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Shanthakumar R. Tyavanagimatt · SciRah

Researcher profile · Semantic Scholar

Shanthakumar R. Tyavanagimatt

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Shanthakumar R. Tyavanagimatt — researcher profile on SciRah

h-index: 16
Works: 22
Citations: 1,079

Most-cited papers

A Novel Inhibitor of Dengue Virus Replication That Targets the Capsid Protein
Chelsea M. Byrd, Dong-Cheng Dai, D. Grosenbach, Aklile Berhanu +13 more
2012Antimicrobial Agents and Chemotherapy145 citations Open access
Semantic Scholar
ST-246 Antiviral Efficacy in a Nonhuman Primate Monkeypox Model: Determination of the Minimal Effective Dose and Human Dose Justification
R. Jordan, A. Goff, Annie M. Frimm, M. Corrado +14 more
2009Antimicrobial Agents and Chemotherapy129 citations Open access
Semantic Scholar
Development of ST-246® for Treatment of Poxvirus Infections
R. Jordan, J. Leeds, Shanthakumar R. Tyavanagimatt, D. Hruby
2010Viruses114 citations Open access
Semantic Scholar
Pacritinib is a potent ACVR1 inhibitor with significant anemia benefit in patients with myelofibrosis
Stephen T. Oh, R. Mesa, C. Harrison, P. Bose +14 more
2022Blood Advances94 citations Open access
Semantic Scholar
Determining the recommended dose of pacritinib: results from the PAC203 dose-finding trial in advanced myelofibrosis.
A. Gerds, M. Savona, B. Scott, M. Talpaz +22 more
2020Blood Advances91 citations Open access
Semantic Scholar
Novel Benzoxazole Inhibitor of Dengue Virus Replication That Targets the NS3 Helicase
Chelsea M. Byrd, D. Grosenbach, Aklile Berhanu, Dong-Cheng Dai +15 more
2013Antimicrobial Agents and Chemotherapy88 citations Open access
Semantic Scholar
Single-Dose Safety and Pharmacokinetics of ST-246, a Novel Orthopoxvirus Egress Inhibitor
R. Jordan, D. Tien, T. Bolken, Kevin F. Jones +6 more
2008Antimicrobial Agents and Chemotherapy70 citations Open access
Semantic Scholar
A potent Lassa virus antiviral targets an arenavirus virulence determinant
Ikenna G Madu, Megan A. Files, Dima N Gharaibeh, Amy L. Moore +10 more
2018PLoS Pathogens55 citations Open access
Semantic Scholar
Safety and Pharmacokinetics of the Anti-Orthopoxvirus Compound ST-246 following a Single Daily Oral Dose for 14 Days in Human Volunteers
J. Chinsangaram, Kady M. Honeychurch, Shanthakumar R. Tyavanagimatt, J. Leeds +13 more
2012Antimicrobial Agents and Chemotherapy52 citations Open access
Semantic Scholar
Safety and Pharmacokinetics of the Antiorthopoxvirus Compound ST-246 following Repeat Oral Dosing in Healthy Adult Subjects
R. Jordan, J. Chinsangaram, T. Bolken, Shanthakumar R. Tyavanagimatt +9 more
2010Antimicrobial Agents and Chemotherapy49 citations Open access
Semantic Scholar
SAR analysis of a series of acylthiourea derivatives possessing broad-spectrum antiviral activity.
James R. Burgeson, Amy L. Moore, J. Boutilier, N. Cerruti +7 more
2012Bioorganic & Medicinal Chemistry Letters45 citations
Semantic Scholar
Immune responses to the smallpox vaccine given in combination with ST-246, a small-molecule inhibitor of poxvirus dissemination
D. Grosenbach, R. Jordan, David S. King, Aklile Berhanu +7 more
2007Vaccine34 citations Open access
Semantic Scholar
Results of PAC203: A Randomized Phase 2 Dose-Finding Study and Determination of the Recommended Dose of Pacritinib
A. Gerds, M. Savona, B. Scott, M. Talpaz +11 more
2019Blood25 citations Open access
Semantic Scholar
Comparison of the Safety and Pharmacokinetics of ST-246® after IV Infusion or Oral Administration in Mice, Rabbits and Monkeys
Yali Chen, A. Amantana, Shanthakumar R. Tyavanagimatt, Daniela Zima +17 more
2011PLoS ONE22 citations Open access
Semantic Scholar
Pharmacokinetic and Pharmacodynamic Modeling To Determine the Dose of ST-246 To Protect against Smallpox in Humans
J. Leeds, F. Fenneteau, Nathalie H. Gosselin, M. Mouksassi +10 more
2012Antimicrobial Agents and Chemotherapy21 citations Open access
Semantic Scholar
Pharmacokinetic Comparison of a Single Oral Dose of Polymorph Form I versus Form V Capsules of the Antiorthopoxvirus Compound ST-246 in Human Volunteers
J. Chinsangaram, Kady M. Honeychurch, Shanthakumar R. Tyavanagimatt, T. Bolken +10 more
2012Antimicrobial Agents and Chemotherapy19 citations Open access
Semantic Scholar
Pharmacokinetics and Interspecies Allometric Scaling of ST-246, an Oral Antiviral Therapeutic for Treatment of Orthopoxvirus Infection
A. Amantana, Yali Chen, Shanthakumar R. Tyavanagimatt, Kevin F. Jones +5 more
2013PLoS ONE15 citations Open access
Semantic Scholar
MPN-145 Retrospective Analysis of Anemia Benefit of Pacritinib From the PERSIST-2 Trial.
Stephen T. Oh, R. Mesa, C. Harrison, P. Bose +7 more
2022Clinical Lymphoma, Myeloma & Leukemia9 citations
Semantic Scholar
Identiﬁcation and Characterization of a Small Molecule Bcl-2 Functional Converter
P. R. Kopparapu, Martin C. Pearce, C. Löhr, C. Duong +5 more
3 citations
Semantic Scholar
Small Molecule Functional Converter of B-Cell Lymphoma-2 (Bcl-2) Suppresses Breast Cancer Lung Metastasis.
P. R. Kopparapu, C. Löhr, Martin C. Pearce, Shanthakumar R. Tyavanagimatt +2 more
2024ACS Pharmacology & Translational Science2 citations
Semantic Scholar
Plots of mean plasma concentration versus time profiles in beagle dogs, following repeat oral administrations of ST-246 by gavage at a dose of 30 mg/kg seven consecutive days.
A. Amantana, Yali Chen, Shanthakumar R. Tyavanagimatt, Kevin F. Jones +5 more
20130 citations Open access
Semantic Scholar
Safety and Pharmacokinetics of the Antiorthopoxvirus Compound ST-246 following Repeat Oral Dosing in Healthy Adult Subjects (cid:1)
R. Jordan, J. Chinsangaram, T. Bolken, Shanthakumar R. Tyavanagimatt +9 more
20100 citations
Semantic Scholar

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D. Hruby×15
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J. Chinsangaram

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