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D. Hruby · SciRah

Researcher profile · Semantic Scholar

D. Hruby

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D. Hruby — researcher profile on SciRah

h-index: 52
Works: 182
Citations: 8,245

Most-cited papers

Clinical features and management of human monkeypox: a retrospective observational study in the UK
Hugh Adler, S. Gould, P. Hine, L. Snell +135 more
2022Lancet. Infectious Diseases (Print)997 citations Open access
Semantic Scholar
Oral Tecovirimat for the Treatment of Smallpox
D. Grosenbach, Kady M. Honeychurch, E. Rose, J. Chinsangaram +6 more
2018New England Journal of Medicine309 citations Open access
Semantic Scholar
Severe eczema vaccinatum in a household contact of a smallpox vaccinee.
S. Vora, I. Damon, V. Fulginiti, S. Weber +25 more
2008Clinical Infectious Diseases208 citations
Semantic Scholar
An overview of tecovirimat for smallpox treatment and expanded anti-orthopoxvirus applications
Andrew T. Russo, D. Grosenbach, J. Chinsangaram, Kady M. Honeychurch +5 more
2020Expert Review of Anti-Infective Therapy176 citations Open access
Semantic Scholar
Nonhuman Primates Are Protected from Smallpox Virus or Monkeypox Virus Challenges by the Antiviral Drug ST-246
J. Huggins, A. Goff, Lisa E. Hensley, E. Mucker +12 more
2009Antimicrobial Agents and Chemotherapy166 citations Open access
Semantic Scholar
A Novel Inhibitor of Dengue Virus Replication That Targets the Capsid Protein
Chelsea M. Byrd, Dong-Cheng Dai, D. Grosenbach, Aklile Berhanu +13 more
2012Antimicrobial Agents and Chemotherapy145 citations Open access
Semantic Scholar
Identification of a Broad-Spectrum Arenavirus Entry Inhibitor
Ryan A. Larson, Dong-Cheng Dai, Virginia T Hosack, Ying Tan +3 more
2008Journal of Virology137 citations Open access
Semantic Scholar
ST-246 Antiviral Efficacy in a Nonhuman Primate Monkeypox Model: Determination of the Minimal Effective Dose and Human Dose Justification
R. Jordan, A. Goff, Annie M. Frimm, M. Corrado +14 more
2009Antimicrobial Agents and Chemotherapy129 citations Open access
Semantic Scholar
Synergistic Efficacy of the Combination of ST-246 with CMX001 against Orthopoxviruses
D. Quenelle, M. Prichard, Kathy Keith, D. Hruby +4 more
2007Antimicrobial Agents and Chemotherapy126 citations Open access
Semantic Scholar
Development of ST-246® for Treatment of Poxvirus Infections
R. Jordan, J. Leeds, Shanthakumar R. Tyavanagimatt, D. Hruby
2010Viruses114 citations Open access
Semantic Scholar
ST-246 is a key antiviral to inhibit the viral F13L phospholipase, one of the essential proteins for orthopoxvirus wrapping
S. Duraffour, M. Lorenzo, Gudrun Zöller, D. Topalis +6 more
2015Journal of Antimicrobial Chemotherapy112 citations Open access
Semantic Scholar
Progressive vaccinia: case description and laboratory-guided therapy with vaccinia immune globulin, ST-246, and CMX001.
E. Lederman, W. Davidson, Harold L. Groff, Scott K. Smith +14 more
2012Journal of Infectious Diseases110 citations Open access
Semantic Scholar
Efficacy of the antipoxvirus compound ST-246 for treatment of severe orthopoxvirus infection.
E. Sbrana, R. Jordan, D. Hruby, Rosa I Mateo +5 more
2007American Journal of Tropical Medicine and Hygiene104 citations Open access
Semantic Scholar
Vaccination of BALB/c Mice with Escherichia coli-Expressed Vaccinia Virus Proteins A27L, B5R, and D8L Protects Mice from Lethal Vaccinia Virus Challenge
Aklile Berhanu, Rebecca L. Wilson, Dana L Kirkwood-Watts, David S. King +10 more
2008Journal of Virology102 citations Open access
Semantic Scholar
Treatment with the Smallpox Antiviral Tecovirimat (ST-246) Alone or in Combination with ACAM2000 Vaccination Is Effective as a Postsymptomatic Therapy for Monkeypox Virus Infection
Aklile Berhanu, J. Prigge, P. Silvera, Kady M. Honeychurch +2 more
2015Antimicrobial Agents and Chemotherapy97 citations Open access
Semantic Scholar
Evaluation of Lassa Antiviral Compound ST-193 in a Guinea Pig Model
Kathleen A. Cashman, M. Smith, N. Twenhafel, Ryan A. Larson +9 more
2011Antiviral Research95 citations Open access
Semantic Scholar
Development of the small-molecule antiviral ST-246® as a smallpox therapeutic
D. Grosenbach, R. Jordan, D. Hruby
2011Future Virology93 citations Open access
