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R. Hargreaves · SciRah

Researcher profile · Semantic Scholar

R. Hargreaves

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R. Hargreaves — researcher profile on SciRah

h-index: 48
Works: 207
Citations: 8,089

Most-cited papers

Thalamic sensitization transforms localized pain into widespread allodynia
R. Burstein, M. Jakubowski, Esther Garcı́a-Nicas, V. Kainz +4 more
2010Annals of Neurology381 citations Open access
Semantic Scholar
Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice
N. B. Hastings, Xiaohai Wang, Li-Xin Song, B. D. Butts +23 more
2017Molecular Neurodegeneration152 citations Open access
Semantic Scholar
In Vivo Quantification of Calcitonin Gene-Related Peptide Receptor Occupancy by Telcagepant in Rhesus Monkey and Human Brain Using the Positron Emission Tomography Tracer [11C]MK-4232
E. Hostetler, Aniket D. Joshi, S. Sanabria-Bohórquez, H. Fan +29 more
2013Journal of Pharmacology and Experimental Therapeutics134 citations
Semantic Scholar
Biomarkers for chronic pain and analgesia. Part 1: the need, reality, challenges, and solutions.
D. Borsook, L. Becerra, R. Hargreaves
2011Discover medicine113 citations
Semantic Scholar
Calcitonin Gene‐Related Peptide Modulators – The History and Renaissance of a New Migraine Drug Class
R. Hargreaves, J. Olesen
2019Headache110 citations
Semantic Scholar
Lost but making progress—Where will new analgesic drugs come from?
D. Borsook, R. Hargreaves, C. Bountra, F. Porreca
2014Science Translational Medicine104 citations Open access
Semantic Scholar
Structure-dependent Impairment of Intracellular Apolipoprotein E4 Trafficking and Its Detrimental Effects Are Rescued by Small-molecule Structure Correctors*
J. Brodbeck, J. McGuire, Zhaoping Liu, A. Meyer-Franke +15 more
2011Journal of Biological Chemistry104 citations Open access
Semantic Scholar
Development of aprepitant, the first neurokinin‐1 receptor antagonist for the prevention of chemotherapy‐induced nausea and vomiting
R. Hargreaves, J. Ferreira, D. Hughes, J. Brands +3 more
2011Annals of the New York Academy of Sciences97 citations
Semantic Scholar
Dual In Vivo Quantification of Integrin-targeted and Protease-activated Agents in Cancer Using Fluorescence Molecular Tomography (FMT)
S. Kossodo, M. Pickarski, Shu-An Lin, Alexa Gleason +16 more
2010Molecular Imaging and Biology94 citations
Semantic Scholar
Excitatory neurotransmitters in brain regions in interictal migraine patients
A. Prescot, L. Becerra, G. Pendse, S. Tully +5 more
2009Molecular Pain90 citations Open access
Semantic Scholar
Widespread cell stress and mitochondrial dysfunction occur in patients with early Alzheimer’s disease
Ashwin V. Venkataraman, A. Mansur, G. Rizzo, Courtney A. Bishop +16 more
2022Science Translational Medicine81 citations Open access
Semantic Scholar
Correlation Between Arterial FDG Uptake and Biomarkers in Peripheral Artery Disease
Kelly S. Myers, J. Rudd, E. Hailman, J. Bolognese +6 more
2012JACC Cardiovascular Imaging69 citations Open access
Semantic Scholar
Imaging Drugs with and without Clinical Analgesic Efficacy
J. Upadhyay, Julie A. Anderson, A. Schwarz, Alexandre Coimbra +14 more
2011Neuropsychopharmacology68 citations Open access
Semantic Scholar
Biomarkers for chronic pain and analgesia. Part 2: how, where, and what to look for using functional imaging.
D. Borsook, L. Becerra, R. Hargreaves
2011Discover medicine68 citations
Semantic Scholar
Reducing Abuse Liability of GABAA/Benzodiazepine Ligands via Selective Partial Agonist Efficacy at α1 and α2/3 Subtypes
N. Ator, J. Atack, R. Hargreaves, H. Burns +1 more
2010Journal of Pharmacology and Experimental Therapeutics67 citations Open access
Semantic Scholar
In Vitro and in Vivo Properties of 3-tert-Butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABAA Receptor α5 Subtype-Selective Inverse Agonist
J. Atack, K. Maubach, K. Wafford, D. O'Connor +20 more
2009Journal of Pharmacology and Experimental Therapeutics67 citations
Semantic Scholar
Absorption, Metabolism, and Excretion, In Vitro Pharmacology, and Clinical Pharmacokinetics of Ozanimod, a Novel Sphingosine 1-Phosphate Receptor Modulator
