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J. Falke · SciRah

Researcher profile · Semantic Scholar

J. Falke

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J. Falke — researcher profile on SciRah

h-index: 62
Works: 177
Citations: 12K

Most-cited papers

Bacterial chemoreceptors: high-performance signaling in networked arrays.
G. L. Hazelbauer, J. Falke, J. Parkinson
2008TIBS -Trends in Biochemical Sciences. Regular ed625 citations Open access
Semantic Scholar
Evidence that opioids may have toll like receptor 4 and MD-2 effects
M. Hutchinson, Ying-Ning Zhang, M. Shridhar, J. H. Evans +17 more
2009Brain, behavior, and immunity528 citations Open access
Semantic Scholar
Signaling and sensory adaptation in Escherichia coli chemoreceptors: 2015 update
J. Parkinson, G. L. Hazelbauer, J. Falke
2015Trends in Microbiology407 citations Open access
Semantic Scholar
Single molecule diffusion of membrane-bound proteins: window into lipid contacts and bilayer dynamics.
J. Knight, Michael G. Lerner, Joan G Marcano-Velázquez, R. Pastor +1 more
2010Biophysical Journal165 citations Open access
Semantic Scholar
Ca2+ influx is an essential component of the positive-feedback loop that maintains leading-edge structure and activity in macrophages
J. H. Evans, J. Falke
2007Proceedings of the National Academy of Sciences of the United States of America157 citations Open access
Semantic Scholar
Specific translocation of protein kinase Calpha to the plasma membrane requires both Ca2+ and PIP2 recognition by its C2 domain.
J. H. Evans, D. Murray, C. Leslie, J. Falke
2005Molecular Biology of the Cell121 citations Open access
Semantic Scholar
Engineered Socket Study of Signaling through a 4-Helix Bundle: Evidence for a Yin-Yang Mechanism in the Kinase Control Module of the Aspartate Receptor
Kalin E. Swain, Miguel A. Gonzalez, J. Falke
2009Biochemistry109 citations Open access
Semantic Scholar
Single-molecule fluorescence studies of a PH domain: new insights into the membrane docking reaction.
J. Knight, J. Falke
2009Biophysical Journal104 citations Open access
Semantic Scholar
Structure of the conserved HAMP domain in an intact, membrane-bound chemoreceptor: a disulfide mapping study.
Kalin E. Swain, J. Falke
2007Biochemistry104 citations Open access
Semantic Scholar
Molecular Mechanism of an Oncogenic Mutation That Alters Membrane Targeting: Glu17Lys Modifies the PIP Lipid Specificity of the AKT1 PH Domain
K. Landgraf, Carissa Pilling, J. Falke
2008Biochemistry103 citations Open access
Semantic Scholar
Evidence that tricyclic small molecules may possess Toll-like receptor and MD-2 activity
Mark R. Hutchinson, L. Loram, Ying-Ning Zhang, M. Shridhar +10 more
2010Neuroscience101 citations Open access
Semantic Scholar
Mechanism of specific membrane targeting by C2 domains: localized pools of target lipids enhance Ca2+ affinity.
J. Corbin, J. H. Evans, K. Landgraf, J. Falke
2007Biochemistry101 citations Open access
Semantic Scholar
GRP1 pleckstrin homology domain: activation parameters and novel search mechanism for rare target lipid.
J. Corbin, R. Dirkx, J. Falke
2004Biochemistry87 citations Open access
Semantic Scholar
Use of site-directed cysteine and disulfide chemistry to probe protein structure and dynamics: applications to soluble and transmembrane receptors of bacterial chemotaxis.
Randal B. Bass, S. Butler, S. Chervitz, S. Gloor +1 more
2007Methods in Enzymology86 citations Open access
Semantic Scholar
New Insights into Bacterial Chemoreceptor Array Structure and Assembly from Electron Cryotomography
A. Briegel, M. Wong, H. L. Hodges, Catherine M. Oikonomou +7 more
2014Biochemistry83 citations Open access
Semantic Scholar
The 3.2 Å resolution structure of a Receptor:CheA:CheW signaling complex defines overlapping binding sites and key residue interactions within bacterial chemosensory arrays
Xiaoxiao Li, A. Fleetwood, Camille A. Bayas, A. Bilwes +4 more
