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G. Posner · SciRah

Researcher profile · Semantic Scholar

G. Posner

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G. Posner — researcher profile on SciRah

h-index: 58
Works: 466
Citations: 15K

Most-cited papers

Accumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependent
C. L. Hartwig, Andrew S. Rosenthal, John G. D'Angelo, Carol E. Griffin +2 more
2008Biochemical Pharmacology148 citations Open access
Semantic Scholar
Second generation, orally active, antimalarial, artemisinin-derived trioxane dimers with high stability, efficacy, and anticancer activity.
Ik-hyeon Paik, Su-Ji Xie, T. Shapiro, Tanzina Labonte +3 more
2006Journal of Medicinal Chemistry110 citations
Semantic Scholar
Antimalarial peroxides: advances in drug discovery and design
Rachel D. Slack, Alexander M. Jacobine, G. Posner
2012101 citations
Semantic Scholar
In Vitro Inhibition of Toxoplasma gondii by Four New Derivatives of Artemisinin
L. Jones-Brando, John G. D'Angelo, G. Posner, R. Yolken
2006Antimicrobial Agents and Chemotherapy98 citations Open access
Semantic Scholar
Effect of artemisinins and other endoperoxides on nitric oxide-related signaling pathway in RAW 264.7 mouse macrophage cells.
V. Konkimalla, M. Blunder, B. Korn, Shahid A Soomro +5 more
2008Nitric oxide90 citations Open access
Semantic Scholar
Artemisinin derivatives inhibit Toxoplasma gondii in vitro at multiple steps in the lytic cycle.
John G. D'Angelo, C. Bordón, G. Posner, R. Yolken +1 more
2009Journal of Antimicrobial Chemotherapy76 citations Open access
Semantic Scholar
Malaria-Infected Mice Are Cured by a Single Oral Dose of New Dimeric Trioxane Sulfones Which Are Also Selectively and Powerfully Cytotoxic to Cancer Cells
Andrew S. Rosenthal, Xiao-Chun Chen, Jun O. Liu, Diana C. West +3 more
2009Journal of Medicinal Chemistry70 citations Open access
Semantic Scholar
Thiazole, Oxadiazole, and Carboxamide Derivatives of Artemisinin are Highly Selective and Potent Inhibitors of Toxoplasma gondii
Christopher P. Hencken, L. Jones-Brando, C. Bordón, R. Stohler +4 more
2010Journal of Medicinal Chemistry64 citations Open access
Semantic Scholar
Synthetic Approaches to Vitamin D
H. Dai, G. Posner
201063 citations
Semantic Scholar
An Artemisinin-Derived Dimer Has Highly Potent Anti-Cytomegalovirus (CMV) and Anti-Cancer Activities
Ran He, Bryan T. Mott, Andrew S. Rosenthal, D. Genna +2 more
2011PLoS ONE59 citations Open access
Semantic Scholar
Malaria-infected mice are cured by a single dose of novel artemisinin derivatives.
G. Posner, Ik-hyeon Paik, Wonsuk Chang, Kristina Borstnik +3 more
2007Journal of Medicinal Chemistry58 citations Open access
Semantic Scholar
Biological mechanisms of action of novel C-10 non-acetal trioxane dimers in prostate cancer cell lines.
Adebusola A. Alagbala, Andrew J. Mcriner, Kristina Borstnik, Tanzina Labonte +4 more
2006Journal of Medicinal Chemistry58 citations Open access
Semantic Scholar
Artemisinin-Derived Dimers Have Greatly Improved Anti-Cytomegalovirus Activity Compared to Artemisinin Monomers
R. Arav-Boger, Ran He, C. Chiou, Jianyong Liu +5 more
2010PLoS ONE56 citations Open access
Semantic Scholar
In Vitro Combination of Anti-Cytomegalovirus Compounds Acting through Different Targets: Role of the Slope Parameter and Insights into Mechanisms of Action
Hongyi Cai, A. Kapoor, Ran He, Rajkumar Venkatadri +3 more
2013Antimicrobial Agents and Chemotherapy55 citations Open access
Semantic Scholar
Vitamin D analogues targeting CYP24 in chronic kidney disease.
G. Posner, C. Helvig, D. Cuerrier, Drew Collop +4 more
2010Journal of Steroid Biochemistry and Molecular Biology48 citations
Semantic Scholar
Apc(MIN) modulation of vitamin D secosteroid growth control.
Haibo Xu, G. Posner, M. Stevenson, F. Campbell
2010Carcinogenesis46 citations Open access
Semantic Scholar
Malaria-infected mice are cured by oral administration of new artemisinin derivatives.