Sekhar Surapaneni, Usha Yerramilli, A. Bai, D. Dalvie +9 more
2021Drug Metabolism And Disposition66 citations Open access
Semantic Scholar
Lack of efficacy of L-759274, a novel neurokinin 1 (substance P) receptor antagonist, for the treatment of generalized anxiety disorder.
D. Michelson, R. Hargreaves, R. Alexander, Paulette Ceesay +3 more
2013International Journal of Neuropsychopharmacology62 citations Open access
Semantic Scholar
Translational PET imaging research.
R. Hargreaves, E. Rabiner
2014Neurobiology of Disease55 citations Open access
Semantic Scholar
Modulation of CNS pain circuitry by intravenous and sublingual doses of buprenorphine
J. Upadhyay, Julie W. Anderson, R. Baumgartner, Alexandre Coimbra +15 more
2012NeuroImage55 citations
Semantic Scholar
Equivalent Dynamic Human Brain NK1‐Receptor Occupancy Following Single‐Dose i.v. Fosaprepitant vs. Oral Aprepitant as Assessed by PET Imaging
K. van Laere, J. D. de Hoon, G. Bormans, M. Koole +18 more
2012Clinical pharmacology and therapy47 citations
Semantic Scholar
Synthesis, characterization, and monkey PET studies of [18F]MK‐1312, a PET tracer for quantification of mGluR1 receptor occupancy by MK‐5435
E. Hostetler, W. Eng, Aniket D. Joshi, S. Sanabria-Bohórquez +14 more
2011Synapse47 citations
Semantic Scholar
Can Functional Magnetic Resonance Imaging Improve Success Rates in CNS Drug Discovery?
D. Borsook, R. Hargreaves, L. Becerra
2011Expert Opinion on Drug Discovery46 citations Open access
Semantic Scholar
Decision-making using fMRI in clinical drug development: revisiting NK-1 receptor antagonists for pain.
D. Borsook, J. Upadhyay, M. Klimas, A. Schwarz +10 more
2012Drug Discovery Today45 citations
Semantic Scholar
Ex Vivo Imaging of Pancreatic Beta Cells using a Radiolabeled GLP-1 Receptor Agonist
Brett M. Connolly, Amy Vanko, P. Mcquade, I. Guenther +6 more
2012Molecular Imaging and Biology45 citations
Semantic Scholar
fMRI of pain processing in the brain: A within-animal comparative study of BOLD vs. CBV and noxious electrical vs. noxious mechanical stimulation in rat
Fuqiang Zhao, D. Welsh, Mangay Williams, Alexandre Coimbra +4 more
2012NeuroImage44 citations
Semantic Scholar
Parallel Buprenorphine phMRI Responses in Conscious Rodents and Healthy Human Subjects
L. Becerra, J. Upadhyay, Pei-Ching Chang, J. Bishop +14 more
2013Journal of Pharmacology and Experimental Therapeutics41 citations
Semantic Scholar
Benzodiazepine Binding Site Occupancy by the Novel GABAA Receptor Subtype-Selective Drug 7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in Rats, Primates, and Humans
J. Atack, D. Wong, T. Fryer, Christine Ryan +16 more
2010Journal of Pharmacology and Experimental Therapeutics41 citations
Semantic Scholar
Inverse agonist histamine H3 receptor PET tracers labelled with carbon‐11 or fluorine‐18
T. Hamill, Nagaaki Sato, Makoto Jitsuoka, S. Tokita +11 more
2009Synapse40 citations
Semantic Scholar
Effect of odanacatib on bone turnover markers, bone density and geometry of the spine and hip of ovariectomized monkeys: a head-to-head comparison with alendronate.
Donald S. Williams, P. McCracken, Mona Purcell, M. Pickarski +17 more
2013Bone38 citations Open access
Semantic Scholar
High-resolution peripheral quantitative computed tomography and finite element analysis of bone strength at the distal radius in ovariectomized adult rhesus monkey demonstrate efficacy of odanacatib and differentiation from alendronate.
A. Cabal, Richa Y. Jayakar, S. Sardesai, E. Phillips +15 more
2013Bone37 citations Open access
Semantic Scholar
Pain fMRI in rat cervical spinal cord: An echo planar imaging evaluation of sensitivity of BOLD and blood volume-weighted fMRI
Fuqiang Zhao, Mangay Williams, Xiangjun Meng, D. Welsh +3 more
2009NeuroImage34 citations
Semantic Scholar
Discovery of MK-3168: A PET Tracer for Imaging Brain Fatty Acid Amide Hydrolase.
Ping Liu, T. Hamill, M. Chioda, H. Chobanian +40 more
2013ACS Medicinal Chemistry Letters33 citations Open access
Semantic Scholar
Challenges in developing drugs for primary headaches