2013Biochemistry79 citations Open access
Semantic Scholar
The Core Signaling Proteins of Bacterial Chemotaxis Assemble to Form an Ultrastable Complex
Annette H. Erbse, J. Falke
2009Biochemistry77 citations Open access
Semantic Scholar
Conserved glycine residues in the cytoplasmic domain of the aspartate receptor play essential roles in kinase coupling and on-off switching.
M. D. Coleman, Randal B. Bass, R. Mehan, J. Falke
2005Biochemistry72 citations Open access
Semantic Scholar
Lateral Diffusion of Peripheral Membrane Proteins on Supported Lipid Bilayers Is Controlled by the Additive Frictional Drags of 1) Bound Lipids and 2) Protein Domains Penetrating into the Bilayer Hydrocarbon Core
B. Ziemba, J. Falke
2013Chemistry and Physics of Lipids71 citations Open access
Semantic Scholar
Adaptation mechanism of the aspartate receptor: electrostatics of the adaptation subdomain play a key role in modulating kinase activity.
D. J. Starrett, J. Falke
2005Biochemistry70 citations Open access
Semantic Scholar
Regulation of PI3K by PKC and MARCKS: Single-Molecule Analysis of a Reconstituted Signaling Pathway.
B. Ziemba, J. Burke, G. Masson, Roger L. Williams +1 more
2016Biophysical Journal67 citations Open access
Semantic Scholar
Use of EPR power saturation to analyze the membrane-docking geometries of peripheral proteins: applications to C2 domains.
Nathan J Malmberg, J. Falke
2005Annual Review of Biophysics and Biomolecular Structure67 citations Open access
Semantic Scholar
Single-Molecule Study Reveals How Receptor and Ras Synergistically Activate PI3Kα and PIP3 Signaling
Thomas C. Buckles, B. Ziemba, G. Masson, Roger L. Williams +1 more
2017Biophysical Journal66 citations Open access
Semantic Scholar
Molecular Mechanism of Membrane Binding of the GRP1 PH Domain
Chun-Liang Lai, Anand Srivastava, Carissa Pilling, A. R. Chase +2 more
2013Journal of Molecular Biology64 citations Open access
Semantic Scholar
CheA Kinase of bacterial chemotaxis: chemical mapping of four essential docking sites.
Aaron S Miller, Susy C. Kohout, K. Gilman, J. Falke
2006Biochemistry62 citations Open access
Semantic Scholar
Membrane Docking Geometry and Target Lipid Stoichiometry of Membrane-Bound PKCα C2 Domain: A Combined Molecular Dynamics and Experimental Study
Chun-Liang Lai, K. Landgraf, G. Voth, J. Falke
2010Journal of Molecular Biology55 citations Open access
Semantic Scholar
Architecture and Signal Transduction Mechanism of the Bacterial Chemosensory Array: Progress, Controversies, and Challenges
J. Falke, Kene N. Piasta
2014Current Opinion in Structural Biology52 citations Open access
Semantic Scholar
The Piston Rises Again
J. Falke, Annette H. Erbse
2009Structure50 citations Open access
Semantic Scholar
Self-induced docking site of a deeply embedded peripheral membrane protein.
Simon Jaud, D. Tobias, J. Falke, S. White
2007Biophysical Journal49 citations Open access
Semantic Scholar
Effect of PIP2 Binding on the Membrane Docking Geometry of PKCα C2 Domain: An EPR Site-Directed Spin-Labeling and Relaxation Study
K. Landgraf, Nathan J Malmberg, J. Falke
2008Biochemistry47 citations Open access
Semantic Scholar
Defining a Key Receptor-CheA Kinase Contact and Elucidating Its Function in the Membrane-Bound Bacterial Chemosensory Array: A Disulfide Mapping and TAM-IDS Study
Kene N. Piasta, Caleb J Ulliman, P. Slivka, B. R. Crane +1 more
2013Biochemistry43 citations Open access
Semantic Scholar
Evidence that the adaptation region of the aspartate receptor is a dynamic four-helix bundle: cysteine and disulfide scanning studies.
S. E. Winston, R. Mehan, J. Falke
2005Biochemistry42 citations Open access
Semantic Scholar
Hydrophobic Contributions to the Membrane Docking of Synaptotagmin 7 C2A Domain: Mechanistic Contrast Between Isoforms 1 and 7
D. Brandt, M. Coffman, J. Falke, J. Knight
2012Biochemistry41 citations Open access
Semantic Scholar