G. Posner, Wonsuk Chang, Lindsey C. Hess, L. Woodard +15 more
2008Journal of Medicinal Chemistry46 citations
Semantic Scholar
Synthesis and Antimalarial Efficacy of Two-Carbon Linked, Artemisinin-Derived, Trioxane Dimers in Combination with Known Antimalarial Drugs
Bryan T. Mott, A. Tripathi, M. Siegler, C. Moore +2 more
2013Journal of Medicinal Chemistry44 citations Open access
Semantic Scholar
Cyanocuprates convert carboxylic acids directly into ketones.
D. Genna, G. Posner
2011Organic Letters44 citations
Semantic Scholar
A Thiazole Derivative of Artemisinin Moderately Reduces Toxoplasma gondii Cyst Burden in Infected Mice
Tracey L. Schultz, Christopher P. Hencken, L. Woodard, G. Posner +3 more
2014Journal of Parasitology40 citations
Semantic Scholar
Recombinant luciferase-expressing human cytomegalovirus (CMV) for evaluation of CMV inhibitors
Ran He, G. Sandford, G. Hayward, W. Burns +3 more
2011Virology Journal40 citations Open access
Semantic Scholar
Inhibition of Human Cytomegalovirus Replication by Artemisinins: Effects Mediated through Cell Cycle Modulation
Sujayita Roy, Ran He, A. Kapoor, M. Forman +3 more
2015Antimicrobial Agents and Chemotherapy38 citations Open access
Semantic Scholar
Anticancer activity of artemisinin-derived trioxanes
G. Posner, John G. D'Angelo, P. O'Neill, A. Mercer
200638 citations
Semantic Scholar
Three-Component, One-Flask Synthesis of Rhodanines (Thiazolidinones)
Alexander M. Jacobine, G. Posner
2011Journal of Organic Chemistry37 citations Open access
Semantic Scholar
Artemisinin-Derived Dimer Diphenyl Phosphate Is an Irreversible Inhibitor of Human Cytomegalovirus Replication
Ran He, Kyoungsook Park, Hongyi Cai, A. Kapoor +4 more
2012Antimicrobial Agents and Chemotherapy36 citations Open access
Semantic Scholar
Artemisinin-Derived Dimer Phosphate Esters as Potent Anti-Cytomegalovirus (Anti-CMV) and Anti-Cancer Agents: A Structure-Activity Study
Bryan T. Mott, Ran He, Xiao-Chun Chen, J. M. Fox +3 more
2013Bioorganic & Medicinal Chemistry32 citations Open access
Semantic Scholar
Unique and Highly Selective Anticytomegalovirus Activities of Artemisinin-Derived Dimer Diphenyl Phosphate Stem from Combination of Dimer Unit and a Diphenyl Phosphate Moiety
Ran He, M. Forman, Bryan T. Mott, Rajkumar Venkatadri +2 more
2013Antimicrobial Agents and Chemotherapy30 citations Open access
Semantic Scholar
Malaria-Infected Mice Live Until At Least Day 30 After A New Monomeric Trioxane Combined with Mefloquine Are Administered Together In A Single Low Oral Dose
L. Woodard, Wonsuk Chang, Xiao-Chun Chen, Jun O. Liu +2 more
2009Journal of Medicinal Chemistry30 citations Open access
Semantic Scholar
Artemisinin-derived dimer ART-838 potently inhibited human acute leukemias, persisted in vivo, and synergized with antileukemic drugs
J. M. Fox, James Moynihan, Bryan T. Mott, Jennifer R. Mazzone +8 more
2016OncoTarget29 citations Open access
Semantic Scholar
Malaria-Infected Mice are Completely Cured by One 6 mg/kg Oral Dose of a New Monomeric Trioxane Sulfide Combined with Mefloquine
Rachel D. Slack, Bryan T. Mott, L. Woodard, Abhai Triphati +5 more
2011Journal of Medicinal Chemistry28 citations Open access
Semantic Scholar
Asymmetric, Organocatalytic, Three-Step Synthesis of α-Hydroxy-(E)-β,γ-Unsaturated Esters
Lindsey C. Hess, G. Posner
2010Organic Letters24 citations Open access
Semantic Scholar
Vitamin D analogs as anti-carcinogenic agents.
E. Agoston, M. Hatcher, T. Kensler, G. Posner
2006Anti-Cancer Agents in Medicinal Chemistry23 citations
Semantic Scholar
Cyclopentanone ring expansion leading to functionalized delta-lactams: short synthesis of simple sedum alkaloids.
W. A. Maio, Sandra Sinishtaj, G. Posner
2007Organic Letters22 citations
Semantic Scholar
Antitumor Effects of Two Less-Calcemic Vitamin D Analogs (Paricalcitol and QW-1624F2-2) in Squamous Cell Carcinoma Cells
Adebusola A. Alagbala, Candace S. Johnson, D. Trump, G. Posner +1 more
2007Oncology22 citations
Semantic Scholar