Semantic Scholar
Effects of Treatment Delay on Efficacy of Tecovirimat Following Lethal Aerosol Monkeypox Virus Challenge in Cynomolgus Macaques
Andrew T. Russo, D. Grosenbach, T. Brasel, R. Baker +7 more
2018Journal of Infectious Diseases91 citations Open access
Semantic Scholar
Efficacy of Tecovirimat (ST-246) in Nonhuman Primates Infected with Variola Virus (Smallpox)
E. Mucker, A. Goff, Joshua D. Shamblin, D. Grosenbach +9 more
2013Antimicrobial Agents and Chemotherapy91 citations Open access
Semantic Scholar
Effective Antiviral Treatment of Systemic Orthopoxvirus Disease: ST-246 Treatment of Prairie Dogs Infected with Monkeypox Virus
Scott K. Smith, Joshua S. Self, Sonja Weiss, D. Carroll +6 more
2011Journal of Virology91 citations Open access
Semantic Scholar
Co-administration of Tecovirimat and ACAM2000™ in Non-human Primates: Effect of Tecovirimat Treatment on ACAM2000 Immunogenicity and Efficacy Versus Lethal Monkeypox Virus Challenge.
Andrew T. Russo, Aklile Berhanu, C. Bigger, J. Prigge +3 more
2019Vaccine90 citations Open access
Semantic Scholar
Novel Benzoxazole Inhibitor of Dengue Virus Replication That Targets the NS3 Helicase
Chelsea M. Byrd, D. Grosenbach, Aklile Berhanu, Dong-Cheng Dai +15 more
2013Antimicrobial Agents and Chemotherapy88 citations Open access
Semantic Scholar
Listeria monocytogenes 10403S HtrA Is Necessary for Resistance to Cellular Stress and Virulence
Rebecca L. Wilson, Lindsay L Brown, Dana L Kirkwood-Watts, Travis K. Warren +4 more
2006Infection and Immunity86 citations Open access
Semantic Scholar
In Vitro Efficacy of ST246 against Smallpox and Monkeypox
Scott K. Smith, V. Olson, K. Karem, R. Jordan +2 more
2008Antimicrobial Agents and Chemotherapy83 citations Open access
Semantic Scholar
Activity of the Anti-Orthopoxvirus Compound ST-246 against Vaccinia, Cowpox and Camelpox Viruses in Cell Monolayers and Organotypic Raft Cultures
S. Duraffour, R. Snoeck, R. de Vos, J. van den Oord +6 more
2007Antiviral Therapy83 citations Open access
Semantic Scholar
Tecovirimat is effective against human Monkeypox virus in vitro at nanomolar concentrations
Gaelle Frénois-Veyrat, F. Gallardo, Olivier Gorgé, E. Marcheteau +14 more
2022Nature Microbiology79 citations Open access
Semantic Scholar
Evaluation of orally delivered ST-246 as postexposure prophylactic and antiviral therapeutic in an aerosolized rabbitpox rabbit model.
Aysegul Nalca, J. Hatkin, N. Garza, D. Nichols +3 more
2008Antiviral Research78 citations
Semantic Scholar
Single-Dose Safety and Pharmacokinetics of ST-246, a Novel Orthopoxvirus Egress Inhibitor
R. Jordan, D. Tien, T. Bolken, Kevin F. Jones +6 more
2008Antimicrobial Agents and Chemotherapy70 citations Open access
Semantic Scholar
Vaccinia virus p37 interacts with host proteins associated with LE-derived transport vesicle biogenesis
Yali Chen, Kady M. Honeychurch, Guang Yang, Chelsea M. Byrd +3 more
2009Virology Journal66 citations Open access
Semantic Scholar
N-(3,3a,4,4a,5,5a,6,6a-Octahydro-1,3-dioxo-4,6- ethenocycloprop[f]isoindol-2-(1H)-yl)carboxamides: Identification of novel orthopoxvirus egress inhibitors.
T. R. Bailey, Susan R. Rippin, Elizabeth A. Opsitnick, C. Burns +12 more
2007Journal of Medicinal Chemistry62 citations Open access
Semantic Scholar
Efficacy of ST-246 versus lethal poxvirus challenge in immunodeficient mice
D. Grosenbach, Aklile Berhanu, David S. King, S. Mosier +4 more
2009Proceedings of the National Academy of Sciences of the United States of America58 citations Open access
Semantic Scholar
ST-246 Inhibits In Vivo Poxvirus Dissemination, Virus Shedding, and Systemic Disease Manifestation
Aklile Berhanu, David S. King, S. Mosier, Robert H. Jordan +3 more
2009Antimicrobial Agents and Chemotherapy55 citations Open access
Semantic Scholar
Discovery of small molecule inhibitors of ubiquitin-like poxvirus proteinase I7L using homology modeling and covalent docking approaches
V. Katritch, Chelsea M. Byrd, V. Tseitin, Dong-Cheng Dai +5 more
2007J. Comput. Aided Mol. Des.53 citations Open access
Semantic Scholar
Safety and Pharmacokinetics of the Anti-Orthopoxvirus Compound ST-246 following a Single Daily Oral Dose for 14 Days in Human Volunteers