Single-Molecule Studies Reveal a Hidden Key Step in the Activation Mechanism of Membrane-Bound Protein Kinase C-α
B. Ziemba, Jianing Li, K. Landgraf, J. Knight +2 more
2014Biochemistry39 citations Open access
Semantic Scholar
The PH Domain of PDK1 Exhibits a Novel, Phospho-Regulated Monomer-Dimer Equilibrium With Important Implications for Kinase Domain Activation: Single Molecule and Ensemble Studies
B. Ziemba, Carissa Pilling, V. Calleja, B. Larijani +1 more
2013Biochemistry35 citations Open access
Semantic Scholar
A PKC-MARCKS-PI3K regulatory module links Ca2+ and PIP3 signals at the leading edge of polarized macrophages
B. Ziemba, J. Falke
2018PLoS ONE34 citations Open access
Semantic Scholar
Interactions of Protein Kinase C-α C1A and C1B Domains with Membranes: A Combined Computational and Experimental Study
Jianing Li, B. Ziemba, J. Falke, G. A. Voth
2014Journal of the American Chemical Society30 citations Open access
Semantic Scholar
Assembly of Membrane-Bound Protein Complexes: Detection and Analysis by Single Molecule Diffusion
B. Ziemba, J. Knight, J. Falke
2012Biochemistry30 citations Open access
Semantic Scholar
Thermal Domain Motions of CheA Kinase in Solution: Disulfide Trapping Reveals the Motional Constraints Leading to Trans-autophosphorylation
S. Gloor, J. Falke
2009Biochemistry28 citations Open access
Semantic Scholar
Structure, Function and On-Off Switching of a Core Unit Contact between CheA Kinase and CheW Adaptor Protein in the Bacterial Chemosensory Array: A Disulfide Mapping and TAM-IDS Study
Andrew M. Natale, Jane Duplantis, Kene N. Piasta, J. Falke
2013Biochemistry27 citations Open access
Semantic Scholar
Membrane Docking Geometry of GRP1 PH Domain Bound to a Target Lipid Bilayer: An EPR Site-Directed Spin-Labeling and Relaxation Study
Huai-Chun Chen, B. Ziemba, K. Landgraf, J. Corbin +1 more
2012PLoS ONE27 citations Open access
Semantic Scholar
GRP1 PH Domain, Like AKT1 PH Domain, Possesses a Sentry Glutamate Residue Essential for Specific Targeting to Plasma Membrane PI(3,4,5)P3
Carissa Pilling, K. Landgraf, J. Falke
2011Biochemistry27 citations Open access
Semantic Scholar
Interplay between phosphoinositide lipids and calcium signals at the leading edge of chemotaxing ameboid cells
J. Falke, B. Ziemba
2014Chemistry and Physics of Lipids24 citations Open access
Semantic Scholar
Ca2+ activation of the cPLA2 C2 domain: ordered binding of two Ca2+ ions with positive cooperativity.
Nathan J Malmberg, S. Varma, E. Jakobsson, J. Falke
2004Biochemistry21 citations Open access
Semantic Scholar
Chemotaxis Receptor Complexes: From Signaling to Assembly
R. G. Endres, J. Falke, N. Wingreen
2007PLoS Comput. Biol.19 citations Open access
Semantic Scholar
The Isolated Bacterial Chemosensory Array Possesses Quasi- and Ultra-Stable Components: Functional Links between Array Stability, Cooperativity, and Order
P. Slivka, J. Falke
2012Biochemistry18 citations Open access
Semantic Scholar
Regulation of a Coupled MARCKS–PI3K Lipid Kinase Circuit by Calmodulin: Single-Molecule Analysis of a Membrane-Bound Signaling Module
B. Ziemba, G. H. Swisher, G. Masson, J. Burke +2 more
2016Biochemistry16 citations Open access
Semantic Scholar
Increasing and Decreasing the Ultrastability of Bacterial Chemotaxis Core Signaling Complexes by Modifying Protein−Protein Contacts
Kene N. Piasta, J. Falke
2014Biochemistry15 citations Open access
Semantic Scholar
Piston versus Scissors: Chemotaxis Receptors versus Sensor His-Kinase Receptors in Two-Component Signaling Pathways
J. Falke
2014Structure15 citations Open access
Semantic Scholar
Regulation of a Class III PI3K Lipid Kinase (VPS34 Complex II) by the Small G Protein Rab5A: Single Molecule Analysis Reveals a Dual Regulatory Mechanism.
Thomas C. Buckles, Y. Ohashi, S. Tremel, S. McLaughlin +5 more
2020Biophysical Journal13 citations Open access
Semantic Scholar

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G. Voth — researcher profile on SciRah