A furoxan–amodiaquine hybrid as a potential therapeutic for three parasitic diseases
Bryan T. Mott, Ken Cheng, R. Guha, Valerie P. Kommer +10 more
2012MedChemComm21 citations Open access
Semantic Scholar
A single, low, oral dose of a 5-carbon-linked trioxane dimer orthoester plus mefloquine cures malaria-infected mice
D. K. Moon, A. Tripathi, D. Sullivan, M. Siegler +2 more
2010Bioorganic & Medicinal Chemistry Letters20 citations Open access
Semantic Scholar
Asymmetric, Organocatalytic, 3-Step Synthesis of γ-Hydroxy-(E)-α-β-Unsaturated Sulfones and Esters
Kimberly S. Petersen, G. Posner
2008Organic Letters20 citations Open access
Semantic Scholar
Antimalarial Chemotherapy: Artemisinin-Derived Dimer Carbonates and Thiocarbonates
Jennifer R. Mazzone, Ryan C. Conyers, A. Tripathi, D. Sullivan +1 more
2014Bioorganic & Medicinal Chemistry Letters19 citations Open access
Semantic Scholar
A 24-Phenylsulfone Analog of Vitamin D Inhibits 1α,25-Dihydroxyvitamin D3 Degradation in Vitamin D Metabolism-Competent Cells
D. Lechner, T. Manhardt, E. Bajna, G. Posner +1 more
2007Journal of Pharmacology and Experimental Therapeutics19 citations
Semantic Scholar
Artemisinins target the intermediate filament protein vimentin for human cytomegalovirus inhibition
Sujayita Roy, A. Kapoor, F. Zhu, Rupkatha Mukhopadhyay +5 more
2020Journal of Biological Chemistry17 citations Open access
Semantic Scholar
Differentiation-inducing potency of the seco-steroid JK-1624F2-2 can be increased by combination with an antioxidant and a p38MAPK inhibitor which upregulates the JNK pathway.
Jing Zhang, G. Posner, M. Danilenko, G. Studzinski
2007Journal of Steroid Biochemistry and Molecular Biology17 citations Open access
Semantic Scholar
Antiproliferative, low-calcemic, fluorinated sulfone analogs of 1alpha,25-dihydroxyvitamin D3: chemical synthesis and biological evaluation.
Aimee R. Usera, P. Dolan, T. Kensler, G. Posner
2007Bioorganic & Medicinal Chemistry17 citations Open access
Semantic Scholar
Ground state oxygen in synthesis of cyclic peroxides. Part 1: Benzo fused ketals
Junwon Kim, Hong-Bin Li, Andrew S. Rosenthal, Dongpei Sang +3 more
200617 citations
Semantic Scholar
Differential photoprotective effects of 1,25-dihydroxyvitamin D3 and a low calcaemic deltanoid
K. Dixon, V. B. Sequeira, S. Deo, Ritu Mohan +2 more
2012Photochemical and Photobiological Sciences16 citations Open access
Semantic Scholar
The Survival Times Of Malaria-Infected Mice Are Prolonged More By Several New Two-Carbon-Linked Artemisinin-Derived Dimer Carbamates Than By The Trioxane Antimalarial Drug Artemether
Ryan C. Conyers, Jennifer R. Mazzone, M. Siegler, A. Tripathi +3 more
2014Bioorganic & Medicinal Chemistry Letters15 citations Open access
Semantic Scholar
Malaria-Infected Mice Live Until At Least Day 30 After A New Artemisinin-Derived Thioacetal Thiocarbonate Combined with Mefloquine Are Administered Together In A Single, Low, Oral Dose
Alexander M. Jacobine, Jennifer R. Mazzone, Rachel D. Slack, A. Tripathi +2 more
2012Journal of Medicinal Chemistry15 citations Open access
Semantic Scholar
Copper and silicon mediated, HMPA-free, n+3 ring expansions for the construction of medium sized lactones and lactams: short synthesis of (+)-cis-lauthisan
G. Posner, M. Hatcher, W. A. Maio
201614 citations Open access
Semantic Scholar
Antimalarial chemotherapy: Orally curative artemisinin-derived trioxane dimer esters
Ryan C. Conyers, Jennifer R. Mazzone, A. Tripathi, D. Sullivan +1 more
2014Bioorganic & Medicinal Chemistry Letters14 citations Open access
Semantic Scholar
Inhibition of P-glycoprotein by two artemisinin derivatives
Babette Steglich, Anne Mahringer, Ying Li, G. Posner +2 more
2012Natural Products and Bioprospecting12 citations Open access
Semantic Scholar
α-Chloro-β,γ-ethylenic esters: enantiocontrolled synthesis and substitutions.
D. Genna, Christopher P. Hencken, M. Siegler, G. Posner
2010Organic Letters12 citations
Semantic Scholar

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