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A. Nussenzweig · SciRah

Researcher profile · Semantic Scholar

A. Nussenzweig

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A. Nussenzweig — researcher profile on SciRah

h-index: 100
Works: 275
Citations: 41K

Most-cited papers

The multifaceted roles of PARP1 in DNA repair and chromatin remodelling
Arnab Ray Chaudhuri, A. Nussenzweig
2017Nature reviews. Molecular cell biology1,609 citations Open access
Semantic Scholar
Endogenous DNA Damage as a Source of Genomic Instability in Cancer
Anthony T. Tubbs, A. Nussenzweig
2017Cell1,297 citations Open access
Semantic Scholar
Replication Fork Stability Confers Chemoresistance in BRCA-deficient Cells
A. Chaudhuri, E. Callen, Xia Ding, E. Gogola +22 more
2016Nature889 citations Open access
Semantic Scholar
DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity
Rajat Gupta, Kumar Somyajit, Takeo Narita, Elina Maskey +8 more
2018Cell445 citations Open access
Semantic Scholar
The Energetics and Physiological Impact of Cohesin Extrusion
Laura Vian, A. Pękowska, Suhas S. P. Rao, Kyong-Rim Kieffer-Kwon +29 more
2018Cell433 citations Open access
Semantic Scholar
The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development
Ana Ortega-Molina, Isaac W. Boss, A. Canela, H. Pan +24 more
2015Nature Medicine411 citations Open access
Semantic Scholar
Human topoisomerases and their roles in genome stability and organization
Y. Pommier, A. Nussenzweig, S. Takeda, C. Austin
2022Nature reviews. Molecular cell biology391 citations Open access
Semantic Scholar
ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells
S. Yazinski, Valentine Comaills, R. Buisson, Marie-Michelle Genois +12 more
2017Genes & Development374 citations Open access
Semantic Scholar
Genome Organization Drives Chromosome Fragility
A. Canela, Yaakov Maman, Seolkyoung Jung, N. Wong +13 more
2017Cell369 citations Open access
Semantic Scholar
Replication fork reversal triggers fork degradation in BRCA2-defective cells
S. Mijic, Ralph Zellweger, Nagaraja Chappidi, Matteo Berti +7 more
2017Nature Communications358 citations Open access
Semantic Scholar
Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance
D. Zatreanu, H. Robinson, O. Alkhatib, M. Boursier +57 more
2021Nature Communications333 citations Open access
Semantic Scholar
DNA Breaks and End Resection Measured Genome-wide by End Sequencing
A. Canela, Sriram Sridharan, Nicholas Sciascia, Anthony T. Tubbs +3 more
2016Molecules and Cells265 citations Open access
Semantic Scholar
Neuronal enhancers are hotspots for DNA single-strand break repair
Wei Wu, Sarah E. Kargbo-Hill, W. Nathan, Jacob Paiano +21 more
2020Nature206 citations Open access
Semantic Scholar
Dual Roles of Poly(dA:dT) Tracts in Replication Initiation and Fork Collapse
Anthony T. Tubbs, Sriram Sridharan, Niek van Wietmarschen, Yaakov Maman +16 more
2018Cell189 citations Open access
Semantic Scholar
Repeat expansions confer WRN dependence in microsatellite-unstable cancers
Niek van Wietmarschen, Sriram Sridharan, W. Nathan, Anthony T. Tubbs +29 more
2020Nature177 citations Open access
Semantic Scholar
Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity
A. Canela, Yaakov Maman, Shar-yin N. Huang, G. Wutz +9 more
2019Molecules and Cells176 citations Open access
Semantic Scholar
ATR inhibition potentiates ionizing radiation‐induced interferon response via cytosolic nucleic acid‐sensing pathways
Xu Feng, Anthony T. Tubbs, Chun-Chao Zhang, Mengfan Tang +11 more
2020EMBO Journal128 citations Open access
