, Katsu Takahashi, H. Slavkin +2 more
1999Developmental Biology66 citations Open access
Semantic Scholar
WEE1 inhibition targets cell cycle checkpoints for triple negative breast cancers to overcome cisplatin resistance
Hongping Zheng, Fangyuan Shao, S. Martin, Xiao-Ling Xu +1 more
2017Scientific Reports62 citations Open access
Semantic Scholar
Ammonium tetrathiomolybdate treatment targets the copper transporter ATP7A and enhances sensitivity of breast cancer to cisplatin
C. Chisholm, Hai-Tao Wang, A. Wong, Guelaguetza Vázquez-Ortíz +3 more
2016OncoTarget61 citations Open access
Semantic Scholar
Necroptosis in Niemann–Pick disease, type C1: a potential therapeutic target
A. Cougnoux, C. Cluzeau, S. Mitra, Rong Li +6 more
2016Cell Death and Disease57 citations Open access
Semantic Scholar
Absence of full-length Brca1 sensitizes mice to oxidative stress and carcinogen-induced tumorigenesis in the esophagus and forestomach.
Liu Cao, Xiao-Ling Xu, Long-Yue L. Cao, Rui-Hong Wang +3 more
2007Carcinogenesis55 citations
Semantic Scholar
Generation of Fgfr1 conditional knockout mice
Xiao-Ling Xu, W. Qiao, Cui-ling Li, Chu-Xia Deng
2002Genesis53 citations Open access
Semantic Scholar
Uterus Hyperplasia and Increased Carcinogen-Induced Tumorigenesis in Mice Carrying a Targeted Mutation of the Chk2 Phosphorylation Site in Brca1
S. Kim, Liu Cao, Cui-ling Li, Xiao-Ling Xu +3 more
2004Molecular and Cellular Biology52 citations Open access
Semantic Scholar
Synergistic action of Smad4 and Pten in suppressing pancreatic ductal adenocarcinoma formation in mice
Xiao-Ling Xu, B. Ehdaie, N. Ohara, T. Yoshino +1 more
2010Oncogene51 citations Open access
Semantic Scholar
SIRT1 Deacetylates TopBP1 and Modulates Intra-S-Phase Checkpoint and DNA Replication Origin Firing
Rui-Hong Wang, T. Lahusen, Qiang Chen, Xiao-Ling Xu +7 more
2014International Journal on Biological Sciences48 citations Open access
Semantic Scholar

Frequent co-authors

Invite them to SciRah by sharing their profile.

Chu-Xia Deng×42
Invite
Chu-Xia Deng — researcher profile on SciRah
Cui-ling Li×18
Invite
Cui-ling Li — researcher profile on SciRah
Rui-Hong Wang×17
Invite
Rui-Hong Wang — researcher profile on SciRah
C. Xiao×12
Invite
C. Xiao — researcher profile on SciRah

×10

Invite

Liu Cao — researcher profile on SciRah

Invite

T. Lahusen — researcher profile on SciRah

Invite

W. Qiao — researcher profile on SciRah

Invite

Qiang Chen — researcher profile on SciRah

Hyun-Seok Kim×6

Invite

Hyun-Seok Kim — researcher profile on SciRah

Invite

S. Brodie — researcher profile on SciRah

Invite

Kai Miao — researcher profile on SciRah

Invite

T. Ried — researcher profile on SciRah