J. Chinsangaram, Kady M. Honeychurch, Shanthakumar R. Tyavanagimatt, J. Leeds +13 more
2012Antimicrobial Agents and Chemotherapy52 citations Open access
Semantic Scholar
Evaluation of disease and viral biomarkers as triggers for therapeutic intervention in respiratory mousepox - an animal model of smallpox
S. Parker, N. Chen, Scott Foster, H. Hartzler +9 more
2012Antiviral Research52 citations Open access
Semantic Scholar
The Vaccinia Virus F13L YPPL Motif Is Required for Efficient Release of Extracellular Enveloped Virus
Kady M. Honeychurch, Guang Yang, R. Jordan, D. Hruby
2007Journal of Virology52 citations Open access
Semantic Scholar
Safety and Pharmacokinetics of the Antiorthopoxvirus Compound ST-246 following Repeat Oral Dosing in Healthy Adult Subjects
R. Jordan, J. Chinsangaram, T. Bolken, Shanthakumar R. Tyavanagimatt +9 more
2010Antimicrobial Agents and Chemotherapy49 citations Open access
Semantic Scholar
SAR analysis of a series of acylthiourea derivatives possessing broad-spectrum antiviral activity.
James R. Burgeson, Amy L. Moore, J. Boutilier, N. Cerruti +7 more
2012Bioorganic & Medicinal Chemistry Letters45 citations
Semantic Scholar
Vaccinia virus proteolysis—a review
Chelsea M. Byrd, D. Hruby
2006Reviews in Medical Virology37 citations Open access
Semantic Scholar
Immune responses to the smallpox vaccine given in combination with ST-246, a small-molecule inhibitor of poxvirus dissemination
D. Grosenbach, R. Jordan, David S. King, Aklile Berhanu +7 more
2007Vaccine34 citations Open access
Semantic Scholar
Discovery and optimization of potent broad-spectrum arenavirus inhibitors derived from benzimidazole.
Dong-Cheng Dai, James R. Burgeson, Dima N Gharaibeh, Amy L. Moore +5 more
2013Bioorganic & Medicinal Chemistry Letters31 citations
Semantic Scholar
Specific Targeting of the F13L Protein by St-246 Affects Orthopoxvirus Production Differently
S. Duraffour, S. Vigne, K. Vermeire, A. Garcel +9 more
2008Antiviral Therapy27 citations Open access
Semantic Scholar
Smallpox antiviral drug development: satisfying the animal efficacy rule
R. Jordan, D. Hruby
2006Expert Review of Anti-Infective Therapy27 citations Open access
Semantic Scholar
Deletion of the vaccinia virus F13L gene results in a highly attenuated virus that mounts a protective immune response against subsequent vaccinia virus challenge.
I. Vliegen, Guang Yang, D. Hruby, R. Jordan +1 more
2012Antiviral Research26 citations
Semantic Scholar
A trans-Golgi Network Resident Protein, golgin-97, Accumulates in Viral Factories and Incorporates into Virions during Poxvirus Infection
D. Alzhanova, D. Hruby
2006Journal of Virology24 citations Open access
Semantic Scholar
Comparison of the Safety and Pharmacokinetics of ST-246® after IV Infusion or Oral Administration in Mice, Rabbits and Monkeys
Yali Chen, A. Amantana, Shanthakumar R. Tyavanagimatt, Daniela Zima +17 more
2011PLoS ONE22 citations Open access
Semantic Scholar
Impact of ST-246® on ACAM2000™ smallpox vaccine reactogenicity, immunogenicity, and protective efficacy in immunodeficient mice
Aklile Berhanu, David S. King, S. Mosier, R. Jordan +3 more
2010Vaccine22 citations Open access
Semantic Scholar
Overview of the regulatory approval of tecovirimat intravenous formulation for treatment of smallpox: potential impact on smallpox outbreak response capabilities, and future tecovirimat development potential
Andrew T. Russo, D. Grosenbach, Kady M. Honeychurch, Paul G. Long +1 more
2023Expert Review of Anti-Infective Therapy21 citations Open access
Semantic Scholar
Lead optimization of an acylhydrazone scaffold possessing antiviral activity against Lassa virus
James R. Burgeson, Dima N Gharaibeh, Amy L. Moore, Ryan A. Larson +4 more
2013Bioorganic & Medicinal Chemistry Letters21 citations Open access
Semantic Scholar
Pharmacokinetic and Pharmacodynamic Modeling To Determine the Dose of ST-246 To Protect against Smallpox in Humans
J. Leeds, F. Fenneteau, Nathalie H. Gosselin, M. Mouksassi +10 more
2012Antimicrobial Agents and Chemotherapy21 citations Open access
Semantic Scholar

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Kevin F. Jones×13
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Shanthakumar R. Tyavanagimatt

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