Semantic Scholar
53BP1 Enforces Distinct Pre- and Post-Resection Blocks on Homologous Recombination
E. Callen, D. Zong, Wei Wu, N. Wong +16 more
2019Molecules and Cells117 citations Open access
Semantic Scholar
BRCA1 haploinsufficiency is masked by RNF168-mediated chromatin ubiquitylation
D. Zong, Salomé Adam, Yi-Fan Wang, H. Sasanuma +13 more
2019Molecules and Cells105 citations Open access
Semantic Scholar
ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis
Jacob Paiano, Wei Wu, Shintaro Yamada, Nicholas Sciascia +7 more
2019Nature Communications101 citations Open access
Semantic Scholar
BRCA1 ensures genome integrity by eliminating estrogen-induced pathological topoisomerase II–DNA complexes
H. Sasanuma, M. Tsuda, Suguru Morimoto, L. Saha +13 more
2018Proceedings of the National Academy of Sciences of the United States of America97 citations Open access
Semantic Scholar
Active DNA demethylation promotes cell fate specification and the DNA damage response
Dongpeng Wang, Wei Wu, E. Callen, R. Pavani +14 more
2022Science96 citations Open access
Semantic Scholar
BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance
Joseph Nacson, J. Krais, Andrea J. Bernhardy, Emma Clausen +16 more
2018Cell Reports91 citations Open access
Semantic Scholar
Efficacy of ATR inhibitors as single agents in Ewing sarcoma
Maria Nieto-Soler, Isabel Morgado-Palacin, V. Lafarga, E. Lecona +7 more
2016OncoTarget75 citations Open access
Semantic Scholar
Centromeres as universal hotspots of DNA breakage, driving RAD51-mediated recombination during quiescence
Xanita Saayman, Emily Graham, W. Nathan, A. Nussenzweig +1 more
2023Molecules and Cells64 citations Open access
Semantic Scholar
The threat of programmed DNA damage to neuronal genome integrity and plasticity
K. Caldecott, Michael E. Ward, A. Nussenzweig
2022Nature Genetics64 citations Open access
Semantic Scholar
Multiscale reorganization of the genome following DNA damage facilitates chromosome translocations via nuclear actin polymerization
Jennifer Zagelbaum, A. Schooley, Junfei Zhao, B. Schrank +7 more
2022Nature Structural & Molecular Biology63 citations Open access
Semantic Scholar
Targeting the kinase activities of ATR and ATM exhibits therapeutic potential in a mouse model of MLL-rearranged AML
Isabel Morgado-Palacin, Amanda M. Day, M. Murga, V. Lafarga +15 more
2016Science Signaling63 citations Open access
Semantic Scholar
CTCF is a barrier for 2C-like reprogramming
Teresa Olbrich, Maria Vega-Sendino, Desiree Tillo, Wei Wu +13 more
2021Nature Communications59 citations Open access
Semantic Scholar
BRCA1 mutational complementation induces synthetic viability
Joseph Nacson, D. Di Marcantonio, Yi-Fan Wang, Andrea J. Bernhardy +12 more
2020Molecules and Cells57 citations Open access
Semantic Scholar
RNA: a double-edged sword in genome maintenance
D. Zong, Philipp Oberdoerffer, Pedro J. Batista, A. Nussenzweig
2020Nature reviews genetics53 citations
Semantic Scholar
Diminished apoptotic priming and ATM signalling confer a survival advantage onto aged haematopoietic stem cells in response to DNA damage
P. Gutierrez-Martinez, L. Hogdal, Manavi Nagai, Miriama Krutá +6 more
2018Nature Cell Biology53 citations Open access
Semantic Scholar
Role of 53BP1 in end protection and DNA synthesis at DNA breaks
Jacob Paiano, Nicholas Zolnerowich, Wei Wu, R. Pavani +7 more
2021Genes & Development51 citations Open access
Semantic Scholar
S1-END-seq Reveals DNA Secondary Structures In Human Cells
Gabriel Matos-Rodrigues, Niek van Wietmarschen, Wei Wu, Veenu Tripathi +11 more