H. Schytz, R. Hargreaves, M. Ashina
2017Progress in neurobiology30 citations
Semantic Scholar
Synthesis, characterization, and monkey positron emission tomography (PET) studies of [18F]Y1-973, a PET tracer for the neuropeptide Y Y1 receptor
E. Hostetler, S. Sanabria-Bohórquez, H. Fan, Zhi-Zhen Zeng +15 more
2011NeuroImage30 citations
Semantic Scholar
A procedural framework for good imaging practice in pharmacological fMRI studies applied to drug development #1: processes and requirements.
A. Schwarz, L. Becerra, J. Upadhyay, Julie W. Anderson +9 more
2011Drug Discovery Today30 citations
Semantic Scholar
The synthesis and preclinical evaluation in rhesus monkey of [18F]MK‐6577 and [11C]CMPyPB glycine transporter 1 positron emission tomography radiotracers
T. Hamill, W. Eng, Andrew S. R. Jennings, Richard T. Lewis +14 more
2011Synapse30 citations
Semantic Scholar
Evaluation of high-resolution peripheral quantitative computed tomography, finite element analysis and biomechanical testing in a pre-clinical model of osteoporosis: a study with odanacatib treatment in the ovariectomized adult rhesus monkey.
Richa Y. Jayakar, A. Cabal, J. Szumiloski, S. Sardesai +10 more
2012Bone29 citations Open access
Semantic Scholar
A procedural framework for good imaging practice in pharmacological fMRI studies applied to drug development #2: protocol optimization and best practices.
A. Schwarz, L. Becerra, J. Upadhyay, Julie W. Anderson +9 more
2011Drug Discovery Today29 citations
Semantic Scholar
Comparison of the Vasoconstrictor Effects of the Calcitonin Gene-related Peptide Receptor Antagonist Telcagepant (MK-0974) and Zolmitriptan in Human Isolated Coronary Arteries
J. J. Lynch, C. Regan, L. Edvinsson, R. Hargreaves +1 more
2010Journal of Cardiovascular Pharmacology28 citations
Semantic Scholar
11C-MK-8278 PET as a Tool for Pharmacodynamic Brain Occupancy of Histamine 3 Receptor Inverse Agonists
K. van Laere, S. Sanabria-Bohórquez, D. P. Mozley, Donald H. Burns +13 more
2014Journal of Nuclear Medicine27 citations Open access
Semantic Scholar
[18F]Fluoroazabenzoxazoles as potential amyloid plaque PET tracers: synthesis and in vivo evaluation in rhesus monkey.
E. Hostetler, S. Sanabria-Bohórquez, H. Fan, Zhi-Zhen Zeng +12 more
2011Nuclear Medicine and Biology26 citations Open access
Semantic Scholar
Functional imaging of olfaction by CBV fMRI in monkeys: Insight into the role of olfactory bulb in habituation
Fuqiang Zhao, M. Holahan, A. Houghton, R. Hargreaves +3 more
2015NeuroImage25 citations
Semantic Scholar
Why Does Sleep Stop Migraine?
M. Bigal, R. Hargreaves
2013Current Pain and Headache Reports25 citations
Semantic Scholar
Improved characterization of BOLD responses for evoked sensory stimuli
J. Upadhyay, G. Pendse, Julie W. Anderson, A. Schwarz +11 more
2010NeuroImage25 citations
Semantic Scholar
[(11)C]MK-4232: The First Positron Emission Tomography Tracer for the Calcitonin Gene-Related Peptide Receptor.
I. M. Bell, S. N. Gallicchio, Craig A. Stump, Joseph G. Bruno +20 more
2013ACS Medicinal Chemistry Letters24 citations Open access
Semantic Scholar
Potent, brain-penetrant, hydroisoindoline-based human neurokinin-1 receptor antagonists.
Jin-Long Jiang, J. Bunda, G. A. Doss, G. Chicchi +18 more
2009Journal of Medicinal Chemistry24 citations Open access
Semantic Scholar
A Critical Evaluation of Validity and Utility of Translational Imaging in Pain and Analgesia: Utilizing Functional Imaging to Enhance the Process
J. Upadhyay, C. Geber, R. Hargreaves, F. Birklein +1 more
2017Neuroscience and Biobehavioral Reviews20 citations Open access
Semantic Scholar
Ten Years of Rizatriptan: From Development to Clinical Science and Future Directions
R. Hargreaves, Christopher R. Lines, Alan Rapoport, T. Ho +1 more
2009Headache20 citations
Semantic Scholar
Qualification of fMRI as a biomarker for pain in anesthetized rats by comparison with behavioral response in conscious rats
Fuqiang Zhao, Mangay Williams, M. Bowlby, A. Houghton +3 more
2014NeuroImage19 citations
Semantic Scholar

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