2022Molecules and Cells50 citations Open access
Semantic Scholar
FMN2 makes perinuclear actin to protect nuclei during confined migration and promote metastasis
Colleen T. Skau, Robert S. Fischer, P. Gurel, H. Thiam +8 more
2016Cell50 citations Open access
Semantic Scholar
53BP1 ablation rescues genomic instability in mice expressing ‘RING‐less’ BRCA1
Min-Xing Li, F. Cole, Dharm S Patel, Sarah M Misenko +10 more
2016EMBO Reports48 citations Open access
Semantic Scholar
END-seq: An Unbiased, High-Resolution, and Genome-Wide Approach to Map DNA Double-Strand Breaks and Resection in Human Cells.
N. Wong, Sam John, A. Nussenzweig, A. Canela
2020Methods in molecular biology47 citations
Semantic Scholar
Erratum: Replication fork stability confers chemoresistance in BRCA-deficient cells
A. Chaudhuri, E. Callen, Xia Ding, E. Gogola +22 more
2016Nature44 citations Open access
Semantic Scholar
Mechanisms driving chromosomal translocations: lost in time and space
D. Ramsden, A. Nussenzweig
2021Oncogene43 citations Open access
Semantic Scholar
RIF1 acts in DNA repair through phosphopeptide recognition of 53BP1
Dheva Setiaputra, Cristina Escribano-Díaz, J. Reinert, P. Sadana +7 more
2021bioRxiv40 citations Open access
Semantic Scholar
Suppressing proteasome mediated processing of topoisomerase II DNA-protein complexes preserves genome integrity
Nicholas Sciascia, Wei Wu, D. Zong, Yi-Lun Sun +7 more
2020eLife37 citations Open access
Semantic Scholar
A PTIP–PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex
L. Starnes, D. Su, Laura M Pikkupeura, B. Weinert +17 more
2016Genes & Development37 citations Open access
Semantic Scholar
Histone H2AX deficiency causes neurobehavioral deficits and impaired redox homeostasis
U. Weyemi, B. Paul, A. Snowman, Parthav Jailwala +3 more
2018Nature Communications33 citations Open access
Semantic Scholar
TP53 loss initiates chromosomal instability in fallopian tube epithelial cells
Daniel Bronder, A. Tighe, Darawalee Wangsa, D. Zong +13 more
2021Disease Models & Mechanisms31 citations Open access
Semantic Scholar
Dual histone methyl reader ZCWPW1 facilitates repair of meiotic double strand breaks in male mice
M. Mahgoub, Jacob Paiano, Melania Bruno, Wei Wu +6 more
2020eLife31 citations Open access
Semantic Scholar
The incidence of leukaemia in women with BRCA1 and BRCA2 mutations: an International Prospective Cohort Study
J. Iqbal, A. Nussenzweig, J. Lubiński, T. Byrski +7 more
2016British Journal of Cancer31 citations Open access
Semantic Scholar
Ectopic expression of RNF168 and 53BP1 increases mutagenic but not physiological non-homologous end joining
D. Zong, E. Callen, Gianluca Pegoraro, C. Lukas +2 more
2015Nucleic Acids Research30 citations Open access
Semantic Scholar
Lsh/HELLS is required for B lymphocyte development and immunoglobulin class switch recombination
Yafeng He, Jian-Ke Ren, Xiaoping Xu, Kai Ni +9 more
2020Proceedings of the National Academy of Sciences of the United States of America29 citations Open access
Semantic Scholar
The WRN helicase: resolving a new target in microsatellite unstable cancers.
Niek van Wietmarschen, W. Nathan, A. Nussenzweig
2021Current Opinion in Genetics and Development27 citations
Semantic Scholar
Comprehensive mapping of cell fates in microsatellite unstable cancer cells supports dual targeting of WRN and ATR
D. Zong, Natasha C. Koussa, James A Cornwell, Ajith V. Pankajam +5 more
2023Genes & Development25 citations Open access
Semantic Scholar

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